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Protein

Vesicle-associated membrane protein 3

Gene

Vamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion regulated exocytosis Source: MGI
  • Golgi to plasma membrane protein transport Source: MGI
  • negative regulation of secretion by cell Source: MGI
  • positive regulation of receptor recycling Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: UniProtKB
  • SNARE complex assembly Source: BHF-UCL
  • substrate adhesion-dependent cell spreading Source: UniProtKB
  • vesicle-mediated transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:Vamp3
Synonyms:Syb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1321389. Vamp3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 81CytoplasmicSequence analysisAdd BLAST80
Transmembranei82 – 102Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini103VesicularSequence analysis1

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • clathrin-coated vesicle Source: MGI
  • clathrin-coated vesicle membrane Source: Ensembl
  • cytoplasmic vesicle Source: MGI
  • cytosol Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • neuron projection Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: MGI
  • secretory granule Source: MGI
  • SNARE complex Source: MGI
  • synapse Source: UniProtKB-KW

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002067292 – 103Vesicle-associated membrane protein 3Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP63024.
MaxQBiP63024.
PaxDbiP63024.
PeptideAtlasiP63024.
PRIDEiP63024.

PTM databases

iPTMnetiP63024.
PhosphoSitePlusiP63024.
SwissPalmiP63024.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028955.
CleanExiMM_VAMP3.
GenevisibleiP63024. MM.

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204496. 4 interactors.
IntActiP63024. 4 interactors.
MINTiMINT-4139722.
STRINGi10090.ENSMUSP00000030797.

Structurei

3D structure databases

ProteinModelPortaliP63024.
SMRiP63024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 78v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiP63024.
KOiK13505.
OMAiIIIWACS.
OrthoDBiEOG091G0MPE.
PhylomeDBiP63024.
TreeFamiTF313666.

Family and domain databases

InterProiView protein in InterPro
IPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
PfamiView protein in Pfam
PF00957. Synaptobrevin. 1 hit.
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiView protein in PROSITE
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL
60 70 80 90 100
DDRADALQAG ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW

CVS
Length:103
Mass (Da):11,480
Last modified:August 31, 2004 - v1
Checksum:iEB502BBE5D0F5981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60961 mRNA. Translation: AAB03490.1.
AF308434, AF308433 Genomic DNA. Translation: AAG42468.1.
AK051272 mRNA. Translation: BAC34586.1.
AK051691 mRNA. Translation: BAC34723.1.
AK165947 mRNA. Translation: BAE38479.1.
AK168413 mRNA. Translation: BAE40328.1.
AK169056 mRNA. Translation: BAE40844.1.
AK169087 mRNA. Translation: BAE40871.1.
BC060045 mRNA. Translation: AAH60045.1.
CCDSiCCDS18979.1.
RefSeqiNP_033524.1. NM_009498.4.
UniGeneiMm.273930.

Genome annotation databases

EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955.
GeneIDi22319.
KEGGimmu:22319.
UCSCiuc008vyj.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVAMP3_MOUSE
AccessioniPrimary (citable) accession number: P63024
Secondary accession number(s): Q3TH70, Q64271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 5, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families