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P63024 (VAMP3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicle-associated membrane protein 3

Short name=VAMP-3
Alternative name(s):
Cellubrevin
Short name=CEB
Synaptobrevin-3
Gene names
Name:Vamp3
Synonyms:Syb3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length103 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network By similarity.

Subunit structure

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum. Ref.5 Ref.6

Subcellular location

Membrane; Single-pass type IV membrane protein Probable. Cell junctionsynapsesynaptosome By similarity.

Sequence similarities

Belongs to the synaptobrevin family.

Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCell junction
Membrane
Synapse
Synaptosome
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGolgi to plasma membrane protein transport

Inferred from mutant phenotype PubMed 20582536. Source: MGI

calcium ion-dependent exocytosis

Inferred from mutant phenotype PubMed 15920476. Source: MGI

neurotransmitter secretion

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of receptor recycling

Inferred from direct assay Ref.6. Source: UniProtKB

protein complex assembly

Inferred from electronic annotation. Source: Ensembl

retrograde transport, endosome to Golgi

Inferred from sequence or structural similarity. Source: UniProtKB

substrate adhesion-dependent cell spreading

Inferred from direct assay Ref.6. Source: UniProtKB

vesicle fusion

Inferred from Biological aspect of Ancestor. Source: RefGenome

vesicle-mediated transport

Inferred from direct assay Ref.6. Source: UniProtKB

   Cellular_componentSNARE complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

apical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cell junction

Inferred from electronic annotation. Source: UniProtKB-KW

clathrin-coated vesicle membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from direct assay PubMed 18505797. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay Ref.6. Source: UniProtKB

recycling endosome

Inferred from sequence orthology PubMed 19061864PubMed 23269685. Source: MGI

secretory granule

Inferred from direct assay PubMed 18321981. Source: MGI

synaptic vesicle

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionSNAP receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

SNARE binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 103103Vesicle-associated membrane protein 3
PRO_0000206729

Regions

Topological domain1 – 8181Cytoplasmic Potential
Transmembrane82 – 10221Helical; Anchor for type IV membrane protein; Potential
Topological domain1031Vesicular Potential
Domain18 – 7861v-SNARE coiled-coil homology

Sequences

Sequence LengthMass (Da)Tools
P63024 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: EB502BBE5D0F5981

FASTA10311,480
        10         20         30         40         50         60 
MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL DDRADALQAG 

        70         80         90        100 
ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW CVS 

« Hide

References

« Hide 'large scale' references
[1]Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking."
Yang C.M., Mora S., Ryder J.W., Coker K.J., Hansen P., Allen L.A., Pessin J.E.
Mol. Cell. Biol. 21:1573-1580(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6x129SV/J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart, Liver, Lung and Spinal ganglion.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[5]"Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31."
Annaert W.G., Becker B., Kistner U., Reth M., Jahn R.
J. Cell Biol. 139:1397-1410(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BCAP31.
[6]"Identification of a novel Bves function: regulation of vesicular transport."
Hager H.A., Roberts R.J., Cross E.E., Proux-Gillardeaux V., Bader D.M.
EMBO J. 29:532-545(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BVES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60961 mRNA. Translation: AAB03490.1.
AF308434, AF308433 Genomic DNA. Translation: AAG42468.1.
AK051272 mRNA. Translation: BAC34586.1.
AK051691 mRNA. Translation: BAC34723.1.
AK165947 mRNA. Translation: BAE38479.1.
AK168413 mRNA. Translation: BAE40328.1.
AK169056 mRNA. Translation: BAE40844.1.
AK169087 mRNA. Translation: BAE40871.1.
BC060045 mRNA. Translation: AAH60045.1.
RefSeqNP_033524.1. NM_009498.4.
UniGeneMm.273930.

3D structure databases

ProteinModelPortalP63024.
SMRP63024. Positions 15-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204496. 3 interactions.
IntActP63024. 3 interactions.
MINTMINT-4139722.

PTM databases

PhosphoSiteP63024.

Proteomic databases

PaxDbP63024.
PRIDEP63024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955.
GeneID22319.
KEGGmmu:22319.
UCSCuc008vyj.1. mouse.

Organism-specific databases

CTD9341.
MGIMGI:1321389. Vamp3.

Phylogenomic databases

eggNOGCOG5143.
GeneTreeENSGT00550000074449.
HOGENOMHOG000042711.
HOVERGENHBG006675.
InParanoidP63024.
KOK13505.
OMAFTHACAF.
OrthoDBEOG7MSMRJ.
PhylomeDBP63024.
TreeFamTF313666.

Gene expression databases

BgeeP63024.
CleanExMM_VAMP3.
GenevestigatorP63024.

Family and domain databases

InterProIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
IPR028706. VAMP3.
[Graphical view]
PANTHERPTHR21136:SF37. PTHR21136:SF37. 1 hit.
PfamPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSPR00219. SYNAPTOBREVN.
PROSITEPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302533.
PROP63024.
SOURCESearch...

Entry information

Entry nameVAMP3_MOUSE
AccessionPrimary (citable) accession number: P63024
Secondary accession number(s): Q3TH70, Q64271
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot