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P63015

- PAX6_MOUSE

UniProt

P63015 - PAX6_MOUSE

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Protein
Paired box protein Pax-6
Gene
Pax6, Pax-6, Sey
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi210 – 26960Homeobox
Add
BLAST

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. DNA binding Source: MGI
  3. HMG box domain binding Source: UniProtKB
  4. R-SMAD binding Source: BHF-UCL
  5. RNA polymerase II core promoter sequence-specific DNA binding Source: BHF-UCL
  6. chromatin binding Source: MGI
  7. co-SMAD binding Source: BHF-UCL
  8. double-stranded DNA binding Source: Ensembl
  9. histone acetyltransferase binding Source: BHF-UCL
  10. protein binding Source: IntAct
  11. protein kinase binding Source: BHF-UCL
  12. sequence-specific DNA binding Source: MGI
  13. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
  14. sequence-specific DNA binding transcription factor activity Source: MGI
  15. transcription factor binding Source: BHF-UCL
  16. transcription regulatory region DNA binding Source: MGI
  17. ubiquitin protein ligase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. astrocyte differentiation Source: MGI
  3. axon guidance Source: MGI
  4. axonogenesis Source: MGI
  5. blood vessel development Source: Ensembl
  6. brain development Source: MGI
  7. camera-type eye development Source: MGI
  8. cell differentiation Source: MGI
  9. cell fate commitment Source: MGI
  10. cell fate determination Source: MGI
  11. cerebral cortex regionalization Source: MGI
  12. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  13. cornea development in camera-type eye Source: Ensembl
  14. dorsal/ventral axis specification Source: MGI
  15. dorsal/ventral pattern formation Source: MGI
  16. embryonic camera-type eye morphogenesis Source: MGI
  17. eye photoreceptor cell development Source: MGI
  18. forebrain anterior/posterior pattern specification Source: MGI
  19. forebrain development Source: MGI
  20. forebrain dorsal/ventral pattern formation Source: MGI
  21. forebrain-midbrain boundary formation Source: MGI
  22. glucose homeostasis Source: Ensembl
  23. hindbrain development Source: Ensembl
  24. iris morphogenesis Source: Ensembl
  25. keratinocyte differentiation Source: MGI
  26. lacrimal gland development Source: MGI
  27. lens development in camera-type eye Source: MGI
  28. negative regulation of cell proliferation Source: MGI
  29. negative regulation of epithelial cell proliferation Source: MGI
  30. negative regulation of neuron differentiation Source: MGI
  31. neuron migration Source: MGI
  32. oligodendrocyte cell fate specification Source: MGI
  33. pallium development Source: MGI
  34. pancreatic A cell development Source: BHF-UCL
  35. pituitary gland development Source: MGI
  36. positive regulation of cell fate specification Source: Ensembl
  37. positive regulation of epithelial cell differentiation Source: MGI
  38. positive regulation of gene expression Source: BHF-UCL
  39. positive regulation of neuroblast proliferation Source: MGI
  40. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  41. positive regulation of transcription, DNA-templated Source: BHF-UCL
  42. protein localization to organelle Source: MGI
  43. regulation of cell migration Source: MGI
  44. regulation of gene expression Source: MGI
  45. regulation of neurogenesis Source: MGI
  46. regulation of timing of cell differentiation Source: MGI
  47. regulation of transcription from RNA polymerase II promoter Source: MGI
  48. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: MGI
  49. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
  50. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI
  51. regulation of transcription, DNA-templated Source: MGI
  52. response to wounding Source: Ensembl
  53. retina development in camera-type eye Source: MGI
  54. salivary gland morphogenesis Source: MGI
  55. signal transduction involved in regulation of gene expression Source: MGI
  56. smoothened signaling pathway Source: MGI
  57. telencephalon regionalization Source: MGI
  58. transcription from RNA polymerase II promoter Source: BHF-UCL
  59. type B pancreatic cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-6
Alternative name(s):
Oculorhombin
Gene namesi
Name:Pax6
Synonyms:Pax-6, Sey
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:97490. Pax6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. intracellular Source: MGI
  3. nuclear chromatin Source: BHF-UCL
  4. nucleus Source: MGI
  5. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Paired box protein Pax-6
PRO_0000050186Add
BLAST

Post-translational modificationi

Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. Isoform 3 is sumoylated by SUMO1 at 'Lys-91'.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiP63015.

PTM databases

PhosphoSiteiP63015.

Expressioni

Tissue specificityi

Isoform 1 and isoform 3 are the major isoforms among different eye tissues. Isoform 1 and isoform 3 are expressed in the retina and cornea. In the lens epithelium, isoform 1 is relatively abundant, but isoform 3 is barely detectable.1 Publication

Developmental stagei

Expressed in the developing eye, nose, brain and pancreas. At 9 dpc, expressed in the telencephalon, diencephalon, neural tube, optic vesicle and pancreas. Throughout development, expression continues in the dorsal and ventral pancreas. Expressed during cortical neurogenesis from 11 to 18 dpc. High levels in the early radial glial progenitors from 11 to 14 dpc and gradually decrease thereafter (at protein level). During corticogenesis, the protein level declines faster than that of the mRNA, due to proteasomal degradation. In newborn animals, becomes restricted to endocrine cells of the islets of Langerhans. Isoform 3 is expressed in the developing eye at day 9.5 of embryonic development and the expression becomes much stronger at day 11.5 of embryonic development. At these stages, it is detected in neural tube and optic and lens vesicles. Isoform 3 expression is down-regulated by day 12.5 of embryonic development and becomes significantly decreased from day 14.5 to day 18.5 of embryonic development. Isoform 1 and isoform 3 are the major isoforms in the eye tissues of newborn mice, but a considerable amount of isoform 5a is also detected.2 Publications

Gene expression databases

ArrayExpressiP63015.
BgeeiP63015.
CleanExiMM_PAX6.
GenevestigatoriP63015.

Interactioni

Subunit structurei

Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4O358452EBI-1395428,EBI-371515

Protein-protein interaction databases

BioGridi202033. 18 interactions.
DIPiDIP-38879N.
IntActiP63015. 3 interactions.
MINTiMINT-1782085.

Structurei

3D structure databases

ProteinModelPortaliP63015.
SMRiP63015. Positions 4-136, 211-278.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 130127Paired
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 20979Gln/Gly-rich
Add
BLAST
Compositional biasi279 – 422144Pro/Ser/Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.
Contains 1 paired domain.

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOVERGENiHBG009115.
KOiK08031.
OMAiAGENTNS.
OrthoDBiEOG7WT431.
TreeFamiTF320146.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P63015-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN    50
GCVSKILGRY YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW 100
EIRDRLLSEG VCTNDNIPSV SSINRVLRNL ASEKQQMGAD GMYDKLRMLN 150
GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ EGGGENTNSI SSNGEDSDEA 200
QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR ERLAAKIDLP 250
EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 300
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ 350
TSSYSCMLPT SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG 400
VSVPVQVPGS EPDMSQYWPR LQ 422
Length:422
Mass (Da):46,683
Last modified:August 31, 2004 - v1
Checksum:iC33CDD2C1B13C397
GO
Isoform 5a (identifier: P63015-2) [UniParc]FASTAAdd to Basket

Also known as: Pax6-5a

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: Q → QTHADAKVQVLDNEN

Show »
Length:436
Mass (Da):48,219
Checksum:i76CCA1E7313E2C31
GO
Isoform 3 (identifier: P63015-3) [UniParc]FASTAAdd to Basket

Also known as: p32

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Show »
Length:286
Mass (Da):31,769
Checksum:iB21F60204FC01176
GO

Sequence cautioni

The sequence AAA40109.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti259 – 2591S → P in Pax6(4Neu); defective. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 136136Missing in isoform 3.
VSP_054294Add
BLAST
Alternative sequencei47 – 471Q → QTHADAKVQVLDNEN in isoform 5a.
VSP_011530

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181G → E in BAC25729. 1 Publication
Sequence conflicti31 – 311E → Q in BAC25729. 1 Publication
Sequence conflicti287 – 2871I → T in AAA40109. 1 Publication
Sequence conflicti421 – 4222Missing in AAA40109. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63963 mRNA. Translation: CAA45379.1.
X63963 mRNA. Translation: CAA45380.1.
Y19196 Genomic DNA. Translation: CAC80516.1.
Y19199 Genomic DNA. Translation: CAC80519.1.
AK028059 mRNA. Translation: BAC25729.1.
AK139054 mRNA. Translation: BAE23875.1.
BC011272 mRNA. Translation: AAH11272.1.
BC036957 mRNA. Translation: AAH36957.1.
M77842 mRNA. Translation: AAA40109.1. Different initiation.
CCDSiCCDS16499.1. [P63015-2]
CCDS57181.1. [P63015-1]
PIRiS42234.
RefSeqiNP_001231127.1. NM_001244198.1. [P63015-2]
NP_001231129.1. NM_001244200.1. [P63015-2]
NP_001231130.1. NM_001244201.1. [P63015-1]
NP_001231131.1. NM_001244202.1. [P63015-1]
NP_038655.1. NM_013627.5. [P63015-2]
XP_006498976.1. XM_006498913.1. [P63015-2]
XP_006498977.1. XM_006498914.1. [P63015-2]
XP_006498978.1. XM_006498915.1. [P63015-1]
XP_006498979.1. XM_006498916.1. [P63015-3]
XP_006498980.1. XM_006498917.1. [P63015-3]
UniGeneiMm.33870.
Mm.3608.
Mm.487124.

Genome annotation databases

EnsembliENSMUST00000090391; ENSMUSP00000087870; ENSMUSG00000027168. [P63015-2]
ENSMUST00000090397; ENSMUSP00000087878; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111082; ENSMUSP00000106711; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111083; ENSMUSP00000106712; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111085; ENSMUSP00000106714; ENSMUSG00000027168. [P63015-2]
ENSMUST00000111086; ENSMUSP00000106715; ENSMUSG00000027168. [P63015-2]
ENSMUST00000111087; ENSMUSP00000106716; ENSMUSG00000027168. [P63015-1]
ENSMUST00000167211; ENSMUSP00000129344; ENSMUSG00000027168. [P63015-2]
GeneIDi18508.
KEGGimmu:18508.
UCSCiuc008lkv.2. mouse. [P63015-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63963 mRNA. Translation: CAA45379.1 .
X63963 mRNA. Translation: CAA45380.1 .
Y19196 Genomic DNA. Translation: CAC80516.1 .
Y19199 Genomic DNA. Translation: CAC80519.1 .
AK028059 mRNA. Translation: BAC25729.1 .
AK139054 mRNA. Translation: BAE23875.1 .
BC011272 mRNA. Translation: AAH11272.1 .
BC036957 mRNA. Translation: AAH36957.1 .
M77842 mRNA. Translation: AAA40109.1 . Different initiation.
CCDSi CCDS16499.1. [P63015-2 ]
CCDS57181.1. [P63015-1 ]
PIRi S42234.
RefSeqi NP_001231127.1. NM_001244198.1. [P63015-2 ]
NP_001231129.1. NM_001244200.1. [P63015-2 ]
NP_001231130.1. NM_001244201.1. [P63015-1 ]
NP_001231131.1. NM_001244202.1. [P63015-1 ]
NP_038655.1. NM_013627.5. [P63015-2 ]
XP_006498976.1. XM_006498913.1. [P63015-2 ]
XP_006498977.1. XM_006498914.1. [P63015-2 ]
XP_006498978.1. XM_006498915.1. [P63015-1 ]
XP_006498979.1. XM_006498916.1. [P63015-3 ]
XP_006498980.1. XM_006498917.1. [P63015-3 ]
UniGenei Mm.33870.
Mm.3608.
Mm.487124.

3D structure databases

ProteinModelPortali P63015.
SMRi P63015. Positions 4-136, 211-278.
ModBasei Search...

Protein-protein interaction databases

BioGridi 202033. 18 interactions.
DIPi DIP-38879N.
IntActi P63015. 3 interactions.
MINTi MINT-1782085.

PTM databases

PhosphoSitei P63015.

Proteomic databases

PRIDEi P63015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090391 ; ENSMUSP00000087870 ; ENSMUSG00000027168 . [P63015-2 ]
ENSMUST00000090397 ; ENSMUSP00000087878 ; ENSMUSG00000027168 . [P63015-1 ]
ENSMUST00000111082 ; ENSMUSP00000106711 ; ENSMUSG00000027168 . [P63015-1 ]
ENSMUST00000111083 ; ENSMUSP00000106712 ; ENSMUSG00000027168 . [P63015-1 ]
ENSMUST00000111085 ; ENSMUSP00000106714 ; ENSMUSG00000027168 . [P63015-2 ]
ENSMUST00000111086 ; ENSMUSP00000106715 ; ENSMUSG00000027168 . [P63015-2 ]
ENSMUST00000111087 ; ENSMUSP00000106716 ; ENSMUSG00000027168 . [P63015-1 ]
ENSMUST00000167211 ; ENSMUSP00000129344 ; ENSMUSG00000027168 . [P63015-2 ]
GeneIDi 18508.
KEGGi mmu:18508.
UCSCi uc008lkv.2. mouse. [P63015-1 ]

Organism-specific databases

CTDi 5080.
MGIi MGI:97490. Pax6.

Phylogenomic databases

eggNOGi NOG326044.
GeneTreei ENSGT00680000099553.
HOVERGENi HBG009115.
KOi K08031.
OMAi AGENTNS.
OrthoDBi EOG7WT431.
TreeFami TF320146.

Miscellaneous databases

NextBioi 294236.
PROi P63015.
SOURCEi Search...

Gene expression databases

ArrayExpressi P63015.
Bgeei P63015.
CleanExi MM_PAX6.
Genevestigatori P63015.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pax-6, a murine paired box gene, is expressed in the developing CNS."
    Walther C., Gruss P.
    Development 113:1435-1449(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5A), PARTIAL PROTEIN SEQUENCE.
  2. "Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus."
    Favor J., Peters H., Hermann T., Schmahl W., Chatterjee B., Neuhauser-Klaus A., Sandulache R.
    Genetics 159:1689-1700(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5A), VARIANT PRO-259.
    Strain: C3H.
    Tissue: Head.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5A).
    Strain: Czech II.
    Tissue: Eye and Mammary tumor.
  5. "Pax: a murine multigene family of paired box-containing genes."
    Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
    Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-131 (ISOFORM 1).
  6. "Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene."
    Ton C.C.T., Miwa H., Saunders G.F.
    Genomics 13:251-256(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-422 (ISOFORM 1).
    Tissue: Embryo.
  7. "Mouse small eye results from mutations in a paired-like homeobox-containing gene."
    Hill R.E., Favor J., Hogan B.L.M., Ton C.C.T., Saunders G.F., Hanson I.M., Prosser J., Jordan T., Hastie N.D., van Heyningen V.
    Nature 354:522-525(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SEY.
  8. "Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas."
    St Onge L., Sosa-Pineda B., Chowdhury K., Mansouri A., Gruss P.
    Nature 387:406-409(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PANCREAS.
  9. "Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression."
    Gosmain Y., Avril I., Mamin A., Philippe J.
    J. Biol. Chem. 282:35024-35034(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAF AND MAFB.
  10. "Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system."
    Tuoc T.C., Stoykova A.
    Genes Dev. 22:1972-1986(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRIM11, UBIQUITINATION, DEVELOPMENTAL STAGE.
  11. "Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development."
    Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen P.C., Hu X., Liu J., Qin J., Xiao L., Huang X.Q., Zhang J., Li D.W.
    Proc. Natl. Acad. Sci. U.S.A. 107:21034-21039(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUMOYLATION.

Entry informationi

Entry nameiPAX6_MOUSE
AccessioniPrimary (citable) accession number: P63015
Secondary accession number(s): P32117
, P70601, Q3UTV5, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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