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Protein

Translationally-controlled tumor protein

Gene

Tpt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: GO_Central
  • cell proliferation Source: RGD
  • spermatogenesis Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
Lens epithelial protein
Gene namesi
Name:Tpt1
Synonyms:Trt
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi621623. Tpt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112721 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46Phosphoserine; by PLK1By similarity1
Modified residuei53PhosphoserineBy similarity1
Modified residuei64Phosphoserine; by PLK1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP63029.
PRIDEiP63029.

2D gel databases

World-2DPAGE0004:P63029.

PTM databases

iPTMnetiP63029.
PhosphoSitePlusiP63029.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001049.
GenevisibleiP63029. RN.

Interactioni

Subunit structurei

Interacts with STEAP3 (By similarity). Seems to self-interact.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP63029. 4 interactors.
MINTiMINT-2634284.
STRINGi10116.ENSRNOP00000001383.

Structurei

3D structure databases

ProteinModelPortaliP63029.
SMRiP63029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation
Contains 1 TCTP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP63029.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
PhylomeDBiP63029.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK
110 120 130 140 150
GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPFM IFFKDGLEME KC
Length:172
Mass (Da):19,462
Last modified:August 31, 2004 - v1
Checksum:i7F46751DA2D281D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20525 mRNA. Translation: AAA62507.1.
BC086358 mRNA. Translation: AAH86358.1.
RefSeqiNP_446319.1. NM_053867.1.
UniGeneiRn.156654.
Rn.36610.

Genome annotation databases

EnsembliENSRNOT00000001383; ENSRNOP00000001383; ENSRNOG00000001049.
GeneIDi116646.
KEGGirno:116646.
UCSCiRGD:621623. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20525 mRNA. Translation: AAA62507.1.
BC086358 mRNA. Translation: AAH86358.1.
RefSeqiNP_446319.1. NM_053867.1.
UniGeneiRn.156654.
Rn.36610.

3D structure databases

ProteinModelPortaliP63029.
SMRiP63029.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63029. 4 interactors.
MINTiMINT-2634284.
STRINGi10116.ENSRNOP00000001383.

PTM databases

iPTMnetiP63029.
PhosphoSitePlusiP63029.

2D gel databases

World-2DPAGE0004:P63029.

Proteomic databases

PaxDbiP63029.
PRIDEiP63029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001383; ENSRNOP00000001383; ENSRNOG00000001049.
GeneIDi116646.
KEGGirno:116646.
UCSCiRGD:621623. rat.

Organism-specific databases

CTDi7178.
RGDi621623. Tpt1.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOGENOMiHOG000203361.
HOVERGENiHBG002282.
InParanoidiP63029.
OMAiCYEDASM.
OrthoDBiEOG091G0OTA.
PhylomeDBiP63029.
TreeFamiTF300238.

Miscellaneous databases

PROiP63029.

Gene expression databases

BgeeiENSRNOG00000001049.
GenevisibleiP63029. RN.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
PS51797. TCTP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCTP_RAT
AccessioniPrimary (citable) accession number: P63029
Secondary accession number(s): P14701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.