Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Asc-type amino acid transporter 1

Gene

Slc7a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

GO - Molecular functioni

  1. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. D-alanine transport Source: MGI
  2. D-serine transport Source: MGI
  3. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_323105. Basigin interactions.

Protein family/group databases

TCDBi2.A.3.8.13. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Asc-type amino acid transporter 1
Short name:
Asc-1
Alternative name(s):
D-serine transporter
Solute carrier family 7 member 10
Gene namesi
Name:Slc7a10
Synonyms:Asc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1858261. Slc7a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei394 – 41421HelicalSequence AnalysisAdd
BLAST
Transmembranei430 – 45021HelicalSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Asc-type amino acid transporter 1PRO_0000054277Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP63115.
PRIDEiP63115.

PTM databases

PhosphoSiteiP63115.

Expressioni

Tissue specificityi

Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine.1 Publication

Gene expression databases

BgeeiP63115.
ExpressionAtlasiP63115. baseline and differential.
GenevestigatoriP63115.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP63115.
SMRiP63115. Positions 45-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiP63115.
KOiK13782.
OMAiAFTNVAY.
PhylomeDBiP63115.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.

Sequencei

Sequence statusi: Complete.

P63115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRDSDMASH IQQPGGHGNP GPAPSPSPGP GPGPGASERV ALKKEIGLVS
60 70 80 90 100
ACTIIIGNII GSGIFISPKG VLEHSGSVGL ALFVWVLGGG VTALGSLCYA
110 120 130 140 150
ELGVAIPKSG GDYAYVTEIF GGLAGFLLLW SAVLIMYPTS LAVISMTFSN
160 170 180 190 200
YVLQPVFPNC IPPATASRVL SMACLMLLTW VNSSSVRWAT RIQVIFTGGK
210 220 230 240 250
LLALSLIITV GFVQIFQGHF EELRPTNAFA FWMTPSVGHL ALAFLQGSFA
260 270 280 290 300
FSGWNFLNYV TEELVDPRKN LPRAIFISIP LVTFVYTFTN VAYFTAMSPQ
310 320 330 340 350
ELLSSNAVAV TFGEKLLGYF SWVMPVSVAL STFGGINGYL FTSSRLCFSG
360 370 380 390 400
AREGHLPSFL AMIHVRRCTP IPALLVCCGA TAVIMLVGDT YTLINYVSFI
410 420 430 440 450
NYLCYGVTIL GLLVLRWRRP ALHRPIKVNL LVPVVYLVFW AFLLVFSFIS
460 470 480 490 500
EPMVCGVGII IILTGVPIFF LGVFWRSKPK CVHRFTESMT RWGQELCFVV
510 520 530
YPQGSLEEEE NGPMGQPSPL PITDKPLKTQ
Length:530
Mass (Da):57,549
Last modified:September 12, 2004 - v1
Checksum:i0C5A80BF922DB54D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026688 mRNA. Translation: BAA93617.1.
BC054765 mRNA. Translation: AAH54765.1.
AK005282 mRNA. Translation: BAB23930.1.
CCDSiCCDS21146.1.
RefSeqiNP_059090.3. NM_017394.4.
UniGeneiMm.35567.

Genome annotation databases

EnsembliENSMUST00000001854; ENSMUSP00000001854; ENSMUSG00000030495.
GeneIDi53896.
KEGGimmu:53896.
UCSCiuc009gjn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026688 mRNA. Translation: BAA93617.1.
BC054765 mRNA. Translation: AAH54765.1.
AK005282 mRNA. Translation: BAB23930.1.
CCDSiCCDS21146.1.
RefSeqiNP_059090.3. NM_017394.4.
UniGeneiMm.35567.

3D structure databases

ProteinModelPortaliP63115.
SMRiP63115. Positions 45-376.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.3.8.13. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiP63115.

Proteomic databases

PaxDbiP63115.
PRIDEiP63115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001854; ENSMUSP00000001854; ENSMUSG00000030495.
GeneIDi53896.
KEGGimmu:53896.
UCSCiuc009gjn.2. mouse.

Organism-specific databases

CTDi56301.
MGIiMGI:1858261. Slc7a10.

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiP63115.
KOiK13782.
OMAiAFTNVAY.
PhylomeDBiP63115.
TreeFamiTF313355.

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_323105. Basigin interactions.

Miscellaneous databases

NextBioi310795.
PROiP63115.
SOURCEiSearch...

Gene expression databases

BgeeiP63115.
ExpressionAtlasiP63115. baseline and differential.
GenevestigatoriP63115.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a Na+-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L- amino acids."
    Fukasawa Y., Segawa H., Kim J.Y., Chairoungdua A., Kim D.K., Matsuo H., Cha S.H., Endou H., Kanai Y.
    J. Biol. Chem. 275:9690-9698(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-530.
    Strain: C57BL/6J.
    Tissue: Cerebellum.

Entry informationi

Entry nameiAAA1_MOUSE
AccessioniPrimary (citable) accession number: P63115
Secondary accession number(s): Q9CW25, Q9JMH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 12, 2004
Last sequence update: September 12, 2004
Last modified: March 31, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.