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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Camelus dromedarius (Dromedary) (Arabian camel)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)
Metal bindingi87 – 871Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiCamelus dromedarius (Dromedary) (Arabian camel)
Taxonomic identifieri9838 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaTylopodaCamelidaeCamelus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin subunit alphaPRO_0000052579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei7 – 71N6-succinyllysineBy similarity
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei11 – 111N6-succinyllysineBy similarity
Modified residuei16 – 161N6-acetyllysine; alternateBy similarity
Modified residuei16 – 161N6-succinyllysine; alternateBy similarity
Modified residuei24 – 241PhosphotyrosineBy similarity
Modified residuei40 – 401N6-succinyllysineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei108 – 1081PhosphothreonineBy similarity
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei134 – 1341PhosphothreonineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1714Combined sources
Turni18 – 203Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 426Combined sources
Helixi53 – 7018Combined sources
Helixi76 – 794Combined sources
Helixi81 – 899Combined sources
Helixi96 – 11217Combined sources
Turni114 – 1163Combined sources
Helixi119 – 13719Combined sources
Helixi138 – 1403Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GDJX-ray2.00A/C1-141[»]
ProteinModelPortaliP63106.
SMRiP63106. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63106.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSSKDKTNV KTAFGKIGGH AAEYGAEALE RMFLGFPTTK TYFPHFDLSH
60 70 80 90 100
GSAQVKAHGK KVGDALTKAA DHLDDLPSAL SALSDLHAHK LRVDPVNFKL
110 120 130 140
LSHCLLVTVA AHHPGDFTPS VHASLDKFLA NVSTVLTSKY R
Length:141
Mass (Da):15,172
Last modified:July 21, 1986 - v1
Checksum:i2E9DB0CF6B676E5C
GO

Sequence databases

PIRiB91685. HACMA.
RefSeqiXP_010989388.1. XM_010991086.1.
XP_010989389.1. XM_010991087.1.
XP_010998809.1. XM_011000507.1.

Genome annotation databases

GeneIDi105098414.
105098415.
105106729.

Cross-referencesi

Sequence databases

PIRiB91685. HACMA.
RefSeqiXP_010989388.1. XM_010991086.1.
XP_010989389.1. XM_010991087.1.
XP_010998809.1. XM_011000507.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3GDJX-ray2.00A/C1-141[»]
ProteinModelPortaliP63106.
SMRiP63106. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105098414.
105098415.
105106729.

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP63106.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Respiration at high altitudes, phosphate-protein interaction: the sequence of hemoglobins from guinea pig and dromedary."
    Braunitzer G., Schrank B., Stangl A., Wiesner H.
    Hoppe-Seyler's Z. Physiol. Chem. 360:1941-1946(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiHBA_CAMDR
AccessioniPrimary (citable) accession number: P63106
Secondary accession number(s): P01974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.