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P63011

- RAB3A_MOUSE

UniProt

P63011 - RAB3A_MOUSE

Protein

Ras-related protein Rab-3A

Gene

Rab3a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 368GTPBy similarity
    Nucleotide bindingi48 – 547GTPBy similarity
    Nucleotide bindingi77 – 815GTPBy similarity
    Nucleotide bindingi135 – 1384GTPBy similarity

    GO - Molecular functioni

    1. ATPase activator activity Source: Ensembl
    2. GTPase activity Source: Ensembl
    3. GTP binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. lung development Source: MGI
    3. maintenance of presynaptic active zone structure Source: MGI
    4. mitochondrion organization Source: MGI
    5. neuromuscular synaptic transmission Source: MGI
    6. post-embryonic development Source: MGI
    7. protein transport Source: UniProtKB-KW
    8. regulation of exocytosis Source: MGI
    9. regulation of synaptic vesicle fusion to presynaptic membrane Source: MGI
    10. respiratory system process Source: MGI
    11. response to electrical stimulus Source: MGI
    12. sensory perception of touch Source: MGI
    13. small GTPase mediated signal transduction Source: InterPro
    14. synaptic vesicle exocytosis Source: MGI
    15. synaptic vesicle maturation Source: MGI

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_205038. Acetylcholine Neurotransmitter Release Cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-3A
    Gene namesi
    Name:Rab3a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:97843. Rab3a.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. acrosomal vesicle Source: MGI
    2. cytosol Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell
    4. protein complex Source: Ensembl
    5. synaptic vesicle Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Ras-related protein Rab-3APRO_0000121078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi218 – 2181S-geranylgeranyl cysteineBy similarity
    Modified residuei220 – 2201Cysteine methyl esterBy similarity
    Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiP63011.
    PaxDbiP63011.
    PRIDEiP63011.

    PTM databases

    PhosphoSiteiP63011.

    Expressioni

    Gene expression databases

    ArrayExpressiP63011.
    BgeeiP63011.
    CleanExiMM_RAB3A.
    GenevestigatoriP63011.

    Interactioni

    Subunit structurei

    Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Rph3aP477082EBI-398393,EBI-398376
    SYTL5Q8TDW52EBI-398393,EBI-2939487From a different organism.

    Protein-protein interaction databases

    BioGridi202544. 7 interactions.
    DIPiDIP-31051N.
    IntActiP63011. 12 interactions.
    MINTiMINT-85820.

    Structurei

    3D structure databases

    ProteinModelPortaliP63011.
    SMRiP63011. Positions 18-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 599Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP63011.
    KOiK07882.
    OMAiQLTEQPA.
    OrthoDBiEOG7JQBPC.
    PhylomeDBiP63011.
    TreeFamiTF313199.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA    50
    FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL 100
    MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG 150
    RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG 200
    AKQGPQLTDQ QAPPHQDCAC 220
    Length:220
    Mass (Da):24,970
    Last modified:August 31, 2004 - v1
    Checksum:i1A3E9F8C9D09EB40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72966 Genomic DNA. Translation: CAA51470.1.
    AK005362 mRNA. Translation: BAB23976.1.
    AK158727 mRNA. Translation: BAE34630.1.
    AK161975 mRNA. Translation: BAE36661.1.
    BC053519 mRNA. Translation: AAH53519.1.
    CCDSiCCDS22379.1.
    PIRiS34070.
    RefSeqiNP_001159871.1. NM_001166399.2.
    NP_033027.1. NM_009001.6.
    XP_006509665.1. XM_006509602.1.
    XP_006509666.1. XM_006509603.1.
    UniGeneiMm.5083.

    Genome annotation databases

    EnsembliENSMUST00000034301; ENSMUSP00000034301; ENSMUSG00000031840.
    ENSMUST00000110090; ENSMUSP00000105717; ENSMUSG00000031840.
    ENSMUST00000110092; ENSMUSP00000105719; ENSMUSG00000031840.
    ENSMUST00000110093; ENSMUSP00000105720; ENSMUSG00000031840.
    GeneIDi19339.
    KEGGimmu:19339.
    UCSCiuc009mbi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72966 Genomic DNA. Translation: CAA51470.1 .
    AK005362 mRNA. Translation: BAB23976.1 .
    AK158727 mRNA. Translation: BAE34630.1 .
    AK161975 mRNA. Translation: BAE36661.1 .
    BC053519 mRNA. Translation: AAH53519.1 .
    CCDSi CCDS22379.1.
    PIRi S34070.
    RefSeqi NP_001159871.1. NM_001166399.2.
    NP_033027.1. NM_009001.6.
    XP_006509665.1. XM_006509602.1.
    XP_006509666.1. XM_006509603.1.
    UniGenei Mm.5083.

    3D structure databases

    ProteinModelPortali P63011.
    SMRi P63011. Positions 18-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202544. 7 interactions.
    DIPi DIP-31051N.
    IntActi P63011. 12 interactions.
    MINTi MINT-85820.

    PTM databases

    PhosphoSitei P63011.

    Proteomic databases

    MaxQBi P63011.
    PaxDbi P63011.
    PRIDEi P63011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034301 ; ENSMUSP00000034301 ; ENSMUSG00000031840 .
    ENSMUST00000110090 ; ENSMUSP00000105717 ; ENSMUSG00000031840 .
    ENSMUST00000110092 ; ENSMUSP00000105719 ; ENSMUSG00000031840 .
    ENSMUST00000110093 ; ENSMUSP00000105720 ; ENSMUSG00000031840 .
    GeneIDi 19339.
    KEGGi mmu:19339.
    UCSCi uc009mbi.2. mouse.

    Organism-specific databases

    CTDi 5864.
    MGIi MGI:97843. Rab3a.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P63011.
    KOi K07882.
    OMAi QLTEQPA.
    OrthoDBi EOG7JQBPC.
    PhylomeDBi P63011.
    TreeFami TF313199.

    Enzyme and pathway databases

    Reactomei REACT_205038. Acetylcholine Neurotransmitter Release Cycle.

    Miscellaneous databases

    ChiTaRSi RAB3A. mouse.
    NextBioi 296339.
    PROi P63011.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P63011.
    Bgeei P63011.
    CleanExi MM_RAB3A.
    Genevestigatori P63011.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes."
      Baumert M., Fischer von Mollard G., Jahn R., Suedhof T.C.
      Biochem. J. 293:157-163(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Visual cortex.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 13-35; 42-60; 73-83; 122-136; 152-167 AND 179-202, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. Cited for: INTERACTION WITH RIMS2.
    6. "Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha-helix motifs."
      Wang X., Hu B., Zimmermann B., Kilimann M.W.
      J. Biol. Chem. 276:32480-32488(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS1.
    7. "Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2.Piccolo complex in cAMP-dependent exocytosis."
      Fujimoto K., Shibasaki T., Yokoi N., Kashima Y., Matsumoto M., Sasaki T., Tajima N., Iwanaga T., Seino S.
      J. Biol. Chem. 277:50497-50502(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS2.
    8. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
      Fukuda M.
      J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIMS1; RIMS2; RPH3A AND RPH3AL.
    9. "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells."
      Fukuda M.
      J. Biol. Chem. 278:15390-15396(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYTL4.
    10. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."
      Yang H., Sasaki T., Minoshima S., Shimizu N.
      Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SGSM1 AND SGSM3.

    Entry informationi

    Entry nameiRAB3A_MOUSE
    AccessioniPrimary (citable) accession number: P63011
    Secondary accession number(s): P05713, Q3TSL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3