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Protein

Translationally-controlled tumor protein

Gene

Tpt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in calcium binding and microtubule stabilization.By similarity

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • poly(A) RNA binding Source: MGI
  • transcription factor binding Source: BHF-UCL

GO - Biological processi

  • negative regulation of ectoderm development Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  • stem cell population maintenance Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally-controlled tumor protein
Short name:
TCTP
Alternative name(s):
21 kDa polypeptide
p21
p23
Gene namesi
Name:Tpt1
Synonyms:Trt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104890. Tpt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Translationally-controlled tumor proteinPRO_0000211269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineCombined sources
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei64 – 641Phosphoserine; by PLK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP63028.
MaxQBiP63028.
PaxDbiP63028.
PRIDEiP63028.
TopDownProteomicsiP63028.

2D gel databases

REPRODUCTION-2DPAGEIPI00129685.
P63028.
SWISS-2DPAGEP63028.

PTM databases

iPTMnetiP63028.
PhosphoSiteiP63028.
SwissPalmiP63028.

Expressioni

Developmental stagei

Preferentially synthesized in cells of the early growth phase of Ehrlich ascites tumor.1 Publication

Gene expression databases

BgeeiP63028.
CleanExiMM_TPT1.
ExpressionAtlasiP63028. baseline and differential.
GenevisibleiP63028. MM.

Interactioni

Subunit structurei

Seems to self-interact. Interacts with STEAP3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NclP094054EBI-1635228,EBI-641864

GO - Molecular functioni

  • transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi204334. 4 interactions.
IntActiP63028. 13 interactions.
MINTiMINT-4137285.
STRINGi10090.ENSMUSP00000106519.

Structurei

3D structure databases

ProteinModelPortaliP63028.
SMRiP63028. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCTP family.Curated

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiP63028.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
PhylomeDBiP63028.
TreeFamiTF300238.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIYRDLISH DELFSDIYKI REIADGLCLE VEGKMVSRTE GAIDDSLIGG
60 70 80 90 100
NASAEGPEGE GTESTVVTGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSLK
110 120 130 140 150
GKLEEQKPER VKPFMTGAAE QIKHILANFN NYQFFIGENM NPDGMVALLD
160 170
YREDGVTPFM IFFKDGLEME KC
Length:172
Mass (Da):19,462
Last modified:August 31, 2004 - v1
Checksum:i7F46751DA2D281D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171I → N in BAE30347 (PubMed:16141072).Curated
Sequence conflicti52 – 521A → V in BAE35146 (PubMed:16141072).Curated
Sequence conflicti57 – 571P → Q in BAE35188 (PubMed:16141072).Curated
Sequence conflicti80 – 801E → G in BAE29613 (PubMed:16141072).Curated
Sequence conflicti80 – 801E → G in BAE38361 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06407 mRNA. Translation: CAA29697.1.
AY186881 Genomic DNA. Translation: AAP23875.1.
AK149695 mRNA. Translation: BAE29032.1.
AK150300 mRNA. Translation: BAE29452.1.
AK150500 mRNA. Translation: BAE29613.1.
AK150858 mRNA. Translation: BAE29913.1.
AK151059 mRNA. Translation: BAE30076.1.
AK151266 mRNA. Translation: BAE30253.1.
AK151375 mRNA. Translation: BAE30347.1.
AK151894 mRNA. Translation: BAE30778.1.
AK152690 mRNA. Translation: BAE31421.1.
AK152808 mRNA. Translation: BAE31513.1.
AK159516 mRNA. Translation: BAE35146.1.
AK159565 mRNA. Translation: BAE35188.1.
AK165736 mRNA. Translation: BAE38361.1.
AK166584 mRNA. Translation: BAE38873.1.
AK167413 mRNA. Translation: BAE39502.1.
AK167936 mRNA. Translation: BAE39940.1.
AK168151 mRNA. Translation: BAE40116.1.
AK169730 mRNA. Translation: BAE41334.1.
BC092381 mRNA. Translation: AAH92381.1.
CCDSiCCDS36980.1.
PIRiS00775.
RefSeqiNP_033455.1. NM_009429.3.
UniGeneiMm.297482.

