Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P63043 (STMN4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name=RB3
Gene names
Name:Stmn4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Exhibits microtubule-destabilizing activity. Ref.2 Ref.3 Ref.4

Subcellular location

Golgi apparatus. Cell projectiongrowth cone. Cell projectionaxon Ref.3.

Tissue specificity

Nervous tissue. Ref.1 Ref.2

Sequence similarities

Belongs to the stathmin family.

Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
   Cellular componentCell projection
Golgi apparatus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMLipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of microtubule polymerization or depolymerization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

axon

Inferred from electronic annotation. Source: UniProtKB-SubCell

growth cone

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P63043-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P63043-2)

Also known as: RB3';

The sequence of this isoform differs from the canonical sequence as follows:
     171-189: DKHAEEVRKNKELKEEASR → EPPAAR
Isoform 3 (identifier: P63043-3)

Also known as: RB3'';

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: E → EGWCGRQCRRKGQSQRKGSADWRERREQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Stathmin-4
PRO_0000182408

Regions

Domain48 – 189142SLD
Coiled coil90 – 189100 Potential

Amino acid modifications

Lipidation201S-palmitoyl cysteine By similarity
Lipidation221S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence361E → EGWCGRQCRRKGQSQRKGSA DWRERREQ in isoform 3.
VSP_006280
Alternative sequence171 – 18919DKHAE…EEASR → EPPAAR in isoform 2.
VSP_006281

Secondary structure

........ 189
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: 4D61AAE5E8131551

FASTA18922,087
        10         20         30         40         50         60 
MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS 

        70         80         90        100        110        120 
GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR 

       130        140        150        160        170        180 
EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN 


KELKEEASR 

« Hide

Isoform 2 (RB3') [UniParc] [UniParc].

Checksum: E83184AE7B73766F
Show »

FASTA17620,430
Isoform 3 (RB3'') [UniParc] [UniParc].

Checksum: 8B63BB54E7C641A7
Show »

FASTA21625,375

References

[1]"The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system."
Ozon S., Maucuer A., Sobel A.
Eur. J. Biochem. 248:794-806(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Corpus striatum.
[2]"Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain."
Nakao C., Itoh T.J., Hotani H., Mori N.
J. Biol. Chem. 279:23014-23021(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[3]"Regulation and subcellular localization of the microtubule-destabilizing stathmin family phosphoproteins in cortical neurons."
Gavet O., El Messari S., Ozon S., Sobel A.
J. Neurosci. Res. 68:535-550(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain."
Ravelli R.B., Gigant B., Curmi P.A., Jourdain I., Lachkar S., Sobel A., Knossow M.
Nature 428:198-202(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.58 ANGSTROMS) OF 49-189 IN COMPLEX WITH TUBULIN HETERODIMER, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF026528 mRNA. Translation: AAC95061.1.
AF026529 mRNA. Translation: AAC95062.1.
AF026530 mRNA. Translation: AAC95063.1.
RefSeqNP_001257785.1. NM_001270856.1.
NP_001257787.1. NM_001270858.1.
NP_062049.1. NM_019176.2.
XP_006252210.1. XM_006252148.1.
XP_006252211.1. XM_006252149.1.
XP_006252212.1. XM_006252150.1.
XP_006252213.1. XM_006252151.1.
XP_006252214.1. XM_006252152.1.
XP_006252216.1. XM_006252154.1.
XP_006252219.1. XM_006252157.1.
UniGeneRn.5658.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SA0X-ray3.58E49-189[»]
1SA1X-ray4.20E49-189[»]
1Z2BX-ray4.10E49-189[»]
3DU7X-ray4.10E49-189[»]
3E22X-ray3.80E49-189[»]
3HKBX-ray3.65E49-189[»]
3HKCX-ray3.80E49-189[»]
3HKDX-ray3.70E49-189[»]
3HKEX-ray3.60E49-189[»]
3N2GX-ray4.00E49-189[»]
3N2KX-ray4.00E49-189[»]
3RYCX-ray2.10E49-189[»]
3RYFX-ray2.52E49-189[»]
3RYHX-ray2.80E49-189[»]
3RYIX-ray2.40E49-189[»]
3UT5X-ray2.73E49-189[»]
4EB6X-ray3.47E49-189[»]
4I4TX-ray1.80E49-189[»]
4I50X-ray2.30E49-189[»]
4I55X-ray2.20E49-189[»]
4IHJX-ray2.00E49-189[»]
4IIJX-ray2.60E49-189[»]
4O2AX-ray2.50E49-189[»]
4O2BX-ray2.30E49-189[»]
4O4HX-ray2.10E49-189[»]
ProteinModelPortalP63043.
SMRP63043. Positions 50-185.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP63043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000058952; ENSRNOP00000055733; ENSRNOG00000009186. [P63043-1]
ENSRNOT00000058953; ENSRNOP00000055734; ENSRNOG00000009186. [P63043-3]
GeneID79423.
KEGGrno:79423.
UCSCRGD:69349. rat.

Organism-specific databases

CTD81551.
RGD69349. Stmn4.

Phylogenomic databases

eggNOGNOG70176.
GeneTreeENSGT00390000003691.
HOGENOMHOG000013197.
HOVERGENHBG054037.
OMAKAFEENN.
OrthoDBEOG744TBN.
TreeFamTF326935.

Gene expression databases

GenevestigatorP63043.

Family and domain databases

InterProIPR028834. Stathmin-4.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFPIRSF002285. Stathmin. 1 hit.
PRINTSPR00345. STATHMIN.
SUPFAMSSF101494. SSF101494. 1 hit.
PROSITEPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP63043.
NextBio614762.
PROP63043.

Entry information

Entry nameSTMN4_RAT
AccessionPrimary (citable) accession number: P63043
Secondary accession number(s): O35414, O35415, O35416
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references