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P63083

- S10A5_RAT

UniProt

P63083 - S10A5_RAT

Protein

Protein S100-A5

Gene

S100a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi20 – 33141; low affinityAdd
    BLAST
    Calcium bindingi61 – 72122; high affinityAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. zinc ion binding Source: UniProtKB

    Keywords - Ligandi

    Calcium, Copper, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A5
    Alternative name(s):
    Protein S-100D
    S100 calcium-binding protein A5
    Gene namesi
    Name:S100a5
    Synonyms:S100d
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi1308996. S100a5.

    Subcellular locationi

    GO - Cellular componenti

    1. neuronal cell body Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9393Protein S100-A5PRO_0000143982Add
    BLAST

    Proteomic databases

    PRIDEiP63083.

    Expressioni

    Gene expression databases

    GenevestigatoriP63083.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP63083.
    SMRiP63083. Positions 1-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini48 – 8336EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG46820.
    GeneTreeiENSGT00740000114986.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP63083.
    OMAiLCLGEKM.
    OrthoDBiEOG7R833W.
    PhylomeDBiP63083.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028497. S100-A5.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view]
    PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
    PfamiPF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63083-1 [UniParc]FASTAAdd to Basket

    « Hide

    METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE   50
    SSIDNLMKSL DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK 93
    Length:93
    Mass (Da):10,812
    Last modified:September 13, 2004 - v1
    Checksum:i9A922E1898D202A4
    GO

    Mass spectrometryi

    Molecular mass is 10878 Da from positions 1 - 93. Determined by ESI. 1 Publication

    Sequence databases

    RefSeqiNP_001099908.1. NM_001106438.1.
    XP_006232663.1. XM_006232601.1.
    UniGeneiRn.11640.

    Genome annotation databases

    EnsembliENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748.
    GeneIDi295211.
    KEGGirno:295211.
    UCSCiRGD:1308996. rat.

    Cross-referencesi

    Sequence databases

    RefSeqi NP_001099908.1. NM_001106438.1.
    XP_006232663.1. XM_006232601.1.
    UniGenei Rn.11640.

    3D structure databases

    ProteinModelPortali P63083.
    SMRi P63083. Positions 1-93.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P63083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015712 ; ENSRNOP00000015712 ; ENSRNOG00000011748 .
    GeneIDi 295211.
    KEGGi rno:295211.
    UCSCi RGD:1308996. rat.

    Organism-specific databases

    CTDi 6276.
    RGDi 1308996. S100a5.

    Phylogenomic databases

    eggNOGi NOG46820.
    GeneTreei ENSGT00740000114986.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P63083.
    OMAi LCLGEKM.
    OrthoDBi EOG7R833W.
    PhylomeDBi P63083.
    TreeFami TF332727.

    Miscellaneous databases

    NextBioi 297771.
    PROi P63083.

    Gene expression databases

    Genevestigatori P63083.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR028497. S100-A5.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    [Graphical view ]
    PANTHERi PTHR11639:SF65. PTHR11639:SF65. 1 hit.
    Pfami PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
      Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
      J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiS10A5_RAT
    AccessioniPrimary (citable) accession number: P63083
    Secondary accession number(s): O88945, P82540
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3