Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P63043

- STMN4_RAT

UniProt

P63043 - STMN4_RAT

Protein

Stathmin-4

Gene

Stmn4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Exhibits microtubule-destabilizing activity.3 Publications

    GO - Biological processi

    1. regulation of microtubule polymerization or depolymerization Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stathmin-4
    Alternative name(s):
    Stathmin-like protein B3
    Short name:
    RB3
    Gene namesi
    Name:Stmn4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi69349. Stmn4.

    Subcellular locationi

    Golgi apparatus 1 Publication. Cell projectiongrowth cone 1 Publication. Cell projectionaxon 1 Publication

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. growth cone Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Stathmin-4PRO_0000182408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi20 – 201S-palmitoyl cysteineBy similarity
    Lipidationi22 – 221S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP63043.

    Expressioni

    Tissue specificityi

    Nervous tissue.2 Publications

    Gene expression databases

    GenevestigatoriP63043.

    Structurei

    Secondary structure

    1
    189
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 588
    Beta strandi61 – 699
    Helixi91 – 18494
    Turni185 – 1884

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SA0X-ray3.58E49-189[»]
    1SA1X-ray4.20E49-189[»]
    1Z2BX-ray4.10E49-189[»]
    3DU7X-ray4.10E49-189[»]
    3E22X-ray3.80E49-189[»]
    3HKBX-ray3.65E49-189[»]
    3HKCX-ray3.80E49-189[»]
    3HKDX-ray3.70E49-189[»]
    3HKEX-ray3.60E49-189[»]
    3N2GX-ray4.00E49-189[»]
    3N2KX-ray4.00E49-189[»]
    3RYCX-ray2.10E49-189[»]
    3RYFX-ray2.52E49-189[»]
    3RYHX-ray2.80E49-189[»]
    3RYIX-ray2.40E49-189[»]
    3UT5X-ray2.73E49-189[»]
    4EB6X-ray3.47E49-189[»]
    4I4TX-ray1.80E49-189[»]
    4I50X-ray2.30E49-189[»]
    4I55X-ray2.20E49-189[»]
    4IHJX-ray2.00E49-189[»]
    4IIJX-ray2.60E49-189[»]
    4O2AX-ray2.50E49-189[»]
    4O2BX-ray2.30E49-189[»]
    4O4HX-ray2.10E49-189[»]
    4O4IX-ray2.40E49-189[»]
    4O4JX-ray2.20E49-189[»]
    4O4LX-ray2.20E49-189[»]
    ProteinModelPortaliP63043.
    SMRiP63043. Positions 50-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP63043.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 189142SLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili90 – 189100Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the stathmin family.Curated
    Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG70176.
    GeneTreeiENSGT00390000003691.
    HOGENOMiHOG000013197.
    HOVERGENiHBG054037.
    OMAiTVDLTWC.
    OrthoDBiEOG744TBN.
    TreeFamiTF326935.

    Family and domain databases

    InterProiIPR028834. Stathmin-4.
    IPR000956. Stathmin_fam.
    [Graphical view]
    PANTHERiPTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF6. PTHR10104:SF6. 1 hit.
    PfamiPF00836. Stathmin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002285. Stathmin. 1 hit.
    PRINTSiPR00345. STATHMIN.
    SUPFAMiSSF101494. SSF101494. 1 hit.
    PROSITEiPS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P63043-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM    50
    EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA 100
    AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME 150
    SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR 189
    Length:189
    Mass (Da):22,087
    Last modified:August 31, 2004 - v1
    Checksum:i4D61AAE5E8131551
    GO
    Isoform 2 (identifier: P63043-2) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: RB3'

    The sequence of this isoform differs from the canonical sequence as follows:
         171-189: DKHAEEVRKNKELKEEASR → EPPAAR

    Show »
    Length:176
    Mass (Da):20,430
    Checksum:iE83184AE7B73766F
    GO
    Isoform 3 (identifier: P63043-3) [UniParc] [UniParc]FASTAAdd to Basket

    Also known as: RB3''

    The sequence of this isoform differs from the canonical sequence as follows:
         36-36: E → EGWCGRQCRRKGQSQRKGSADWRERREQ

    Show »
    Length:216
    Mass (Da):25,375
    Checksum:i8B63BB54E7C641A7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei36 – 361E → EGWCGRQCRRKGQSQRKGSA DWRERREQ in isoform 3. 1 PublicationVSP_006280
    Alternative sequencei171 – 18919DKHAE…EEASR → EPPAAR in isoform 2. 1 PublicationVSP_006281Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026528 mRNA. Translation: AAC95061.1.
    AF026529 mRNA. Translation: AAC95062.1.
    AF026530 mRNA. Translation: AAC95063.1.
    RefSeqiNP_001257785.1. NM_001270856.1. [P63043-1]
    NP_001257787.1. NM_001270858.1. [P63043-2]
    NP_062049.1. NM_019176.2. [P63043-3]
    XP_006252210.1. XM_006252148.1. [P63043-3]
    XP_006252211.1. XM_006252149.1. [P63043-3]
    XP_006252212.1. XM_006252150.1. [P63043-3]
    XP_006252213.1. XM_006252151.1. [P63043-3]
    XP_006252214.1. XM_006252152.1. [P63043-3]
    XP_006252216.1. XM_006252154.1. [P63043-1]
    XP_006252219.1. XM_006252157.1. [P63043-2]
    UniGeneiRn.5658.