Genome annotation databases

EnsembliENSMUST00000110894; ENSMUSP00000106519; ENSMUSG00000060126.
GeneIDi22070.
KEGGimmu:22070.
UCSCiuc007uqz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06407 mRNA. Translation: CAA29697.1.
AY186881 Genomic DNA. Translation: AAP23875.1.
AK149695 mRNA. Translation: BAE29032.1.
AK150300 mRNA. Translation: BAE29452.1.
AK150500 mRNA. Translation: BAE29613.1.
AK150858 mRNA. Translation: BAE29913.1.
AK151059 mRNA. Translation: BAE30076.1.
AK151266 mRNA. Translation: BAE30253.1.
AK151375 mRNA. Translation: BAE30347.1.
AK151894 mRNA. Translation: BAE30778.1.
AK152690 mRNA. Translation: BAE31421.1.
AK152808 mRNA. Translation: BAE31513.1.
AK159516 mRNA. Translation: BAE35146.1.
AK159565 mRNA. Translation: BAE35188.1.
AK165736 mRNA. Translation: BAE38361.1.
AK166584 mRNA. Translation: BAE38873.1.
AK167413 mRNA. Translation: BAE39502.1.
AK167936 mRNA. Translation: BAE39940.1.
AK168151 mRNA. Translation: BAE40116.1.
AK169730 mRNA. Translation: BAE41334.1.
BC092381 mRNA. Translation: AAH92381.1.
CCDSiCCDS36980.1.
PIRiS00775.
RefSeqiNP_033455.1. NM_009429.3.
UniGeneiMm.297482.

3D structure databases

ProteinModelPortaliP63028.
SMRiP63028. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204334. 4 interactions.
IntActiP63028. 13 interactions.
MINTiMINT-4137285.
STRINGi10090.ENSMUSP00000106519.

PTM databases

iPTMnetiP63028.
PhosphoSiteiP63028.
SwissPalmiP63028.

2D gel databases

REPRODUCTION-2DPAGEIPI00129685.
P63028.
SWISS-2DPAGEP63028.

Proteomic databases

EPDiP63028.
MaxQBiP63028.
PaxDbiP63028.
PRIDEiP63028.
TopDownProteomicsiP63028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110894; ENSMUSP00000106519; ENSMUSG00000060126.
GeneIDi22070.
KEGGimmu:22070.
UCSCiuc007uqz.2. mouse.

Organism-specific databases

CTDi7178.
MGIiMGI:104890. Tpt1.

Phylogenomic databases

eggNOGiKOG1727. Eukaryota.
ENOG4111FVP. LUCA.
GeneTreeiENSGT00390000006051.
HOVERGENiHBG002282.
InParanoidiP63028.
OMAiCAMIEEG.
OrthoDBiEOG7SJD61.
PhylomeDBiP63028.
TreeFamiTF300238.

Miscellaneous databases

PROiP63028.
SOURCEiSearch...

Gene expression databases

BgeeiP63028.
CleanExiMM_TPT1.
ExpressionAtlasiP63028. baseline and differential.
GenevisibleiP63028. MM.

Family and domain databases

Gene3Di2.170.150.10. 1 hit.
InterProiIPR011057. Mss4-like.
IPR011323. Mss4/transl-control_tumor.
IPR018103. Translation_control_tumour_CS.
IPR018105. Translational_control_tumour_p.
[Graphical view]
PANTHERiPTHR11991. PTHR11991. 1 hit.
PfamiPF00838. TCTP. 1 hit.
[Graphical view]
PRINTSiPR01653. TCTPROTEIN.
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS01002. TCTP_1. 1 hit.
PS01003. TCTP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells."
    Makrides S., Chitpatima S.T., Bandyopadhyay R., Brawerman G.
    Nucleic Acids Res. 16:2350-2350(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure."
    Boehm H., Beendorf R., Gaestel M., Gross B., Nuernberg P., Kraft R., Otto A., Bielka H.
    Biochem. Int. 19:277-286(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, DEVELOPMENTAL STAGE.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ, C57BL/6J, DBA/2J and NOD.
    Tissue: Bone marrow, Brain, Placenta and Thymus.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  6. Lubec G., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 6-19, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Hippocampus.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTCTP_MOUSE
AccessioniPrimary (citable) accession number: P63028
Secondary accession number(s): P14701
, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.