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Protein

DnaJ homolog subfamily A member 1

Gene

Dnaja1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity). Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Zinc 1By similarity1
Metal bindingi137Zinc 1By similarity1
Metal bindingi150Zinc 2By similarity1
Metal bindingi153Zinc 2By similarity1
Metal bindingi177Zinc 2By similarity1
Metal bindingi180Zinc 2By similarity1
Metal bindingi193Zinc 1By similarity1
Metal bindingi196Zinc 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 205CR-typeAdd BLAST85

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 1
Alternative name(s):
DnaJ-like protein 1
Heat shock protein J2
Short name:
HSJ-2
Gene namesi
Name:Dnaja1
Synonyms:Hsj2, Rdj1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620942 Dnaja1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710101 – 394DnaJ homolog subfamily A member 1Add BLAST394
PropeptideiPRO_0000396755395 – 397Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66N6-acetyllysineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei381PhosphotyrosineBy similarity1
Modified residuei394Cysteine methyl esterBy similarity1
Lipidationi394S-farnesyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP63036
PRIDEiP63036

PTM databases

iPTMnetiP63036
PhosphoSitePlusiP63036

Expressioni

Tissue specificityi

Detected in liver (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000007029
GenevisibleiP63036 RN

Interactioni

Subunit structurei

Identified in a complex with HSPA1B and BAX. Interacts with RNF207.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249221, 3 interactors
CORUMiP63036
IntActiP63036, 2 interactors
STRINGi10116.ENSRNOP00000010061

Structurei

3D structure databases

ProteinModelPortaliP63036
SMRiP63036
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 68JAdd BLAST63
Repeati134 – 141CXXCXGXG motif8
Repeati150 – 157CXXCXGXG motif8
Repeati177 – 184CXXCXGXG motif8
Repeati193 – 200CXXCXGXG motif8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 96Gly-richAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 205CR-typeAdd BLAST85

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00860000133716
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiP63036
KOiK09502
OMAiCDGHGMK
OrthoDBiEOG091G0CAC
PhylomeDBiP63036
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd10719 DnaJ_zf, 1 hit
Gene3Di1.10.287.110, 1 hit
HAMAPiMF_01152 DnaJ, 1 hit
InterProiView protein in InterPro
IPR012724 DnaJ
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR001305 HSP_DnaJ_Cys-rich_dom
IPR036410 HSP_DnaJ_Cys-rich_dom_sf
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PF00684 DnaJ_CXXCXGXG, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 3 hits
SSF57938 SSF57938, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51188 ZF_CR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63036-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKETTYYDV LGVKPNATQE ELKKAYRKLA LKYHPDKNPN EGEKFKQISQ
60 70 80 90 100
AYEVLADSKK RELYDKGGEQ AIKEGGAGGG FGSPMDIFDM FFGGGGRMQR
110 120 130 140 150
ERRGKNVVHQ LSVTLEDLYN GATRKLALQK NVICDKCEGR GGKKGAVECC
160 170 180 190 200
PNCRGTGMQI RIHQIGPGMV QQIQSVCMEC QGHGERISPK DRCKSCNGRK
210 220 230 240 250
IVREKKILEV HIDKGMKDGQ KITFHGEGDQ EPGLEPGDII IVLDQKDHAV
260 270 280 290 300
FTRRGEDLFM CMDIQLVEAL CGFQKPISTL DNRTIVITSH PGQIVKHGDI
310 320 330 340 350
KCVLNEGMPI YRRPYEKGRL IIEFKVNFPE NGFLSPDKLS LLEKLLPERK
360 370 380 390
EVEETDEMDQ VELVDFDPNQ ERRRHYNGEA YEDDEHHPRG GVQCQTS
Length:397
Mass (Da):44,868
Last modified:August 31, 2004 - v1
Checksum:i1783CE3D5C4CD558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53922 mRNA Translation: AAA98855.1
BC062009 mRNA Translation: AAH62009.1
RefSeqiNP_075223.1, NM_022934.1
XP_006238161.1, XM_006238099.2
UniGeneiRn.64562

Genome annotation databases

EnsembliENSRNOT00000010061; ENSRNOP00000010061; ENSRNOG00000007029
GeneIDi65028
KEGGirno:65028
UCSCiRGD:620942 rat

Similar proteinsi

Entry informationi

Entry nameiDNJA1_RAT
AccessioniPrimary (citable) accession number: P63036
Secondary accession number(s): P54102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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