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P62984

- RL40_MOUSE

UniProt

P62984 - RL40_MOUSE

Protein

Ubiquitin-60S ribosomal protein L40

Gene

Uba52

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.1 Publication
    60S ribosomal protein L40: Component of the 60S subunit of the ribosome.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541Activating enzyme
    Sitei68 – 681Essential for function
    Binding sitei72 – 721Activating enzyme

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_188939. Glycogen synthesis.
    REACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196519. Regulation of innate immune responses to cytosolic DNA.
    REACT_196549. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_196640. Stimuli-sensing channels.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_198526. Spry regulation of FGF signaling.
    REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198532. Negative regulators of RIG-I/MDA5 signaling.
    REACT_198536. IRAK2 mediated activation of TAK1 complex.
    REACT_198539. TRAF6 mediated induction of TAK1 complex.
    REACT_198543. IRAK1 recruits IKK complex.
    REACT_198546. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
    REACT_198634. Regulation of signaling by CBL.
    REACT_198690. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_199100. Downregulation of ERBB4 signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_199121. Activation of NF-kappaB in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_203841. Myoclonic epilepsy of Lafora.
    REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_203917. EGFR downregulation.
    REACT_203973. Asymmetric localization of PCP proteins.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207044. TCF dependent signaling in response to WNT.
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_213035. regulation of FZD by ubiquitination.
    REACT_214670. p75NTR recruits signalling complexes.
    REACT_215733. Downregulation of TGF-beta receptor signaling.
    REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_218887. NF-kB is activated and signals survival.
    REACT_219118. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
    REACT_219129. degradation of AXIN.
    REACT_219771. deactivation of the beta-catenin transactivating complex.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_224208. Interleukin-1 signaling.
    REACT_225145. Downstream TCR signaling.
    REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226192. IKK complex recruitment mediated by RIP1.
    REACT_227429. degradation of DVL.
    REACT_24972. Circadian Clock.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-60S ribosomal protein L40
    Alternative name(s):
    Ubiquitin A-52 residue ribosomal protein fusion product 1
    Cleaved into the following 2 chains:
    Alternative name(s):
    CEP52
    Gene namesi
    Name:Uba52
    Synonyms:Ubcep2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:98887. Uba52.

    Subcellular locationi

    Chain Ubiquitin : Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: Ensembl
    3. lysosomal membrane Source: Ensembl
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676UbiquitinPRO_0000396435Add
    BLAST
    Chaini77 – 1285260S ribosomal protein L40PRO_0000138752Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61N6-acetyllysine; alternateBy similarity
    Cross-linki6 – 6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
    Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki29 – 29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei48 – 481N6-acetyllysine; alternateBy similarity
    Cross-linki48 – 48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
    Cross-linki63 – 63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei65 – 651Phosphoserine; by PINK1By similarity
    Cross-linki76 – 76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
    Modified residuei88 – 881N6-acetyllysineBy similarity
    Modified residuei98 – 981N6,N6,N6-trimethyllysineBy similarity

    Post-translational modificationi

    Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy By similarity.By similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP62984.
    PRIDEiP62984.

    2D gel databases

    REPRODUCTION-2DPAGEP62991.

    PTM databases

    PhosphoSiteiP62984.

    Expressioni

    Gene expression databases

    BgeeiP62984.
    GenevestigatoriP62984.

    Interactioni

    Subunit structurei

    Ribosomal protein L40 is part of the 60S ribosomal subunit.By similarity

    Protein-protein interaction databases

    BioGridi204401. 6 interactions.
    MINTiMINT-1214732.

    Structurei

    Secondary structure

    128
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 66
    Beta strandi12 – 176
    Helixi23 – 3412
    Helixi38 – 403
    Beta strandi42 – 454
    Helixi57 – 593
    Beta strandi66 – 705

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AI5X-ray1.40A1-74[»]
    ProteinModelPortaliP62984.
    SMRiP62984. Positions 1-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62984.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 7676Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the ubiquitin family.Curated
    In the C-terminal section; belongs to the ribosomal protein L40e family.Curated
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5272.
    HOVERGENiHBG079132.
    InParanoidiP62984.
    KOiK02927.
    OrthoDBiEOG7JDR1W.
    PhylomeDBiP62984.
    TreeFamiTF352129.

    Family and domain databases

    InterProiIPR001975. Ribosomal_L40e.
    IPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    [Graphical view]
    PfamiPF01020. Ribosomal_L40e. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    PRINTSiPR00348. UBIQUITIN.
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62984-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL    50
    EDGRTLSDYN IQKESTLHLV LRLRGGIIEP SLRQLAQKYN CDKMICRKCY 100
    ARLHPRAVNC RKKKCGHTNN LRPKKKVK 128
    Length:128
    Mass (Da):14,728
    Last modified:August 10, 2010 - v2
    Checksum:i7BCB602ABEFAD02A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118402 mRNA. Translation: AAD14688.1.
    AK018726 mRNA. Translation: BAB31371.1.
    BC054413 mRNA. Translation: AAH54413.1.
    CCDSiCCDS22371.1.
    PIRiS11248.
    RefSeqiNP_063936.1. NM_019883.3.
    UniGeneiMm.297372.
    Mm.482129.

    Genome annotation databases

    EnsembliENSMUST00000081940; ENSMUSP00000080608; ENSMUSG00000090137.
    ENSMUST00000089430; ENSMUSP00000086852; ENSMUSG00000068240.
    ENSMUST00000125184; ENSMUSP00000120096; ENSMUSG00000090137.
    ENSMUST00000129909; ENSMUSP00000121149; ENSMUSG00000090137.
    ENSMUST00000135446; ENSMUSP00000123562; ENSMUSG00000090137.
    ENSMUST00000140679; ENSMUSP00000123263; ENSMUSG00000090137.
    ENSMUST00000165126; ENSMUSP00000137461; ENSMUSG00000090137.
    GeneIDi22186.
    KEGGimmu:22186.
    UCSCiuc009mam.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118402 mRNA. Translation: AAD14688.1 .
    AK018726 mRNA. Translation: BAB31371.1 .
    BC054413 mRNA. Translation: AAH54413.1 .
    CCDSi CCDS22371.1.
    PIRi S11248.
    RefSeqi NP_063936.1. NM_019883.3.
    UniGenei Mm.297372.
    Mm.482129.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AI5 X-ray 1.40 A 1-74 [» ]
    ProteinModelPortali P62984.
    SMRi P62984. Positions 1-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204401. 6 interactions.
    MINTi MINT-1214732.

    PTM databases

    PhosphoSitei P62984.

    2D gel databases

    REPRODUCTION-2DPAGE P62991.

    Proteomic databases

    PaxDbi P62984.
    PRIDEi P62984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081940 ; ENSMUSP00000080608 ; ENSMUSG00000090137 .
    ENSMUST00000089430 ; ENSMUSP00000086852 ; ENSMUSG00000068240 .
    ENSMUST00000125184 ; ENSMUSP00000120096 ; ENSMUSG00000090137 .
    ENSMUST00000129909 ; ENSMUSP00000121149 ; ENSMUSG00000090137 .
    ENSMUST00000135446 ; ENSMUSP00000123562 ; ENSMUSG00000090137 .
    ENSMUST00000140679 ; ENSMUSP00000123263 ; ENSMUSG00000090137 .
    ENSMUST00000165126 ; ENSMUSP00000137461 ; ENSMUSG00000090137 .
    GeneIDi 22186.
    KEGGi mmu:22186.
    UCSCi uc009mam.1. mouse.

    Organism-specific databases

    CTDi 7311.
    MGIi MGI:98887. Uba52.

    Phylogenomic databases

    eggNOGi COG5272.
    HOVERGENi HBG079132.
    InParanoidi P62984.
    KOi K02927.
    OrthoDBi EOG7JDR1W.
    PhylomeDBi P62984.
    TreeFami TF352129.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_188939. Glycogen synthesis.
    REACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196519. Regulation of innate immune responses to cytosolic DNA.
    REACT_196549. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_196640. Stimuli-sensing channels.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_198518. Endosomal Sorting Complex Required For Transport (ESCRT).
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_198526. Spry regulation of FGF signaling.
    REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_198532. Negative regulators of RIG-I/MDA5 signaling.
    REACT_198536. IRAK2 mediated activation of TAK1 complex.
    REACT_198539. TRAF6 mediated induction of TAK1 complex.
    REACT_198543. IRAK1 recruits IKK complex.
    REACT_198546. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
    REACT_198634. Regulation of signaling by CBL.
    REACT_198690. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
    REACT_198693. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_199100. Downregulation of ERBB4 signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199108. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_199115. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_199121. Activation of NF-kappaB in B cells.
    REACT_199123. Signaling by constitutively active EGFR.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_202271. NRIF signals cell death from the nucleus.
    REACT_203517. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_203841. Myoclonic epilepsy of Lafora.
    REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_203917. EGFR downregulation.
    REACT_203973. Asymmetric localization of PCP proteins.
    REACT_204812. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_207044. TCF dependent signaling in response to WNT.
    REACT_207679. Separation of Sister Chromatids.
    REACT_210462. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_212633. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_213035. regulation of FZD by ubiquitination.
    REACT_214670. p75NTR recruits signalling complexes.
    REACT_215733. Downregulation of TGF-beta receptor signaling.
    REACT_218318. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_218887. NF-kB is activated and signals survival.
    REACT_219118. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
    REACT_219129. degradation of AXIN.
    REACT_219771. deactivation of the beta-catenin transactivating complex.
    REACT_219800. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
    REACT_219897. APC/C:Cdc20 mediated degradation of Securin.
    REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_224208. Interleukin-1 signaling.
    REACT_225145. Downstream TCR signaling.
    REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
    REACT_225686. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_226135. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_226192. IKK complex recruitment mediated by RIP1.
    REACT_227429. degradation of DVL.
    REACT_24972. Circadian Clock.

    Miscellaneous databases

    EvolutionaryTracei P62984.
    NextBioi 302153.
    PROi P62984.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62984.
    Genevestigatori P62984.

    Family and domain databases

    InterProi IPR001975. Ribosomal_L40e.
    IPR019956. Ubiquitin.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    IPR019954. Ubiquitin_CS.
    [Graphical view ]
    Pfami PF01020. Ribosomal_L40e. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    PRINTSi PR00348. UBIQUITIN.
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00299. UBIQUITIN_1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification of a murine ubiquitin/60S ribosomal fusion protein and expression study in mouse kidney."
      Sun L., Wuethrich R.P.
      Biochem. Genet. 37:139-147(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: SJL.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Liver and Mammary tumor.
    4. "The emerging complexity of protein ubiquitination."
      Komander D.
      Biochem. Soc. Trans. 37:937-953(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, FUNCTION.

    Entry informationi

    Entry nameiRL40_MOUSE
    AccessioniPrimary (citable) accession number: P62984
    Secondary accession number(s): P02248
    , P02249, P02250, P62991, Q29120, Q62317, Q64223, Q8VCH1, Q91887, Q91888, Q9CXY4, Q9CZM0, Q9D1R5, Q9D8D9, Q9ET23, Q9ET24, Q9Z0H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3