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P63077

- GBG8_RAT

UniProt

P63077 - GBG8_RAT

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

Gng8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. nervous system development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620808. Gng8.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012653Add
BLAST
Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012654

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Cysteine methyl esterBy similarity
Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP63077.

Expressioni

Tissue specificityi

Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb.1 Publication

Developmental stagei

During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult.1 Publication

Gene expression databases

GenevestigatoriP63077.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP63077.
SMRiP63077. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG267672.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP63077.
KOiK04544.
OMAiWSTHANR.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63077.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63077-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCTLL
Length:70
Mass (Da):7,843
Last modified:September 13, 2004 - v1
Checksum:i153206AC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35921 mRNA. Translation: AAA73553.1.
PIRiA56181.
RefSeqiNP_631924.1. NM_139185.1.
XP_006228446.1. XM_006228384.2.
XP_006228447.1. XM_006228385.2.
UniGeneiRn.11233.

Genome annotation databases

EnsembliENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
GeneIDi245986.
KEGGirno:245986.
UCSCiRGD:620808. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35921 mRNA. Translation: AAA73553.1 .
PIRi A56181.
RefSeqi NP_631924.1. NM_139185.1.
XP_006228446.1. XM_006228384.2.
XP_006228447.1. XM_006228385.2.
UniGenei Rn.11233.

3D structure databases

ProteinModelPortali P63077.
SMRi P63077. Positions 8-63.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P63077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022441 ; ENSRNOP00000022441 ; ENSRNOG00000016701 .
GeneIDi 245986.
KEGGi rno:245986.
UCSCi RGD:620808. rat.

Organism-specific databases

CTDi 94235.
RGDi 620808. Gng8.

Phylogenomic databases

eggNOGi NOG267672.
GeneTreei ENSGT00760000119218.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P63077.
KOi K04544.
OMAi WSTHANR.
OrthoDBi EOG7H1JP7.
PhylomeDBi P63077.
TreeFami TF319909.

Miscellaneous databases

NextBioi 286701.
PROi P63077.

Gene expression databases

Genevestigatori P63077.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia."
    Ryba N.J.P., Tirindelli R.
    J. Biol. Chem. 270:6757-6767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Wistar.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiGBG8_RAT
AccessioniPrimary (citable) accession number: P63077
Secondary accession number(s): P43426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3