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Protein

Pleiotrophin

Gene

Ptn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotrophin
Short name:
PTN
Alternative name(s):
Heparin-binding brain mitogen
Short name:
HBBM
Heparin-binding growth factor 8
Short name:
HBGF-8
Heparin-binding growth-associated molecule
Short name:
HB-GAM
Heparin-binding neutrophic factor
Short name:
HBNF
Osteoblast-specific factor 1
Short name:
OSF-1
Gene namesi
Name:Ptn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97804. Ptn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Add
BLAST
Chaini33 – 168136PleiotrophinPRO_0000024660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 76By similarity
Disulfide bondi55 ↔ 85By similarity
Disulfide bondi62 ↔ 89By similarity
Disulfide bondi99 ↔ 131By similarity
Disulfide bondi109 ↔ 141By similarity

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP63089.
PaxDbiP63089.
PRIDEiP63089.

PTM databases

PhosphoSiteiP63089.

Expressioni

Tissue specificityi

Osteoblast and brain.2 Publications

Gene expression databases

BgeeiP63089.
CleanExiMM_PTN.
ExpressionAtlasiP63089. baseline and differential.
GenevisibleiP63089. MM.

Interactioni

Subunit structurei

Interacts with ALK and NEK6.By similarity

Protein-protein interaction databases

IntActiP63089. 2 interactions.
MINTiMINT-1605619.
STRINGi10090.ENSMUSP00000099073.

Structurei

3D structure databases

ProteinModelPortaliP63089.
SMRiP63089. Positions 45-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP63089.
KOiK16642.
OMAiRMQSQQY.
OrthoDBiEOG7B05G6.
PhylomeDBiP63089.
TreeFamiTF332376.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQQYQQQR RKFAAAFLAL IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAD CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,869
Last modified:September 13, 2004 - v1
Checksum:i2127DA167D2DD33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90225 mRNA. Translation: BAA14260.1.
S52357
, S52338, S52345, S52353 Genomic DNA. Translation: AAB24477.1.
AK011346 mRNA. Translation: BAB27557.1.
BC002064 mRNA. Translation: AAH02064.1.
BC061695 mRNA. Translation: AAH61695.1.
S88460 Genomic DNA. No translation available.
S88462 Genomic DNA. No translation available.
S88464 Genomic DNA. No translation available.
S88466 Genomic DNA. No translation available.
S88468 Genomic DNA. No translation available.
CCDSiCCDS20005.1.
PIRiA37087.
RefSeqiNP_032999.1. NM_008973.2.
XP_006505820.2. XM_006505757.2.
UniGeneiMm.279690.

Genome annotation databases

EnsembliENSMUST00000101534; ENSMUSP00000099073; ENSMUSG00000029838.
GeneIDi19242.
KEGGimmu:19242.
UCSCiuc009bja.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90225 mRNA. Translation: BAA14260.1.
S52357
, S52338, S52345, S52353 Genomic DNA. Translation: AAB24477.1.
AK011346 mRNA. Translation: BAB27557.1.
BC002064 mRNA. Translation: AAH02064.1.
BC061695 mRNA. Translation: AAH61695.1.
S88460 Genomic DNA. No translation available.
S88462 Genomic DNA. No translation available.
S88464 Genomic DNA. No translation available.
S88466 Genomic DNA. No translation available.
S88468 Genomic DNA. No translation available.
CCDSiCCDS20005.1.
PIRiA37087.
RefSeqiNP_032999.1. NM_008973.2.
XP_006505820.2. XM_006505757.2.
UniGeneiMm.279690.

3D structure databases

ProteinModelPortaliP63089.
SMRiP63089. Positions 45-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63089. 2 interactions.
MINTiMINT-1605619.
STRINGi10090.ENSMUSP00000099073.

PTM databases

PhosphoSiteiP63089.

Proteomic databases

MaxQBiP63089.
PaxDbiP63089.
PRIDEiP63089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101534; ENSMUSP00000099073; ENSMUSG00000029838.
GeneIDi19242.
KEGGimmu:19242.
UCSCiuc009bja.1. mouse.

Organism-specific databases

CTDi5764.
MGIiMGI:97804. Ptn.

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP63089.
KOiK16642.
OMAiRMQSQQY.
OrthoDBiEOG7B05G6.
PhylomeDBiP63089.
TreeFamiTF332376.

Miscellaneous databases

PROiP63089.
SOURCEiSearch...

Gene expression databases

BgeeiP63089.
CleanExiMM_PTN.
ExpressionAtlasiP63089. baseline and differential.
GenevisibleiP63089. MM.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues."
    Tezuka K.I., Takeshita S., Hakeda Y., Kumegawa M., Kikuno R., Hashimoto-Gotoh T.
    Biochem. Biophys. Res. Commun. 173:246-251(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Genomic organization of the mouse OSF-1 gene."
    Katoh K., Takeshita S., Sato M., Ito T., Amann E.
    DNA Cell Biol. 11:735-743(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland and Olfactory epithelium.
  5. "Similarity of the genomic structure between the two members in a new family of heparin-binding factors."
    Naito A., Yoshikura H., Iwamoto A.
    Biochem. Biophys. Res. Commun. 183:701-707(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5; 34-44; 92-102; 146-156 AND 165-168, GENOMIC ORGANIZATION.
  6. "Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
    Kretschmer P.J., Fairhurst J.L., Decker M.M., Chan C.P., Gluzman Y., Boehlen P., Kovesdi I.
    Growth Factors 5:99-114(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiPTN_MOUSE
AccessioniPrimary (citable) accession number: P63089
Secondary accession number(s): P20935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.