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Protein

Protein S100-A5

Gene

S100a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityAdd BLAST14
Calcium bindingi61 – 722; high affinityAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100a5
Synonyms:S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1308996 S100a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439821 – 93Protein S100-A5Add BLAST93

Proteomic databases

PaxDbiP63083
PRIDEiP63083

Expressioni

Gene expression databases

BgeeiENSRNOG00000011748
GenevisibleiP63083 RN

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015712

Structurei

3D structure databases

ProteinModelPortaliP63083
SMRiP63083
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZNS Eukaryota
ENOG4111EF4 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP63083
OMAiLCLGEKM
OrthoDBiEOG091G10JX
PhylomeDBiP63083
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR028497 S100-A5
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF65 PTHR11639:SF65, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P63083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE
60 70 80 90
SSIDNLMKSL DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK
Length:93
Mass (Da):10,812
Last modified:September 13, 2004 - v1
Checksum:i9A922E1898D202A4
GO

Mass spectrometryi

Molecular mass is 10878 Da from positions 1 - 93. Determined by ESI. 1 Publication

Sequence databases

RefSeqiNP_001099908.1, NM_001106438.1
XP_006232663.1, XM_006232601.3
XP_017446250.1, XM_017590761.1
XP_017446251.1, XM_017590762.1
XP_017446252.1, XM_017590763.1
UniGeneiRn.11640

Genome annotation databases

EnsembliENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748
GeneIDi295211
KEGGirno:295211
UCSCiRGD:1308996 rat

Similar proteinsi

Entry informationi

Entry nameiS10A5_RAT
AccessioniPrimary (citable) accession number: P63083
Secondary accession number(s): O88945, P82540
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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