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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

Gng8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons.1 Publication

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
  2. nervous system development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_242287. Activation of G protein gated Potassium channels.
REACT_249237. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:Gng8
Synonyms:Gng9, Gngt9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620808. Gng8.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012653Add
BLAST
Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012654

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Cysteine methyl esterBy similarity
Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiP63077.

Expressioni

Tissue specificityi

Detected in the olfactory epithelium, the vomeronasal epithelium and, to a lesser extent, the olfactory bulb.1 Publication

Developmental stagei

During development, expression in the olfactory epithelium parallels neurogenesis, peaking shortly after birth and declining in the adult.1 Publication

Gene expression databases

GenevestigatoriP63077.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP63077.
SMRiP63077. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG267672.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP63077.
KOiK04544.
OMAiRMMVSKA.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63077.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63077-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCTLL
Length:70
Mass (Da):7,843
Last modified:September 13, 2004 - v1
Checksum:i153206AC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35921 mRNA. Translation: AAA73553.1.
PIRiA56181.
RefSeqiNP_631924.1. NM_139185.1.
XP_006228446.1. XM_006228384.2.
XP_006228447.1. XM_006228385.2.
UniGeneiRn.11233.

Genome annotation databases

EnsembliENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
GeneIDi245986.
KEGGirno:245986.
UCSCiRGD:620808. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35921 mRNA. Translation: AAA73553.1.
PIRiA56181.
RefSeqiNP_631924.1. NM_139185.1.
XP_006228446.1. XM_006228384.2.
XP_006228447.1. XM_006228385.2.
UniGeneiRn.11233.

3D structure databases

ProteinModelPortaliP63077.
SMRiP63077. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP63077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022441; ENSRNOP00000022441; ENSRNOG00000016701.
GeneIDi245986.
KEGGirno:245986.
UCSCiRGD:620808. rat.

Organism-specific databases

CTDi94235.
RGDi620808. Gng8.

Phylogenomic databases

eggNOGiNOG267672.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP63077.
KOiK04544.
OMAiRMMVSKA.
OrthoDBiEOG7H1JP7.
PhylomeDBiP63077.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_242287. Activation of G protein gated Potassium channels.
REACT_249237. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

NextBioi286701.
PROiP63077.

Gene expression databases

GenevestigatoriP63077.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia."
    Ryba N.J.P., Tirindelli R.
    J. Biol. Chem. 270:6757-6767(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Wistar.
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiGBG8_RAT
AccessioniPrimary (citable) accession number: P63077
Secondary accession number(s): P43426
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.