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Protein

Translationally-controlled tumor protein

Gene

Tpt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • microtubule binding Source: GO_Central
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • cell differentiation Source: GO_Central
  • negative regulation of ectoderm development Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • spermatogenesis Source: Ensembl
  • stem cell population maintenance Source: BHF-UCL

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
21 kDa polypeptide
p21
p23
Gene namesi
Name:Tpt1
Synonyms:Trt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104890 Tpt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112691 – 172Translationally-controlled tumor proteinAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei64Phosphoserine; by PLK1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP63028
MaxQBiP63028
PaxDbiP63028
PeptideAtlasiP63028
PRIDEiP63028
TopDownProteomicsiP63028

2D gel databases

REPRODUCTION-2DPAGEIPI00129685
P63028
SWISS-2DPAGEP63028

PTM databases

iPTMnetiP63028
PhosphoSitePlusiP63028
SwissPalmiP63028

Expressioni

Developmental stagei

Preferentially synthesized in cells of the early growth phase of Ehrlich ascites tumor.1 Publication

Gene expression databases

BgeeiENSMUSG00000060126
CleanExiMM_TPT1
ExpressionAtlasiP63028 baseline and differential
GenevisibleiP63028 MM

Interactioni

Subunit structurei

Seems to self-interact. Interacts with STEAP3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NclP094054EBI-1635228,EBI-641864

GO - Molecular functioni

  • microtubule binding Source: GO_Central
  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi204334, 4 interactors
IntActiP63028, 13 interactors
MINTiP63028
STRINGi10090.ENSMUSP00000106519

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9KX-ray4.01A/B1-172[»]
ProteinModelPortaliP63028
SMRiP63028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 172TCTPPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1727 Eukaryota
ENOG4111FVP LUCA
GeneTreeiENSGT00390000006051
HOVERGENiHBG002282
InParanoidiP63028
OMAiFKDFEFY
OrthoDBiEOG091G0OTA
PhylomeDBiP63028
TreeFamiTF300238

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumor
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01002 TCTP_1, 1 hit
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P63028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK
110 120 130 140 150
GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPFM IFFKDGLEME KC
Length:172
Mass (Da):19,462
Last modified:August 31, 2004 - v1
Checksum:i7F46751DA2D281D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17I → N in BAE30347 (PubMed:16141072).Curated1
Sequence conflicti52A → V in BAE35146 (PubMed:16141072).Curated1
Sequence conflicti57P → Q in BAE35188 (PubMed:16141072).Curated1
Sequence conflicti80E → G in BAE29613 (PubMed:16141072).Curated1
Sequence conflicti80E → G in BAE38361 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06407 mRNA Translation: CAA29697.1
AY186881 Genomic DNA Translation: AAP23875.1
AK149695 mRNA Translation: BAE29032.1
AK150300 mRNA Translation: BAE29452.1
AK150500 mRNA Translation: BAE29613.1
AK150858 mRNA Translation: BAE29913.1
AK151059 mRNA Translation: BAE30076.1
AK151266 mRNA Translation: BAE30253.1
AK151375 mRNA Translation: BAE30347.1
AK151894 mRNA Translation: BAE30778.1
AK152690 mRNA Translation: BAE31421.1
AK152808 mRNA Translation: BAE31513.1
AK159516 mRNA Translation: BAE35146.1
AK159565 mRNA Translation: BAE35188.1
AK165736 mRNA Translation: BAE38361.1
AK166584 mRNA Translation: BAE38873.1
AK167413 mRNA Translation: BAE39502.1
AK167936 mRNA Translation: BAE39940.1
AK168151 mRNA Translation: BAE40116.1
AK169730 mRNA Translation: BAE41334.1
BC092381 mRNA Translation: AAH92381.1
CCDSiCCDS36980.1
PIRiS00775
RefSeqiNP_033455.1, NM_009429.3
UniGeneiMm.297482

Genome annotation databases

EnsembliENSMUST00000110894; ENSMUSP00000106519; ENSMUSG00000060126
GeneIDi22070
KEGGimmu:22070
UCSCiuc007uqz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTCTP_MOUSE
AccessioniPrimary (citable) accession number: P63028
Secondary accession number(s): P14701
, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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