Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amino-terminal enhancer of split

Gene

Aes

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-terminal enhancer of split
Short name:
Amino enhancer of split
Alternative name(s):
Grg-5
Groucho-related protein 5
Protein ESP1
Short name:
R-esp1
Protein GRG
Gene namesi
Name:Aes
Synonyms:Esp1, Grg, Grg5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2731. Aes.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508361 – 197Amino-terminal enhancer of splitAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by XIAP/BIRC4.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP63003.

PTM databases

iPTMnetiP63003.
PhosphoSitePlusiP63003.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with other family members. Binds TCF7 and the NF-kappa-B subunit RELA. Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts with SIX6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi248109. 1 interactor.
STRINGi10116.ENSRNOP00000059140.

Structurei

3D structure databases

ProteinModelPortaliP63003.
SMRiP63003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 197CCN domainAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 131Gln-rich (Q domain)Add BLAST131
Compositional biasi132 – 165Gly/Pro-rich (GP domain)Add BLAST34

Domaini

Lacks the C-terminal WD repeats.

Sequence similaritiesi

Belongs to the WD repeat Groucho/TLE family.Curated

Phylogenomic databases

eggNOGiKOG0639. Eukaryota.
ENOG410XPX3. LUCA.
HOGENOMiHOG000033830.
HOVERGENiHBG000205.
InParanoidiP63003.
PhylomeDBiP63003.

Family and domain databases

InterProiView protein in InterPro
IPR005617. Groucho/TLE_N.
PfamiView protein in Pfam
PF03920. TLE_N. 1 hit.

Sequencei

Sequence statusi: Complete.

P63003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL
60 70 80 90 100
ASEKSEMQRH YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH
110 120 130 140 150
QQQVLGAIER AKQVTAPELN SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ
160 170 180 190
PPSLPAVSAG TGLLSLSALG SQTHLSKEDK NGHDGDTHQE DDGEKSD
Length:197
Mass (Da):22,000
Last modified:August 31, 2004 - v1
Checksum:i2C00233AA6921A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14462 mRNA. Translation: AAC37639.1.
BC101855 mRNA. Translation: AAI01856.1.
PIRiA49555.
RefSeqiNP_062093.1. NM_019220.1.
UniGeneiRn.11495.

Genome annotation databases

GeneIDi29466.
KEGGirno:29466.
UCSCiRGD:2731. rat.

Similar proteinsi

Entry informationi

Entry nameiAES_RAT
AccessioniPrimary (citable) accession number: P63003
Secondary accession number(s): Q06195, Q3MIF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: August 30, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families