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Protein

V-type proton ATPase 16 kDa proteolipid subunit

Gene

Atp6v0c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Essential for proton translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 16 kDa proteolipid subunit
Short name:
V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 16 kDa proteolipid subunit
Gene namesi
Name:Atp6v0c
Synonyms:Atp6c, Atp6l, Atpl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621394. Atp6v0c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 33HelicalSequence analysisAdd BLAST23
Topological domaini34 – 55CytoplasmicSequence analysisAdd BLAST22
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 92LumenalSequence analysisAdd BLAST16
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 155LumenalSequence analysis3

GO - Cellular componenti

  • Golgi apparatus Source: RGD
  • integral component of membrane Source: GO_Central
  • lysosome Source: RGD
  • vacuolar proton-transporting V-type ATPase, V0 domain Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717451 – 155V-type proton ATPase 16 kDa proteolipid subunitAdd BLAST155

Post-translational modificationi

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP63081.
PRIDEiP63081.

PTM databases

PhosphoSitePlusiP63081.
SwissPalmiP63081.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006542.
GenevisibleiP63081. RN.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway (By similarity).By similarity

Protein-protein interaction databases

IntActiP63081. 2 interactors.
STRINGi10116.ENSRNOP00000008736.

Structurei

3D structure databases

ProteinModelPortaliP63081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00550000074873.
HOGENOMiHOG000056520.
HOVERGENiHBG002712.
InParanoidiP63081.
KOiK02155.
OMAiVEDNDMF.
OrthoDBiEOG091G0U1Y.
PhylomeDBiP63081.
TreeFamiTF300025.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.

Sequencei

Sequence statusi: Complete.

P63081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIKNNPEY SSFFGVMGAS SAMVFSAMGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
LIMKSIIPVV MAGIIAIYGL VVAVLIANSL TDGITLYRSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,808
Last modified:September 13, 2004 - v1
Checksum:i880C280C5AEB0C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10874 mRNA. Translation: BAA01643.1.
BC063154 mRNA. Translation: AAH63154.1.
PIRiJX0226.
RefSeqiNP_570836.1. NM_130823.3.
XP_006245960.1. XM_006245898.1.
UniGeneiRn.1869.

Genome annotation databases

EnsembliENSRNOT00000008736; ENSRNOP00000008736; ENSRNOG00000006542.
GeneIDi170667.
KEGGirno:170667.
UCSCiRGD:621394. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10874 mRNA. Translation: BAA01643.1.
BC063154 mRNA. Translation: AAH63154.1.
PIRiJX0226.
RefSeqiNP_570836.1. NM_130823.3.
XP_006245960.1. XM_006245898.1.
UniGeneiRn.1869.

3D structure databases

ProteinModelPortaliP63081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63081. 2 interactors.
STRINGi10116.ENSRNOP00000008736.

PTM databases

PhosphoSitePlusiP63081.
SwissPalmiP63081.

Proteomic databases

PaxDbiP63081.
PRIDEiP63081.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008736; ENSRNOP00000008736; ENSRNOG00000006542.
GeneIDi170667.
KEGGirno:170667.
UCSCiRGD:621394. rat.

Organism-specific databases

CTDi527.
RGDi621394. Atp6v0c.

Phylogenomic databases

eggNOGiKOG0232. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00550000074873.
HOGENOMiHOG000056520.
HOVERGENiHBG002712.
InParanoidiP63081.
KOiK02155.
OMAiVEDNDMF.
OrthoDBiEOG091G0U1Y.
PhylomeDBiP63081.
TreeFamiTF300025.

Enzyme and pathway databases

ReactomeiR-RNO-1222556. ROS, RNS production in response to bacteria.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-77387. Insulin receptor recycling.
R-RNO-917977. Transferrin endocytosis and recycling.
R-RNO-983712. Ion channel transport.

Miscellaneous databases

PROiP63081.

Gene expression databases

BgeeiENSRNOG00000006542.
GenevisibleiP63081. RN.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
IPR011555. ATPase_proteolipid_su_C_euk.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
TIGRFAMsiTIGR01100. V_ATP_synt_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVATL_RAT
AccessioniPrimary (citable) accession number: P63081
Secondary accession number(s): P23967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.