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Protein

Mitogen-activated protein kinase 1

Gene

Mapk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation (By similarity).By similarity
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-183 and Tyr-185 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-27 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Binding sitei52InhibitorBy similarity1
Binding sitei106Inhibitor; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei112InhibitorBy similarity1
Active sitei147Proton acceptorPROSITE-ProRule annotation1
Binding sitei152InhibitorBy similarity1
Binding sitei164InhibitorBy similarity1
Binding sitei165InhibitorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: MGI
  • MAP kinase activity Source: MGI
  • phosphatase binding Source: MGI
  • phosphotyrosine binding Source: MGI
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: UniProtKB
  • RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • apoptotic process Source: UniProtKB-KW
  • B cell receptor signaling pathway Source: MGI
  • Bergmann glial cell differentiation Source: MGI
  • cardiac neural crest cell development involved in heart development Source: MGI
  • caveolin-mediated endocytosis Source: UniProtKB
  • cell cycle Source: UniProtKB-KW
  • cellular response to DNA damage stimulus Source: MGI
  • cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: MGI
  • cytosine metabolic process Source: MGI
  • ERBB signaling pathway Source: MGI
  • ERK1 and ERK2 cascade Source: MGI
  • face development Source: MGI
  • heart development Source: MGI
  • labyrinthine layer blood vessel development Source: MGI
  • lipopolysaccharide-mediated signaling pathway Source: MGI
  • long-term synaptic potentiation Source: MGI
  • lung morphogenesis Source: MGI
  • mammary gland epithelial cell proliferation Source: MGI
  • MAPK cascade Source: MGI
  • MAPK import into nucleus Source: Ensembl
  • negative regulation of cell differentiation Source: MGI
  • neural crest cell development Source: MGI
  • outer ear morphogenesis Source: MGI
  • peptidyl-serine phosphorylation Source: UniProtKB
  • peptidyl-threonine phosphorylation Source: UniProtKB
  • positive regulation of cell migration Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of peptidyl-threonine phosphorylation Source: MGI
  • positive regulation of telomerase activity Source: MGI
  • positive regulation of telomere capping Source: MGI
  • positive regulation of telomere maintenance via telomerase Source: MGI
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • positive regulation of translation Source: Ensembl
  • protein phosphorylation Source: MGI
  • regulation of cytoskeleton organization Source: UniProtKB
  • regulation of early endosome to late endosome transport Source: UniProtKB
  • regulation of Golgi inheritance Source: UniProtKB
  • regulation of ossification Source: MGI
  • regulation of protein stability Source: UniProtKB
  • regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • regulation of stress-activated MAPK cascade Source: UniProtKB
  • response to epidermal growth factor Source: UniProtKB
  • response to estrogen Source: Ensembl
  • response to exogenous dsRNA Source: MGI
  • response to lipopolysaccharide Source: MGI
  • response to toxic substance Source: Ensembl
  • sensory perception of pain Source: Ensembl
  • T cell receptor signaling pathway Source: MGI
  • thymus development Source: MGI
  • thyroid gland development Source: MGI
  • trachea formation Source: MGI
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 3474.
ReactomeiR-MMU-111995. phospho-PLA2 pathway.
R-MMU-112409. RAF-independent MAPK1/3 activation.
R-MMU-112411. MAPK1 (ERK2) activation.
R-MMU-1295596. Spry regulation of FGF signaling.
R-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-MMU-198753. ERK/MAPK targets.
R-MMU-202670. ERKs are inactivated.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-437239. Recycling pathway of L1.
R-MMU-442742. CREB phosphorylation through the activation of Ras.
R-MMU-444257. RSK activation.
R-MMU-445144. Signal transduction by L1.
R-MMU-450341. Activation of the AP-1 family of transcription factors.
R-MMU-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-5674135. MAP2K and MAPK activation.
R-MMU-5674499. Negative feedback regulation of MAPK pathway.
R-MMU-5675221. Negative regulation of MAPK pathway.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 1 (EC:2.7.11.24)
Short name:
MAP kinase 1
Short name:
MAPK 1
Alternative name(s):
ERT1
Extracellular signal-regulated kinase 2
Short name:
ERK-2
MAP kinase isoform p42
Short name:
p42-MAPK
Mitogen-activated protein kinase 2
Short name:
MAP kinase 2
Short name:
MAPK 2
Gene namesi
Name:Mapk1
Synonyms:Erk2, Mapk, Prkm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1346858. Mapk1.

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • caveola Source: UniProtKB
  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB
  • cytosol Source: UniProtKB
  • dendrite cytoplasm Source: Ensembl
  • early endosome Source: UniProtKB
  • extracellular exosome Source: MGI
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • late endosome Source: UniProtKB
  • microtubule cytoskeleton Source: MGI
  • microtubule organizing center Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
  • mitotic spindle Source: UniProtKB
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • perikaryon Source: Ensembl
  • protein complex Source: Ensembl
  • pseudopodium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001862482 – 358Mitogen-activated protein kinase 1Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei27Phosphoserine; by SGK1By similarity1
Modified residuei179PhosphothreonineBy similarity1
Modified residuei183Phosphothreonine; by MAP2K1 and MAP2K2Combined sources1 Publication1
Modified residuei185Phosphotyrosine; by MAP2K1 and MAP2K2Combined sources1 Publication1
Modified residuei188Phosphothreonine; by autocatalysisBy similarity1
Modified residuei244PhosphoserineBy similarity1
Modified residuei246PhosphoserineBy similarity1
Modified residuei282PhosphoserineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation (By similarity). Dephosphorylated by PTPRJ at Tyr-185 (By similarity). Phosphorylated upon FLT3 and KIT signaling (By similarity).By similarity
ISGylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP63085.
MaxQBiP63085.
PaxDbiP63085.
PeptideAtlasiP63085.
PRIDEiP63085.

PTM databases

iPTMnetiP63085.
PhosphoSitePlusiP63085.
SwissPalmiP63085.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000063358.
CleanExiMM_MAPK1.
ExpressionAtlasiP63085. baseline and differential.
GenevisibleiP63085. MM.

Interactioni

Subunit structurei

Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (via phosphorylated form) with TPR (via C-terminal region and phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation (By similarity). Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation (By similarity). Interacts with DCC (By similarity). Interacts with MORG1, PEA15 and MKNK2. MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation. The phosphorylated form interacts with PML (By similarity). Interacts with STYX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-397697,EBI-397697
Dlg4Q621083EBI-397697,EBI-300895
Dusp6Q9DBB12EBI-397697,EBI-7812384
GSK3BP498412EBI-397697,EBI-373586From a different organism.
Hivep1Q031724EBI-397697,EBI-646850
Mknk2Q8CDB023EBI-397697,EBI-646209
Nup58Q8R332-13EBI-397697,EBI-646962
PtprrQ621325EBI-397697,EBI-6954051
Rps6ka4Q9Z2B93EBI-397697,EBI-412887

GO - Molecular functioni

  • phosphatase binding Source: MGI
  • phosphotyrosine binding Source: MGI

Protein-protein interaction databases

BioGridi204966. 35 interactors.
DIPiDIP-661N.
IntActiP63085. 23 interactors.
MINTiMINT-125264.
STRINGi10090.ENSMUSP00000023462.

Chemistry databases

BindingDBiP63085.

Structurei

3D structure databases

ProteinModelPortaliP63085.
SMRiP63085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 311Protein kinasePROSITE-ProRule annotationAdd BLAST289

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 106Inhibitor-bindingBy similarity4
Regioni151 – 152Inhibitor-bindingBy similarity2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 185TXY3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 7Poly-Ala6

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074298.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP63085.
KOiK04371.
OMAiEEAESHH.
OrthoDBiEOG091G08QL.
PhylomeDBiP63085.
TreeFamiTF105097.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA
60 70 80 90 100
IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY
110 120 130 140 150
IVQDLMETDL YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP
160 170 180 190 200
SNLLLNTTCD LKICDFGLAR VADPDHDHTG FLTEYVATRW YRAPEIMLNS
210 220 230 240 250
KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG ILGSPSQEDL
260 270 280 290 300
NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI
310 320 330 340 350
EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA

RFQPGYRS
Length:358
Mass (Da):41,276
Last modified:January 23, 2007 - v3
Checksum:i3BBCF22471EDBA0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58712 mRNA. Translation: CAA41548.1.
AK035386 mRNA. Translation: BAC29053.1.
AK048127 mRNA. Translation: BAC33251.1.
AK087925 mRNA. Translation: BAC40044.1.
AK132241 mRNA. Translation: BAE21053.1.
BC058258 mRNA. Translation: AAH58258.1.
D10939 mRNA. Translation: BAA01733.1.
CCDSiCCDS27992.1.
PIRiS16444.
RefSeqiNP_001033752.1. NM_001038663.1.
NP_036079.1. NM_011949.3.
XP_006522210.1. XM_006522147.3.
UniGeneiMm.196581.

Genome annotation databases

EnsembliENSMUST00000023462; ENSMUSP00000023462; ENSMUSG00000063358.
ENSMUST00000069107; ENSMUSP00000065983; ENSMUSG00000063358.
ENSMUST00000115731; ENSMUSP00000111396; ENSMUSG00000063358.
GeneIDi26413.
KEGGimmu:26413.
UCSCiuc007yjq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58712 mRNA. Translation: CAA41548.1.
AK035386 mRNA. Translation: BAC29053.1.
AK048127 mRNA. Translation: BAC33251.1.
AK087925 mRNA. Translation: BAC40044.1.
AK132241 mRNA. Translation: BAE21053.1.
BC058258 mRNA. Translation: AAH58258.1.
D10939 mRNA. Translation: BAA01733.1.
CCDSiCCDS27992.1.
PIRiS16444.
RefSeqiNP_001033752.1. NM_001038663.1.
NP_036079.1. NM_011949.3.
XP_006522210.1. XM_006522147.3.
UniGeneiMm.196581.

3D structure databases

ProteinModelPortaliP63085.
SMRiP63085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204966. 35 interactors.
DIPiDIP-661N.
IntActiP63085. 23 interactors.
MINTiMINT-125264.
STRINGi10090.ENSMUSP00000023462.

Chemistry databases

BindingDBiP63085.
ChEMBLiCHEMBL2207.

PTM databases

iPTMnetiP63085.
PhosphoSitePlusiP63085.
SwissPalmiP63085.

Proteomic databases

EPDiP63085.
MaxQBiP63085.
PaxDbiP63085.
PeptideAtlasiP63085.
PRIDEiP63085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023462; ENSMUSP00000023462; ENSMUSG00000063358.
ENSMUST00000069107; ENSMUSP00000065983; ENSMUSG00000063358.
ENSMUST00000115731; ENSMUSP00000111396; ENSMUSG00000063358.
GeneIDi26413.
KEGGimmu:26413.
UCSCiuc007yjq.1. mouse.

Organism-specific databases

CTDi5594.
MGIiMGI:1346858. Mapk1.

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
GeneTreeiENSGT00550000074298.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP63085.
KOiK04371.
OMAiEEAESHH.
OrthoDBiEOG091G08QL.
PhylomeDBiP63085.
TreeFamiTF105097.

Enzyme and pathway databases

BRENDAi2.7.11.24. 3474.
ReactomeiR-MMU-111995. phospho-PLA2 pathway.
R-MMU-112409. RAF-independent MAPK1/3 activation.
R-MMU-112411. MAPK1 (ERK2) activation.
R-MMU-1295596. Spry regulation of FGF signaling.
R-MMU-162658. Golgi Cisternae Pericentriolar Stack Reorganization.
R-MMU-198753. ERK/MAPK targets.
R-MMU-202670. ERKs are inactivated.
R-MMU-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-437239. Recycling pathway of L1.
R-MMU-442742. CREB phosphorylation through the activation of Ras.
R-MMU-444257. RSK activation.
R-MMU-445144. Signal transduction by L1.
R-MMU-450341. Activation of the AP-1 family of transcription factors.
R-MMU-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5663213. RHO GTPases Activate WASPs and WAVEs.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-5674135. MAP2K and MAPK activation.
R-MMU-5674499. Negative feedback regulation of MAPK pathway.
R-MMU-5675221. Negative regulation of MAPK pathway.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-881907. Gastrin-CREB signalling pathway via PKC and MAPK.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

ChiTaRSiMapk1. mouse.
PROiP63085.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063358.
CleanExiMM_MAPK1.
ExpressionAtlasiP63085. baseline and differential.
GenevisibleiP63085. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMK01_MOUSE
AccessioniPrimary (citable) accession number: P63085
Secondary accession number(s): P27703, Q3V1U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.