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P63032

- RHES_MOUSE

UniProt

P63032 - RHES_MOUSE

Protein

GTP-binding protein Rhes

Gene

Rasd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 338GTPBy similarity
    Nucleotide bindingi73 – 775GTPBy similarity
    Nucleotide bindingi140 – 1434GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. locomotory behavior Source: UniProtKB
    3. negative regulation of protein ubiquitination Source: Ensembl
    4. positive regulation of protein kinase B signaling Source: UniProtKB
    5. positive regulation of protein sumoylation Source: Ensembl
    6. regulation of cAMP-mediated signaling Source: UniProtKB
    7. small GTPase mediated signal transduction Source: InterPro
    8. synaptic transmission, dopaminergic Source: UniProtKB

    Keywords - Biological processi

    Behavior

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein Rhes
    Alternative name(s):
    Ras homolog enriched in striatum
    Gene namesi
    Name:Rasd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1922391. Rasd2.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Shows behavioral abnormalities, displaying a gender-dependent increase in anxiety levels and a clear motor coordination deficit and a mild hyperactive phenotype. Mice are more sensitive to D2 receptor stimulation and have decreased body weight.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263GTP-binding protein RhesPRO_0000082721Add
    BLAST
    Propeptidei264 – 2663Removed in mature formBy similarityPRO_0000281376

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631Cysteine methyl esterBy similarity
    Lipidationi263 – 2631S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting By similarity.By similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiP63032.

    PTM databases

    PhosphoSiteiP63032.

    Expressioni

    Tissue specificityi

    Highly expressed in brain; prominently in the striatum and weakly in kidney, thyroid, lung, heart and testis. Not expressed in liver. Expressed in pancreatic cell lines and in a embryonic stem cell line.2 Publications

    Developmental stagei

    Expressed in the brain from E13.5.1 Publication

    Inductioni

    Down-regulated in hypothyroid conditions and up-regulated by glibenclamide.2 Publications

    Gene expression databases

    ArrayExpressiP63032.
    BgeeiP63032.
    CleanExiMM_RASD2.
    GenevestigatoriP63032.

    Interactioni

    Subunit structurei

    Monomer Potential. Interacts with PIK3CA and UBE2I. Interacts with GNB1, GNB2 and GNB3 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi217250. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP63032.
    SMRiP63032. Positions 18-191.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni189 – 23547Interaction with GNB1, GNB2 and GNB3By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 569Effector region

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. RasD family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117225.
    HOVERGENiHBG009351.
    InParanoidiP63032.
    KOiK07844.
    OMAiDMDAYGM.
    OrthoDBiEOG7M0NSN.
    TreeFamiTF316238.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P63032-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKTLSSGNC TLNVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP    50
    TIEDFHRKVY NIHGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL 100
    DSRESFDEVK RLQKQILEVK SCLKNKTKEA AELPMVICGN KNDHSELCRQ 150
    VPAMEAELLV SGDENCAYFE VSAKKNTNVN EMFYVLFSMA KLPHEMSPAL 200
    HHKISVQYGD AFHPRPFCMR RTKVAGAYGM VSPFARRPSV NSDLKYIKAK 250
    VLREGQARER DKCSIQ 266
    Length:266
    Mass (Da):30,197
    Last modified:August 31, 2004 - v1
    Checksum:i21B00C11CADD40B0
    GO

    Sequence cautioni

    The sequence AAH26377.1 differs from that shown. Reason: Contaminating sequence.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015898 mRNA. Translation: BAB30023.1.
    BC026377 mRNA. Translation: AAH26377.1. Sequence problems.
    CCDSiCCDS52602.1.
    RefSeqiNP_083458.1. NM_029182.1.
    UniGeneiMm.179267.

    Genome annotation databases

    EnsembliENSMUST00000132133; ENSMUSP00000120717; ENSMUSG00000034472.
    ENSMUST00000139848; ENSMUSP00000118070; ENSMUSG00000034472.
    GeneIDi75141.
    KEGGimmu:75141.
    UCSCiuc009mhg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015898 mRNA. Translation: BAB30023.1 .
    BC026377 mRNA. Translation: AAH26377.1 . Sequence problems.
    CCDSi CCDS52602.1.
    RefSeqi NP_083458.1. NM_029182.1.
    UniGenei Mm.179267.

    3D structure databases

    ProteinModelPortali P63032.
    SMRi P63032. Positions 18-191.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 217250. 8 interactions.

    PTM databases

    PhosphoSitei P63032.

    Proteomic databases

    PRIDEi P63032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000132133 ; ENSMUSP00000120717 ; ENSMUSG00000034472 .
    ENSMUST00000139848 ; ENSMUSP00000118070 ; ENSMUSG00000034472 .
    GeneIDi 75141.
    KEGGi mmu:75141.
    UCSCi uc009mhg.2. mouse.

    Organism-specific databases

    CTDi 23551.
    MGIi MGI:1922391. Rasd2.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117225.
    HOVERGENi HBG009351.
    InParanoidi P63032.
    KOi K07844.
    OMAi DMDAYGM.
    OrthoDBi EOG7M0NSN.
    TreeFami TF316238.

    Miscellaneous databases

    NextBioi 342319.
    PROi P63032.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63032.
    Bgeei P63032.
    CleanExi MM_RASD2.
    Genevestigatori P63032.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-266.
      Tissue: Salivary gland.
    3. Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    4. "Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process."
      Taylor J.P., Jackson D.A., Morgan N.G., Chan S.L.
      Biochem. Biophys. Res. Commun. 349:809-815(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY EFAROXAN AND GLIBENCLAMIDE, TISSUE SPECIFICITY.
    5. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behavior."
      Vallortigara J., Alfos S., Micheau J., Higueret P., Enderlin V.
      Neurobiol. Dis. 31:378-385(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY HYPOTHYROIDISM.
    7. "The Ras homolog Rhes affects dopamine D1 and D2 receptor-mediated behavior in mice."
      Quintero G.C., Spano D., Lahoste G.J., Harrison L.M.
      NeuroReport 19:1563-1566(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiRHES_MOUSE
    AccessioniPrimary (citable) accession number: P63032
    Secondary accession number(s): Q9WVD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3