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P63078 (GBG8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene names
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
PRO_0000012651
Propeptide68 – 703Removed in mature form By similarity
PRO_0000012652

Amino acid modifications

Modified residue671Cysteine methyl ester By similarity
Lipidation671S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63078 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 153206AC7F38EE40

FASTA707,843
        10         20         30         40         50         60 
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF 

        70 
RDKRLFCTLL 

« Hide

References

[1]"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF188180 Genomic DNA. Translation: AAF04570.1.
RefSeqNP_034450.1. NM_010320.3.
XP_006539610.1. XM_006539547.1.
XP_006539611.1. XM_006539548.1.
XP_006539612.1. XM_006539549.1.
UniGeneMm.103770.

3D structure databases

ProteinModelPortalP63078.
SMRP63078. Positions 8-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP63078. 1 interaction.

Proteomic databases

PRIDEP63078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000078182; ENSMUSP00000077314; ENSMUSG00000063594.
GeneID14709.
KEGGmmu:14709.
UCSCuc009fik.1. mouse.

Organism-specific databases

CTD94235.
MGIMGI:109163. Gng8.

Phylogenomic databases

eggNOGNOG267672.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidP63078.
KOK04544.
OMARMMVSKA.
OrthoDBEOG7H1JP7.
PhylomeDBP63078.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressP63078.
BgeeP63078.
GenevestigatorP63078.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286701.
PROP63078.
SOURCESearch...

Entry information

Entry nameGBG8_MOUSE
AccessionPrimary (citable) accession number: P63078
Secondary accession number(s): P43426
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot