UniProtKB - P63025 (VAMP3_RAT)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Vesicle-associated membrane protein 3
Gene
Vamp3
Organism
Rattus norvegicus (Rat)
Status
Functioni
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: RGD
- syntaxin-1 binding Source: RGD
GO - Biological processi
- calcium ion regulated exocytosis Source: RGD
- cellular response to interferon-gamma Source: RGD
- exocytosis Source: GO_Central
- Golgi to plasma membrane protein transport Source: RGD
- negative regulation of secretion by cell Source: RGD
- positive regulation of receptor recycling Source: UniProtKB
- protein complex assembly Source: RGD
- retrograde transport, endosome to Golgi Source: UniProtKB
- SNARE complex assembly Source: RGD
- substrate adhesion-dependent cell spreading Source: UniProtKB
- vesicle fusion Source: GO_Central
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-1236974. ER-Phagosome pathway. R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network. R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis. R-RNO-8856828. Clathrin-mediated endocytosis. |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 3Short name: VAMP-3 Alternative name(s): Cellubrevin Short name: CEB Synaptobrevin-3 |
Gene namesi | Name:Vamp3 Synonyms:Syb3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61880. Vamp3. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 81 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 82 – 102 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 | VesicularSequence analysis | 1 |
Keywords - Cellular componenti
Cell junction, Membrane, Synapse, SynaptosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206730 | 1 – 103 | Vesicle-associated membrane protein 3Add BLAST | 103 |
Proteomic databases
PaxDbi | P63025. |
PRIDEi | P63025. |
PTM databases
iPTMneti | P63025. |
PhosphoSitePlusi | P63025. |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSRNOG00000030055. |
Genevisiblei | P63025. RN. |
Interactioni
Subunit structurei
Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum (By similarity).By similarity
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Bves | Q9ES83 | 3 | EBI-7705696,EBI-7705661 | From Mus musculus. |
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: RGD
- syntaxin-1 binding Source: RGD
Protein-protein interaction databases
BioGridi | 248164. 1 interactor. |
CORUMi | P63025. |
IntActi | P63025. 3 interactors. |
MINTi | P63025. |
STRINGi | 10116.ENSRNOP00000048364. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 15 – 75 | Combined sources | 61 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5KJ7 | X-ray | 3.50 | A/G | 14-76 | [»] | |
5KJ8 | X-ray | 4.10 | A/G | 14-76 | [»] | |
ProteinModelPortali | P63025. | |||||
SMRi | P63025. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 78 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the synaptobrevin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0860. Eukaryota. COG5143. LUCA. |
GeneTreei | ENSGT00550000074449. |
HOGENOMi | HOG000042711. |
HOVERGENi | HBG006675. |
InParanoidi | P63025. |
KOi | K13505. |
OMAi | IIIWACS. |
OrthoDBi | EOG091G0MPE. |
PhylomeDBi | P63025. |
TreeFami | TF313666. |
Family and domain databases
InterProi | View protein in InterPro IPR001388. Synaptobrevin. IPR016444. Synaptobrevin/VAMP. |
Pfami | View protein in Pfam PF00957. Synaptobrevin. 1 hit. |
PIRSFi | PIRSF005409. Synaptobrevin_euk. 1 hit. |
PRINTSi | PR00219. SYNAPTOBREVN. |
PROSITEi | View protein in PROSITE PS00417. SYNAPTOBREVIN. 1 hit. PS50892. V_SNARE. 1 hit. |
i Sequence
Sequence statusi: Complete.
P63025-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL
60 70 80 90 100
DDRADALQAG ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW
CVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S63830 mRNA. Translation: AAB27554.1. BC088119 mRNA. Translation: AAH88119.1. |
PIRi | S35077. |
RefSeqi | NP_476438.1. NM_057097.2. |
UniGenei | Rn.219999. |
Genome annotation databases
Ensembli | ENSRNOT00000051554; ENSRNOP00000048364; ENSRNOG00000030055. |
GeneIDi | 29528. |
KEGGi | rno:29528. |
UCSCi | RGD:61880. rat. |
Similar proteinsi
Entry informationi
Entry namei | VAMP3_RAT | |
Accessioni | P63025Primary (citable) accession number: P63025 Secondary accession number(s): Q64271 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | February 28, 2018 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |