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P63006

- LHX1_MOUSE

UniProt

P63006 - LHX1_MOUSE

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Protein

LIM/homeobox protein Lhx1

Gene

Lhx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. transcription corepressor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: MGI
  2. anatomical structure morphogenesis Source: MGI
  3. anterior/posterior axis specification Source: MGI
  4. anterior/posterior pattern specification Source: MGI
  5. branching involved in ureteric bud morphogenesis Source: UniProtKB
  6. cell-cell signaling Source: MGI
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cerebellar Purkinje cell differentiation Source: MGI
  9. cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Source: MGI
  10. cerebellum development Source: MGI
  11. cervix development Source: UniProtKB
  12. comma-shaped body morphogenesis Source: UniProtKB
  13. dorsal/ventral pattern formation Source: MGI
  14. ectoderm formation Source: MGI
  15. embryonic pattern specification Source: MGI
  16. embryonic retina morphogenesis in camera-type eye Source: UniProtKB
  17. embryonic viscerocranium morphogenesis Source: UniProtKB
  18. endoderm formation Source: MGI
  19. epithelium development Source: UniProtKB
  20. forebrain regionalization Source: MGI
  21. gastrulation with mouth forming second Source: MGI
  22. head development Source: UniProtKB
  23. horizontal cell localization Source: UniProtKB
  24. kidney development Source: MGI
  25. lateral motor column neuron migration Source: UniProtKB
  26. mesonephric duct development Source: Ensembl
  27. mesonephros development Source: UniProtKB
  28. metanephric comma-shaped body morphogenesis Source: Ensembl
  29. metanephric glomerulus development Source: Ensembl
  30. metanephric part of ureteric bud development Source: Ensembl
  31. metanephric renal vesicle morphogenesis Source: UniProtKB
  32. metanephric S-shaped body morphogenesis Source: UniProtKB
  33. metanephros development Source: UniProtKB
  34. motor neuron axon guidance Source: UniProtKB
  35. negative regulation of transcription, DNA-templated Source: UniProtKB
  36. nephric duct elongation Source: UniProtKB
  37. nephric duct morphogenesis Source: UniProtKB
  38. oviduct development Source: UniProtKB
  39. oviduct epithelium development Source: UniProtKB
  40. paramesonephric duct development Source: UniProtKB
  41. pattern specification process Source: MGI
  42. positive regulation of anterior head development Source: UniProtKB
  43. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  44. positive regulation of embryonic development Source: UniProtKB
  45. positive regulation of gastrulation Source: UniProtKB
  46. positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
  47. positive regulation of transcription, DNA-templated Source: UniProtKB
  48. post-embryonic development Source: MGI
  49. primitive streak formation Source: UniProtKB
  50. pronephros development Source: UniProtKB
  51. regulation of gene expression Source: MGI
  52. renal system development Source: MGI
  53. renal vesicle morphogenesis Source: UniProtKB
  54. retina development in camera-type eye Source: UniProtKB
  55. retina layer formation Source: UniProtKB
  56. somite rostral/caudal axis specification Source: MGI
  57. spinal cord association neuron differentiation Source: UniProtKB
  58. spinal cord development Source: UniProtKB
  59. S-shaped body morphogenesis Source: UniProtKB
  60. telencephalon development Source: UniProtKB
  61. transcription from RNA polymerase II promoter Source: UniProtKB
  62. ureteric bud development Source: MGI
  63. urogenital system development Source: MGI
  64. uterine epithelium development Source: UniProtKB
  65. uterus development Source: UniProtKB
  66. vagina development Source: UniProtKB
  67. ventral spinal cord development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx1
Short name:
LIM homeobox protein 1
Alternative name(s):
Homeobox protein Lim-1
Gene namesi
Name:Lhx1
Synonyms:Lim-1, Lim1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:99783. Lhx1.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: UniProtKB
  3. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 281C → G: Disrupts LDB1-binding; when associated with G-88. 1 Publication
Mutagenesisi88 – 881C → G: Disrupts LDB1-binding; when associated with G-28. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406LIM/homeobox protein Lhx1PRO_0000075771Add
BLAST

Proteomic databases

MaxQBiP63006.
PRIDEiP63006.

Expressioni

Tissue specificityi

In mid to late stage embryos, expressed in a restricted region of mesoderm in the primitive streak. At 7.5 days, expressed in a horseshoe shape at the periphery of the node, as well as along both sides of the adjacent notochord. Also present in presumptive lateral and intermediate mesoderm. Later, expression become progressively restricted to intermediate mesoderm, and the developing excretory system including the pronephric region, mesonephros, nephric duct and metanephros. In the metanephros, strongly expressed in renal vesicles and S-shaped and coma-shaped bodies, as well as in the ureteric bud and its derivatives. Also expressed in the dorsal root ganglia. By stage 10.5, also expressed in regions of the central nervous system in the telencephalon through to the spinal cord. In adults, expressed in the cerebellum/medulla and kidney, and at very low levels in the cerebrum.3 Publications

Developmental stagei

Expressed in both embryos and adults.1 Publication

Gene expression databases

BgeeiP63006.
CleanExiMM_LHX1.
ExpressionAtlasiP63006. baseline and differential.
GenevestigatoriP63006.

