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Protein

LIM/homeobox protein Lhx1

Gene

Lhx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi180 – 239HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • anatomical structure morphogenesis Source: MGI
  • anterior/posterior axis specification Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • branching involved in ureteric bud morphogenesis Source: UniProtKB
  • cell-cell signaling Source: MGI
  • cellular response to fibroblast growth factor stimulus Source: Ensembl
  • cerebellar Purkinje cell differentiation Source: MGI
  • cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Source: MGI
  • cerebellum development Source: MGI
  • cervix development Source: UniProtKB
  • comma-shaped body morphogenesis Source: UniProtKB
  • dorsal/ventral pattern formation Source: MGI
  • ectoderm formation Source: MGI
  • embryonic pattern specification Source: MGI
  • embryonic retina morphogenesis in camera-type eye Source: UniProtKB
  • embryonic viscerocranium morphogenesis Source: UniProtKB
  • endoderm formation Source: MGI
  • epithelium development Source: UniProtKB
  • forebrain regionalization Source: MGI
  • gastrulation with mouth forming second Source: MGI
  • head development Source: UniProtKB
  • horizontal cell localization Source: UniProtKB
  • kidney development Source: MGI
  • lateral motor column neuron migration Source: UniProtKB
  • mesonephric duct development Source: Ensembl
  • mesonephros development Source: UniProtKB
  • metanephric comma-shaped body morphogenesis Source: Ensembl
  • metanephric glomerulus development Source: Ensembl
  • metanephric part of ureteric bud development Source: Ensembl
  • metanephric renal vesicle morphogenesis Source: UniProtKB
  • metanephric S-shaped body morphogenesis Source: UniProtKB
  • metanephros development Source: UniProtKB
  • motor neuron axon guidance Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nephric duct elongation Source: UniProtKB
  • nephric duct morphogenesis Source: UniProtKB
  • oviduct development Source: UniProtKB
  • oviduct epithelium development Source: UniProtKB
  • paramesonephric duct development Source: UniProtKB
  • pattern specification process Source: MGI
  • positive regulation of anterior head development Source: UniProtKB
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of embryonic development Source: UniProtKB
  • positive regulation of gastrulation Source: UniProtKB
  • positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • post-embryonic development Source: MGI
  • primitive streak formation Source: UniProtKB
  • pronephros development Source: UniProtKB
  • regulation of gene expression Source: MGI
  • renal system development Source: MGI
  • renal vesicle morphogenesis Source: UniProtKB
  • retina development in camera-type eye Source: UniProtKB
  • retina layer formation Source: UniProtKB
  • somite rostral/caudal axis specification Source: MGI
  • spinal cord association neuron differentiation Source: UniProtKB
  • spinal cord development Source: UniProtKB
  • S-shaped body morphogenesis Source: UniProtKB
  • telencephalon development Source: UniProtKB
  • transcription by RNA polymerase II Source: UniProtKB
  • ureteric bud development Source: MGI
  • urogenital system development Source: MGI
  • uterine epithelium development Source: UniProtKB
  • uterus development Source: UniProtKB
  • vagina development Source: UniProtKB
  • ventral spinal cord development Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx1
Short name:
LIM homeobox protein 1
Alternative name(s):
Homeobox protein Lim-1
Gene namesi
Name:Lhx1
Synonyms:Lim-1, Lim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:99783 Lhx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28C → G: Disrupts LDB1-binding; when associated with G-88. 1 Publication1
Mutagenesisi88C → G: Disrupts LDB1-binding; when associated with G-28. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757711 – 406LIM/homeobox protein Lhx1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP63006
PRIDEiP63006

PTM databases

PhosphoSitePlusiP63006

Expressioni

Tissue specificityi

In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptive lateral and intermediate mesoderm. Later, expression become progressively restricted to intermediate mesoderm, and the developing excretory system including the pronephric region, mesonephros, nephric duct and metanephros. In the metanephros, strongly expressed in renal vesicles and S-shaped and coma-shaped bodies, as well as in the ureteric bud and its derivatives. Also expressed in the dorsal root ganglia. By stage 10.5, also expressed in regions of the central nervous system in the telencephalon through to the spinal cord. In adults, expressed in the cerebellum/medulla and kidney, and at very low levels in the cerebrum.3 Publications

Developmental stagei

Expressed in both embryos and adults.1 Publication

Gene expression databases

BgeeiENSMUSG00000018698
CleanExiMM_LHX1
ExpressionAtlasiP63006 baseline and differential
GenevisibleiP63006 MM

Interactioni

Subunit structurei

Interacts with LDB1 via the tandem LIM domains.2 Publications

Protein-protein interaction databases

BioGridi201154, 2 interactors
STRINGi10090.ENSMUSP00000018842

Structurei

3D structure databases

ProteinModelPortaliP63006
SMRiP63006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 54LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST51
Domaini63 – 117LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST55

Domaini

The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).By similarity

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00760000118921
HOGENOMiHOG000231630
HOVERGENiHBG006263
InParanoidiP63006
KOiK09372
OMAiDDQNLGG
OrthoDBiEOG091G0BSD
PhylomeDBiP63006
TreeFamiTF315442

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00132 LIM, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

P63006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY
60 70 80 90 100
CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST
110 120 130 140 150
GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ
160 170 180 190 200
DDAKDSESAN VSDKEGGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
310 320 330 340 350
PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP
360 370 380 390 400
PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM

NEAAVW
Length:406
Mass (Da):44,780
Last modified:August 31, 2004 - v1
Checksum:iCC8637984998ADAF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12L → LARQVRPVL (PubMed:7904966).Curated1
Sequence conflicti24 – 31Missing in AAC60669 (PubMed:7904966).Curated8
Sequence conflicti236R → A in AAC60669 (PubMed:7904966).Curated1
Sequence conflicti335H → HH in AAC60669 (PubMed:7904966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27410 mRNA Translation: CAA81797.1
S68107 mRNA Translation: AAC60669.2
AF039706, AF039705 Genomic DNA Translation: AAD02169.1
CCDSiCCDS25187.1
PIRiI48637
RefSeqiNP_032524.1, NM_008498.2
UniGeneiMm.4965

Genome annotation databases

EnsembliENSMUST00000018842; ENSMUSP00000018842; ENSMUSG00000018698
GeneIDi16869
KEGGimmu:16869
UCSCiuc007kqo.1 mouse

Entry informationi

Entry nameiLHX1_MOUSE
AccessioniPrimary (citable) accession number: P63006
Secondary accession number(s): P36199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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