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Protein

Stathmin-4

Gene

Stmn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits microtubule-destabilizing activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name:
RB3
Gene namesi
Name:Stmn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1931224. Stmn4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Stathmin-4PRO_0000182407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201S-palmitoyl cysteineBy similarity
Lipidationi22 – 221S-palmitoyl cysteineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP63042.
MaxQBiP63042.
PaxDbiP63042.
PRIDEiP63042.

PTM databases

iPTMnetiP63042.
PhosphoSiteiP63042.

Expressioni

Gene expression databases

BgeeiP63042.
CleanExiMM_STMN4.
ExpressionAtlasiP63042. baseline and differential.
GenevisibleiP63042. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074113.

Structurei

3D structure databases

ProteinModelPortaliP63042.
SMRiP63042. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 189142SLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili90 – 189100Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJEC. Eukaryota.
ENOG410ZIRZ. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP63042.
PhylomeDBiP63042.
TreeFamiTF326935.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Length:189
Mass (Da):22,087
Last modified:August 31, 2004 - v1
Checksum:i4D61AAE5E8131551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105222 mRNA. Translation: AAC96328.1.
BC046752 mRNA. Translation: AAH46752.1.
CCDSiCCDS27222.1.
RefSeqiNP_001297451.1. NM_001310522.1.
NP_001297452.1. NM_001310523.1.
NP_062649.1. NM_019675.3.
UniGeneiMm.35474.

Genome annotation databases

EnsembliENSMUST00000074523; ENSMUSP00000074113; ENSMUSG00000022044.
GeneIDi56471.
KEGGimmu:56471.
UCSCiuc007ukf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105222 mRNA. Translation: AAC96328.1.
BC046752 mRNA. Translation: AAH46752.1.
CCDSiCCDS27222.1.
RefSeqiNP_001297451.1. NM_001310522.1.
NP_001297452.1. NM_001310523.1.
NP_062649.1. NM_019675.3.
UniGeneiMm.35474.

3D structure databases

ProteinModelPortaliP63042.
SMRiP63042. Positions 50-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074113.

PTM databases

iPTMnetiP63042.
PhosphoSiteiP63042.

Proteomic databases

EPDiP63042.
MaxQBiP63042.
PaxDbiP63042.
PRIDEiP63042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074523; ENSMUSP00000074113; ENSMUSG00000022044.
GeneIDi56471.
KEGGimmu:56471.
UCSCiuc007ukf.1. mouse.

Organism-specific databases

CTDi81551.
MGIiMGI:1931224. Stmn4.

Phylogenomic databases

eggNOGiENOG410IJEC. Eukaryota.
ENOG410ZIRZ. LUCA.
GeneTreeiENSGT00390000003691.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP63042.
PhylomeDBiP63042.
TreeFamiTF326935.

Miscellaneous databases

PROiP63042.
SOURCEiSearch...

Gene expression databases

BgeeiP63042.
CleanExiMM_STMN4.
ExpressionAtlasiP63042. baseline and differential.
GenevisibleiP63042. MM.

Family and domain databases

InterProiIPR028834. Stathmin-4.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF6. PTHR10104:SF6. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ozon S., Sobel A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiSTMN4_MOUSE
AccessioniPrimary (citable) accession number: P63042
Secondary accession number(s): O35414, O35415, O35416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.