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Protein

Protein S100-A5

Gene

S100a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi20 – 33141; low affinityAdd
BLAST
Calcium bindingi61 – 72122; high affinityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. zinc ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100a5
Synonyms:S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi1308996. S100a5.

Subcellular locationi

GO - Cellular componenti

  1. neuronal cell body Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Protein S100-A5PRO_0000143982Add
BLAST

Proteomic databases

PRIDEiP63083.

Expressioni

Gene expression databases

GenevestigatoriP63083.

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP63083.
SMRiP63083. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 4736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini48 – 8336EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG46820.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP63083.
OMAiELCLGEM.
OrthoDBiEOG7R833W.
PhylomeDBiP63083.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE
60 70 80 90
SSIDNLMKSL DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK
Length:93
Mass (Da):10,812
Last modified:September 13, 2004 - v1
Checksum:i9A922E1898D202A4
GO

Mass spectrometryi

Molecular mass is 10878 Da from positions 1 - 93. Determined by ESI. 1 Publication

Sequence databases

RefSeqiNP_001099908.1. NM_001106438.1.
XP_006232663.1. XM_006232601.2.
UniGeneiRn.11640.

Genome annotation databases

EnsembliENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748.
GeneIDi295211.
KEGGirno:295211.
UCSCiRGD:1308996. rat.

Cross-referencesi

Sequence databases

RefSeqiNP_001099908.1. NM_001106438.1.
XP_006232663.1. XM_006232601.2.
UniGeneiRn.11640.

3D structure databases

ProteinModelPortaliP63083.
SMRiP63083. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP63083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748.
GeneIDi295211.
KEGGirno:295211.
UCSCiRGD:1308996. rat.

Organism-specific databases

CTDi6276.
RGDi1308996. S100a5.

Phylogenomic databases

eggNOGiNOG46820.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP63083.
OMAiELCLGEM.
OrthoDBiEOG7R833W.
PhylomeDBiP63083.
TreeFamiTF332727.

Miscellaneous databases

NextBioi297771.
PROiP63083.

Gene expression databases

GenevestigatoriP63083.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERiPTHR11639:SF65. PTHR11639:SF65. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
    Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
    J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiS10A5_RAT
AccessioniPrimary (citable) accession number: P63083
Secondary accession number(s): O88945, P82540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.