ID   GBG8_MOUSE              Reviewed;          70 AA.
AC   P63078; P43426;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   27-MAR-2024, entry version 145.
DE   RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;
DE   AltName: Full=Gamma-9;
DE   Flags: Precursor;
GN   Name=Gng8; Synonyms=Gng9, Gngt9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10819326; DOI=10.1093/dnares/7.2.111;
RA   Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I.,
RA   Shizuya H.;
RT   "Genomic characterization of the human heterotrimeric G protein alpha,
RT   beta, and gamma subunit genes.";
RL   DNA Res. 7:111-120(2000).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction. This subunit may have a very specific role in the
CC       development and turnover of olfactory and vomeronasal neurons.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR   EMBL; AF188180; AAF04570.1; -; Genomic_DNA.
DR   CCDS; CCDS20856.1; -.
DR   RefSeq; NP_034450.1; NM_010320.3.
DR   RefSeq; XP_006539610.1; XM_006539547.3.
DR   RefSeq; XP_006539611.1; XM_006539548.1.
DR   RefSeq; XP_006539612.1; XM_006539549.3.
DR   RefSeq; XP_011248738.1; XM_011250436.2.
DR   AlphaFoldDB; P63078; -.
DR   SMR; P63078; -.
DR   BioGRID; 199993; 1.
DR   IntAct; P63078; 1.
DR   STRING; 10090.ENSMUSP00000077314; -.
DR   PaxDb; 10090-ENSMUSP00000077314; -.
DR   ProteomicsDB; 273419; -.
DR   Antibodypedia; 31465; 55 antibodies from 14 providers.
DR   DNASU; 14709; -.
DR   Ensembl; ENSMUST00000078182.6; ENSMUSP00000077314.5; ENSMUSG00000063594.6.
DR   Ensembl; ENSMUST00000205459.2; ENSMUSP00000145533.2; ENSMUSG00000063594.6.
DR   Ensembl; ENSMUST00000205716.2; ENSMUSP00000145567.2; ENSMUSG00000063594.6.
DR   GeneID; 14709; -.
DR   KEGG; mmu:14709; -.
DR   UCSC; uc009fik.1; mouse.
DR   AGR; MGI:109163; -.
DR   CTD; 94235; -.
DR   MGI; MGI:109163; Gng8.
DR   VEuPathDB; HostDB:ENSMUSG00000063594; -.
DR   eggNOG; KOG4119; Eukaryota.
DR   GeneTree; ENSGT01100000263497; -.
DR   HOGENOM; CLU_168377_0_1_1; -.
DR   InParanoid; P63078; -.
DR   OMA; LMSYCES; -.
DR   OrthoDB; 2872810at2759; -.
DR   PhylomeDB; P63078; -.
DR   TreeFam; TF319909; -.
DR   Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-MMU-202040; G-protein activation.
DR   Reactome; R-MMU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-MMU-392170; ADP signalling through P2Y purinoceptor 12.
DR   Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
DR   Reactome; R-MMU-392851; Prostacyclin signalling through prostacyclin receptor.
DR   Reactome; R-MMU-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR   Reactome; R-MMU-4086398; Ca2+ pathway.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   Reactome; R-MMU-418217; G beta:gamma signalling through PLC beta.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-418592; ADP signalling through P2Y purinoceptor 1.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-418597; G alpha (z) signalling events.
DR   Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR   Reactome; R-MMU-428930; Thromboxane signalling through TP receptor.
DR   Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-MMU-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR   Reactome; R-MMU-500657; Presynaptic function of Kainate receptors.
DR   Reactome; R-MMU-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-MMU-8964315; G beta:gamma signalling through BTK.
DR   Reactome; R-MMU-8964616; G beta:gamma signalling through CDC42.
DR   Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling.
DR   Reactome; R-MMU-9634597; GPER1 signaling.
DR   Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   BioGRID-ORCS; 14709; 0 hits in 73 CRISPR screens.
DR   PRO; PR:P63078; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P63078; Protein.
DR   Bgee; ENSMUSG00000063594; Expressed in habenula and 71 other cell types or tissues.
DR   ExpressionAtlas; P63078; baseline and differential.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR   GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR   GO; GO:0071444; P:cellular response to pheromone; IMP:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0043584; P:nose development; IMP:MGI.
DR   GO; GO:0035176; P:social behavior; IMP:MGI.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR001770; Gprotein-gamma.
DR   PANTHER; PTHR13809:SF19; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-8; 1.
DR   PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   PRINTS; PR00321; GPROTEING.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
DR   Genevisible; P63078; MM.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW   Reference proteome; Transducer.
FT   CHAIN           1..67
FT                   /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT                   subunit gamma-8"
FT                   /id="PRO_0000012651"
FT   PROPEP          68..70
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000012652"
FT   MOD_RES         67
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           67
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  7843 MW;  153206AC7F38EE40 CRC64;
     MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF
     RDKRLFCTLL
//