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P63058

- THA_MOUSE

UniProt

P63058 - THA_MOUSE

Protein

Thyroid hormone receptor alpha

Gene

Thra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (19 Jan 2010)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281Thyroid hormoneBy similarity
    Binding sitei277 – 2771Thyroid hormone; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi53 – 12775Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri53 – 7321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri91 – 11525NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin DNA binding Source: MGI
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    3. protein binding Source: UniProtKB
    4. protein complex binding Source: MGI
    5. single-stranded RNA binding Source: MGI
    6. steroid hormone receptor activity Source: InterPro
    7. steroid receptor RNA activator RNA binding Source: MGI
    8. thyroid hormone binding Source: UniProtKB
    9. thyroid hormone receptor activity Source: UniProtKB
    10. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cartilage condensation Source: MGI
    2. cytoplasmic sequestering of transcription factor Source: MGI
    3. erythrocyte differentiation Source: MGI
    4. female courtship behavior Source: MGI
    5. intracellular receptor signaling pathway Source: GOC
    6. learning or memory Source: MGI
    7. negative regulation of DNA-templated transcription, initiation Source: Ensembl
    8. negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: Ensembl
    9. negative regulation of transcription, DNA-templated Source: MGI
    10. organ morphogenesis Source: MGI
    11. ossification Source: MGI
    12. positive regulation of female receptivity Source: MGI
    13. positive regulation of myotube differentiation Source: MGI
    14. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    15. regulation of heart contraction Source: MGI
    16. regulation of lipid catabolic process Source: MGI
    17. regulation of myeloid cell apoptotic process Source: MGI
    18. regulation of thyroid hormone mediated signaling pathway Source: MGI
    19. response to cold Source: MGI
    20. thyroid gland development Source: MGI
    21. Type I pneumocyte differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyroid hormone receptor alpha
    Alternative name(s):
    Nuclear receptor subfamily 1 group A member 1
    c-erbA-1
    c-erbA-alpha
    Gene namesi
    Name:Thra
    Synonyms:C-erba-alpha, Nr1a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98742. Thra.

    Subcellular locationi

    Isoform Alpha-deltaE6 : Cytoplasm
    Note: Sequesters isoform Alpha-1 into this compartment.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: Ensembl
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Thyroid hormone receptor alphaPRO_0000053425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki190 – 190Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiP63058.

    PTM databases

    PhosphoSiteiP63058.

    Expressioni

    Tissue specificityi

    Ubiquitous (Isoform Alpha-deltaE6).1 Publication

    Gene expression databases

    ArrayExpressiP63058.
    BgeeiP63058.
    CleanExiMM_THRA.
    GenevestigatoriP63058.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13. Interacts with C1D. Interacts with TP53INP2. Interacts with PER2.3 Publications

    Protein-protein interaction databases

    BioGridi204183. 4 interactions.
    DIPiDIP-43752N.
    IntActiP63058. 1 interaction.
    MINTiMINT-3374329.

    Structurei

    3D structure databases

    ProteinModelPortaliP63058.
    SMRiP63058. Positions 49-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5252ModulatingAdd
    BLAST
    Regioni190 – 370181Ligand-bindingAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Isoform Alpha-deltaE6 lacks the hinge region that connects the modulating domain and the DNA binding domain.

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri53 – 7321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri91 – 11525NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG272726.
    GeneTreeiENSGT00740000114969.
    HOVERGENiHBG005606.
    InParanoidiQ80Y90.
    KOiK05547.
    OMAiWLNGPKR.
    OrthoDBiEOG7TBC2V.
    PhylomeDBiP63058.
    TreeFamiTF328382.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Alpha-2 (identifier: P63058-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD    50
    EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID 100
    KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM 150
    IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP 200
    IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL 250
    LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 300
    ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE 350
    HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ 400
    QLLGMHVVQG PQVRQLEQQL GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS 450
    GILHSRAVCG EDDSSEASSL SSSSDTEDTE VCEDQAGKAA SP 492
    Length:492
    Mass (Da):55,023
    Last modified:January 19, 2010 - v2
    Checksum:i870100FCB5C34A10
    GO
    Isoform Alpha-1 (identifier: P63058-2) [UniParc] [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

    Show »
    Length:410
    Mass (Da):46,795
    Checksum:iEC0240EF1ECF4111
    GO
    Isoform Alpha-3 (identifier: P63058-3) [UniParc] [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         371-409: Missing.

