ID VAMP2_RAT Reviewed; 116 AA. AC P63045; Q64357; DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 25-JAN-2012, entry version 76. DE RecName: Full=Vesicle-associated membrane protein 2; DE Short=VAMP-2; DE AltName: Full=Synaptobrevin-2; GN Name=Vamp2; Synonyms=Syb2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Brain; RX MEDLINE=89291844; PubMed=2472388; RA Elferink L.A., Trimble W.S., Scheller R.H.; RT "Two vesicle-associated membrane protein genes are differentially RT expressed in the rat central nervous system."; RL J. Biol. Chem. 264:11061-11064(1989). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PROTEIN SEQUENCE OF 32-47 AND 60-83, AND MASS SPECTROMETRY. RC STRAIN=Sprague-Dawley; TISSUE=Hippocampus; RA Lubec G., Chen W.-Q.; RL Submitted (JAN-2009) to UniProtKB. RN [4] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-97 IN COMPLEX WITH STX1A RP AND SNAP25. RX MEDLINE=98430524; PubMed=9759724; DOI=10.1038/26412; RA Sutton R.B., Fasshauer D., Jahn R., Brunger A.T.; RT "Crystal structure of a SNARE complex involved in synaptic exocytosis RT at 2.4 A resolution."; RL Nature 395:347-353(1998). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 30-94 IN COMPLEX WITH STX1A; RP CPLX1 AND SNAP25, AND STRUCTURE BY NMR. RX MEDLINE=21822661; PubMed=11832227; DOI=10.1016/S0896-6273(02)00583-4; RA Chen X., Tomchick D.R., Kovrigin E., Arac D., Machius M., RA Suedhof T.C., Rizo J.; RT "Three-dimensional structure of the complexin/SNARE complex."; RL Neuron 33:397-409(2002). RN [6] RP X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 29-90 IN COMPLEX WITH STX1A RP AND SNAP25. RX MEDLINE=22499607; PubMed=12496247; DOI=10.1074/jbc.M211889200; RA Ernst J.A., Brunger A.T.; RT "High resolution structure, stability, and synaptotagmin binding of a RT truncated neuronal SNARE complex."; RL J. Biol. Chem. 278:8630-8636(2003). CC -!- FUNCTION: Involved in the targeting and/or fusion of transport CC vesicles to their target membrane (By similarity). CC -!- SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 CC and STX1A. This complex binds to CPLX1. Interacts with BVES and CC STX4. Interacts with VAPA and VAPB (By similarity). CC -!- INTERACTION: CC D4A229:-; NbExp=2; IntAct=EBI-520880, EBI-1255458; CC P32851:Stx1a; NbExp=5; IntAct=EBI-520880, EBI-539720; CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, CC synaptic vesicle membrane; Single-pass type IV membrane protein. CC Cell junction, synapse, synaptosome. Note=Neuronal synaptic CC vesicles. CC -!- TISSUE SPECIFICITY: Nervous system specific. A higher level CC expression is seen in the brain as compared to the spinal cord. CC -!- SIMILARITY: Belongs to the synaptobrevin family. CC -!- SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M24105; AAA42321.1; -; mRNA. DR EMBL; BC074003; AAH74003.1; -; mRNA. DR IPI; IPI00781701; -. DR PIR; B34288; B34288. DR RefSeq; NP_036795.1; NM_012663.2. DR UniGene; Rn.12939; -. DR PDB; 1KIL; X-ray; 2.30 A; A=28-92. DR PDB; 1N7S; X-ray; 1.45 A; A=28-89. DR PDB; 1SFC; X-ray; 2.40 A; A/E/I=1-96. DR PDB; 2BU0; Model; -; A=25-88. DR PDB; 2KOG; NMR; -; A=1-116. DR PDB; 3HD7; X-ray; 3.40 A; A/E=30-116. DR PDB; 3IPD; X-ray; 4.80 A; A/E=30-116. DR PDBsum; 1KIL; -. DR PDBsum; 1N7S; -. DR PDBsum; 1SFC; -. DR PDBsum; 2BU0; -. DR PDBsum; 2KOG; -. DR PDBsum; 3HD7; -. DR PDBsum; 3IPD; -. DR ProteinModelPortal; P63045; -. DR SMR; P63045; 30-116. DR DIP; DIP-35503N; -. DR IntAct; P63045; 12. DR MINT; MINT-1487471; -. DR STRING; P63045; -. DR PhosphoSite; P63045; -. DR PRIDE; P63045; -. DR Ensembl; ENSRNOT00000057295; ENSRNOP00000054114; ENSRNOG00000006989. DR GeneID; 24803; -. DR KEGG; rno:24803; -. DR UCSC; NM_012663; rat. DR CTD; 6844; -. DR RGD; 3949; Vamp2. DR eggNOG; veNOG21495; -. DR HOVERGEN; HBG006675; -. DR InParanoid; P63045; -. DR OrthoDB; EOG43JC6B; -. DR NextBio; 604468; -. DR PMAP-CutDB; P63045; -. DR ArrayExpress; P63045; -. DR Genevestigator; P63045; -. DR GermOnline; ENSRNOG00000006989; Rattus norvegicus. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005792; C:microsome; IDA:RGD. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0030141; C:secretory granule; IDA:UniProtKB. DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IDA:MGI. DR GO; GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IDA:MGI. DR GO; GO:0019717; C:synaptosome; IDA:RGD. DR GO; GO:0017022; F:myosin binding; IPI:RGD. DR GO; GO:0008022; F:protein C-terminus binding; IPI:RGD. DR GO; GO:0017075; F:syntaxin-1 binding; IDA:MGI. DR GO; GO:0006461; P:protein complex assembly; IDA:RGD. DR GO; GO:0015031; P:protein transport; IMP:RGD. DR GO; GO:0017157; P:regulation of exocytosis; TAS:UniProtKB. DR GO; GO:0009749; P:response to glucose stimulus; IDA:UniProtKB. DR GO; GO:0016192; P:vesicle-mediated transport; IMP:RGD. DR InterPro; IPR001388; Synaptobrevin. DR InterPro; IPR016444; Synaptobrevin_met/fun. DR KO; K13504; -. DR Pfam; PF00957; Synaptobrevin; 1. DR PIRSF; PIRSF005409; Synaptobrevin_euk; 1. DR PRINTS; PR00219; SYNAPTOBREVN. DR PROSITE; PS00417; SYNAPTOBREVIN; 1. DR PROSITE; PS50892; V_SNARE; 1. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Cell junction; Coiled coil; KW Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; KW Membrane; Phosphoprotein; Reference proteome; Synapse; Synaptosome; KW Transmembrane; Transmembrane helix. FT INIT_MET 1 1 Removed (By similarity). FT CHAIN 2 116 Vesicle-associated membrane protein 2. FT /FTId=PRO_0000206726. FT TOPO_DOM 2 94 Cytoplasmic (Potential). FT TRANSMEM 95 114 Helical; Anchor for type IV membrane FT protein; (Potential). FT TOPO_DOM 115 116 Vesicular (Potential). FT DOMAIN 31 91 v-SNARE coiled-coil homology. FT MOD_RES 2 2 N-acetylserine (By similarity). FT MOD_RES 75 75 Phosphoserine (By similarity). FT HELIX 29 88 SQ SEQUENCE 116 AA; 12691 MW; 4A0D0D56B5409D0A CRC64; MSATAATVPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST //