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Protein

Ubiquitin-40S ribosomal protein S27a

Gene

RPS27A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).By similarity
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54Activating enzyme1
Sitei68Essential for function1
Binding sitei72Activating enzyme1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 144C4-typeAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-110312. Translesion synthesis by REV1.
R-BTA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-BTA-110320. Translesion Synthesis by POLH.
R-BTA-1169091. Activation of NF-kappaB in B cells.
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-BTA-1253288. Downregulation of ERBB4 signaling.
R-BTA-1295596. Spry regulation of FGF signaling.
R-BTA-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-BTA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-BTA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-BTA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-BTA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-BTA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-182971. EGFR downregulation.
R-BTA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-BTA-195253. Degradation of beta-catenin by the destruction complex.
R-BTA-201681. TCF dependent signaling in response to WNT.
R-BTA-202424. Downstream TCR signaling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-BTA-2173788. Downregulation of TGF-beta receptor signaling.
R-BTA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-BTA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-2559585. Oncogene Induced Senescence.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-2672351. Stimuli-sensing channels.
R-BTA-2871837. FCERI mediated NF-kB activation.
R-BTA-3134975. Regulation of innate immune responses to cytosolic DNA.
R-BTA-3322077. Glycogen synthesis.
R-BTA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-BTA-382556. ABC-family proteins mediated transport.
R-BTA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-BTA-446652. Interleukin-1 signaling.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-BTA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-BTA-4608870. Asymmetric localization of PCP proteins.
R-BTA-4641257. Degradation of AXIN.
R-BTA-4641258. Degradation of DVL.
R-BTA-4641263. Regulation of FZD by ubiquitination.
R-BTA-5205685. Pink/Parkin Mediated Mitophagy.
R-BTA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-BTA-5358346. Hedgehog ligand biogenesis.
R-BTA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-BTA-5607764. CLEC7A (Dectin-1) signaling.
R-BTA-5610780. Degradation of GLI1 by the proteasome.
R-BTA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-BTA-5632684. Hedgehog 'on' state.
R-BTA-5654726. Negative regulation of FGFR1 signaling.
R-BTA-5654727. Negative regulation of FGFR2 signaling.
R-BTA-5654732. Negative regulation of FGFR3 signaling.
R-BTA-5654733. Negative regulation of FGFR4 signaling.
R-BTA-5655862. Translesion synthesis by POLK.
R-BTA-5656121. Translesion synthesis by POLI.
R-BTA-5656169. Termination of translesion DNA synthesis.
R-BTA-5658442. Regulation of RAS by GAPs.
R-BTA-5668541. TNFR2 non-canonical NF-kB pathway.
R-BTA-5675221. Negative regulation of MAPK pathway.
R-BTA-5675482. Regulation of necroptotic cell death.
R-BTA-5676590. NIK-->noncanonical NF-kB signaling.
R-BTA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-BTA-5685942. HDR through Homologous Recombination (HRR).
R-BTA-5687128. MAPK6/MAPK4 signaling.
R-BTA-5689603. UCH proteinases.
R-BTA-5689877. Josephin domain DUBs.
R-BTA-5689880. Ub-specific processing proteases.
R-BTA-5689896. Ovarian tumor domain proteases.
R-BTA-5689901. Metalloprotease DUBs.
R-BTA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-BTA-5693607. Processing of DNA double-strand break ends.
R-BTA-5696394. DNA Damage Recognition in GG-NER.
R-BTA-5696395. Formation of Incision Complex in GG-NER.
R-BTA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-BTA-5696400. Dual Incision in GG-NER.
R-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-BTA-6783310. Fanconi Anemia Pathway.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-BTA-6804757. Regulation of TP53 Degradation.
R-BTA-6804760. Regulation of TP53 Activity through Methylation.
R-BTA-6807004. Negative regulation of MET activity.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-BTA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-BTA-69231. Cyclin D associated events in G1.
R-BTA-69298. Association of licensing factors with the pre-replicative complex.
R-BTA-69481. G2/M Checkpoints.
R-BTA-69541. Stabilization of p53.
R-BTA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-BTA-72649. Translation initiation complex formation.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-BTA-72702. Ribosomal scanning and start codon recognition.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-BTA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-BTA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.
R-BTA-8863795. Downregulation of ERBB2 signaling.
R-BTA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-BTA-901032. ER Quality Control Compartment (ERQC).
R-BTA-912631. Regulation of signaling by CBL.
R-BTA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.
R-BTA-937039. IRAK1 recruits IKK complex.
R-BTA-937042. IRAK2 mediated activation of TAK1 complex.
R-BTA-937072. TRAF6 mediated induction of TAK1 complex.
R-BTA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-BTA-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-BTA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-40S ribosomal protein S27a
Alternative name(s):
Ubiquitin carboxyl extension protein 80
Cleaved into the following 2 chains:
Gene namesi
Name:RPS27A
Synonyms:UBA80, UBCEP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

Ubiquitin :

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003964741 – 76UbiquitinAdd BLAST76
ChainiPRO_000013766077 – 15640S ribosomal protein S27aAdd BLAST80

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-linki63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei65Phosphoserine; by PINK1By similarity1
Cross-linki76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Modified residuei104N6-acetyllysineBy similarity1
Modified residuei113N6-acetyllysineBy similarity1
Modified residuei152N6-acetyllysineBy similarity1

Post-translational modificationi

Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62992.
PRIDEiP62992.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015473.

Interactioni

Subunit structurei

Ribosomal protein S27a is part of the 40S ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi159949. 2 interactors.
STRINGi9913.ENSBTAP00000033015.

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi12 – 16Combined sources5
Helixi23 – 34Combined sources12
Turni38 – 40Combined sources3
Beta strandi41 – 45Combined sources5
Helixi57 – 59Combined sources3
Beta strandi66 – 71Combined sources6
Beta strandi73 – 75Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M0WX-ray1.40B1-76[»]
4Y1HX-ray1.40A1-76[»]
4Z9SX-ray2.30A/B/C/D1-76[»]
5BZ0X-ray2.10B1-76[»]
5FERX-ray2.34C/F1-76[»]
5JQSX-ray2.65D1-76[»]
ProteinModelPortaliP62992.
SMRiP62992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 99Lys-rich (highly basic)Add BLAST23
Compositional biasi78 – 107Lys-richAdd BLAST30

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin family.Curated
In the C-terminal section; belongs to the ribosomal protein S27Ae family.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 144C4-typeAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0004. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00860000133816.
HOVERGENiHBG079148.
InParanoidiP62992.
KOiK02977.
OMAiMSILKYY.
OrthoDBiEOG091G178I.
TreeFamiTF300036.

Family and domain databases

InterProiIPR002906. Ribosomal_S27a.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01599. Ribosomal_S27. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM01402. Ribosomal_S27. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL
110 120 130 140 150
AVLKYYKVDE NGKISRLRRE CPSDECGAGV FMASHFDRHY CGKCCLTYCF

NKPEDK
Length:156
Mass (Da):17,965
Last modified:August 10, 2010 - v2
Checksum:i617BC63DF3A904F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141 – 156CGKCC…KPEDK → VANVV in BAC56381 (PubMed:12658628).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058700 mRNA. Translation: AAC77907.1.
AB098891 mRNA. Translation: BAC56381.1.
BC102491 mRNA. Translation: AAI02492.2.
PIRiA28144.
RefSeqiNP_777203.1. NM_174778.1.
XP_005212615.1. XM_005212558.2.
UniGeneiBt.4286.

Genome annotation databases

EnsembliENSBTAT00000033091; ENSBTAP00000033015; ENSBTAG00000015473.
GeneIDi286839.
KEGGibta:286839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058700 mRNA. Translation: AAC77907.1.
AB098891 mRNA. Translation: BAC56381.1.
BC102491 mRNA. Translation: AAI02492.2.
PIRiA28144.
RefSeqiNP_777203.1. NM_174778.1.
XP_005212615.1. XM_005212558.2.
UniGeneiBt.4286.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4M0WX-ray1.40B1-76[»]
4Y1HX-ray1.40A1-76[»]
4Z9SX-ray2.30A/B/C/D1-76[»]
5BZ0X-ray2.10B1-76[»]
5FERX-ray2.34C/F1-76[»]
5JQSX-ray2.65D1-76[»]
ProteinModelPortaliP62992.
SMRiP62992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159949. 2 interactors.
STRINGi9913.ENSBTAP00000033015.

Proteomic databases

PaxDbiP62992.
PRIDEiP62992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000033091; ENSBTAP00000033015; ENSBTAG00000015473.
GeneIDi286839.
KEGGibta:286839.

Organism-specific databases

CTDi6233.

Phylogenomic databases

eggNOGiKOG0004. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00860000133816.
HOVERGENiHBG079148.
InParanoidiP62992.
KOiK02977.
OMAiMSILKYY.
OrthoDBiEOG091G178I.
TreeFamiTF300036.

Enzyme and pathway databases

ReactomeiR-BTA-110312. Translesion synthesis by REV1.
R-BTA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-BTA-110320. Translesion Synthesis by POLH.
R-BTA-1169091. Activation of NF-kappaB in B cells.
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-BTA-1253288. Downregulation of ERBB4 signaling.
R-BTA-1295596. Spry regulation of FGF signaling.
R-BTA-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-BTA-168638. NOD1/2 Signaling Pathway.
R-BTA-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-BTA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-BTA-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-BTA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-BTA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-BTA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-BTA-179409. APC-Cdc20 mediated degradation of Nek2A.
R-BTA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-BTA-182971. EGFR downregulation.
R-BTA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-BTA-195253. Degradation of beta-catenin by the destruction complex.
R-BTA-201681. TCF dependent signaling in response to WNT.
R-BTA-202424. Downstream TCR signaling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-BTA-2173788. Downregulation of TGF-beta receptor signaling.
R-BTA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-BTA-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2559580. Oxidative Stress Induced Senescence.
R-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-2559585. Oncogene Induced Senescence.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-2672351. Stimuli-sensing channels.
R-BTA-2871837. FCERI mediated NF-kB activation.
R-BTA-3134975. Regulation of innate immune responses to cytosolic DNA.
R-BTA-3322077. Glycogen synthesis.
R-BTA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-BTA-382556. ABC-family proteins mediated transport.
R-BTA-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-BTA-446652. Interleukin-1 signaling.
R-BTA-450302. activated TAK1 mediates p38 MAPK activation.
R-BTA-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-BTA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-BTA-4608870. Asymmetric localization of PCP proteins.
R-BTA-4641257. Degradation of AXIN.
R-BTA-4641258. Degradation of DVL.
R-BTA-4641263. Regulation of FZD by ubiquitination.
R-BTA-5205685. Pink/Parkin Mediated Mitophagy.
R-BTA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-BTA-5357905. Regulation of TNFR1 signaling.
R-BTA-5357956. TNFR1-induced NFkappaB signaling pathway.
R-BTA-5358346. Hedgehog ligand biogenesis.
R-BTA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-BTA-5607764. CLEC7A (Dectin-1) signaling.
R-BTA-5610780. Degradation of GLI1 by the proteasome.
R-BTA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-BTA-5632684. Hedgehog 'on' state.
R-BTA-5654726. Negative regulation of FGFR1 signaling.
R-BTA-5654727. Negative regulation of FGFR2 signaling.
R-BTA-5654732. Negative regulation of FGFR3 signaling.
R-BTA-5654733. Negative regulation of FGFR4 signaling.
R-BTA-5655862. Translesion synthesis by POLK.
R-BTA-5656121. Translesion synthesis by POLI.
R-BTA-5656169. Termination of translesion DNA synthesis.
R-BTA-5658442. Regulation of RAS by GAPs.
R-BTA-5668541. TNFR2 non-canonical NF-kB pathway.
R-BTA-5675221. Negative regulation of MAPK pathway.
R-BTA-5675482. Regulation of necroptotic cell death.
R-BTA-5676590. NIK-->noncanonical NF-kB signaling.
R-BTA-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-BTA-5685942. HDR through Homologous Recombination (HRR).
R-BTA-5687128. MAPK6/MAPK4 signaling.
R-BTA-5689603. UCH proteinases.
R-BTA-5689877. Josephin domain DUBs.
R-BTA-5689880. Ub-specific processing proteases.
R-BTA-5689896. Ovarian tumor domain proteases.
R-BTA-5689901. Metalloprotease DUBs.
R-BTA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-BTA-5693607. Processing of DNA double-strand break ends.
R-BTA-5696394. DNA Damage Recognition in GG-NER.
R-BTA-5696395. Formation of Incision Complex in GG-NER.
R-BTA-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-BTA-5696400. Dual Incision in GG-NER.
R-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-BTA-6783310. Fanconi Anemia Pathway.
R-BTA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-BTA-6804756. Regulation of TP53 Activity through Phosphorylation.
R-BTA-6804757. Regulation of TP53 Degradation.
R-BTA-6804760. Regulation of TP53 Activity through Methylation.
R-BTA-6807004. Negative regulation of MET activity.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-BTA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-BTA-69231. Cyclin D associated events in G1.
R-BTA-69298. Association of licensing factors with the pre-replicative complex.
R-BTA-69481. G2/M Checkpoints.
R-BTA-69541. Stabilization of p53.
R-BTA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-BTA-72649. Translation initiation complex formation.
R-BTA-72689. Formation of a pool of free 40S subunits.
R-BTA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-BTA-72702. Ribosomal scanning and start codon recognition.
R-BTA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-BTA-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-BTA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-BTA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-BTA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-BTA-8856828. Clathrin-mediated endocytosis.
R-BTA-8863795. Downregulation of ERBB2 signaling.
R-BTA-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-BTA-901032. ER Quality Control Compartment (ERQC).
R-BTA-912631. Regulation of signaling by CBL.
R-BTA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.
R-BTA-937039. IRAK1 recruits IKK complex.
R-BTA-937042. IRAK2 mediated activation of TAK1 complex.
R-BTA-937072. TRAF6 mediated induction of TAK1 complex.
R-BTA-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-BTA-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-BTA-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-BTA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-BTA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
R-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiENSBTAG00000015473.

Family and domain databases

InterProiIPR002906. Ribosomal_S27a.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF01599. Ribosomal_S27. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM01402. Ribosomal_S27. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS27A_BOVIN
AccessioniPrimary (citable) accession number: P62992
Secondary accession number(s): O97577
, P02248, P02249, P02250, P0CG52, P62990, P80169, Q01235, Q24K23, Q28169, Q28170, Q29120, Q3T0V5, Q3ZCE3, Q862C1, Q862F4, Q862M4, Q862T5, Q862X8, Q91887, Q91888
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.