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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Papio anubis (Olive baboon)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Chromosome 20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000527231 – 142Hemoglobin subunit alphaAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP63111

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP63111
SMRiP63111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119197
HOVERGENiHBG009709
OMAiDKFLCAV
OrthoDBiEOG091G0S0X

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P63111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSPDDKKH VKAAWGKVGE HAGEYGAEAL ERMFLSFPTT KTYFPHFDLS
60 70 80 90 100
HGSDQVNKHG KKVADALTLA VGHVDDMPQA LSKLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL AAHLPAEFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,567
Last modified:January 23, 2007 - v2
Checksum:i275F48E8363B1FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05289 Genomic DNA Translation: CAA28907.1
PIRiC27792
RefSeqiNP_001162287.1, NM_001168816.1
XP_003916331.1, XM_003916282.2
UniGeneiPan.11237

Genome annotation databases

EnsembliENSPANT00000042780; ENSPANP00000022220; ENSPANG00000033097
ENSPANT00000045971; ENSPANP00000035767; ENSPANG00000033555
GeneIDi100137279
101020792

Similar proteinsi

Entry informationi

Entry nameiHBA_PAPAN
AccessioniPrimary (citable) accession number: P63111
Secondary accession number(s): P01931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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