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P63015

- PAX6_MOUSE

UniProt

P63015 - PAX6_MOUSE

Protein

Paired box protein Pax-6

Gene

Pax6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi210 – 26960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. chromatin binding Source: MGI
    3. co-SMAD binding Source: BHF-UCL
    4. DNA binding Source: MGI
    5. double-stranded DNA binding Source: Ensembl
    6. histone acetyltransferase binding Source: BHF-UCL
    7. HMG box domain binding Source: UniProtKB
    8. protein binding Source: IntAct
    9. protein kinase binding Source: BHF-UCL
    10. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    11. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    12. RNA polymerase II core promoter sequence-specific DNA binding Source: BHF-UCL
    13. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
    14. R-SMAD binding Source: BHF-UCL
    15. sequence-specific DNA binding Source: MGI
    16. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: BHF-UCL
    17. sequence-specific DNA binding transcription factor activity Source: MGI
    18. transcription factor binding Source: BHF-UCL
    19. transcription regulatory region DNA binding Source: MGI
    20. ubiquitin protein ligase binding Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. astrocyte differentiation Source: MGI
    3. axon guidance Source: MGI
    4. axonogenesis Source: MGI
    5. blood vessel development Source: Ensembl
    6. brain development Source: MGI
    7. camera-type eye development Source: MGI
    8. cell differentiation Source: MGI
    9. cell fate commitment Source: MGI
    10. cell fate determination Source: MGI
    11. cerebral cortex regionalization Source: MGI
    12. commitment of neuronal cell to specific neuron type in forebrain Source: MGI
    13. cornea development in camera-type eye Source: Ensembl
    14. dorsal/ventral axis specification Source: MGI
    15. dorsal/ventral pattern formation Source: MGI
    16. embryonic camera-type eye morphogenesis Source: MGI
    17. eye photoreceptor cell development Source: MGI
    18. forebrain anterior/posterior pattern specification Source: MGI
    19. forebrain development Source: MGI
    20. forebrain dorsal/ventral pattern formation Source: MGI
    21. forebrain-midbrain boundary formation Source: MGI
    22. glucose homeostasis Source: Ensembl
    23. hindbrain development Source: Ensembl
    24. iris morphogenesis Source: Ensembl
    25. keratinocyte differentiation Source: MGI
    26. lacrimal gland development Source: MGI
    27. lens development in camera-type eye Source: MGI
    28. negative regulation of cell proliferation Source: MGI
    29. negative regulation of epithelial cell proliferation Source: MGI
    30. negative regulation of neural precursor cell proliferation Source: MGI
    31. negative regulation of neuron differentiation Source: MGI
    32. negative regulation of protein phosphorylation Source: MGI
    33. negative regulation of transcription from RNA polymerase II promoter Source: GOC
    34. neuron migration Source: MGI
    35. oligodendrocyte cell fate specification Source: MGI
    36. pallium development Source: MGI
    37. pancreatic A cell development Source: BHF-UCL
    38. pituitary gland development Source: MGI
    39. positive regulation of cell fate specification Source: Ensembl
    40. positive regulation of epithelial cell differentiation Source: MGI
    41. positive regulation of gene expression Source: BHF-UCL
    42. positive regulation of neuroblast proliferation Source: MGI
    43. positive regulation of transcription, DNA-templated Source: BHF-UCL
    44. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    45. protein localization to organelle Source: MGI
    46. regulation of cell migration Source: MGI
    47. regulation of gene expression Source: MGI
    48. regulation of neurogenesis Source: MGI
    49. regulation of timing of cell differentiation Source: MGI
    50. regulation of transcription, DNA-templated Source: MGI
    51. regulation of transcription from RNA polymerase II promoter Source: MGI
    52. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: MGI
    53. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: MGI
    54. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: MGI
    55. response to wounding Source: Ensembl
    56. retina development in camera-type eye Source: MGI
    57. salivary gland morphogenesis Source: MGI
    58. signal transduction involved in regulation of gene expression Source: MGI
    59. smoothened signaling pathway Source: MGI
    60. telencephalon regionalization Source: MGI
    61. transcription from RNA polymerase II promoter Source: BHF-UCL
    62. type B pancreatic cell differentiation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-6
    Alternative name(s):
    Oculorhombin
    Gene namesi
    Name:Pax6
    Synonyms:Pax-6, Sey
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97490. Pax6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. intracellular Source: MGI
    3. nuclear chromatin Source: BHF-UCL
    4. nucleus Source: MGI
    5. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Paired box protein Pax-6PRO_0000050186Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. Isoform 3 is sumoylated by SUMO1 at 'Lys-91'.2 Publications

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiP63015.

