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P63078

- GBG8_MOUSE

UniProt

P63078 - GBG8_MOUSE

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

Gng8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. nervous system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:109163. Gng8.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012651Add
BLAST
Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012652

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Cysteine methyl esterBy similarity
Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP63078.
PRIDEiP63078.

Expressioni

Gene expression databases

BgeeiP63078.
ExpressionAtlasiP63078. baseline and differential.
GenevestigatoriP63078.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

IntActiP63078. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP63078.
SMRiP63078. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG267672.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP63078.
KOiK04544.
OMAiEKRLFCV.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63078.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63078-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCTLL
Length:70
Mass (Da):7,843
Last modified:September 13, 2004 - v1
Checksum:i153206AC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF188180 Genomic DNA. Translation: AAF04570.1.
CCDSiCCDS20856.1.
RefSeqiNP_034450.1. NM_010320.3.
XP_006539610.1. XM_006539547.1.
XP_006539611.1. XM_006539548.1.
XP_006539612.1. XM_006539549.1.
UniGeneiMm.103770.

Genome annotation databases

EnsembliENSMUST00000078182; ENSMUSP00000077314; ENSMUSG00000063594.
GeneIDi14709.
KEGGimmu:14709.
UCSCiuc009fik.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF188180 Genomic DNA. Translation: AAF04570.1 .
CCDSi CCDS20856.1.
RefSeqi NP_034450.1. NM_010320.3.
XP_006539610.1. XM_006539547.1.
XP_006539611.1. XM_006539548.1.
XP_006539612.1. XM_006539549.1.
UniGenei Mm.103770.

3D structure databases

ProteinModelPortali P63078.
SMRi P63078. Positions 8-63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P63078. 1 interaction.

Proteomic databases

MaxQBi P63078.
PRIDEi P63078.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078182 ; ENSMUSP00000077314 ; ENSMUSG00000063594 .
GeneIDi 14709.
KEGGi mmu:14709.
UCSCi uc009fik.1. mouse.

Organism-specific databases

CTDi 94235.
MGIi MGI:109163. Gng8.

Phylogenomic databases

eggNOGi NOG267672.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P63078.
KOi K04544.
OMAi EKRLFCV.
OrthoDBi EOG7H1JP7.
PhylomeDBi P63078.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

NextBioi 286701.
PROi P63078.
SOURCEi Search...

Gene expression databases

Bgeei P63078.
ExpressionAtlasi P63078. baseline and differential.
Genevestigatori P63078.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
    Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
    DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGBG8_MOUSE
AccessioniPrimary (citable) accession number: P63078
Secondary accession number(s): P43426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3