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P63006

- LHX1_MOUSE

UniProt

P63006 - LHX1_MOUSE

Protein

LIM/homeobox protein Lhx1

Gene

Lhx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    4. transcription corepressor activity Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: MGI
    2. anatomical structure morphogenesis Source: MGI
    3. anterior/posterior axis specification Source: MGI
    4. anterior/posterior pattern specification Source: MGI
    5. branching involved in ureteric bud morphogenesis Source: UniProtKB
    6. cell-cell signaling Source: MGI
    7. cellular response to fibroblast growth factor stimulus Source: Ensembl
    8. cerebellar Purkinje cell differentiation Source: MGI
    9. cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Source: MGI
    10. cerebellum development Source: MGI
    11. cervix development Source: UniProtKB
    12. comma-shaped body morphogenesis Source: UniProtKB
    13. dorsal/ventral pattern formation Source: MGI
    14. ectoderm formation Source: MGI
    15. embryonic pattern specification Source: MGI
    16. embryonic retina morphogenesis in camera-type eye Source: UniProtKB
    17. embryonic viscerocranium morphogenesis Source: UniProtKB
    18. endoderm formation Source: MGI
    19. epithelium development Source: UniProtKB
    20. forebrain regionalization Source: MGI
    21. gastrulation with mouth forming second Source: MGI
    22. head development Source: UniProtKB
    23. horizontal cell localization Source: UniProtKB
    24. kidney development Source: MGI
    25. lateral motor column neuron migration Source: UniProtKB
    26. mesonephric duct development Source: Ensembl
    27. mesonephros development Source: UniProtKB
    28. metanephric comma-shaped body morphogenesis Source: Ensembl
    29. metanephric glomerulus development Source: Ensembl
    30. metanephric part of ureteric bud development Source: Ensembl
    31. metanephric renal vesicle morphogenesis Source: UniProtKB
    32. metanephric S-shaped body morphogenesis Source: UniProtKB
    33. metanephros development Source: UniProtKB
    34. motor neuron axon guidance Source: UniProtKB
    35. negative regulation of transcription, DNA-templated Source: UniProtKB
    36. nephric duct elongation Source: UniProtKB
    37. nephric duct morphogenesis Source: UniProtKB
    38. oviduct development Source: UniProtKB
    39. oviduct epithelium development Source: UniProtKB
    40. paramesonephric duct development Source: UniProtKB
    41. pattern specification process Source: MGI
    42. positive regulation of anterior head development Source: UniProtKB
    43. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    44. positive regulation of embryonic development Source: UniProtKB
    45. positive regulation of gastrulation Source: UniProtKB
    46. positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
    47. positive regulation of transcription, DNA-templated Source: UniProtKB
    48. post-embryonic development Source: MGI
    49. primitive streak formation Source: UniProtKB
    50. pronephros development Source: UniProtKB
    51. regulation of gene expression Source: MGI
    52. renal system development Source: MGI
    53. renal vesicle morphogenesis Source: UniProtKB
    54. retina development in camera-type eye Source: UniProtKB
    55. retina layer formation Source: UniProtKB
    56. somite rostral/caudal axis specification Source: MGI
    57. spinal cord association neuron differentiation Source: UniProtKB
    58. spinal cord development Source: UniProtKB
    59. S-shaped body morphogenesis Source: UniProtKB
    60. telencephalon development Source: UniProtKB
    61. transcription from RNA polymerase II promoter Source: UniProtKB
    62. ureteric bud development Source: MGI
    63. urogenital system development Source: MGI
    64. uterine epithelium development Source: UniProtKB
    65. uterus development Source: UniProtKB
    66. vagina development Source: UniProtKB
    67. ventral spinal cord development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM/homeobox protein Lhx1
    Short name:
    LIM homeobox protein 1
    Alternative name(s):
    Homeobox protein Lim-1
    Gene namesi
    Name:Lhx1
    Synonyms:Lim-1, Lim1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:99783. Lhx1.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. nucleus Source: UniProtKB
    3. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi28 – 281C → G: Disrupts LDB1-binding; when associated with G-88. 1 Publication
    Mutagenesisi88 – 881C → G: Disrupts LDB1-binding; when associated with G-28. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406LIM/homeobox protein Lhx1PRO_0000075771Add
    BLAST

    Proteomic databases

    PRIDEiP63006.

    Expressioni

    Tissue specificityi

    In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptive lateral and intermediate mesoderm. Later, expression become progressively restricted to intermediate mesoderm, and the developing excretory system including the pronephric region, mesonephros, nephric duct and metanephros. In the metanephros, strongly expressed in renal vesicles and S-shaped and coma-shaped bodies, as well as in the ureteric bud and its derivatives. Also expressed in the dorsal root ganglia. By stage 10.5, also expressed in regions of the central nervous system in the telencephalon through to the spinal cord. In adults, expressed in the cerebellum/medulla and kidney, and at very low levels in the cerebrum.3 Publications

    Developmental stagei

    Expressed in both embryos and adults.1 Publication

    Gene expression databases

    BgeeiP63006.
    CleanExiMM_LHX1.
    GenevestigatoriP63006.

    Interactioni

    Subunit structurei

    Interacts with LDB1 via the tandem LIM domains.2 Publications

    Protein-protein interaction databases

    BioGridi201154. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP63006.
    SMRiP63006. Positions 4-118, 186-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 5451LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini63 – 11755LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox By similarity.By similarity

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG257130.
    HOGENOMiHOG000231630.
    HOVERGENiHBG006263.
    InParanoidiP63006.
    KOiK09372.
    OMAiDIMSHHP.
    OrthoDBiEOG7PP56T.
    PhylomeDBiP63006.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P63006-1 [UniParc]FASTAAdd to Basket

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    MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY    50
    CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST 100
    GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ 150
    DDAKDSESAN VSDKEGGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA 200
    ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA 250
    FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP 300
    PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP 350
    PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM 400
    NEAAVW 406
    Length:406
    Mass (Da):44,780
    Last modified:August 31, 2004 - v1
    Checksum:iCC8637984998ADAF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121L → LARQVRPVL(PubMed:7904966)Curated
    Sequence conflicti24 – 318Missing in AAC60669. (PubMed:7904966)Curated
    Sequence conflicti236 – 2361R → A in AAC60669. (PubMed:7904966)Curated
    Sequence conflicti335 – 3351H → HH in AAC60669. (PubMed:7904966)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27410 mRNA. Translation: CAA81797.1.
    S68107 mRNA. Translation: AAC60669.2.
    AF039706, AF039705 Genomic DNA. Translation: AAD02169.1.
    CCDSiCCDS25187.1.
    PIRiI48637.
    RefSeqiNP_032524.1. NM_008498.2.
    UniGeneiMm.4965.

    Genome annotation databases

    EnsembliENSMUST00000018842; ENSMUSP00000018842; ENSMUSG00000018698.
    GeneIDi16869.
    KEGGimmu:16869.
    UCSCiuc007kqo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27410 mRNA. Translation: CAA81797.1 .
    S68107 mRNA. Translation: AAC60669.2 .
    AF039706 , AF039705 Genomic DNA. Translation: AAD02169.1 .
    CCDSi CCDS25187.1.
    PIRi I48637.
    RefSeqi NP_032524.1. NM_008498.2.
    UniGenei Mm.4965.

    3D structure databases

    ProteinModelPortali P63006.
    SMRi P63006. Positions 4-118, 186-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201154. 2 interactions.

    Proteomic databases

    PRIDEi P63006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018842 ; ENSMUSP00000018842 ; ENSMUSG00000018698 .
    GeneIDi 16869.
    KEGGi mmu:16869.
    UCSCi uc007kqo.1. mouse.

    Organism-specific databases

    CTDi 3975.
    MGIi MGI:99783. Lhx1.

    Phylogenomic databases

    eggNOGi NOG257130.
    HOGENOMi HOG000231630.
    HOVERGENi HBG006263.
    InParanoidi P63006.
    KOi K09372.
    OMAi DIMSHHP.
    OrthoDBi EOG7PP56T.
    PhylomeDBi P63006.
    TreeFami TF315442.

    Miscellaneous databases

    NextBioi 290830.
    PROi P63006.
    SOURCEi Search...

    Gene expression databases

    Bgeei P63006.
    CleanExi MM_LHX1.
    Genevestigatori P63006.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system."
      Fujii T., Pichel J.G., Taira M., Toyama R., Dawid I.B., Westphal H.
      Dev. Dyn. 199:73-83(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: BALB/c.
      Tissue: Brain.
    2. "Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis."
      Barnes J.D., Crosby J.L., Jones C.M., Wright C.V., Hogan B.L.
      Dev. Biol. 161:168-178(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    3. "Sequence and genomic organization of the mouse Lim1 gene."
      Li Y., Cheah S.S., Deng J.M., Shawlot W., Behringer R.R.
      Mamm. Genome 10:444-446(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvEv.
    4. "The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development."
      Karavanov A.A., Saint-Jeannet J.P., Karavanova I., Taira M., Dawid I.B.
      Int. J. Dev. Biol. 40:453-461(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins."
      Agulnick A.D., Taira M., Breen J.J., Tanaka T., Dawid I.B., Westphal H.
      Nature 384:270-272(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LDB1, MUTAGENESIS OF CYS-28 AND CYS-88.
    6. "Interactions between LIM domains and the LIM domain-binding protein Ldb1."
      Breen J.J., Agulnick A.D., Westphal H., Dawid I.B.
      J. Biol. Chem. 273:4712-4717(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LDB1.

    Entry informationi

    Entry nameiLHX1_MOUSE
    AccessioniPrimary (citable) accession number: P63006
    Secondary accession number(s): P36199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3