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P63075

- FGF17_MOUSE

UniProt

P63075 - FGF17_MOUSE

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Protein

Fibroblast growth factor 17

Gene

Fgf17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

GO - Biological processi

  1. fibroblast growth factor receptor signaling pathway Source: MGI
  2. multicellular organismal development Source: UniProtKB-KW
  3. positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 17
Short name:
FGF-17
Gene namesi
Name:Fgf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1202401. Fgf17.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 216194Fibroblast growth factor 17PRO_0000008986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP63075.

PTM databases

PhosphoSiteiP63075.

Expressioni

Gene expression databases

BgeeiP63075.
CleanExiMM_FGF17.
ExpressionAtlasiP63075. differential.
GenevestigatoriP63075.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63075.
SMRiP63075. Positions 33-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327940.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP63075.
KOiK04358.
OMAiCQTQVTA.
OrthoDBiEOG7DFXD5.
PhylomeDBiP63075.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028287. FGF17.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF71. PTHR11486:SF71. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR
60 70 80 90 100
QIREYQLYSR TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK
110 120 130 140 150
GAESEKYICM NKRGKLIGKP SGKSKDCVFT EIVLENNYTA FQNARHEGWF
160 170 180 190 200
MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ GQLPFPNHAE RQKQFEFVGS
210
APTRRTKRTR RPQSQT
Length:216
Mass (Da):24,924
Last modified:September 13, 2004 - v1
Checksum:i2EE94BDF75220F4C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009250 mRNA. Translation: BAA25430.1.
AK077555 mRNA. Translation: BAC36859.1.
CCDSiCCDS27260.1.
RefSeqiNP_032030.1. NM_008004.4.
XP_006518614.1. XM_006518551.1.
UniGeneiMm.12814.

Genome annotation databases

EnsembliENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101.
GeneIDi14171.
KEGGimmu:14171.
UCSCiuc007uos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009250 mRNA. Translation: BAA25430.1 .
AK077555 mRNA. Translation: BAC36859.1 .
CCDSi CCDS27260.1.
RefSeqi NP_032030.1. NM_008004.4.
XP_006518614.1. XM_006518551.1.
UniGenei Mm.12814.

3D structure databases

ProteinModelPortali P63075.
SMRi P63075. Positions 33-178.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P63075.

Proteomic databases

PRIDEi P63075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022697 ; ENSMUSP00000022697 ; ENSMUSG00000022101 .
GeneIDi 14171.
KEGGi mmu:14171.
UCSCi uc007uos.1. mouse.

Organism-specific databases

CTDi 8822.
MGIi MGI:1202401. Fgf17.

Phylogenomic databases

eggNOGi NOG327940.
HOGENOMi HOG000115986.
HOVERGENi HBG005659.
InParanoidi P63075.
KOi K04358.
OMAi CQTQVTA.
OrthoDBi EOG7DFXD5.
PhylomeDBi P63075.
TreeFami TF331233.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

NextBioi 285334.
PROi P63075.
SOURCEi Search...

Gene expression databases

Bgeei P63075.
CleanExi MM_FGF17.
ExpressionAtlasi P63075. differential.
Genevestigatori P63075.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028287. FGF17.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF71. PTHR11486:SF71. 1 hit.
PRINTSi PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain."
    Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S., Itoh N.
    Biochem. Biophys. Res. Commun. 244:187-191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFGF17_MOUSE
AccessioniPrimary (citable) accession number: P63075
Secondary accession number(s): O70627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3