    Genome annotation databases

    EnsembliENSRNOT00000058952; ENSRNOP00000055733; ENSRNOG00000009186. [P63043-1]
    ENSRNOT00000058953; ENSRNOP00000055734; ENSRNOG00000009186. [P63043-3]
    GeneIDi79423.
    KEGGirno:79423.
    UCSCiRGD:69349. rat.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026528 mRNA. Translation: AAC95061.1 .
    AF026529 mRNA. Translation: AAC95062.1 .
    AF026530 mRNA. Translation: AAC95063.1 .
    RefSeqi NP_001257785.1. NM_001270856.1. [P63043-1 ]
    NP_001257787.1. NM_001270858.1. [P63043-2 ]
    NP_062049.1. NM_019176.2. [P63043-3 ]
    XP_006252210.1. XM_006252148.1. [P63043-3 ]
    XP_006252211.1. XM_006252149.1. [P63043-3 ]
    XP_006252212.1. XM_006252150.1. [P63043-3 ]
    XP_006252213.1. XM_006252151.1. [P63043-3 ]
    XP_006252214.1. XM_006252152.1. [P63043-3 ]
    XP_006252216.1. XM_006252154.1. [P63043-1 ]
    XP_006252219.1. XM_006252157.1. [P63043-2 ]
    UniGenei Rn.5658.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SA0 X-ray 3.58 E 49-189 [» ]
    1SA1 X-ray 4.20 E 49-189 [» ]
    1Z2B X-ray 4.10 E 49-189 [» ]
    3DU7 X-ray 4.10 E 49-189 [» ]
    3E22 X-ray 3.80 E 49-189 [» ]
    3HKB X-ray 3.65 E 49-189 [» ]
    3HKC X-ray 3.80 E 49-189 [» ]
    3HKD X-ray 3.70 E 49-189 [» ]
    3HKE X-ray 3.60 E 49-189 [» ]
    3N2G X-ray 4.00 E 49-189 [» ]
    3N2K X-ray 4.00 E 49-189 [» ]
    3RYC X-ray 2.10 E 49-189 [» ]
    3RYF X-ray 2.52 E 49-189 [» ]
    3RYH X-ray 2.80 E 49-189 [» ]
    3RYI X-ray 2.40 E 49-189 [» ]
    3UT5 X-ray 2.73 E 49-189 [» ]
    4EB6 X-ray 3.47 E 49-189 [» ]
    4I4T X-ray 1.80 E 49-189 [» ]
    4I50 X-ray 2.30 E 49-189 [» ]
    4I55 X-ray 2.20 E 49-189 [» ]
    4IHJ X-ray 2.00 E 49-189 [» ]
    4IIJ X-ray 2.60 E 49-189 [» ]
    4O2A X-ray 2.50 E 49-189 [» ]
    4O2B X-ray 2.30 E 49-189 [» ]
    4O4H X-ray 2.10 E 49-189 [» ]
    4O4I X-ray 2.40 E 49-189 [» ]
    4O4J X-ray 2.20 E 49-189 [» ]
    4O4L X-ray 2.20 E 49-189 [» ]
    ProteinModelPortali P63043.
    SMRi P63043. Positions 50-185.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P63043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000058952 ; ENSRNOP00000055733 ; ENSRNOG00000009186 . [P63043-1 ]
    ENSRNOT00000058953 ; ENSRNOP00000055734 ; ENSRNOG00000009186 . [P63043-3 ]
    GeneIDi 79423.
    KEGGi rno:79423.
    UCSCi RGD:69349. rat.

    Organism-specific databases

    CTDi 81551.
    RGDi 69349. Stmn4.

    Phylogenomic databases

    eggNOGi NOG70176.
    GeneTreei ENSGT00390000003691.
    HOGENOMi HOG000013197.
    HOVERGENi HBG054037.
    OMAi TVDLTWC.
    OrthoDBi EOG744TBN.
    TreeFami TF326935.

    Miscellaneous databases

    EvolutionaryTracei P63043.
    NextBioi 614762.
    PROi P63043.

    Gene expression databases

    Genevestigatori P63043.

    Family and domain databases

    InterProi IPR028834. Stathmin-4.
    IPR000956. Stathmin_fam.
    [Graphical view ]
    PANTHERi PTHR10104. PTHR10104. 1 hit.
    PTHR10104:SF6. PTHR10104:SF6. 1 hit.
    Pfami PF00836. Stathmin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002285. Stathmin. 1 hit.
    PRINTSi PR00345. STATHMIN.
    SUPFAMi SSF101494. SSF101494. 1 hit.
    PROSITEi PS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system."
      Ozon S., Maucuer A., Sobel A.
      Eur. J. Biochem. 248:794-806(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Corpus striatum.
    2. "Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain."
      Nakao C., Itoh T.J., Hotani H., Mori N.
      J. Biol. Chem. 279:23014-23021(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    3. "Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons."
      Gavet O., El Messari S., Ozon S., Sobel A.
      J. Neurosci. Res. 68:535-550(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain."
      Ravelli R.B., Gigant B., Curmi P.A., Jourdain I., Lachkar S., Sobel A., Knossow M.
      Nature 428:198-202(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.58 ANGSTROMS) OF 49-189 IN COMPLEX WITH TUBULIN HETERODIMER, FUNCTION.

    Entry informationi

    Entry nameiSTMN4_RAT
    AccessioniPrimary (citable) accession number: P63043
    Secondary accession number(s): O35414, O35415, O35416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3