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P63083

- S10A5_RAT

UniProt

P63083 - S10A5_RAT

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Protein

Protein S100-A5

Gene

S100a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityAdd
BLAST
Calcium bindingi61 – 72122; high affinityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. zinc ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100a5
Synonyms:S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1308996. S100a5.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Protein S100-A5PRO_0000143982Add
BLAST

Proteomic databases

PRIDEiP63083.

Expressioni

Gene expression databases

GenevestigatoriP63083.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP63083.
SMRiP63083. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini48 – 8336EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG46820.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP63083.
OMAiLCLGEKM.
OrthoDBiEOG7R833W.
PhylomeDBiP63083.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63083-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE
60 70 80 90
SSIDNLMKSL DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK
Length:93
Mass (Da):10,812
Last modified:September 13, 2004 - v1
Checksum:i9A922E1898D202A4
GO

Mass spectrometryi

Molecular mass is 10878 Da from positions 1 - 93. Determined by ESI. 1 Publication

Sequence databases

RefSeqiNP_001099908.1. NM_001106438.1.
XP_006232663.1. XM_006232601.2.
UniGeneiRn.11640.

Genome annotation databases

EnsembliENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748.
GeneIDi295211.
KEGGirno:295211.
UCSCiRGD:1308996. rat.

Cross-referencesi

Sequence databases

RefSeqi NP_001099908.1. NM_001106438.1.
XP_006232663.1. XM_006232601.2.
UniGenei Rn.11640.

3D structure databases

ProteinModelPortali P63083.
SMRi P63083. Positions 1-93.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P63083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015712 ; ENSRNOP00000015712 ; ENSRNOG00000011748 .
GeneIDi 295211.
KEGGi rno:295211.
UCSCi RGD:1308996. rat.

Organism-specific databases

CTDi 6276.
RGDi 1308996. S100a5.

Phylogenomic databases

eggNOGi NOG46820.
GeneTreei ENSGT00760000119034.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P63083.
OMAi LCLGEKM.
OrthoDBi EOG7R833W.
PhylomeDBi P63083.
TreeFami TF332727.

Miscellaneous databases

NextBioi 297771.
PROi P63083.

Gene expression databases

Genevestigatori P63083.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view ]
PANTHERi PTHR11639:SF65. PTHR11639:SF65. 1 hit.
Pfami PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
    Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
    J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS10A5_RAT
AccessioniPrimary (citable) accession number: P63083
Secondary accession number(s): O88945, P82540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3