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Protein

Stathmin-4

Gene

Stmn4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity.3 Publications

GO - Biological processi

  1. regulation of microtubule polymerization or depolymerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name:
RB3
Gene namesi
Name:Stmn4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi69349. Stmn4.

Subcellular locationi

Golgi apparatus 1 Publication. Cell projectiongrowth cone 1 Publication. Cell projectionaxon 1 Publication

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. Golgi apparatus Source: UniProtKB-SubCell
  3. growth cone Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Stathmin-4PRO_0000182408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201S-palmitoyl cysteineBy similarity
Lipidationi22 – 221S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiP63043.

Expressioni

Tissue specificityi

Nervous tissue.2 Publications

Gene expression databases

ExpressionAtlasiP63043. baseline and differential.
GenevestigatoriP63043.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 588Combined sources
Beta strandi61 – 699Combined sources
Helixi91 – 18494Combined sources
Turni185 – 1884Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SA0X-ray3.58E49-189[»]
1SA1X-ray4.20E49-189[»]
1Z2BX-ray4.10E49-189[»]
3DU7X-ray4.10E49-189[»]
3E22X-ray3.80E49-189[»]
3HKBX-ray3.65E49-189[»]
3HKCX-ray3.80E49-189[»]
3HKDX-ray3.70E49-189[»]
3HKEX-ray3.60E49-189[»]
3N2GX-ray4.00E49-189[»]
3N2KX-ray4.00E49-189[»]
3RYCX-ray2.10E49-189[»]
3RYFX-ray2.52E49-189[»]
3RYHX-ray2.80E49-189[»]
3RYIX-ray2.40E49-189[»]
3UT5X-ray2.73E49-189[»]
4EB6X-ray3.47E49-189[»]
4I4TX-ray1.80E49-189[»]
4I50X-ray2.30E49-189[»]
4I55X-ray2.20E49-189[»]
4IHJX-ray2.00E49-189[»]
4IIJX-ray2.60E49-189[»]
4O2AX-ray2.50E49-189[»]
4O2BX-ray2.30E49-189[»]
4O4HX-ray2.10E49-189[»]
4O4IX-ray2.40E49-189[»]
4O4JX-ray2.20E49-189[»]
4O4LX-ray2.20E49-189[»]
4TUYX-ray2.10E49-189[»]
4TV8X-ray2.10E49-189[»]
4TV9X-ray2.00E49-189[»]
4WBNX-ray2.30E49-189[»]
ProteinModelPortaliP63043.
SMRiP63043. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63043.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 189142SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili90 – 189100Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG70176.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP63043.
OMAiTVDLTWC.
OrthoDBiEOG744TBN.
TreeFamiTF326935.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P63043-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Length:189
Mass (Da):22,087
Last modified:August 31, 2004 - v1
Checksum:i4D61AAE5E8131551
GO
Isoform 2 (identifier: P63043-2) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: RB3'

The sequence of this isoform differs from the canonical sequence as follows:
     171-189: DKHAEEVRKNKELKEEASR → EPPAAR

Show »
Length:176
Mass (Da):20,430
Checksum:iE83184AE7B73766F
GO
Isoform 3 (identifier: P63043-3) [UniParc] [UniParc]FASTAAdd to Basket

Also known as: RB3''

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKGQSQRKGSADWRERREQ

Show »
Length:216
Mass (Da):25,375
Checksum:i8B63BB54E7C641A7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 361E → EGWCGRQCRRKGQSQRKGSA DWRERREQ in isoform 3. 1 PublicationVSP_006280
Alternative sequencei171 – 18919DKHAE…EEASR → EPPAAR in isoform 2. 1 PublicationVSP_006281Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026528 mRNA. Translation: AAC95061.1.
AF026529 mRNA. Translation: AAC95062.1.
AF026530 mRNA. Translation: AAC95063.1.
RefSeqiNP_001257785.1. NM_001270856.1. [P63043-1]
NP_001257787.1. NM_001270858.1. [P63043-2]
NP_062049.1. NM_019176.2. [P63043-3]
XP_006252211.1. XM_006252149.2. [P63043-3]
XP_006252213.1. XM_006252151.2. [P63043-3]
UniGeneiRn.5658.