    PTM databases

    PhosphoSiteiP63015.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 3 are the major isoforms among different eye tissues. Isoform 1 and isoform 3 are expressed in the retina and cornea. In the lens epithelium, isoform 1 is relatively abundant, but isoform 3 is barely detectable.1 Publication

    Developmental stagei

    Expressed in the developing eye, nose, brain and pancreas. At 9 dpc, expressed in the telencephalon, diencephalon, neural tube, optic vesicle and pancreas. Throughout development, expression continues in the dorsal and ventral pancreas. Expressed during cortical neurogenesis from 11 to 18 dpc. High levels in the early radial glial progenitors from 11 to 14 dpc and gradually decrease thereafter (at protein level). During corticogenesis, the protein level declines faster than that of the mRNA, due to proteasomal degradation. In newborn animals, becomes restricted to endocrine cells of the islets of Langerhans. Isoform 3 is expressed in the developing eye at day 9.5 of embryonic development and the expression becomes much stronger at day 11.5 of embryonic development. At these stages, it is detected in neural tube and optic and lens vesicles. Isoform 3 expression is down-regulated by day 12.5 of embryonic development and becomes significantly decreased from day 14.5 to day 18.5 of embryonic development. Isoform 1 and isoform 3 are the major isoforms in the eye tissues of newborn mice, but a considerable amount of isoform 5a is also detected.2 Publications

    Gene expression databases

    ArrayExpressiP63015.
    BgeeiP63015.
    CleanExiMM_PAX6.
    GenevestigatoriP63015.

    Interactioni

    Subunit structurei

    Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Smarca4O358452EBI-1395428,EBI-371515

    Protein-protein interaction databases

    BioGridi202033. 18 interactions.
    DIPiDIP-38879N.
    IntActiP63015. 3 interactions.
    MINTiMINT-1782085.

    Structurei

    3D structure databases

    ProteinModelPortaliP63015.
    SMRiP63015. Positions 4-136, 211-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 130127PairedPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi131 – 20979Gln/Gly-richAdd
    BLAST
    Compositional biasi279 – 422144Pro/Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Paired box

    Phylogenomic databases

    eggNOGiNOG326044.
    GeneTreeiENSGT00680000099553.
    HOVERGENiHBG009115.
    KOiK08031.
    OMAiAGENTNS.
    OrthoDBiEOG7WT431.
    TreeFamiTF320146.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P63015-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN    50
    GCVSKILGRY YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW 100
    EIRDRLLSEG VCTNDNIPSV SSINRVLRNL ASEKQQMGAD GMYDKLRMLN 150
    GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ EGGGENTNSI SSNGEDSDEA 200
    QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR ERLAAKIDLP 250
    EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 300
    QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ 350
    TSSYSCMLPT SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG 400
    VSVPVQVPGS EPDMSQYWPR LQ 422
    Length:422
    Mass (Da):46,683
    Last modified:August 31, 2004 - v1
    Checksum:iC33CDD2C1B13C397
    GO
    Isoform 5a (identifier: P63015-2) [UniParc]FASTAAdd to Basket

    Also known as: Pax6-5a

    The sequence of this isoform differs from the canonical sequence as follows:
         47-47: Q → QTHADAKVQVLDNEN

    Show »
    Length:436
    Mass (Da):48,219
    Checksum:i76CCA1E7313E2C31
    GO
    Isoform 3 (identifier: P63015-3) [UniParc]FASTAAdd to Basket

    Also known as: p32

    The sequence of this isoform differs from the canonical sequence as follows:
         1-136: Missing.

    Show »
    Length:286
    Mass (Da):31,769
    Checksum:iB21F60204FC01176
    GO

    Sequence cautioni

    The sequence AAA40109.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181G → E in BAC25729. (PubMed:16141072)Curated
    Sequence conflicti31 – 311E → Q in BAC25729. (PubMed:16141072)Curated
    Sequence conflicti287 – 2871I → T in AAA40109. (PubMed:1612585)Curated
    Sequence conflicti421 – 4222Missing in AAA40109. (PubMed:1612585)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti259 – 2591S → P in Pax6(4Neu); defective. 1 Publication

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 136136Missing in isoform 3. 1 PublicationVSP_054294Add
    BLAST
    Alternative sequencei47 – 471Q → QTHADAKVQVLDNEN in isoform 5a. 2 PublicationsVSP_011530

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63963 mRNA. Translation: CAA45379.1.
    X63963 mRNA. Translation: CAA45380.1.
    Y19196 Genomic DNA. Translation: CAC80516.1.
    Y19199 Genomic DNA. Translation: CAC80519.1.
    AK028059 mRNA. Translation: BAC25729.1.
    AK139054 mRNA. Translation: BAE23875.1.
    BC011272 mRNA. Translation: AAH11272.1.
    BC036957 mRNA. Translation: AAH36957.1.
    M77842 mRNA. Translation: AAA40109.1. Different initiation.
    CCDSiCCDS16499.1. [P63015-2]
    CCDS57181.1. [P63015-1]
    PIRiS42234.
    RefSeqiNP_001231127.1. NM_001244198.1. [P63015-2]
    NP_001231129.1. NM_001244200.1. [P63015-2]
    NP_001231130.1. NM_001244201.1. [P63015-1]
    NP_001231131.1. NM_001244202.1. [P63015-1]
    NP_038655.1. NM_013627.5. [P63015-2]
    XP_006498976.1. XM_006498913.1. [P63015-2]
    XP_006498977.1. XM_006498914.1. [P63015-2]
    XP_006498978.1. XM_006498915.1. [P63015-1]
    XP_006498979.1. XM_006498916.1. [P63015-3]
    XP_006498980.1. XM_006498917.1. [P63015-3]
    UniGeneiMm.33870.
    Mm.3608.
    Mm.487124.

    Genome annotation databases

    EnsembliENSMUST00000090391; ENSMUSP00000087870; ENSMUSG00000027168. [P63015-2]
    ENSMUST00000090397; ENSMUSP00000087878; ENSMUSG00000027168. [P63015-1]
    ENSMUST00000111082; ENSMUSP00000106711; ENSMUSG00000027168. [P63015-1]
    ENSMUST00000111083; ENSMUSP00000106712; ENSMUSG00000027168. [P63015-1]
    ENSMUST00000111085; ENSMUSP00000106714; ENSMUSG00000027168. [P63015-2]
    ENSMUST00000111086; ENSMUSP00000106715; ENSMUSG00000027168. [P63015-2]
    ENSMUST00000111087; ENSMUSP00000106716; ENSMUSG00000027168. [P63015-1]
    ENSMUST00000167211; ENSMUSP00000129344; ENSMUSG00000027168. [P63015-2]
    GeneIDi18508.
    KEGGimmu:18508.
    UCSCiuc008lkv.2. mouse. [P63015-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63963 mRNA. Translation: CAA45379.1 .
    X63963 mRNA. Translation: CAA45380.1 .
    Y19196 Genomic DNA. Translation: CAC80516.1 .
    Y19199 Genomic DNA. Translation: CAC80519.1 .
    AK028059 mRNA. Translation: BAC25729.1 .
    AK139054 mRNA. Translation: BAE23875.1 .
    BC011272 mRNA. Translation: AAH11272.1 .
    BC036957 mRNA. Translation: AAH36957.1 .
    M77842 mRNA. Translation: AAA40109.1 . Different initiation.
    CCDSi CCDS16499.1. [P63015-2 ]
    CCDS57181.1. [P63015-1 ]
    PIRi S42234.
    RefSeqi NP_001231127.1. NM_001244198.1. [P63015-2 ]
    NP_001231129.1. NM_001244200.1. [P63015-2 ]
    NP_001231130.1. NM_001244201.1. [P63015-1 ]
    NP_001231131.1. NM_001244202.1. [P63015-1 ]
    NP_038655.1. NM_013627.5. [P63015-2 ]
    XP_006498976.1. XM_006498913.1. [P63015-2 ]
    XP_006498977.1. XM_006498914.1. [P63015-2 ]
    XP_006498978.1. XM_006498915.1. [P63015-1 ]
    XP_006498979.1. XM_006498916.1. [P63015-3 ]
    XP_006498980.1. XM_006498917.1. [P63015-3 ]
    UniGenei Mm.33870.
    Mm.3608.
    Mm.487124.

