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P63077 (GBG8_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene names
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons. Ref.1

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb. Ref.1

Developmental stage

During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult. Ref.1

Sequence similarities

Belongs to the G protein gamma family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
PRO_0000012653
Propeptide68 – 703Removed in mature form By similarity
PRO_0000012654

Amino acid modifications

Modified residue671Cysteine methyl ester By similarity
Lipidation671S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P63077 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 153206AC7F38EE40

FASTA707,843
        10         20         30         40         50         60 
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF 

        70 
RDKRLFCTLL 

« Hide

References

[1]"A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia."
Ryba N.J.P., Tirindelli R.
J. Biol. Chem. 270:6757-6767(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: Wistar.
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35921 mRNA. Translation: AAA73553.1.
PIRA56181.
RefSeqNP_631924.1. NM_139185.1.
XP_006228446.1. XM_006228384.1.
XP_006228447.1. XM_006228385.1.
UniGeneRn.11233.

3D structure databases

ProteinModelPortalP63077.
SMRP63077. Positions 8-63.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP63077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
GeneID245986.
KEGGrno:245986.
UCSCRGD:620808. rat.

Organism-specific databases

CTD94235.
RGD620808. Gng8.

Phylogenomic databases

eggNOGNOG267672.
GeneTreeENSGT00740000115378.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidP63077.
KOK04544.
OMAWSTHANR.
OrthoDBEOG7H1JP7.
PhylomeDBP63077.
TreeFamTF319909.

Gene expression databases

GenevestigatorP63077.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286701.
PROP63077.

Entry information

Entry nameGBG8_RAT
AccessionPrimary (citable) accession number: P63077
Secondary accession number(s): P43426
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families