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P63077

- GBG8_RAT

UniProt

P63077 - GBG8_RAT

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

Gng8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.1 Publication

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro
    2. nervous system development Source: RGD

    Keywords - Molecular functioni

    Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Alternative name(s):
    Gamma-9
    Gene namesi
    Name:Gng8
    Synonyms:Gng9, Gngt9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620808. Gng8.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012653Add
    BLAST
    Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012654

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671Cysteine methyl esterBy similarity
    Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiP63077.

    Expressioni

    Tissue specificityi

    Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb.1 Publication

    Developmental stagei

    During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult.1 Publication

    Gene expression databases

    GenevestigatoriP63077.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP63077.
    SMRiP63077. Positions 8-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG267672.
    GeneTreeiENSGT00740000115378.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiP63077.
    KOiK04544.
    OMAiWSTHANR.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP63077.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63077-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV   50
    TPVPAAENPF RDKRLFCTLL 70
    Length:70
    Mass (Da):7,843
    Last modified:September 13, 2004 - v1
    Checksum:i153206AC7F38EE40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35921 mRNA. Translation: AAA73553.1.
    PIRiA56181.
    RefSeqiNP_631924.1. NM_139185.1.
    XP_006228446.1. XM_006228384.1.
    XP_006228447.1. XM_006228385.1.
    UniGeneiRn.11233.

    Genome annotation databases

    EnsembliENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
    GeneIDi245986.
    KEGGirno:245986.
    UCSCiRGD:620808. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35921 mRNA. Translation: AAA73553.1 .
    PIRi A56181.
    RefSeqi NP_631924.1. NM_139185.1.
    XP_006228446.1. XM_006228384.1.
    XP_006228447.1. XM_006228385.1.
    UniGenei Rn.11233.

    3D structure databases

    ProteinModelPortali P63077.
    SMRi P63077. Positions 8-63.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P63077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022441 ; ENSRNOP00000022441 ; ENSRNOG00000016701 .
    GeneIDi 245986.
    KEGGi rno:245986.
    UCSCi RGD:620808. rat.

    Organism-specific databases

    CTDi 94235.
    RGDi 620808. Gng8.

    Phylogenomic databases

    eggNOGi NOG267672.
    GeneTreei ENSGT00740000115378.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi P63077.
    KOi K04544.
    OMAi WSTHANR.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P63077.
    TreeFami TF319909.

    Miscellaneous databases

    NextBioi 286701.
    PROi P63077.

    Gene expression databases

    Genevestigatori P63077.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia."
      Ryba N.J.P., Tirindelli R.
      J. Biol. Chem. 270:6757-6767(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: Wistar.
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiGBG8_RAT
    AccessioniPrimary (citable) accession number: P63077
    Secondary accession number(s): P43426
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3