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P63024

- VAMP3_MOUSE

UniProt

P63024 - VAMP3_MOUSE

Protein

Vesicle-associated membrane protein 3

Gene

Vamp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: MGI
    2. Golgi to plasma membrane protein transport Source: MGI
    3. positive regulation of receptor recycling Source: UniProtKB
    4. retrograde transport, endosome to Golgi Source: UniProtKB
    5. SNARE complex assembly Source: BHF-UCL
    6. substrate adhesion-dependent cell spreading Source: UniProtKB
    7. vesicle-mediated transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein 3
    Short name:
    VAMP-3
    Alternative name(s):
    Cellubrevin
    Short name:
    CEB
    Synaptobrevin-3
    Gene namesi
    Name:Vamp3
    Synonyms:Syb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1321389. Vamp3.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. cell surface Source: BHF-UCL
    4. clathrin-coated vesicle membrane Source: Ensembl
    5. cytoplasmic vesicle Source: MGI
    6. integral component of membrane Source: UniProtKB-KW
    7. neuron projection Source: UniProtKB-SubCell
    8. plasma membrane Source: UniProtKB
    9. recycling endosome Source: MGI
    10. secretory granule Source: MGI
    11. SNARE complex Source: Ensembl
    12. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 103103Vesicle-associated membrane protein 3PRO_0000206729Add
    BLAST

    Proteomic databases

    MaxQBiP63024.
    PaxDbiP63024.
    PRIDEiP63024.

    PTM databases

    PhosphoSiteiP63024.

    Expressioni

    Gene expression databases

    BgeeiP63024.
    CleanExiMM_VAMP3.
    GenevestigatoriP63024.

    Interactioni

    Subunit structurei

    Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.2 Publications

    Protein-protein interaction databases

    BioGridi204496. 3 interactions.
    IntActiP63024. 3 interactions.
    MINTiMINT-4139722.

    Structurei

    3D structure databases

    ProteinModelPortaliP63024.
    SMRiP63024. Positions 15-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8181CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1031VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei82 – 10221Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 7861v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptobrevin family.Curated
    Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5143.
    GeneTreeiENSGT00550000074449.
    HOGENOMiHOG000042711.
    HOVERGENiHBG006675.
    InParanoidiP63024.
    KOiK13505.
    OMAiTVADISW.
    OrthoDBiEOG7MSMRJ.
    PhylomeDBiP63024.
    TreeFamiTF313666.

    Family and domain databases

    InterProiIPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view]
    PfamiPF00957. Synaptobrevin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSiPR00219. SYNAPTOBREVN.
    PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL    50
    DDRADALQAG ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW 100
    CVS 103
    Length:103
    Mass (Da):11,480
    Last modified:August 31, 2004 - v1
    Checksum:iEB502BBE5D0F5981
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60961 mRNA. Translation: AAB03490.1.
    AF308434, AF308433 Genomic DNA. Translation: AAG42468.1.
    AK051272 mRNA. Translation: BAC34586.1.
    AK051691 mRNA. Translation: BAC34723.1.
    AK165947 mRNA. Translation: BAE38479.1.
    AK168413 mRNA. Translation: BAE40328.1.
    AK169056 mRNA. Translation: BAE40844.1.
    AK169087 mRNA. Translation: BAE40871.1.
    BC060045 mRNA. Translation: AAH60045.1.
    CCDSiCCDS18979.1.
    RefSeqiNP_033524.1. NM_009498.4.
    UniGeneiMm.273930.

    Genome annotation databases

    EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955.
    GeneIDi22319.
    KEGGimmu:22319.
    UCSCiuc008vyj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60961 mRNA. Translation: AAB03490.1 .
    AF308434 , AF308433 Genomic DNA. Translation: AAG42468.1 .
    AK051272 mRNA. Translation: BAC34586.1 .
    AK051691 mRNA. Translation: BAC34723.1 .
    AK165947 mRNA. Translation: BAE38479.1 .
    AK168413 mRNA. Translation: BAE40328.1 .
    AK169056 mRNA. Translation: BAE40844.1 .
    AK169087 mRNA. Translation: BAE40871.1 .
    BC060045 mRNA. Translation: AAH60045.1 .
    CCDSi CCDS18979.1.
    RefSeqi NP_033524.1. NM_009498.4.
    UniGenei Mm.273930.

    3D structure databases

    ProteinModelPortali P63024.
    SMRi P63024. Positions 15-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204496. 3 interactions.
    IntActi P63024. 3 interactions.
    MINTi MINT-4139722.

    PTM databases

    PhosphoSitei P63024.

    Proteomic databases

    MaxQBi P63024.
    PaxDbi P63024.
    PRIDEi P63024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030797 ; ENSMUSP00000030797 ; ENSMUSG00000028955 .
    GeneIDi 22319.
    KEGGi mmu:22319.
    UCSCi uc008vyj.1. mouse.

    Organism-specific databases

    CTDi 9341.
    MGIi MGI:1321389. Vamp3.

    Phylogenomic databases

    eggNOGi COG5143.
    GeneTreei ENSGT00550000074449.
    HOGENOMi HOG000042711.
    HOVERGENi HBG006675.
    InParanoidi P63024.
    KOi K13505.
    OMAi TVADISW.
    OrthoDBi EOG7MSMRJ.
    PhylomeDBi P63024.
    TreeFami TF313666.

    Miscellaneous databases

    NextBioi 302533.
    PROi P63024.
    SOURCEi Search...

    Gene expression databases

    Bgeei P63024.
    CleanExi MM_VAMP3.
    Genevestigatori P63024.

    Family and domain databases

    InterProi IPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view ]
    Pfami PF00957. Synaptobrevin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSi PR00219. SYNAPTOBREVN.
    PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking."
      Yang C.M., Mora S., Ryder J.W., Coker K.J., Hansen P., Allen L.A., Pessin J.E.
      Mol. Cell. Biol. 21:1573-1580(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6x129SV/J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Liver, Lung and Spinal ganglion.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31."
      Annaert W.G., Becker B., Kistner U., Reth M., Jahn R.
      J. Cell Biol. 139:1397-1410(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCAP31.
    6. "Identification of a novel Bves function: regulation of vesicular transport."
      Hager H.A., Roberts R.J., Cross E.E., Proux-Gillardeaux V., Bader D.M.
      EMBO J. 29:532-545(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BVES.

    Entry informationi

    Entry nameiVAMP3_MOUSE
    AccessioniPrimary (citable) accession number: P63024
    Secondary accession number(s): Q3TH70, Q64271
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3