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Protein

Vesicle-associated membrane protein 3

Gene

Vamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion regulated exocytosis Source: MGI
  • Golgi to plasma membrane protein transport Source: MGI
  • negative regulation of secretion by cell Source: MGI
  • positive regulation of receptor recycling Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • SNARE complex assembly Source: BHF-UCL
  • substrate adhesion-dependent cell spreading Source: UniProtKB
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1236974. ER-Phagosome pathway.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:Vamp3
Synonyms:Syb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1321389. Vamp3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 81CytoplasmicSequence analysisAdd BLAST80
Transmembranei82 – 102Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini103VesicularSequence analysis1

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • clathrin-coated vesicle Source: MGI
  • clathrin-coated vesicle membrane Source: Ensembl
  • cytoplasmic vesicle Source: MGI
  • cytosol Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • neuron projection Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: MGI
  • secretory granule Source: MGI
  • SNARE complex Source: MGI
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002067292 – 103Vesicle-associated membrane protein 3Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP63024.
MaxQBiP63024.
PaxDbiP63024.
PeptideAtlasiP63024.
PRIDEiP63024.

PTM databases

iPTMnetiP63024.
PhosphoSitePlusiP63024.
SwissPalmiP63024.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028955.
CleanExiMM_VAMP3.
GenevisibleiP63024. MM.

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204496. 3 interactors.
IntActiP63024. 4 interactors.
MINTiMINT-4139722.
STRINGi10090.ENSMUSP00000030797.

Structurei

3D structure databases

ProteinModelPortaliP63024.
SMRiP63024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 78v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiP63024.
KOiK13505.
OMAiFTHACAF.
OrthoDBiEOG091G0MPE.
PhylomeDBiP63024.
TreeFamiTF313666.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL
60 70 80 90 100
DDRADALQAG ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW

CVS
Length:103
Mass (Da):11,480
Last modified:August 31, 2004 - v1
Checksum:iEB502BBE5D0F5981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60961 mRNA. Translation: AAB03490.1.
AF308434, AF308433 Genomic DNA. Translation: AAG42468.1.
AK051272 mRNA. Translation: BAC34586.1.
AK051691 mRNA. Translation: BAC34723.1.
AK165947 mRNA. Translation: BAE38479.1.
AK168413 mRNA. Translation: BAE40328.1.
AK169056 mRNA. Translation: BAE40844.1.
AK169087 mRNA. Translation: BAE40871.1.
BC060045 mRNA. Translation: AAH60045.1.
CCDSiCCDS18979.1.
RefSeqiNP_033524.1. NM_009498.4.
UniGeneiMm.273930.

Genome annotation databases

EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955.
GeneIDi22319.
KEGGimmu:22319.
UCSCiuc008vyj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60961 mRNA. Translation: AAB03490.1.
AF308434, AF308433 Genomic DNA. Translation: AAG42468.1.
AK051272 mRNA. Translation: BAC34586.1.
AK051691 mRNA. Translation: BAC34723.1.
AK165947 mRNA. Translation: BAE38479.1.
AK168413 mRNA. Translation: BAE40328.1.
AK169056 mRNA. Translation: BAE40844.1.
AK169087 mRNA. Translation: BAE40871.1.
BC060045 mRNA. Translation: AAH60045.1.
CCDSiCCDS18979.1.
RefSeqiNP_033524.1. NM_009498.4.
UniGeneiMm.273930.

3D structure databases

ProteinModelPortaliP63024.
SMRiP63024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204496. 3 interactors.
IntActiP63024. 4 interactors.
MINTiMINT-4139722.
STRINGi10090.ENSMUSP00000030797.

PTM databases

iPTMnetiP63024.
PhosphoSitePlusiP63024.
SwissPalmiP63024.

Proteomic databases

EPDiP63024.
MaxQBiP63024.
PaxDbiP63024.
PeptideAtlasiP63024.
PRIDEiP63024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955.
GeneIDi22319.
KEGGimmu:22319.
UCSCiuc008vyj.1. mouse.

Organism-specific databases

CTDi9341.
MGIiMGI:1321389. Vamp3.

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiP63024.
KOiK13505.
OMAiFTHACAF.
OrthoDBiEOG091G0MPE.
PhylomeDBiP63024.
TreeFamiTF313666.

Enzyme and pathway databases

ReactomeiR-MMU-1236974. ER-Phagosome pathway.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiVamp3. mouse.
PROiP63024.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028955.
CleanExiMM_VAMP3.
GenevisibleiP63024. MM.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP3_MOUSE
AccessioniPrimary (citable) accession number: P63024
Secondary accession number(s): Q3TH70, Q64271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.