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Protein

Fibroblast growth factor 17

Gene

Fgf17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

GO - Molecular functioni

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: MGI
  • multicellular organismal development Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_317910. FGFR3b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_354830. FGFR1c ligand binding and activation.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_357826. Negative regulation of FGFR3 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359386. Phospholipase C-mediated cascade, FGFR3.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_360961. PI-3K cascade:FGFR3.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 17
Short name:
FGF-17
Gene namesi
Name:Fgf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1202401. Fgf17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 216194Fibroblast growth factor 17PRO_0000008986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP63075.

PTM databases

PhosphoSiteiP63075.

Expressioni

Gene expression databases

BgeeiP63075.
CleanExiMM_FGF17.
ExpressionAtlasiP63075. baseline and differential.
GenevisibleiP63075. MM.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022697.

Structurei

3D structure databases

ProteinModelPortaliP63075.
SMRiP63075. Positions 33-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327940.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP63075.
KOiK04358.
OMAiCQTQVTA.
OrthoDBiEOG7DFXD5.
PhylomeDBiP63075.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028287. FGF17.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF71. PTHR11486:SF71. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR
60 70 80 90 100
QIREYQLYSR TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK
110 120 130 140 150
GAESEKYICM NKRGKLIGKP SGKSKDCVFT EIVLENNYTA FQNARHEGWF
160 170 180 190 200
MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ GQLPFPNHAE RQKQFEFVGS
210
APTRRTKRTR RPQSQT
Length:216
Mass (Da):24,924
Last modified:September 13, 2004 - v1
Checksum:i2EE94BDF75220F4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009250 mRNA. Translation: BAA25430.1.
AK077555 mRNA. Translation: BAC36859.1.
CCDSiCCDS27260.1.
RefSeqiNP_032030.1. NM_008004.4.
XP_006518614.1. XM_006518551.2.
UniGeneiMm.12814.

Genome annotation databases

EnsembliENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101.
GeneIDi14171.
KEGGimmu:14171.
UCSCiuc007uos.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009250 mRNA. Translation: BAA25430.1.
AK077555 mRNA. Translation: BAC36859.1.
CCDSiCCDS27260.1.
RefSeqiNP_032030.1. NM_008004.4.
XP_006518614.1. XM_006518551.2.
UniGeneiMm.12814.

3D structure databases

ProteinModelPortaliP63075.
SMRiP63075. Positions 33-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022697.

PTM databases

PhosphoSiteiP63075.

Proteomic databases

PRIDEiP63075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101.
GeneIDi14171.
KEGGimmu:14171.
UCSCiuc007uos.1. mouse.

Organism-specific databases

CTDi8822.
MGIiMGI:1202401. Fgf17.

Phylogenomic databases

eggNOGiNOG327940.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP63075.
KOiK04358.
OMAiCQTQVTA.
OrthoDBiEOG7DFXD5.
PhylomeDBiP63075.
TreeFamiTF331233.

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_317910. FGFR3b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_354830. FGFR1c ligand binding and activation.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_357826. Negative regulation of FGFR3 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358810. FRS-mediated FGFR3 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359386. Phospholipase C-mediated cascade, FGFR3.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_360961. PI-3K cascade:FGFR3.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361658. FRS2-mediated FGFR4 signaling.
REACT_361860. SHC-mediated cascade:FGFR1.
REACT_361987. SHC-mediated cascade:FGFR3.

Miscellaneous databases

NextBioi285334.
PROiP63075.
SOURCEiSearch...

Gene expression databases

BgeeiP63075.
CleanExiMM_FGF17.
ExpressionAtlasiP63075. baseline and differential.
GenevisibleiP63075. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028287. FGF17.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF71. PTHR11486:SF71. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain."
    Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S., Itoh N.
    Biochem. Biophys. Res. Commun. 244:187-191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFGF17_MOUSE
AccessioniPrimary (citable) accession number: P63075
Secondary accession number(s): O70627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 24, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.