Genome annotation databases

EnsembliENSRNOT00000058952; ENSRNOP00000055733; ENSRNOG00000009186. [P63043-1]
ENSRNOT00000058953; ENSRNOP00000055734; ENSRNOG00000009186. [P63043-3]
GeneIDi79423.
KEGGirno:79423.
UCSCiRGD:69349. rat.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026528 mRNA. Translation: AAC95061.1.
AF026529 mRNA. Translation: AAC95062.1.
AF026530 mRNA. Translation: AAC95063.1.
RefSeqiNP_001257785.1. NM_001270856.1. [P63043-1]
NP_001257787.1. NM_001270858.1. [P63043-2]
NP_062049.1. NM_019176.2. [P63043-3]
XP_006252211.1. XM_006252149.2. [P63043-3]
XP_006252213.1. XM_006252151.2. [P63043-3]
UniGeneiRn.5658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SA0X-ray3.58E49-189[»]
1SA1X-ray4.20E49-189[»]
1Z2BX-ray4.10E49-189[»]
3DU7X-ray4.10E49-189[»]
3E22X-ray3.80E49-189[»]
3HKBX-ray3.65E49-189[»]
3HKCX-ray3.80E49-189[»]
3HKDX-ray3.70E49-189[»]
3HKEX-ray3.60E49-189[»]
3N2GX-ray4.00E49-189[»]
3N2KX-ray4.00E49-189[»]
3RYCX-ray2.10E49-189[»]
3RYFX-ray2.52E49-189[»]
3RYHX-ray2.80E49-189[»]
3RYIX-ray2.40E49-189[»]
3UT5X-ray2.73E49-189[»]
4EB6X-ray3.47E49-189[»]
4I4TX-ray1.80E49-189[»]
4I50X-ray2.30E49-189[»]
4I55X-ray2.20E49-189[»]
4IHJX-ray2.00E49-189[»]
4IIJX-ray2.60E49-189[»]
4O2AX-ray2.50E49-189[»]
4O2BX-ray2.30E49-189[»]
4O4HX-ray2.10E49-189[»]
4O4IX-ray2.40E49-189[»]
4O4JX-ray2.20E49-189[»]
4O4LX-ray2.20E49-189[»]
4TUYX-ray2.10E49-189[»]
4TV8X-ray2.10E49-189[»]
4TV9X-ray2.00E49-189[»]
4WBNX-ray2.30E49-189[»]
ProteinModelPortaliP63043.
SMRiP63043. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP63043.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058952; ENSRNOP00000055733; ENSRNOG00000009186. [P63043-1]
ENSRNOT00000058953; ENSRNOP00000055734; ENSRNOG00000009186. [P63043-3]
GeneIDi79423.
KEGGirno:79423.
UCSCiRGD:69349. rat.

Organism-specific databases

CTDi81551.
RGDi69349. Stmn4.

Phylogenomic databases

eggNOGiNOG70176.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP63043.
OMAiTVDLTWC.
OrthoDBiEOG744TBN.
TreeFamiTF326935.

Miscellaneous databases

EvolutionaryTraceiP63043.
NextBioi614762.
PROiP63043.

Gene expression databases

ExpressionAtlasiP63043. baseline and differential.
GenevestigatoriP63043.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system."
    Ozon S., Maucuer A., Sobel A.
    Eur. J. Biochem. 248:794-806(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Corpus striatum.
  2. "Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain."
    Nakao C., Itoh T.J., Hotani H., Mori N.
    J. Biol. Chem. 279:23014-23021(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  3. "Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons."
    Gavet O., El Messari S., Ozon S., Sobel A.
    J. Neurosci. Res. 68:535-550(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain."
    Ravelli R.B., Gigant B., Curmi P.A., Jourdain I., Lachkar S., Sobel A., Knossow M.
    Nature 428:198-202(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.58 ANGSTROMS) OF 49-189 IN COMPLEX WITH TUBULIN HETERODIMER, FUNCTION.

Entry informationi

Entry nameiSTMN4_RAT
AccessioniPrimary (citable) accession number: P63043
Secondary accession number(s): O35414, O35415, O35416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.