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P63001

- RAC1_MOUSE

UniProt

P63001 - RAC1_MOUSE

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Protein

Ras-related C3 botulinum toxin substrate 1

Gene
Rac1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.1 Publication

Enzyme regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. GTP hydrolysis is stimulated by ARHGAP30 By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP By similarity
Nucleotide bindingi57 – 615GTP By similarity
Nucleotide bindingi115 – 1184GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. GTP binding Source: MGI
  3. GTP-dependent protein binding Source: UniProtKB
  4. protein binding Source: UniProtKB
  5. Rho GDP-dissociation inhibitor binding Source: UniProtKB

GO - Biological processi

  1. actin filament polymerization Source: MGI
  2. anatomical structure arrangement Source: MGI
  3. auditory receptor cell morphogenesis Source: MGI
  4. axon guidance Source: MGI
  5. bone resorption Source: Ensembl
  6. cell adhesion Source: MGI
  7. cell-cell junction organization Source: MGI
  8. cell migration Source: MGI
  9. cell motility Source: UniProtKB
  10. cell proliferation Source: Ensembl
  11. cerebral cortex radially oriented cell migration Source: MGI
  12. cochlea morphogenesis Source: MGI
  13. cytoskeleton organization Source: MGI
  14. dendrite development Source: MGI
  15. dendrite morphogenesis Source: MGI
  16. dopaminergic neuron differentiation Source: MGI
  17. embryonic olfactory bulb interneuron precursor migration Source: MGI
  18. endocytosis Source: MGI
  19. engulfment of apoptotic cell Source: BHF-UCL
  20. epithelial cell morphogenesis Source: MGI
  21. G-protein coupled receptor signaling pathway Source: MGI
  22. hyperosmotic response Source: MGI
  23. lamellipodium assembly Source: MGI
  24. localization within membrane Source: Ensembl
  25. mast cell chemotaxis Source: Ensembl
  26. negative regulation of interleukin-23 production Source: Ensembl
  27. phagocytosis, engulfment Source: UniProtKB
  28. positive regulation of actin filament polymerization Source: MGI
  29. positive regulation of DNA replication Source: Ensembl
  30. positive regulation of lamellipodium assembly Source: MGI
  31. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  32. positive regulation of protein phosphorylation Source: UniProtKB
  33. protein localization to plasma membrane Source: MGI
  34. regulation of cell migration Source: MGI
  35. regulation of respiratory burst Source: Ensembl
  36. ruffle assembly Source: UniProtKB
  37. ruffle organization Source: MGI
  38. semaphorin-plexin signaling pathway Source: UniProtKB
  39. small GTPase mediated signal transduction Source: MGI
  40. substrate adhesion-dependent cell spreading Source: MGI
  41. Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188578. Signaling by SCF-KIT.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_214043. PCP/CE pathway.
REACT_215461. Signal transduction by L1.
REACT_220092. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related C3 botulinum toxin substrate 1
Alternative name(s):
p21-Rac1
Gene namesi
Name:Rac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:97845. Rac1.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Melanosome By similarity. Cytoplasm By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts By similarity.

GO - Cellular componenti

  1. cell projection Source: MGI
  2. cytoplasm Source: MGI
  3. cytoplasmic membrane-bounded vesicle Source: MGI
  4. cytosol Source: UniProtKB
  5. extrinsic component of plasma membrane Source: MGI
  6. Golgi membrane Source: Ensembl
  7. lamellipodium Source: MGI
  8. melanosome Source: UniProtKB-SubCell
  9. membrane Source: MGI
  10. phagocytic cup Source: UniProtKB
  11. ruffle membrane Source: UniProtKB
  12. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi12 – 121G → V: Constitutively active. Interacts with PARD6 proteins. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Ras-related C3 botulinum toxin substrate 1PRO_0000042038Add
BLAST
Propeptidei190 – 1923Removed in mature form By similarityPRO_0000042039

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki147 – 147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Modified residuei189 – 1891Cysteine methyl ester By similarity
Lipidationi189 – 1891S-geranylgeranyl cysteine By similarity

Post-translational modificationi

GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Isopeptide bond, Lipoprotein, Methylation, Prenylation, Ubl conjugation

Proteomic databases

MaxQBiP63001.
PaxDbiP63001.
PRIDEiP63001.

PTM databases

PhosphoSiteiP63001.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiP63001.
BgeeiP63001.
CleanExiMM_RAC1.
GenevestigatoriP63001.

Interactioni

Subunit structurei

Interacts with the GEF proteins PREX1, FARP1, FARP2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with BAIAP2, BAIAP2L1, PLXNB1, CYFIP1/SRA-1 and DEF6. Probably found in a ternary complex composed of DSCAM, PAK1 and RAC1. Interacts with DSCAM; the interaction requires PAK1. Interacts with TBC1D2. Interacts with UNKL. Interacts with USP6. Interacts with SPATA13. Interacts with ITGB4. Interacts with the GTP-bound form of RAB7A. Interacts with ARHGEF2. Interacts with ARHGEF16; mediates activation of RAC1 by EPHA2. Interacts with NOXA1. Interacts with S100A8 and calprotectin (S100A8/9). Interacts with ARHGDIA; the interaction is induced by SEMA5A, mediated through PLXNB3 and inactivates and stabilizes RAC1. Interacts with PACSIN2. Interacts with ITGB1BP1 By similarity. Interacts with the GEF protein RASGRF2, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a complex with MAP2K3, MAP3K3 and CCM2. Interacts with NISCH. Interacts with PIP5K1A. Interacts (GTP-bound form preferentially) with PKN2 (via the REM repeats); the interaction stimulates autophosphorylation and phosphorylation of PKN2. Interacts with SRGAP2. Interacts with PLXNB3. Interacts (when active) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621082EBI-413646,EBI-300895
PAK1Q131533EBI-413646,EBI-1307From a different organism.
Sod1P082284EBI-413646,EBI-1635090

Protein-protein interaction databases

BioGridi202556. 20 interactions.
IntActiP63001. 28 interactions.
MINTiMINT-1602774.

Structurei

3D structure databases

ProteinModelPortaliP63001.
SMRiP63001. Positions 1-177.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region Reviewed prediction

Domaini

The effector region mediates interaction with DEF6 By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00640000091266.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
KOiK04392.
OrthoDBiEOG764747.
PhylomeDBiP63001.
TreeFamiTF101109.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63001-1 [UniParc]FASTAAdd to Basket

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MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP    50
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE 100
VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG 150
AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL 192
Length:192
Mass (Da):21,450
Last modified:August 31, 2004 - v1
Checksum:iACEDF83A45E5EA67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57277 mRNA. Translation: CAA40545.1.
AK009017 mRNA. Translation: BAB26027.1.
AK011072 mRNA. Translation: BAB69451.1.
AK034601 mRNA. Translation: BAC28767.1.
AK047969 mRNA. Translation: BAC33203.1.
AK088825 mRNA. Translation: BAC40596.1.
BC003828 mRNA. Translation: AAH03828.1.
BC051053 mRNA. Translation: AAH51053.1.
CCDSiCCDS19843.1.
PIRiA60347.
RefSeqiNP_033033.1. NM_009007.2.
UniGeneiMm.292510.
Mm.469963.
Mm.475073.

Genome annotation databases

EnsembliENSMUST00000080537; ENSMUSP00000079380; ENSMUSG00000001847.
GeneIDi19353.
KEGGimmu:19353.
UCSCiuc009akk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57277 mRNA. Translation: CAA40545.1 .
AK009017 mRNA. Translation: BAB26027.1 .
AK011072 mRNA. Translation: BAB69451.1 .
AK034601 mRNA. Translation: BAC28767.1 .
AK047969 mRNA. Translation: BAC33203.1 .
AK088825 mRNA. Translation: BAC40596.1 .
BC003828 mRNA. Translation: AAH03828.1 .
BC051053 mRNA. Translation: AAH51053.1 .
CCDSi CCDS19843.1.
PIRi A60347.
RefSeqi NP_033033.1. NM_009007.2.
UniGenei Mm.292510.
Mm.469963.
Mm.475073.

3D structure databases

ProteinModelPortali P63001.
SMRi P63001. Positions 1-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202556. 20 interactions.
IntActi P63001. 28 interactions.
MINTi MINT-1602774.

Chemistry

BindingDBi P63001.
ChEMBLi CHEMBL5628.

PTM databases

PhosphoSitei P63001.

Proteomic databases

MaxQBi P63001.
PaxDbi P63001.
PRIDEi P63001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080537 ; ENSMUSP00000079380 ; ENSMUSG00000001847 .
GeneIDi 19353.
KEGGi mmu:19353.
UCSCi uc009akk.1. mouse.

Organism-specific databases

CTDi 5879.
MGIi MGI:97845. Rac1.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00640000091266.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
KOi K04392.
OrthoDBi EOG764747.
PhylomeDBi P63001.
TreeFami TF101109.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188530. FCERI mediated MAPK activation.
REACT_188578. Signaling by SCF-KIT.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_198649. Factors involved in megakaryocyte development and platelet production.
REACT_199054. Translocation of GLUT4 to the plasma membrane.
REACT_204733. G alpha (12/13) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_214043. PCP/CE pathway.
REACT_215461. Signal transduction by L1.
REACT_220092. GPVI-mediated activation cascade.

Miscellaneous databases

ChiTaRSi RAC1. mouse.
NextBioi 296387.
PROi P63001.
SOURCEi Search...

Gene expression databases

ArrayExpressi P63001.
Bgeei P63001.
CleanExi MM_RAC1.
Genevestigatori P63001.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments."
    Moll J., Sansig G., Fattori E., van der Putten H.
    Oncogene 6:863-866(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Liver, Thymus and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  4. "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways."
    Fan W.-T., Koch C.A., de Hoog C.L., Fam N.P., Moran M.F.
    Curr. Biol. 8:935-938(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASGRF2.
  5. "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42."
    Joberty G., Petersen C., Gao L., Macara I.G.
    Nat. Cell Biol. 2:531-539(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARD6A, MUTAGENESIS OF GLY-12.
  6. "A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity."
    Lin D., Edwards A.S., Fawcett J.P., Mbamalu G., Scott J.D., Pawson T.
    Nat. Cell Biol. 2:540-547(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARD6B.
  7. "Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly."
    Tolias K.F., Hartwig J.H., Ishihara H., Shibasaki Y., Cantley L.C., Carpenter C.L.
    Curr. Biol. 10:153-156(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIP5K1A.
  8. Cited for: INTERACTION WITH MAP3K3; MAP2K3 AND CCM2.
  9. "Regulation of p21-activated kinase-independent Rac1 signal transduction by Nischarin."
    Reddig P.J., Xu D., Juliano R.L.
    J. Biol. Chem. 280:30994-31002(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NISCH.
  10. "Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes."
    Bourguignon L.Y., Gilad E., Peyrollier K., Brightman A., Swanson R.A.
    J. Neurochem. 101:1002-1017(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PKN2.
  11. "Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease."
    Shibata S., Nagase M., Yoshida S., Kawarazaki W., Kurihara H., Tanaka H., Miyoshi J., Takai Y., Fujita T.
    Nat. Med. 14:1370-1376(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis."
    Guerrier S., Coutinho-Budd J., Sassa T., Gresset A., Jordan N.V., Chen K., Jin W.L., Frost A., Polleux F.
    Cell 138:990-1004(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SRGAP2, ENZYME REGULATION.
  13. "Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase."
    Li X., Lee A.Y.
    J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB3.
  14. "The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells."
    Wallace S.W., Magalhaes A., Hall A.
    Mol. Cell. Biol. 31:81-91(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PKN2.

Entry informationi

Entry nameiRAC1_MOUSE
AccessioniPrimary (citable) accession number: P63001
Secondary accession number(s): O95501, P15154, Q9BTB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi