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Protein

Pleiotrophin

Gene

Ptn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotrophin
Short name:
PTN
Alternative name(s):
Heparin-binding brain mitogen
Short name:
HBBM
Heparin-binding growth factor 8
Short name:
HBGF-8
Heparin-binding growth-associated molecule
Short name:
HB-GAM
Heparin-binding neutrophic factor
Short name:
HBNF
Osteoblast-specific factor 1
Short name:
OSF-1
Gene namesi
Name:Ptn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97804 Ptn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Add BLAST32
ChainiPRO_000002466033 – 168PleiotrophinAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76By similarity
Disulfide bondi55 ↔ 85By similarity
Disulfide bondi62 ↔ 89By similarity
Disulfide bondi99 ↔ 131By similarity
Disulfide bondi109 ↔ 141By similarity

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP63089
PRIDEiP63089

PTM databases

PhosphoSitePlusiP63089

Expressioni

Tissue specificityi

Osteoblast and brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000029838
CleanExiMM_PTN
ExpressionAtlasiP63089 baseline and differential
GenevisibleiP63089 MM

Interactioni

Subunit structurei

Interacts with ALK and NEK6. Interacts with PTPRZ1 (probably via chondroitin sulfate groups).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP63089, 2 interactors
MINTiP63089
STRINGi10090.ENSMUSP00000099073

Structurei

3D structure databases

ProteinModelPortaliP63089
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 99Chondroitin sulfate bindingBy similarity8
Regioni123 – 131Chondroitin sulfate bindingBy similarity9
Regioni147 – 168Chondroitin sulfate A bindingBy similarityAdd BLAST22

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWNA Eukaryota
ENOG4111ZWP LUCA
GeneTreeiENSGT00390000007640
HOGENOMiHOG000231473
HOVERGENiHBG008317
InParanoidiP63089
KOiK16642
OMAiGEDICNS
OrthoDBiEOG091G0VCN
PhylomeDBiP63089
TreeFamiTF332376

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850 PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit
PRINTSiPR00269 PTNMIDKINE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592 PTN_MK_hepar_bd, 1 hit
SMARTiView protein in SMART
SM00193 PTN, 1 hit
SUPFAMiSSF57288 SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQQYQQQR RKFAAAFLAL IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAD CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,869
Last modified:September 13, 2004 - v1
Checksum:i2127DA167D2DD33D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90225 mRNA Translation: BAA14260.1
S52357
, S52338, S52345, S52353 Genomic DNA Translation: AAB24477.1
AK011346 mRNA Translation: BAB27557.1
BC002064 mRNA Translation: AAH02064.1
BC061695 mRNA Translation: AAH61695.1
S88460 Genomic DNA No translation available.
S88462 Genomic DNA No translation available.
S88464 Genomic DNA No translation available.
S88466 Genomic DNA No translation available.
S88468 Genomic DNA No translation available.
CCDSiCCDS20005.1
PIRiA37087
RefSeqiNP_032999.1, NM_008973.2
XP_006505820.2, XM_006505757.3
UniGeneiMm.279690

Genome annotation databases

EnsembliENSMUST00000101534; ENSMUSP00000099073; ENSMUSG00000029838
GeneIDi19242
KEGGimmu:19242
UCSCiuc009bja.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPTN_MOUSE
AccessioniPrimary (citable) accession number: P63089
Secondary accession number(s): P20935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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