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Protein

GTP-binding protein Rhes

Gene

Rasd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33GTPBy similarity8
Nucleotide bindingi73 – 77GTPBy similarity5
Nucleotide bindingi140 – 143GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Behavior

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rhes
Alternative name(s):
Ras homolog enriched in striatum
Gene namesi
Name:Rasd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922391. Rasd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Shows behavioral abnormalities, displaying a gender-dependent increase in anxiety levels and a clear motor coordination deficit and a mild hyperactive phenotype. Mice are more sensitive to D2 receptor stimulation and have decreased body weight.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827211 – 263GTP-binding protein RhesAdd BLAST263
PropeptideiPRO_0000281376264 – 266Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263Cysteine methyl esterBy similarity1
Lipidationi263S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63032.
PRIDEiP63032.

PTM databases

iPTMnetiP63032.
PhosphoSitePlusiP63032.

Expressioni

Tissue specificityi

Highly expressed in brain; prominently in the striatum and weakly in kidney, thyroid, lung, heart and testis. Not expressed in liver. Expressed in pancreatic cell lines and in a embryonic stem cell line.2 Publications

Developmental stagei

Expressed in the brain from E13.5.1 Publication

Inductioni

Down-regulated in hypothyroid conditions and up-regulated by glibenclamide.2 Publications

Gene expression databases

BgeeiENSMUSG00000034472.
CleanExiMM_RASD2.
GenevisibleiP63032. MM.

Interactioni

Subunit structurei

Monomer (Potential). Interacts with PIK3CA and UBE2I. Interacts with GNB1, GNB2 and GNB3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217250. 8 interactors.
STRINGi10090.ENSMUSP00000118070.

Structurei

3D structure databases

ProteinModelPortaliP63032.
SMRiP63032.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 235Interaction with GNB1, GNB2 and GNB3By similarityAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 56Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOVERGENiHBG009351.
InParanoidiP63032.
KOiK07844.
OMAiDMDAYGM.
OrthoDBiEOG091G0U2W.
TreeFamiTF316238.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63032-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKTLSSGNC TLNVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP
60 70 80 90 100
TIEDFHRKVY NIHGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL
110 120 130 140 150
DSRESFDEVK RLQKQILEVK SCLKNKTKEA AELPMVICGN KNDHSELCRQ
160 170 180 190 200
VPAMEAELLV SGDENCAYFE VSAKKNTNVN EMFYVLFSMA KLPHEMSPAL
210 220 230 240 250
HHKISVQYGD AFHPRPFCMR RTKVAGAYGM VSPFARRPSV NSDLKYIKAK
260
VLREGQARER DKCSIQ
Length:266
Mass (Da):30,197
Last modified:August 31, 2004 - v1
Checksum:i21B00C11CADD40B0
GO

Sequence cautioni

The sequence AAH26377 differs from that shown. Contaminating sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015898 mRNA. Translation: BAB30023.1.
BC026377 mRNA. Translation: AAH26377.1. Sequence problems.
CCDSiCCDS52602.1.
RefSeqiNP_083458.1. NM_029182.1.
UniGeneiMm.179267.

Genome annotation databases

EnsembliENSMUST00000132133; ENSMUSP00000120717; ENSMUSG00000034472.
ENSMUST00000139848; ENSMUSP00000118070; ENSMUSG00000034472.
GeneIDi75141.
KEGGimmu:75141.
UCSCiuc009mhg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015898 mRNA. Translation: BAB30023.1.
BC026377 mRNA. Translation: AAH26377.1. Sequence problems.
CCDSiCCDS52602.1.
RefSeqiNP_083458.1. NM_029182.1.
UniGeneiMm.179267.

3D structure databases

ProteinModelPortaliP63032.
SMRiP63032.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217250. 8 interactors.
STRINGi10090.ENSMUSP00000118070.

PTM databases

iPTMnetiP63032.
PhosphoSitePlusiP63032.

Proteomic databases

PaxDbiP63032.
PRIDEiP63032.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132133; ENSMUSP00000120717; ENSMUSG00000034472.
ENSMUST00000139848; ENSMUSP00000118070; ENSMUSG00000034472.
GeneIDi75141.
KEGGimmu:75141.
UCSCiuc009mhg.2. mouse.

Organism-specific databases

CTDi23551.
MGIiMGI:1922391. Rasd2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133678.
HOVERGENiHBG009351.
InParanoidiP63032.
KOiK07844.
OMAiDMDAYGM.
OrthoDBiEOG091G0U2W.
TreeFamiTF316238.

Miscellaneous databases

PROiP63032.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034472.
CleanExiMM_RASD2.
GenevisibleiP63032. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHES_MOUSE
AccessioniPrimary (citable) accession number: P63032
Secondary accession number(s): Q9WVD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.