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P63115

- AAA1_MOUSE

UniProt

P63115 - AAA1_MOUSE

Protein

Asc-type amino acid transporter 1

Gene

Slc7a10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.1 Publication

    GO - Molecular functioni

    1. neutral amino acid transmembrane transporter activity Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. D-alanine transport Source: MGI
    2. D-serine transport Source: MGI
    3. neutral amino acid transport Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_211508. Basigin interactions.

    Protein family/group databases

    TCDBi2.A.3.8.13. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Asc-type amino acid transporter 1
    Short name:
    Asc-1
    Alternative name(s):
    D-serine transporter
    Solute carrier family 7 member 10
    Gene namesi
    Name:Slc7a10
    Synonyms:Asc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1858261. Slc7a10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Asc-type amino acid transporter 1PRO_0000054277Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP63115.
    PRIDEiP63115.

    PTM databases

    PhosphoSiteiP63115.

    Expressioni

    Tissue specificityi

    Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiP63115.
    BgeeiP63115.
    GenevestigatoriP63115.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP63115.
    SMRiP63115. Positions 45-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei394 – 41421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei454 – 47421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00730000110280.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiP63115.
    KOiK13782.
    OMAiVPPYMAT.
    PhylomeDBiP63115.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P63115-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRDSDMASH IQQPGGHGNP GPAPSPSPGP GPGPGASERV ALKKEIGLVS    50
    ACTIIIGNII GSGIFISPKG VLEHSGSVGL ALFVWVLGGG VTALGSLCYA 100
    ELGVAIPKSG GDYAYVTEIF GGLAGFLLLW SAVLIMYPTS LAVISMTFSN 150
    YVLQPVFPNC IPPATASRVL SMACLMLLTW VNSSSVRWAT RIQVIFTGGK 200
    LLALSLIITV GFVQIFQGHF EELRPTNAFA FWMTPSVGHL ALAFLQGSFA 250
    FSGWNFLNYV TEELVDPRKN LPRAIFISIP LVTFVYTFTN VAYFTAMSPQ 300
    ELLSSNAVAV TFGEKLLGYF SWVMPVSVAL STFGGINGYL FTSSRLCFSG 350
    AREGHLPSFL AMIHVRRCTP IPALLVCCGA TAVIMLVGDT YTLINYVSFI 400
    NYLCYGVTIL GLLVLRWRRP ALHRPIKVNL LVPVVYLVFW AFLLVFSFIS 450
    EPMVCGVGII IILTGVPIFF LGVFWRSKPK CVHRFTESMT RWGQELCFVV 500
    YPQGSLEEEE NGPMGQPSPL PITDKPLKTQ 530
    Length:530
    Mass (Da):57,549
    Last modified:September 13, 2004 - v1
    Checksum:i0C5A80BF922DB54D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026688 mRNA. Translation: BAA93617.1.
    BC054765 mRNA. Translation: AAH54765.1.
    AK005282 mRNA. Translation: BAB23930.1.
    CCDSiCCDS21146.1.
    RefSeqiNP_059090.3. NM_017394.4.
    UniGeneiMm.35567.

    Genome annotation databases

    EnsembliENSMUST00000001854; ENSMUSP00000001854; ENSMUSG00000030495.
    GeneIDi53896.
    KEGGimmu:53896.
    UCSCiuc009gjn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026688 mRNA. Translation: BAA93617.1 .
    BC054765 mRNA. Translation: AAH54765.1 .
    AK005282 mRNA. Translation: BAB23930.1 .
    CCDSi CCDS21146.1.
    RefSeqi NP_059090.3. NM_017394.4.
    UniGenei Mm.35567.

    3D structure databases

    ProteinModelPortali P63115.
    SMRi P63115. Positions 45-376.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.3.8.13. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei P63115.

    Proteomic databases

    PaxDbi P63115.
    PRIDEi P63115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001854 ; ENSMUSP00000001854 ; ENSMUSG00000030495 .
    GeneIDi 53896.
    KEGGi mmu:53896.
    UCSCi uc009gjn.2. mouse.

    Organism-specific databases

    CTDi 56301.
    MGIi MGI:1858261. Slc7a10.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00730000110280.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi P63115.
    KOi K13782.
    OMAi VPPYMAT.
    PhylomeDBi P63115.
    TreeFami TF313355.

    Enzyme and pathway databases

    Reactomei REACT_211508. Basigin interactions.

    Miscellaneous databases

    NextBioi 310795.
    PROi P63115.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63115.
    Bgeei P63115.
    Genevestigatori P63115.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a Na+-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L- amino acids."
      Fukasawa Y., Segawa H., Kim J.Y., Chairoungdua A., Kim D.K., Matsuo H., Cha S.H., Endou H., Kanai Y.
      J. Biol. Chem. 275:9690-9698(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-530.
      Strain: C57BL/6J.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiAAA1_MOUSE
    AccessioniPrimary (citable) accession number: P63115
    Secondary accession number(s): Q9CW25, Q9JMH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3