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Protein

Noelin-3

Gene

Olfm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Noelin-3
Alternative name(s):
Olfactomedin-3
Optimedin
Gene namesi
Name:Olfm3
Synonyms:Noe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2387329. Olfm3.

Subcellular locationi

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: MGI
  • cell junction Source: UniProtKB-KW
  • extracellular space Source: MGI
  • Golgi apparatus Source: MGI
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002008124 – 478Noelin-3Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi219 ↔ 401PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP63056.
PaxDbiP63056.
PeptideAtlasiP63056.
PRIDEiP63056.

PTM databases

PhosphoSitePlusiP63056.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level).1 Publication

Developmental stagei

Expressed during embryonic development starting from 7 dpc. Expression increases moderately during embryonic development and remains stable in the postnatal brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000027965.
CleanExiMM_OLFM3.
ExpressionAtlasiP63056. baseline and differential.
GenevisibleiP63056. MM.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM3. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (PubMed:22632720). Homodimer. Interacts with MYOC (PubMed:12019210). Interacts with OLFM2 (By similarity).By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060985.

Structurei

3D structure databases

ProteinModelPortaliP63056.
SMRiP63056.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 470Olfactomedin-likePROSITE-ProRule annotationAdd BLAST253

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili77 – 217Sequence analysisAdd BLAST141

Sequence similaritiesi

Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410KCV8. Eukaryota.
ENOG410ZVS0. LUCA.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000232069.
HOVERGENiHBG006513.
InParanoidiP63056.
OMAiIKYSFDT.
OrthoDBiEOG091G05HN.
PhylomeDBiP63056.
TreeFamiTF315964.

Family and domain databases

InterProiIPR031216. Noelin-3.
IPR022082. Noelin_dom.
IPR003112. Olfac-like_dom.
IPR011044. Quino_amine_DH_bsu.
[Graphical view]
PANTHERiPTHR23192:SF36. PTHR23192:SF36. 1 hit.
PfamiPF12308. Noelin-1. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 3 hits.
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P63056-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPLLKLGA VLSTMAMISN WMSQTLPSLV GLNTTRLSAP DTLTQISPKE
60 70 80 90 100
GWQVYSSAQD PDGRCICTVV APEQNLCSRD AKSRQLRQLL EKVQNMSQSI
110 120 130 140 150
EVLNLRTQRD FQYVLKMETQ MKGLKAKFRQ IEDDRKTLMT KHFQELKEKM
160 170 180 190 200
DELLPLIPVL EQYKTDAKLI TQFKEEIRNL SSVLTGIQEE IGAYDYEELH
210 220 230 240 250
QRVLSLETRL RDCMKKLTCG KLMKITGPIT VKTSGTRFGA WMTDPLASEK
260 270 280 290 300
NNRVWYMDSY TNNKIVREYK SIADFVSGAE SRTYNLPFKW AGTNHVVYNG
310 320 330 340 350
SLYFNKYQSN IIIKYSFDLG RVLAQRSLEY AGFHNVYPYT WGGFSDIDLM
360 370 380 390 400
ADEIGLWAVY ATNQNAGNIV ISQLNQDTLE VMKSWSTGYP KRSAGESFMI
410 420 430 440 450
CGTLYVTNSH LTGAKVYYSY STKTSTYEYT DIPFHNQYFH ISMLDYNARD
460 470
RALYAWNNGH QVLFNVTLFH IIKTEDDT
Length:478
Mass (Da):54,886
Last modified:September 13, 2004 - v1
Checksum:iED4250E58213787D
GO
Isoform 2 (identifier: P63056-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MSAPLLKLGAVLSTMAMISNWMSQTLPSLVGLNTTRLSAPDTL → MQARSSFLNLLLLSLLAGLDPSK

Show »
Length:458
Mass (Da):52,841
Checksum:i80371F2B171E58EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118E → K in BAC31867 (PubMed:16141072).Curated1
Sequence conflicti410H → P in BAC33841 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0077471 – 43MSAPL…APDTL → MQARSSFLNLLLLSLLAGLD PSK in isoform 2. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442824 mRNA. Translation: AAL87043.1.
AF442825 mRNA. Translation: AAL87044.1.
AK038569 mRNA. Translation: BAC30048.1.
AK044325 mRNA. Translation: BAC31867.1.
AK044605 mRNA. Translation: BAC32000.1.
AK045482 mRNA. Translation: BAC32389.1.
AK049612 mRNA. Translation: BAC33841.1.
AK079315 mRNA. Translation: BAC37605.1.
CCDSiCCDS17779.1. [P63056-2]
CCDS17780.1.
RefSeqiNP_694797.1. NM_153157.3. [P63056-1]
NP_703188.1. NM_153458.3. [P63056-2]
UniGeneiMm.54183.

Genome annotation databases

EnsembliENSMUST00000051309; ENSMUSP00000060985; ENSMUSG00000027965. [P63056-1]
ENSMUST00000081752; ENSMUSP00000080448; ENSMUSG00000027965. [P63056-2]
GeneIDi229759.
KEGGimmu:229759.
UCSCiuc008rbn.2. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442824 mRNA. Translation: AAL87043.1.
AF442825 mRNA. Translation: AAL87044.1.
AK038569 mRNA. Translation: BAC30048.1.
AK044325 mRNA. Translation: BAC31867.1.
AK044605 mRNA. Translation: BAC32000.1.
AK045482 mRNA. Translation: BAC32389.1.
AK049612 mRNA. Translation: BAC33841.1.
AK079315 mRNA. Translation: BAC37605.1.
CCDSiCCDS17779.1. [P63056-2]
CCDS17780.1.
RefSeqiNP_694797.1. NM_153157.3. [P63056-1]
NP_703188.1. NM_153458.3. [P63056-2]
UniGeneiMm.54183.

3D structure databases

ProteinModelPortaliP63056.
SMRiP63056.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060985.

PTM databases

PhosphoSitePlusiP63056.

Proteomic databases

MaxQBiP63056.
PaxDbiP63056.
PeptideAtlasiP63056.
PRIDEiP63056.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051309; ENSMUSP00000060985; ENSMUSG00000027965. [P63056-1]
ENSMUST00000081752; ENSMUSP00000080448; ENSMUSG00000027965. [P63056-2]
GeneIDi229759.
KEGGimmu:229759.
UCSCiuc008rbn.2. mouse.

Organism-specific databases

CTDi118427.
MGIiMGI:2387329. Olfm3.

Phylogenomic databases

eggNOGiENOG410KCV8. Eukaryota.
ENOG410ZVS0. LUCA.
GeneTreeiENSGT00760000119005.
HOGENOMiHOG000232069.
HOVERGENiHBG006513.
InParanoidiP63056.
OMAiIKYSFDT.
OrthoDBiEOG091G05HN.
PhylomeDBiP63056.
TreeFamiTF315964.

Miscellaneous databases

PROiP63056.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027965.
CleanExiMM_OLFM3.
ExpressionAtlasiP63056. baseline and differential.
GenevisibleiP63056. MM.

Family and domain databases

InterProiIPR031216. Noelin-3.
IPR022082. Noelin_dom.
IPR003112. Olfac-like_dom.
IPR011044. Quino_amine_DH_bsu.
[Graphical view]
PANTHERiPTHR23192:SF36. PTHR23192:SF36. 1 hit.
PfamiPF12308. Noelin-1. 1 hit.
PF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50969. SSF50969. 3 hits.
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOE3_MOUSE
AccessioniPrimary (citable) accession number: P63056
Secondary accession number(s): Q8BKV2
, Q8BLL6, Q8QZW0, Q8R4K3, Q8R4K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.