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Protein

V-type proton ATPase 16 kDa proteolipid subunit

Gene

Atp6v0c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Essential for proton translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556 ROS, RNS production in phagocytes
R-RNO-6798695 Neutrophil degranulation
R-RNO-77387 Insulin receptor recycling
R-RNO-917977 Transferrin endocytosis and recycling
R-RNO-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 16 kDa proteolipid subunit
Short name:
V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 16 kDa proteolipid subunit
Gene namesi
Name:Atp6v0c
Synonyms:Atp6c, Atp6l, Atpl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621394 Atp6v0c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 33HelicalSequence analysisAdd BLAST23
Topological domaini34 – 55CytoplasmicSequence analysisAdd BLAST22
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 92LumenalSequence analysisAdd BLAST16
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 155LumenalSequence analysis3

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717451 – 155V-type proton ATPase 16 kDa proteolipid subunitAdd BLAST155

Post-translational modificationi

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP63081
PRIDEiP63081

PTM databases

PhosphoSitePlusiP63081
SwissPalmiP63081

Expressioni

Gene expression databases

BgeeiENSRNOG00000006542
GenevisibleiP63081 RN

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway (By similarity).By similarity

Protein-protein interaction databases

IntActiP63081, 2 interactors
STRINGi10116.ENSRNOP00000008736

Structurei

3D structure databases

ProteinModelPortaliP63081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0232 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00550000074873
HOGENOMiHOG000056520
HOVERGENiHBG002712
InParanoidiP63081
KOiK02155
OMAiDMFARGI
OrthoDBiEOG091G0U1Y
PhylomeDBiP63081
TreeFamiTF300025

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR011555 ATPase_proteolipid_su_C_euk
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits
TIGRFAMsiTIGR01100 V_ATP_synt_C, 1 hit

Sequencei

Sequence statusi: Complete.

P63081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIKNNPEY SSFFGVMGAS SAMVFSAMGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
LIMKSIIPVV MAGIIAIYGL VVAVLIANSL TDGITLYRSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,808
Last modified:September 13, 2004 - v1
Checksum:i880C280C5AEB0C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10874 mRNA Translation: BAA01643.1
BC063154 mRNA Translation: AAH63154.1
PIRiJX0226
RefSeqiNP_570836.1, NM_130823.3
XP_006245960.1, XM_006245898.1
UniGeneiRn.1869

Genome annotation databases

EnsembliENSRNOT00000008736; ENSRNOP00000008736; ENSRNOG00000006542
GeneIDi170667
KEGGirno:170667
UCSCiRGD:621394 rat

Similar proteinsi

Entry informationi

Entry nameiVATL_RAT
AccessioniPrimary (citable) accession number: P63081
Secondary accession number(s): P23967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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