Stathmin-4 - Rattus norvegicus (Rat)

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P63043 (STMN4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Stathmin-4

Alternative name(s):
Stathmin-like protein B3
Short name=RB3

Gene names

Name:

Stmn4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Exhibits microtubule-destabilizing activity. Ref.2 Ref.3 Ref.4
Subcellular location	Golgi apparatus. Cell projection › growth cone. Cell projection › axon Ref.3.
Tissue specificity	Nervous tissue. Ref.1 Ref.2
Sequence similarities	Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
Cellular component	Cell projection Golgi apparatus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of microtubule polymerization or depolymerization Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell axon Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P63043-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P63043-2) Also known as: RB3'; The sequence of this isoform differs from the canonical sequence as follows: 171-189: DKHAEEVRKNKELKEEASR → EPPAAR

Isoform 3 (identifier: P63043-3) Also known as: RB3''; The sequence of this isoform differs from the canonical sequence as follows: 36-36: E → EGWCGRQCRRKGQSQRKGSADWRERREQ

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 189

189

Stathmin-4

PRO_0000182408

Regions

Domain

48 – 189

142

SLD

Coiled coil

90 – 189

100

Potential

Amino acid modifications

Lipidation

S-palmitoyl cysteine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence

E → EGWCGRQCRRKGQSQRKGSA DWRERREQ in isoform 3.

VSP_006280

Alternative sequence

171 – 189

DKHAE…EEASR → EPPAAR in isoform 2.

VSP_006281

Secondary structure

189

Helix Strand Turn

Details...

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 4D61AAE5E8131551 Show »	FASTA	189	22,087
10 20 30 40 50 60 MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS 70 80 90 100 110 120 GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR 130 140 150 160 170 180 EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR « Hide
Isoform 2 (RB3') [UniParc] [UniParc]. Checksum: E83184AE7B73766F Show »	FASTA	176	20,430
10 20 30 40 50 60 MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS 70 80 90 100 110 120 GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR 130 140 150 160 170 EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK EPPAAR « Hide
Isoform 3 (RB3'') [UniParc] [UniParc]. Checksum: 8B63BB54E7C641A7 Show »	FASTA	216	25,375
10 20 30 40 50 60 MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEGWCG RQCRRKGQSQ RKGSADWRER 70 80 90 100 110 120 REQADTVDLN WCVISDMEVI ELNKCTSGQS FEVILKPPSF DGVPEFNASL PRRRDPSLEE 130 140 150 160 170 180 IQKKLEAAEE RRKYQEAELL KHLAEKREHE REVIQKAIEE NNNFIKMAKE KLAQKMESNK 190 200 210 ENREAHLAAM LERLQEKDKH AEEVRKNKEL KEEASR « Hide

References

[1]	"The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system." Ozon S., Maucuer A., Sobel A. Eur. J. Biochem. 248:794-806(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Corpus striatum.
[2]	"Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain." Nakao C., Itoh T.J., Hotani H., Mori N. J. Biol. Chem. 279:23014-23021(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[3]	"Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons." Gavet O., El Messari S., Ozon S., Sobel A. J. Neurosci. Res. 68:535-550(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain." Ravelli R.B., Gigant B., Curmi P.A., Jourdain I., Lachkar S., Sobel A., Knossow M. Nature 428:198-202(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.58 ANGSTROMS) OF 49-189 IN COMPLEX WITH TUBULIN HETERODIMER, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF026528 mRNA. Translation: AAC95061.1.
AF026529 mRNA. Translation: AAC95062.1.
AF026530 mRNA. Translation: AAC95063.1.

IPI

IPI00202863.
IPI00209337.
IPI00230995.

RefSeq

NP_001257785.1. NM_001270856.1.
NP_001257787.1. NM_001270858.1.
NP_062049.1. NM_019176.2.

UniGene

Rn.5658.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1SA0	X-ray	3.58	E	49-189	[»]
1SA1	X-ray	4.20	E	49-189	[»]
1Z2B	X-ray	4.10	E	49-189	[»]
3DU7	X-ray	4.10	E	49-189	[»]
3E22	X-ray	3.80	E	49-189	[»]
3HKB	X-ray	3.65	E	49-189	[»]
3HKC	X-ray	3.80	E	49-189	[»]
3HKD	X-ray	3.70	E	49-189	[»]
3HKE	X-ray	3.60	E	49-189	[»]
3N2G	X-ray	4.00	E	49-189	[»]
3N2K	X-ray	4.00	E	49-189	[»]
3RYC	X-ray	2.10	E	49-189	[»]
3RYF	X-ray	2.52	E	49-189	[»]
3RYH	X-ray	2.80	E	49-189	[»]
3RYI	X-ray	2.40	E	49-189	[»]
3UT5	X-ray	2.73	E	49-189	[»]
4EB6	X-ray	3.47	E	49-189	[»]
4I4T	X-ray	1.80	E	49-189	[»]
4I50	X-ray	2.30	E	49-189	[»]
4I55	X-ray	2.20	E	49-189	[»]
4IHJ	X-ray	2.00	E	49-189	[»]
4IIJ	X-ray	2.60	E	49-189	[»]

ProteinModelPortal

P63043.

SMR

P63043. Positions 50-185.

ModBase

Search...

Proteomic databases

PRIDE

P63043.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000058952; ENSRNOP00000055733; ENSRNOG00000009186.
ENSRNOT00000058953; ENSRNOP00000055734; ENSRNOG00000009186.

GeneID

79423.

KEGG

rno:79423.

UCSC

RGD:69349. rat.

Organism-specific databases

CTD

81551.

RGD

69349. Stmn4.

Phylogenomic databases

eggNOG

NOG70176.

GeneTree

ENSGT00390000003691.

HOGENOM

HOG000013197.

HOVERGEN

HBG054037.

Gene expression databases

ArrayExpress

P63043.

Genevestigator

P63043.

GermOnline

ENSRNOG00000009186. Rattus norvegicus.

Family and domain databases

InterPro

IPR000956. Stathmin_fam.
[Graphical view]

PANTHER

PTHR10104. PTHR10104. 1 hit.

Pfam

PF00836. Stathmin. 1 hit.
[Graphical view]

PIRSF

PIRSF002285. Stathmin. 1 hit.

PRINTS

PR00345. STATHMIN.

SUPFAM

SSF101494. Stathmin. 1 hit.

PROSITE

PS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P63043.

NextBio

614762.

Entry information

Entry name

STMN4_RAT

Accession

Primary (citable) accession number: P63043
Secondary accession number(s): O35414, O35415, O35416

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents