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P63015 (PAX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-6
Alternative name(s):
Oculorhombin
Gene names
Name:Pax6
Synonyms:Pax-6, Sey
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains By similarity. Ref.8

Subunit structure

Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences. Ref.9 Ref.10

Subcellular location

Nucleus.

Tissue specificity

Isoform 1 and isoform 3 are the major isoforms among different eye tissues. Isoform 1 and isoform 3 are expressed in the retina and cornea. In the lens epithelium, isoform 1 is relatively abundant, but isoform 3 is barely detectable. Ref.11

Developmental stage

Expressed in the developing eye, nose, brain and pancreas. At 9 dpc, expressed in the telencephalon, diencephalon, neural tube, optic vesicle and pancreas. Throughout development, expression continues in the dorsal and ventral pancreas. Expressed during cortical neurogenesis from 11 to 18 dpc. High levels in the early radial glial progenitors from 11 to 14 dpc and gradually decrease thereafter (at protein level). During corticogenesis, the protein level declines faster than that of the mRNA, due to proteasomal degradation. In newborn animals, becomes restricted to endocrine cells of the islets of Langerhans. Isoform 3 is expressed in the developing eye at day 9.5 of embryonic development and the expression becomes much stronger at day 11.5 of embryonic development. At these stages, it is detected in neural tube and optic and lens vesicles. Isoform 3 expression is down-regulated by day 12.5 of embryonic development and becomes significantly decreased from day 14.5 to day 18.5 of embryonic development. Isoform 1 and isoform 3 are the major isoforms in the eye tissues of newborn mice, but a considerable amount of isoform 5a is also detected. Ref.10 Ref.11

Post-translational modification

Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. Isoform 3 is sumoylated by SUMO1 at 'Lys-91'. Ref.10

Involvement in disease

Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Contains 1 paired domain.

Sequence caution

The sequence AAA40109.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processDifferentiation
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DiseaseDisease mutation
   DomainHomeobox
Paired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMUbl conjugation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 12196586. Source: MGI

astrocyte differentiation

Inferred from mutant phenotype PubMed 19258013. Source: MGI

axon guidance

Inferred from mutant phenotype PubMed 11967891PubMed 14586016. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 15514979. Source: MGI

blood vessel development

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from mutant phenotype PubMed 10409504PubMed 12196586. Source: MGI

camera-type eye development

Inferred from mutant phenotype PubMed 11062307PubMed 11069887PubMed 12648492PubMed 12756174PubMed 16080917. Source: MGI

cell differentiation

Inferred from mutant phenotype PubMed 15031110. Source: MGI

cell fate commitment

Inferred from mutant phenotype PubMed 15878992. Source: MGI

cell fate determination

Inferred from mutant phenotype PubMed 12756174. Source: MGI

cerebral cortex regionalization

Inferred from mutant phenotype PubMed 12764040PubMed 23431145. Source: MGI

commitment of neuronal cell to specific neuron type in forebrain

Inferred from mutant phenotype PubMed 11124115. Source: MGI

cornea development in camera-type eye

Inferred from electronic annotation. Source: Ensembl

dorsal/ventral axis specification

Inferred from mutant phenotype PubMed 10588713. Source: MGI

dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 15548580PubMed 15878992. Source: MGI

embryonic camera-type eye morphogenesis

Inferred from genetic interaction PubMed 18653562. Source: MGI

eye photoreceptor cell development

Inferred from mutant phenotype PubMed 12648492. Source: MGI

forebrain anterior/posterior pattern specification

Inferred from mutant phenotype PubMed 9169845. Source: MGI

forebrain development

Inferred from mutant phenotype PubMed 15514979PubMed 15548580PubMed 15758185. Source: MGI

forebrain dorsal/ventral pattern formation

Inferred from mutant phenotype PubMed 11050125PubMed 11124115PubMed 18701439. Source: MGI

forebrain-midbrain boundary formation

Inferred from mutant phenotype PubMed 9169845. Source: MGI

glucose homeostasis

Inferred from electronic annotation. Source: Ensembl

hindbrain development

Inferred from electronic annotation. Source: Ensembl

iris morphogenesis

Inferred from electronic annotation. Source: Ensembl

keratinocyte differentiation

Inferred from mutant phenotype PubMed 16080917. Source: MGI

lacrimal gland development

Inferred from mutant phenotype PubMed 10821755. Source: MGI

lens development in camera-type eye

Inferred from mutant phenotype PubMed 6877261. Source: MGI

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 15548580. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16080917. Source: MGI

negative regulation of neuron differentiation

Inferred from genetic interaction PubMed 16950124. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 15758185. Source: MGI

oligodendrocyte cell fate specification

Inferred from mutant phenotype PubMed 9828088. Source: MGI

pallium development

Inferred from mutant phenotype PubMed 11124115. Source: MGI

pancreatic A cell development

Inferred from mutant phenotype PubMed 20592023. Source: BHF-UCL

pituitary gland development

Inferred from mutant phenotype PubMed 10588713. Source: MGI

positive regulation of cell fate specification

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell differentiation

Inferred from mutant phenotype PubMed 16080917. Source: MGI

positive regulation of gene expression

Inferred from mutant phenotype PubMed 20592023. Source: BHF-UCL

positive regulation of neuroblast proliferation

Inferred from mutant phenotype PubMed 18287938. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16407227. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 20592023. Source: BHF-UCL

protein localization to organelle

Inferred from mutant phenotype PubMed 16024294. Source: MGI

regulation of cell migration

Inferred from mutant phenotype PubMed 10409504PubMed 18701439. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 12764040PubMed 16919471PubMed 18799682. Source: MGI

regulation of neurogenesis

Inferred from mutant phenotype PubMed 15548580. Source: MGI

regulation of timing of cell differentiation

Inferred from mutant phenotype PubMed 9828088. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 19521500. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment

Inferred from mutant phenotype PubMed 9230312. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification

Inferred from mutant phenotype PubMed 9230312. Source: MGI

regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification

Inferred from mutant phenotype PubMed 9230312. Source: MGI

regulation of transcription, DNA-templated

Traceable author statement PubMed 10197584. Source: MGI

response to wounding

Inferred from electronic annotation. Source: Ensembl

retina development in camera-type eye

Inferred from genetic interaction PubMed 19146846. Source: MGI

salivary gland morphogenesis

Inferred from mutant phenotype PubMed 11731698. Source: MGI

signal transduction involved in regulation of gene expression

Inferred from direct assay PubMed 18462699. Source: MGI

smoothened signaling pathway

Inferred from direct assay PubMed 18590716. Source: MGI

transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 20592023. Source: BHF-UCL

type B pancreatic cell differentiation

Inferred from mutant phenotype PubMed 22764048. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

intracellular

Inferred from direct assay PubMed 15793245. Source: MGI

nuclear chromatin

Inferred from direct assay PubMed 20592023. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 11209945PubMed 12050133PubMed 14625556PubMed 16464444PubMed 19409883PubMed 22764048PubMed 23434913PubMed 9230312. Source: MGI

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionAT DNA binding

Inferred from electronic annotation. Source: Ensembl

DNA binding

Inferred from direct assay PubMed 12756174. Source: MGI

HMG box domain binding

Inferred from physical interaction PubMed 16582099. Source: UniProtKB

R-SMAD binding

Inferred from direct assay PubMed 17251190. Source: BHF-UCL

RNA polymerase II core promoter sequence-specific DNA binding

Inferred from direct assay PubMed 16407227PubMed 20592023. Source: BHF-UCL

chromatin binding

Inferred from direct assay PubMed 19146846PubMed 23637604. Source: MGI

co-SMAD binding

Inferred from direct assay PubMed 17251190. Source: BHF-UCL

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase binding

Inferred from direct assay PubMed 16407227. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 16675956. Source: IntAct

protein kinase binding

Inferred from physical interaction PubMed 16407227. Source: BHF-UCL

sequence-specific DNA binding

Inferred from direct assay Ref.11. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 16407227PubMed 20592023. Source: BHF-UCL

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 18287938. Source: MGI

transcription factor binding

Inferred from physical interaction PubMed 16407227. Source: BHF-UCL

transcription regulatory region DNA binding

Inferred from direct assay PubMed 19521500. Source: MGI

ubiquitin protein ligase binding

Inferred from physical interaction Ref.10. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Smarca4O358452EBI-1395428,EBI-371515

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P63015-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 5a (identifier: P63015-2)

Also known as: Pax6-5a;

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: Q → QTHADAKVQVLDNEN
Isoform 3 (identifier: P63015-3)

Also known as: p32;

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Paired box protein Pax-6
PRO_0000050186

Regions

Domain4 – 130127Paired
DNA binding210 – 26960Homeobox
Compositional bias131 – 20979Gln/Gly-rich
Compositional bias279 – 422144Pro/Ser/Thr-rich

Natural variations

Alternative sequence1 – 136136Missing in isoform 3.
VSP_054294
Alternative sequence471Q → QTHADAKVQVLDNEN in isoform 5a.
VSP_011530
Natural variant2591S → P in Pax6(4Neu); defective. Ref.2

Experimental info

Sequence conflict181G → E in BAC25729. Ref.3
Sequence conflict311E → Q in BAC25729. Ref.3
Sequence conflict2871I → T in AAA40109. Ref.6
Sequence conflict421 – 4222Missing in AAA40109. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: C33CDD2C1B13C397

FASTA42246,683
        10         20         30         40         50         60 
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY 

        70         80         90        100        110        120 
YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV 

       130        140        150        160        170        180 
SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ 

       190        200        210        220        230        240 
EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR 

       250        260        270        280        290        300 
ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 

       310        320        330        340        350        360 
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT 

       370        380        390        400        410        420 
SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR 


LQ 

« Hide

Isoform 5a (Pax6-5a) [UniParc].

Checksum: 76CCA1E7313E2C31
Show »

FASTA43648,219
Isoform 3 (p32) [UniParc].

Checksum: B21F60204FC01176
Show »

FASTA28631,769

References

« Hide 'large scale' references
[1]"Pax-6, a murine paired box gene, is expressed in the developing CNS."
Walther C., Gruss P.
Development 113:1435-1449(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5A), PARTIAL PROTEIN SEQUENCE.
[2]"Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus."
Favor J., Peters H., Hermann T., Schmahl W., Chatterjee B., Neuhauser-Klaus A., Sandulache R.
Genetics 159:1689-1700(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5A), VARIANT PRO-259.
Strain: C3H.
Tissue: Head.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: C57BL/6J.
Tissue: Cerebellum.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5A).
Strain: Czech II.
Tissue: Eye and Mammary tumor.
[5]"Pax: a murine multigene family of paired box-containing genes."
Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-131 (ISOFORM 1).
[6]"Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene."
Ton C.C.T., Miwa H., Saunders G.F.
Genomics 13:251-256(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-422 (ISOFORM 1).
Tissue: Embryo.
[7]"Mouse small eye results from mutations in a paired-like homeobox-containing gene."
Hill R.E., Favor J., Hogan B.L.M., Ton C.C.T., Saunders G.F., Hanson I.M., Prosser J., Jordan T., Hastie N.D., van Heyningen V.
Nature 354:522-525(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN SEY.
[8]"Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas."
St Onge L., Sosa-Pineda B., Chowdhury K., Mansouri A., Gruss P.
Nature 387:406-409(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN PANCREAS.
[9]"Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression."
Gosmain Y., Avril I., Mamin A., Philippe J.
J. Biol. Chem. 282:35024-35034(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MAF AND MAFB.
[10]"Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system."
Tuoc T.C., Stoykova A.
Genes Dev. 22:1972-1986(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRIM11, UBIQUITINATION, DEVELOPMENTAL STAGE.
[11]"Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development."
Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen P.C., Hu X., Liu J., Qin J., Xiao L., Huang X.Q., Zhang J., Li D.W.
Proc. Natl. Acad. Sci. U.S.A. 107:21034-21039(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUMOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63963 mRNA. Translation: CAA45379.1.
X63963 mRNA. Translation: CAA45380.1.
Y19196 Genomic DNA. Translation: CAC80516.1.
Y19199 Genomic DNA. Translation: CAC80519.1.
AK028059 mRNA. Translation: BAC25729.1.
AK139054 mRNA. Translation: BAE23875.1.
BC011272 mRNA. Translation: AAH11272.1.
BC036957 mRNA. Translation: AAH36957.1.
M77842 mRNA. Translation: AAA40109.1. Different initiation.
CCDSCCDS16499.1. [P63015-2]
CCDS57181.1. [P63015-1]
PIRS42234.
RefSeqNP_001231127.1. NM_001244198.1. [P63015-2]
NP_001231129.1. NM_001244200.1. [P63015-2]
NP_001231130.1. NM_001244201.1. [P63015-1]
NP_001231131.1. NM_001244202.1. [P63015-1]
NP_038655.1. NM_013627.5. [P63015-2]
XP_006498976.1. XM_006498913.1. [P63015-2]
XP_006498977.1. XM_006498914.1. [P63015-2]
XP_006498978.1. XM_006498915.1. [P63015-1]
XP_006498979.1. XM_006498916.1. [P63015-3]
XP_006498980.1. XM_006498917.1. [P63015-3]
UniGeneMm.33870.
Mm.3608.
Mm.487124.

3D structure databases

ProteinModelPortalP63015.
SMRP63015. Positions 4-136, 211-278.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202033. 18 interactions.
DIPDIP-38879N.
IntActP63015. 3 interactions.
MINTMINT-1782085.

PTM databases

PhosphoSiteP63015.

Proteomic databases

PRIDEP63015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090391; ENSMUSP00000087870; ENSMUSG00000027168. [P63015-2]
ENSMUST00000090397; ENSMUSP00000087878; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111082; ENSMUSP00000106711; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111083; ENSMUSP00000106712; ENSMUSG00000027168. [P63015-1]
ENSMUST00000111085; ENSMUSP00000106714; ENSMUSG00000027168. [P63015-2]
ENSMUST00000111086; ENSMUSP00000106715; ENSMUSG00000027168. [P63015-2]
ENSMUST00000111087; ENSMUSP00000106716; ENSMUSG00000027168. [P63015-1]
ENSMUST00000167211; ENSMUSP00000129344; ENSMUSG00000027168. [P63015-2]
GeneID18508.
KEGGmmu:18508.
UCSCuc008lkv.2. mouse. [P63015-1]

Organism-specific databases

CTD5080.
MGIMGI:97490. Pax6.

Phylogenomic databases

eggNOGNOG326044.
GeneTreeENSGT00680000099553.
HOVERGENHBG009115.
KOK08031.
OMAAGENTNS.
OrthoDBEOG7WT431.
TreeFamTF320146.

Gene expression databases

ArrayExpressP63015.
BgeeP63015.
CleanExMM_PAX6.
GenevestigatorP63015.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294236.
PROP63015.
SOURCESearch...

Entry information

Entry namePAX6_MOUSE
AccessionPrimary (citable) accession number: P63015
Secondary accession number(s): P32117 expand/collapse secondary AC list , P70601, Q3UTV5, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot