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Protein

Ras-related protein Rab-3A

Gene

Rab3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • evoked neurotransmitter secretion Source: ParkinsonsUK-UCL
  • lung development Source: MGI
  • maintenance of presynaptic active zone structure Source: MGI
  • mitochondrion organization Source: MGI
  • neuromuscular synaptic transmission Source: MGI
  • positive regulation of regulated secretory pathway Source: MGI
  • post-embryonic development Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: MGI
  • regulation of long-term synaptic potentiation Source: ParkinsonsUK-UCL
  • regulation of short-term neuronal synaptic plasticity Source: ParkinsonsUK-UCL
  • regulation of synaptic vesicle fusion to presynaptic membrane Source: ParkinsonsUK-UCL
  • respiratory system process Source: MGI
  • response to electrical stimulus Source: MGI
  • sensory perception of touch Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
  • synaptic vesicle exocytosis Source: ParkinsonsUK-UCL
  • synaptic vesicle maturation Source: MGI
  • synaptic vesicle recycling Source: ParkinsonsUK-UCL
  • synaptic vesicle transport Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-181430. Norepinephrine Neurotransmitter Release Cycle.
R-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-264642. Acetylcholine Neurotransmitter Release Cycle.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.
R-MMU-888590. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3A
Gene namesi
Name:Rab3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97843. Rab3a.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
  • axon Source: ParkinsonsUK-UCL
  • cytosol Source: Ensembl
  • endosome Source: MGI
  • extracellular vesicle Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • protein complex Source: Ensembl
  • synaptic vesicle Source: MGI
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210781 – 220Ras-related protein Rab-3AAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Lipidationi218S-geranylgeranyl cysteineBy similarity1
Modified residuei220Cysteine methyl esterBy similarity1
Lipidationi220S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP63011.
PaxDbiP63011.
PeptideAtlasiP63011.
PRIDEiP63011.

PTM databases

iPTMnetiP63011.
PhosphoSitePlusiP63011.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031840.
CleanExiMM_RAB3A.
ExpressionAtlasiP63011. baseline and differential.
GenevisibleiP63011. MM.

Interactioni

Subunit structurei

Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Rph3aP477082EBI-398393,EBI-398376
SYTL5Q8TDW52EBI-398393,EBI-2939487From a different organism.

GO - Molecular functioni

  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

Protein-protein interaction databases

BioGridi202544. 7 interactors.
DIPiDIP-31051N.
IntActiP63011. 52 interactors.
MINTiMINT-85820.
STRINGi10090.ENSMUSP00000034301.

Structurei

3D structure databases

ProteinModelPortaliP63011.
SMRiP63011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP63011.
KOiK07882.
OMAiQLTEQPA.
OrthoDBiEOG091G0J64.
PhylomeDBiP63011.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG
160 170 180 190 200
RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG
210 220
AKQGPQLTDQ QAPPHQDCAC
Length:220
Mass (Da):24,970
Last modified:August 31, 2004 - v1
Checksum:i1A3E9F8C9D09EB40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72966 Genomic DNA. Translation: CAA51470.1.
AK005362 mRNA. Translation: BAB23976.1.
AK158727 mRNA. Translation: BAE34630.1.
AK161975 mRNA. Translation: BAE36661.1.
BC053519 mRNA. Translation: AAH53519.1.
CCDSiCCDS22379.1.
PIRiS34070.
RefSeqiNP_001159871.1. NM_001166399.2.
NP_001314976.1. NM_001328047.1.
NP_033027.1. NM_009001.6.
XP_006509666.1. XM_006509603.3.
UniGeneiMm.5083.

Genome annotation databases

EnsembliENSMUST00000034301; ENSMUSP00000034301; ENSMUSG00000031840.
ENSMUST00000110090; ENSMUSP00000105717; ENSMUSG00000031840.
ENSMUST00000110092; ENSMUSP00000105719; ENSMUSG00000031840.
ENSMUST00000110093; ENSMUSP00000105720; ENSMUSG00000031840.
GeneIDi19339.
KEGGimmu:19339.
UCSCiuc009mbi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72966 Genomic DNA. Translation: CAA51470.1.
AK005362 mRNA. Translation: BAB23976.1.
AK158727 mRNA. Translation: BAE34630.1.
AK161975 mRNA. Translation: BAE36661.1.
BC053519 mRNA. Translation: AAH53519.1.
CCDSiCCDS22379.1.
PIRiS34070.
RefSeqiNP_001159871.1. NM_001166399.2.
NP_001314976.1. NM_001328047.1.
NP_033027.1. NM_009001.6.
XP_006509666.1. XM_006509603.3.
UniGeneiMm.5083.

3D structure databases

ProteinModelPortaliP63011.
SMRiP63011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202544. 7 interactors.
DIPiDIP-31051N.
IntActiP63011. 52 interactors.
MINTiMINT-85820.
STRINGi10090.ENSMUSP00000034301.

PTM databases

iPTMnetiP63011.
PhosphoSitePlusiP63011.

Proteomic databases

EPDiP63011.
PaxDbiP63011.
PeptideAtlasiP63011.
PRIDEiP63011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034301; ENSMUSP00000034301; ENSMUSG00000031840.
ENSMUST00000110090; ENSMUSP00000105717; ENSMUSG00000031840.
ENSMUST00000110092; ENSMUSP00000105719; ENSMUSG00000031840.
ENSMUST00000110093; ENSMUSP00000105720; ENSMUSG00000031840.
GeneIDi19339.
KEGGimmu:19339.
UCSCiuc009mbi.2. mouse.

Organism-specific databases

CTDi5864.
MGIiMGI:97843. Rab3a.

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP63011.
KOiK07882.
OMAiQLTEQPA.
OrthoDBiEOG091G0J64.
PhylomeDBiP63011.
TreeFamiTF313199.

Enzyme and pathway databases

ReactomeiR-MMU-181430. Norepinephrine Neurotransmitter Release Cycle.
R-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-264642. Acetylcholine Neurotransmitter Release Cycle.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.
R-MMU-888590. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

ChiTaRSiRab3a. mouse.
PROiP63011.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031840.
CleanExiMM_RAB3A.
ExpressionAtlasiP63011. baseline and differential.
GenevisibleiP63011. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3A_MOUSE
AccessioniPrimary (citable) accession number: P63011
Secondary accession number(s): P05713, Q3TSL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.