    3D structure databases

    ProteinModelPortali P63015.
    SMRi P63015. Positions 4-136, 211-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202033. 18 interactions.
    DIPi DIP-38879N.
    IntActi P63015. 3 interactions.
    MINTi MINT-1782085.

    PTM databases

    PhosphoSitei P63015.

    Proteomic databases

    PRIDEi P63015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090391 ; ENSMUSP00000087870 ; ENSMUSG00000027168 . [P63015-2 ]
    ENSMUST00000090397 ; ENSMUSP00000087878 ; ENSMUSG00000027168 . [P63015-1 ]
    ENSMUST00000111082 ; ENSMUSP00000106711 ; ENSMUSG00000027168 . [P63015-1 ]
    ENSMUST00000111083 ; ENSMUSP00000106712 ; ENSMUSG00000027168 . [P63015-1 ]
    ENSMUST00000111085 ; ENSMUSP00000106714 ; ENSMUSG00000027168 . [P63015-2 ]
    ENSMUST00000111086 ; ENSMUSP00000106715 ; ENSMUSG00000027168 . [P63015-2 ]
    ENSMUST00000111087 ; ENSMUSP00000106716 ; ENSMUSG00000027168 . [P63015-1 ]
    ENSMUST00000167211 ; ENSMUSP00000129344 ; ENSMUSG00000027168 . [P63015-2 ]
    GeneIDi 18508.
    KEGGi mmu:18508.
    UCSCi uc008lkv.2. mouse. [P63015-1 ]

    Organism-specific databases

    CTDi 5080.
    MGIi MGI:97490. Pax6.

    Phylogenomic databases

    eggNOGi NOG326044.
    GeneTreei ENSGT00680000099553.
    HOVERGENi HBG009115.
    KOi K08031.
    OMAi AGENTNS.
    OrthoDBi EOG7WT431.
    TreeFami TF320146.

    Miscellaneous databases

    NextBioi 294236.
    PROi P63015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63015.
    Bgeei P63015.
    CleanExi MM_PAX6.
    Genevestigatori P63015.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00389. HOX. 1 hit.
    SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pax-6, a murine paired box gene, is expressed in the developing CNS."
      Walther C., Gruss P.
      Development 113:1435-1449(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5A), PARTIAL PROTEIN SEQUENCE.
    2. "Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus."
      Favor J., Peters H., Hermann T., Schmahl W., Chatterjee B., Neuhauser-Klaus A., Sandulache R.
      Genetics 159:1689-1700(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 5A), VARIANT PRO-259.
      Strain: C3H.
      Tissue: Head.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5A).
      Strain: Czech II.
      Tissue: Eye and Mammary tumor.
    5. "Pax: a murine multigene family of paired box-containing genes."
      Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
      Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-131 (ISOFORM 1).
    6. "Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene."
      Ton C.C.T., Miwa H., Saunders G.F.
      Genomics 13:251-256(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-422 (ISOFORM 1).
      Tissue: Embryo.
    7. "Mouse small eye results from mutations in a paired-like homeobox-containing gene."
      Hill R.E., Favor J., Hogan B.L.M., Ton C.C.T., Saunders G.F., Hanson I.M., Prosser J., Jordan T., Hastie N.D., van Heyningen V.
      Nature 354:522-525(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SEY.
    8. "Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas."
      St Onge L., Sosa-Pineda B., Chowdhury K., Mansouri A., Gruss P.
      Nature 387:406-409(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PANCREAS.
    9. "Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression."
      Gosmain Y., Avril I., Mamin A., Philippe J.
      J. Biol. Chem. 282:35024-35034(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAF AND MAFB.
    10. "Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system."
      Tuoc T.C., Stoykova A.
      Genes Dev. 22:1972-1986(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRIM11, UBIQUITINATION, DEVELOPMENTAL STAGE.
    11. "Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development."
      Yan Q., Gong L., Deng M., Zhang L., Sun S., Liu J., Ma H., Yuan D., Chen P.C., Hu X., Liu J., Qin J., Xiao L., Huang X.Q., Zhang J., Li D.W.
      Proc. Natl. Acad. Sci. U.S.A. 107:21034-21039(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUMOYLATION.

    Entry informationi

    Entry nameiPAX6_MOUSE
    AccessioniPrimary (citable) accession number: P63015
    Secondary accession number(s): P32117
    , P70601, Q3UTV5, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3