Interactioni

Subunit structurei

Interacts with LDB1 via the tandem LIM domains.2 Publications

Protein-protein interaction databases

BioGridi201154. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP63006.
SMRiP63006. Positions 4-118, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 5451LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 11755LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).By similarity

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG257130.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiP63006.
KOiK09372.
OMAiDIMSHHP.
OrthoDBiEOG7PP56T.
PhylomeDBiP63006.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P63006 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY
60 70 80 90 100
CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST
110 120 130 140 150
GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ
160 170 180 190 200
DDAKDSESAN VSDKEGGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
310 320 330 340 350
PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP
360 370 380 390 400
PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM

NEAAVW
Length:406
Mass (Da):44,780
Last modified:August 31, 2004 - v1
Checksum:iCC8637984998ADAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121L → LARQVRPVL(PubMed:7904966)Curated
Sequence conflicti24 – 318Missing in AAC60669. (PubMed:7904966)Curated
Sequence conflicti236 – 2361R → A in AAC60669. (PubMed:7904966)Curated
Sequence conflicti335 – 3351H → HH in AAC60669. (PubMed:7904966)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27410 mRNA. Translation: CAA81797.1.
S68107 mRNA. Translation: AAC60669.2.
AF039706, AF039705 Genomic DNA. Translation: AAD02169.1.
CCDSiCCDS25187.1.
PIRiI48637.
RefSeqiNP_032524.1. NM_008498.2.
UniGeneiMm.4965.

Genome annotation databases

EnsembliENSMUST00000018842; ENSMUSP00000018842; ENSMUSG00000018698.
GeneIDi16869.
KEGGimmu:16869.
UCSCiuc007kqo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27410 mRNA. Translation: CAA81797.1 .
S68107 mRNA. Translation: AAC60669.2 .
AF039706 , AF039705 Genomic DNA. Translation: AAD02169.1 .
CCDSi CCDS25187.1.
PIRi I48637.
RefSeqi NP_032524.1. NM_008498.2.
UniGenei Mm.4965.

3D structure databases

ProteinModelPortali P63006.
SMRi P63006. Positions 4-118, 186-236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201154. 2 interactions.

Proteomic databases

MaxQBi P63006.
PRIDEi P63006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018842 ; ENSMUSP00000018842 ; ENSMUSG00000018698 .
GeneIDi 16869.
KEGGi mmu:16869.
UCSCi uc007kqo.1. mouse.

Organism-specific databases

CTDi 3975.
MGIi MGI:99783. Lhx1.

Phylogenomic databases

eggNOGi NOG257130.
HOGENOMi HOG000231630.
HOVERGENi HBG006263.
InParanoidi P63006.
KOi K09372.
OMAi DIMSHHP.
OrthoDBi EOG7PP56T.
PhylomeDBi P63006.
TreeFami TF315442.

Miscellaneous databases

NextBioi 290830.
PROi P63006.
SOURCEi Search...

Gene expression databases

Bgeei P63006.
CleanExi MM_LHX1.
ExpressionAtlasi P63006. baseline and differential.
Genevestigatori P63006.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system."
    Fujii T., Pichel J.G., Taira M., Toyama R., Dawid I.B., Westphal H.
    Dev. Dyn. 199:73-83(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Brain.
  2. "Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis."
    Barnes J.D., Crosby J.L., Jones C.M., Wright C.V., Hogan B.L.
    Dev. Biol. 161:168-178(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  3. "Sequence and genomic organization of the mouse Lim1 gene."
    Li Y., Cheah S.S., Deng J.M., Shawlot W., Behringer R.R.
    Mamm. Genome 10:444-446(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvEv.
  4. "The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development."
    Karavanov A.A., Saint-Jeannet J.P., Karavanova I., Taira M., Dawid I.B.
    Int. J. Dev. Biol. 40:453-461(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins."
    Agulnick A.D., Taira M., Breen J.J., Tanaka T., Dawid I.B., Westphal H.
    Nature 384:270-272(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDB1, MUTAGENESIS OF CYS-28 AND CYS-88.
  6. "Interactions between LIM domains and the LIM domain-binding protein Ldb1."
    Breen J.J., Agulnick A.D., Westphal H., Dawid I.B.
    J. Biol. Chem. 273:4712-4717(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LDB1.

Entry informationi

Entry nameiLHX1_MOUSE
AccessioniPrimary (citable) accession number: P63006
Secondary accession number(s): P36199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3