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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

Gng8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-RNO-1296041 Activation of G protein gated Potassium channels
R-RNO-202040 G-protein activation
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392170 ADP signalling through P2Y purinoceptor 12
R-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-392851 Prostacyclin signalling through prostacyclin receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-4086398 Ca2+ pathway
R-RNO-416476 G alpha (q) signalling events
R-RNO-416482 G alpha (12/13) signalling events
R-RNO-418217 G beta:gamma signalling through PLC beta
R-RNO-418555 G alpha (s) signalling events
R-RNO-418592 ADP signalling through P2Y purinoceptor 1
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-420092 Glucagon-type ligand receptors
R-RNO-428930 Thromboxane signalling through TP receptor
R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-500657 Presynaptic function of Kainate receptors
R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-RNO-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620808 Gng8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126531 – 67Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8Add BLAST67
PropeptideiPRO_000001265468 – 70Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Cysteine methyl esterBy similarity1
Lipidationi67S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63077
PRIDEiP63077

Expressioni

Tissue specificityi

Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb.1 Publication

Developmental stagei

During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult.1 Publication

Gene expression databases

BgeeiENSRNOG00000016701
GenevisibleiP63077 RN

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022441

Structurei

3D structure databases

ProteinModelPortaliP63077
SMRiP63077
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP63077
KOiK04544
OMAiNIERMMV
OrthoDBiEOG091G17J0
PhylomeDBiP63077
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCTLL
Length:70
Mass (Da):7,843
Last modified:September 13, 2004 - v1
Checksum:i153206AC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35921 mRNA Translation: AAA73553.1
PIRiA56181
RefSeqiNP_631924.1, NM_139185.1
XP_006228446.1, XM_006228384.3
XP_006228447.1, XM_006228385.3
UniGeneiRn.11233

Genome annotation databases

EnsembliENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701
ENSRNOT00000090417; ENSRNOP00000072099; ENSRNOG00000016701
GeneIDi245986
KEGGirno:245986
UCSCiRGD:620808 rat

Similar proteinsi

Entry informationi

Entry nameiGBG8_RAT
AccessioniPrimary (citable) accession number: P63077
Secondary accession number(s): P43426
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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