P63077 (GBG8_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Alternative name(s):
Gamma-9

Gene names

Name:	Gng8
Synonyms:	Gng9, Gngt9

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons. Ref.1
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Tissue specificity	Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb. Ref.1
Developmental stage	During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult. Ref.1
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro nervous system development Inferred from expression pattern Ref.1. Source: RGD
Cellular_component	heterotrimeric G-protein complex Traceable author statement Ref.1. Source: RGD
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 67	67	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8		PRO_0000012653
	Propeptide	68 – 70	3	Removed in mature form By similarity		PRO_0000012654
Amino acid modifications
	Modified residue	67	1	Cysteine methyl ester By similarity
	Lipidation	67	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P63077 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 153206AC7F38EE40	FASTA	70	7,843
	10 20 30 40 50 60 MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF 70 RDKRLFCTLL

References

[1]

"A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia." Ryba N.J.P., Tirindelli R. J. Biol. Chem. 270:6757-6767(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Wistar. Tissue: Olfactory epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35921 mRNA. Translation: AAA73553.1.
IPI	IPI00200357.
PIR	A56181.
RefSeq	NP_631924.1. NM_139185.1.
UniGene	Rn.11233.
3D structure databases
ProteinModelPortal	P63077.
SMR	P63077. Positions 8-63.
ModBase	Search...
Proteomic databases
PRIDE	P63077.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
GeneID	245986.
KEGG	rno:245986.
UCSC	RGD:620808. rat.
Organism-specific databases
CTD	94235.
RGD	620808. Gng8.
Phylogenomic databases
eggNOG	NOG267672.
GeneTree	ENSGT00550000074352.
HOGENOM	HOG000231034.
HOVERGEN	HBG014983.
InParanoid	P63077.
KO	K04544.
OMA	RMMVSKA.
OrthoDB	EOG4KH2WP.
Gene expression databases
Genevestigator	P63077.
GermOnline	ENSRNOG00000016701. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286701.

Entry information

Entry name

GBG8_RAT

Accession

Primary (citable) accession number: P63077
Secondary accession number(s): P43426

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	September 13, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program