    Show »
    Length:453
    Mass (Da):50,954
    Checksum:i6DE1FECA97686CAF
    GO
    Isoform Alpha-deltaE6 (identifier: P63058-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-197: AMDLVLDDSK...RRKFLPDDIG → GTSP
         371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

    Note: Due to mismatches with the underlying genomic sequence that lie within a microexon, this isoform has been proposed to undergo RNA editing involving both base insertion and deletion.

    Show »
    Length:337
    Mass (Da):37,926
    Checksum:i27137623BED67783
    GO

    Sequence cautioni

    The sequence CAM46188.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061Q → H in CAA36241. (PubMed:2349106)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei121 – 19777AMDLV…PDDIG → GTSP in isoform Alpha-deltaE6. CuratedVSP_038640Add
    BLAST
    Alternative sequencei371 – 492122EREVQ…KAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1 and isoform Alpha-deltaE6. 3 PublicationsVSP_003624Add
    BLAST
    Alternative sequencei371 – 40939Missing in isoform Alpha-3. 1 PublicationVSP_003625Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07750 mRNA. Translation: CAA30575.1.
    X07751 mRNA. Translation: CAA30576.1.
    X07752 mRNA. Translation: CAA30577.1.
    X51983 mRNA. Translation: CAA36241.1.
    AK078233 mRNA. Translation: BAC37186.1.
    AL590963 Genomic DNA. Translation: CAM46188.1. Sequence problems.
    AL590963 Genomic DNA. Translation: CAM46189.1.
    AL590963 Genomic DNA. Translation: CAM46190.1.
    CH466556 Genomic DNA. Translation: EDL16164.1.
    CH466556 Genomic DNA. Translation: EDL16165.1.
    BC046795 mRNA. Translation: AAH46795.1.
    CCDSiCCDS25362.1. [P63058-2]
    PIRiS14416.
    S14417.
    S14418.
    S14690. QRMSA1.
    RefSeqiNP_835161.1. NM_178060.3. [P63058-2]
    UniGeneiMm.265917.
    Mm.442648.

    Genome annotation databases

    EnsembliENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756. [P63058-1]
    ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756. [P63058-2]
    ENSMUST00000124072; ENSMUSP00000115323; ENSMUSG00000058756.
    GeneIDi21833.
    KEGGimmu:21833.
    UCSCiuc007lhe.1. mouse. [P63058-2]
    uc007lhf.1. mouse.
    uc007lhg.1. mouse. [P63058-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07750 mRNA. Translation: CAA30575.1 .
    X07751 mRNA. Translation: CAA30576.1 .
    X07752 mRNA. Translation: CAA30577.1 .
    X51983 mRNA. Translation: CAA36241.1 .
    AK078233 mRNA. Translation: BAC37186.1 .
    AL590963 Genomic DNA. Translation: CAM46188.1 . Sequence problems.
    AL590963 Genomic DNA. Translation: CAM46189.1 .
    AL590963 Genomic DNA. Translation: CAM46190.1 .
    CH466556 Genomic DNA. Translation: EDL16164.1 .
    CH466556 Genomic DNA. Translation: EDL16165.1 .
    BC046795 mRNA. Translation: AAH46795.1 .
    CCDSi CCDS25362.1. [P63058-2 ]
    PIRi S14416.
    S14417.
    S14418.
    S14690. QRMSA1.
    RefSeqi NP_835161.1. NM_178060.3. [P63058-2 ]
    UniGenei Mm.265917.
    Mm.442648.

