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P63083 (S10A5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene names
Name:S100a5
Synonyms:S100d
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites. Ref.1

Subunit structure

Homodimer. Ref.1

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Mass spectrometry

Molecular mass is 10878 Da from positions 1 - 93. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9393Protein S100-A5
PRO_0000143982

Regions

Domain12 – 4736EF-hand 1
Domain48 – 8336EF-hand 2
Calcium binding20 – 33141; low affinity
Calcium binding61 – 72122; high affinity

Sequences

Sequence LengthMass (Da)Tools
P63083 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 9A922E1898D202A4

FASTA9310,812
        10         20         30         40         50         60 
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE SSIDNLMKSL 

        70         80         90 
DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK 

« Hide

References

[1]"Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily."
Schaefer B.W., Fritschy J.-M., Murmann P., Troxler H., Durussel I., Heizmann C.W., Cox J.A.
J. Biol. Chem. 275:30623-30630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, SUBUNIT, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

RefSeqNP_001099908.1. NM_001106438.1.
XP_006232663.1. XM_006232601.1.
UniGeneRn.11640.

3D structure databases

ProteinModelPortalP63083.
SMRP63083. Positions 1-93.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP63083.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015712; ENSRNOP00000015712; ENSRNOG00000011748.
GeneID295211.
KEGGrno:295211.
UCSCRGD:1308996. rat.

Organism-specific databases

CTD6276.
RGD1308996. S100a5.

Phylogenomic databases

eggNOGNOG46820.
GeneTreeENSGT00740000114986.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP63083.
OMAELCLGEM.
OrthoDBEOG7R833W.
PhylomeDBP63083.
TreeFamTF332727.

Gene expression databases

GenevestigatorP63083.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028497. S100-A5/S100-A6.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PANTHERPTHR11639:SF14. PTHR11639:SF14. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297771.
PROP63083.

Entry information

Entry nameS10A5_RAT
AccessionPrimary (citable) accession number: P63083
Secondary accession number(s): O88945, P82540
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families