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Protein

Thyroid hormone receptor alpha

Gene

Thra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281Thyroid hormoneBy similarity
Binding sitei277 – 2771Thyroid hormone; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi53 – 12775Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 11525NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  3. protein complex binding Source: MGI
  4. protein domain specific binding Source: MGI
  5. sequence-specific DNA binding transcription factor activity Source: MGI
  6. single-stranded RNA binding Source: MGI
  7. steroid hormone receptor activity Source: InterPro
  8. steroid receptor RNA activator RNA binding Source: MGI
  9. TBP-class protein binding Source: MGI
  10. thyroid hormone binding Source: UniProtKB
  11. thyroid hormone receptor activity Source: UniProtKB
  12. transcription factor binding Source: MGI
  13. transcription regulatory region DNA binding Source: MGI
  14. zinc ion binding Source: InterPro

GO - Biological processi

  1. cartilage condensation Source: MGI
  2. cytoplasmic sequestering of transcription factor Source: MGI
  3. erythrocyte differentiation Source: MGI
  4. female courtship behavior Source: MGI
  5. hormone-mediated signaling pathway Source: MGI
  6. intracellular receptor signaling pathway Source: MGI
  7. learning or memory Source: MGI
  8. negative regulation of DNA-templated transcription, initiation Source: MGI
  9. negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
  10. negative regulation of transcription, DNA-templated Source: MGI
  11. organ morphogenesis Source: MGI
  12. ossification Source: MGI
  13. positive regulation of female receptivity Source: MGI
  14. positive regulation of myotube differentiation Source: MGI
  15. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  16. regulation of heart contraction Source: MGI
  17. regulation of lipid catabolic process Source: MGI
  18. regulation of myeloid cell apoptotic process Source: MGI
  19. regulation of thyroid hormone mediated signaling pathway Source: MGI
  20. regulation of transcription from RNA polymerase II promoter Source: MGI
  21. response to cold Source: MGI
  22. thyroid gland development Source: MGI
  23. transcription from RNA polymerase II promoter Source: MGI
  24. Type I pneumocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
c-erbA-1
c-erbA-alpha
Gene namesi
Name:Thra
Synonyms:C-erba-alpha, Nr1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98742. Thra.

Subcellular locationi

Isoform Alpha-deltaE6 : Cytoplasm
Note: Sequesters isoform Alpha-1 into this compartment.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Thyroid hormone receptor alphaPRO_0000053425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki190 – 190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP63058.
PRIDEiP63058.

PTM databases

PhosphoSiteiP63058.

Expressioni

Tissue specificityi

Ubiquitous (Isoform Alpha-deltaE6).1 Publication

Gene expression databases

BgeeiP63058.
CleanExiMM_THRA.
ExpressionAtlasiP63058. baseline and differential.
GenevestigatoriP63058.

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13. Interacts with C1D. Interacts with TP53INP2. Interacts with PER2.3 Publications

Protein-protein interaction databases

BioGridi204183. 5 interactions.
DIPiDIP-43752N.
IntActiP63058. 1 interaction.
MINTiMINT-3374329.

Structurei

3D structure databases

ProteinModelPortaliP63058.
SMRiP63058. Positions 50-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5252ModulatingAdd
BLAST
Regioni190 – 370181Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Isoform Alpha-deltaE6 lacks the hinge region that connects the modulating domain and the DNA binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri53 – 7321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri91 – 11525NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOVERGENiHBG005606.
InParanoidiP63058.
KOiK05547.
OMAiSSMSGYI.
OrthoDBiEOG7TBC2V.
PhylomeDBiP63058.
TreeFamiTF328382.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha-2 (identifier: P63058-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHSRAVCG EDDSSEASSL SSSSDTEDTE VCEDQAGKAA SP
Length:492
Mass (Da):55,023
Last modified:January 19, 2010 - v2
Checksum:i870100FCB5C34A10
GO
Isoform Alpha-1 (identifier: P63058-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

Show »
Length:410
Mass (Da):46,795
Checksum:iEC0240EF1ECF4111
GO
Isoform Alpha-3 (identifier: P63058-3) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-409: Missing.

Show »
Length:453
Mass (Da):50,954
Checksum:i6DE1FECA97686CAF
GO
Isoform Alpha-deltaE6 (identifier: P63058-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-197: AMDLVLDDSK...RRKFLPDDIG → GTSP
     371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

Note: Due to mismatches with the underlying genomic sequence that lie within a microexon, this isoform has been proposed to undergo RNA editing involving both base insertion and deletion.

Show »
Length:337
Mass (Da):37,926
Checksum:i27137623BED67783
GO

Sequence cautioni

The sequence CAM46188.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061Q → H in CAA36241 (PubMed:2349106).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei121 – 19777AMDLV…PDDIG → GTSP in isoform Alpha-deltaE6. CuratedVSP_038640Add
BLAST
Alternative sequencei371 – 492122EREVQ…KAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1 and isoform Alpha-deltaE6. 3 PublicationsVSP_003624Add
BLAST
Alternative sequencei371 – 40939Missing in isoform Alpha-3. 1 PublicationVSP_003625Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07750 mRNA. Translation: CAA30575.1.
X07751 mRNA. Translation: CAA30576.1.
X07752 mRNA. Translation: CAA30577.1.
X51983 mRNA. Translation: CAA36241.1.
AK078233 mRNA. Translation: BAC37186.1.
AL590963 Genomic DNA. Translation: CAM46188.1. Sequence problems.
AL590963 Genomic DNA. Translation: CAM46189.1.
AL590963 Genomic DNA. Translation: CAM46190.1.
CH466556 Genomic DNA. Translation: EDL16164.1.
CH466556 Genomic DNA. Translation: EDL16165.1.
BC046795 mRNA. Translation: AAH46795.1.
CCDSiCCDS25362.1. [P63058-2]
PIRiS14416.
S14417.
S14418.
S14690. QRMSA1.
RefSeqiNP_835161.1. NM_178060.3. [P63058-2]
UniGeneiMm.265917.
Mm.442648.

Genome annotation databases

EnsembliENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756. [P63058-1]
ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756. [P63058-2]
GeneIDi21833.
KEGGimmu:21833.
UCSCiuc007lhe.1. mouse. [P63058-2]
uc007lhf.1. mouse.
uc007lhg.1. mouse. [P63058-3]

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07750 mRNA. Translation: CAA30575.1.
X07751 mRNA. Translation: CAA30576.1.
X07752 mRNA. Translation: CAA30577.1.
X51983 mRNA. Translation: CAA36241.1.
AK078233 mRNA. Translation: BAC37186.1.
AL590963 Genomic DNA. Translation: CAM46188.1. Sequence problems.
AL590963 Genomic DNA. Translation: CAM46189.1.
AL590963 Genomic DNA. Translation: CAM46190.1.
CH466556 Genomic DNA. Translation: EDL16164.1.
CH466556 Genomic DNA. Translation: EDL16165.1.
BC046795 mRNA. Translation: AAH46795.1.
CCDSiCCDS25362.1. [P63058-2]
PIRiS14416.
S14417.
S14418.
S14690. QRMSA1.
RefSeqiNP_835161.1. NM_178060.3. [P63058-2]
UniGeneiMm.265917.
Mm.442648.

3D structure databases

ProteinModelPortaliP63058.
SMRiP63058. Positions 50-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204183. 5 interactions.
DIPiDIP-43752N.
IntActiP63058. 1 interaction.
MINTiMINT-3374329.

Chemistry

GuidetoPHARMACOLOGYi588.

PTM databases

PhosphoSiteiP63058.

Proteomic databases

MaxQBiP63058.
PRIDEiP63058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756. [P63058-1]
ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756. [P63058-2]
GeneIDi21833.
KEGGimmu:21833.
UCSCiuc007lhe.1. mouse. [P63058-2]
uc007lhf.1. mouse.
uc007lhg.1. mouse. [P63058-3]

Organism-specific databases

CTDi7067.
MGIiMGI:98742. Thra.

Phylogenomic databases

eggNOGiNOG272726.
GeneTreeiENSGT00780000121834.
HOVERGENiHBG005606.
InParanoidiP63058.
KOiK05547.
OMAiSSMSGYI.
OrthoDBiEOG7TBC2V.
PhylomeDBiP63058.
TreeFamiTF328382.

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi301282.
PROiP63058.
SOURCEiSearch...

Gene expression databases

BgeeiP63058.
CleanExiMM_THRA.
ExpressionAtlasiP63058. baseline and differential.
GenevestigatoriP63058.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001728. ThyrH_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00546. THYROIDHORMR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries."
    Prost E., Koenig R.J., Moore D.D., Larsen P.R., Whalen R.G.
    Nucleic Acids Res. 16:6248-6248(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-452 (ISOFORMS ALPHA-2 AND ALPHA-3).
    Strain: C3H.
    Tissue: Muscle.
  2. "Nucleotide sequence of the murine thyroid hormone receptor (alpha-1) cDNA."
    Masuda M., Yasuhara S., Yamashita M., Shibuya M., Odaka T.
    Nucleic Acids Res. 18:3055-3055(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1).
    Strain: C3H.
    Tissue: Testis.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1).
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-2).
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
    Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
    Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C1D.
  8. "Cloning and characterization of RAP250, a nuclear receptor coactivator."
    Caira F., Antonson P., Pelto-Huikko M., Treuter E., Gustafsson J.-A.
    J. Biol. Chem. 275:5308-5317(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NCOA6.
  9. "Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation."
    Casas F., Busson M., Grandemange S., Seyer P., Carazo A., Pessemesse L., Wrutniak-Cabello C., Cabello G.
    Mol. Endocrinol. 20:749-763(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS ALPHA-1 AND ALPHA-DELTAE6), POTENTIAL RNA EDITING OF ISOFORM ALPHA-DELTAE6, FUNCTION, TISSUE SPECIFICITY.
  10. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
    Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
    Genes Dev. 24:345-357(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PER2.

Entry informationi

Entry nameiTHA_MOUSE
AccessioniPrimary (citable) accession number: P63058
Secondary accession number(s): A3KFN4
, P10685, P15827, P16416, P37241, Q542U8, Q63107, Q63195, Q63196, Q80Y90, Q99146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 19, 2010
Last modified: April 1, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.