    3D structure databases

    ProteinModelPortali P63058.
    SMRi P63058. Positions 49-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204183. 4 interactions.
    DIPi DIP-43752N.
    IntActi P63058. 1 interaction.
    MINTi MINT-3374329.

    Chemistry

    GuidetoPHARMACOLOGYi 588.

    PTM databases

    PhosphoSitei P63058.

    Proteomic databases

    PRIDEi P63058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000064187 ; ENSMUSP00000068281 ; ENSMUSG00000058756 . [P63058-1 ]
    ENSMUST00000103139 ; ENSMUSP00000099428 ; ENSMUSG00000058756 . [P63058-2 ]
    ENSMUST00000124072 ; ENSMUSP00000115323 ; ENSMUSG00000058756 .
    GeneIDi 21833.
    KEGGi mmu:21833.
    UCSCi uc007lhe.1. mouse. [P63058-2 ]
    uc007lhf.1. mouse.
    uc007lhg.1. mouse. [P63058-3 ]

    Organism-specific databases

    CTDi 7067.
    MGIi MGI:98742. Thra.

    Phylogenomic databases

    eggNOGi NOG272726.
    GeneTreei ENSGT00740000114969.
    HOVERGENi HBG005606.
    InParanoidi Q80Y90.
    KOi K05547.
    OMAi WLNGPKR.
    OrthoDBi EOG7TBC2V.
    PhylomeDBi P63058.
    TreeFami TF328382.

    Miscellaneous databases

    NextBioi 301282.
    PROi P63058.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63058.
    Bgeei P63058.
    CleanExi MM_THRA.
    Genevestigatori P63058.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001728. ThyrH_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    PR00546. THYROIDHORMR.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries."
      Prost E., Koenig R.J., Moore D.D., Larsen P.R., Whalen R.G.
      Nucleic Acids Res. 16:6248-6248(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1), NUCLEOTIDE SEQUENCE [MRNA] OF 1-452 (ISOFORMS ALPHA-2 AND ALPHA-3).
      Strain: C3H.
      Tissue: Muscle.
    2. "Nucleotide sequence of the murine thyroid hormone receptor (alpha-1) cDNA."
      Masuda M., Yasuhara S., Yamashita M., Shibuya M., Odaka T.
      Nucleic Acids Res. 18:3055-3055(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1).
      Strain: C3H.
      Tissue: Testis.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-1).
      Strain: C57BL/6J.
      Tissue: Olfactory bulb.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-2).
      Strain: C57BL/6.
      Tissue: Brain.
    7. "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex."
      Zamir I., Dawson J., Lavinsky R.M., Glass C.K., Rosenfeld M.G., Lazar M.A.
      Proc. Natl. Acad. Sci. U.S.A. 94:14400-14405(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH C1D.
    8. "Cloning and characterization of RAP250, a nuclear receptor coactivator."
      Caira F., Antonson P., Pelto-Huikko M., Treuter E., Gustafsson J.-A.
      J. Biol. Chem. 275:5308-5317(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCOA6.
    9. "Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation."
      Casas F., Busson M., Grandemange S., Seyer P., Carazo A., Pessemesse L., Wrutniak-Cabello C., Cabello G.
      Mol. Endocrinol. 20:749-763(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS ALPHA-1 AND ALPHA-DELTAE6), POTENTIAL RNA EDITING OF ISOFORM ALPHA-DELTAE6, FUNCTION, TISSUE SPECIFICITY.
    10. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
      Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
      Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PER2.

    Entry informationi

    Entry nameiTHA_MOUSE
    AccessioniPrimary (citable) accession number: P63058
    Secondary accession number(s): A3KFN4
    , P10685, P15827, P16416, P37241, Q542U8, Q63107, Q63195, Q63196, Q80Y90, Q99146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3