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P62979

- RS27A_HUMAN

UniProt

P62979 - RS27A_HUMAN

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Protein
Ubiquitin-40S ribosomal protein S27a
Gene
RPS27A, UBA80, UBCEP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541Activating enzyme
Sitei68 – 681Essential for function
Binding sitei72 – 721Activating enzyme

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri121 – 14424C4-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
  2. DNA repair Source: Reactome
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. G1/S transition of mitotic cell cycle Source: Reactome
  5. G2/M transition of mitotic cell cycle Source: Reactome
  6. I-kappaB kinase/NF-kappaB signaling Source: Reactome
  7. JNK cascade Source: Reactome
  8. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  9. MyD88-independent toll-like receptor signaling pathway Source: Reactome
  10. Notch receptor processing Source: Reactome
  11. Notch signaling pathway Source: Reactome
  12. RNA metabolic process Source: Reactome
  13. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  14. T cell receptor signaling pathway Source: Reactome
  15. TRIF-dependent toll-like receptor signaling pathway Source: Reactome
  16. activation of MAPK activity Source: Reactome
  17. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
  18. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  19. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  20. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  21. apoptotic process Source: Reactome
  22. apoptotic signaling pathway Source: Reactome
  23. carbohydrate metabolic process Source: Reactome
  24. cellular protein metabolic process Source: Reactome
  25. cellular response to hypoxia Source: Reactome
  26. cytokine-mediated signaling pathway Source: Reactome
  27. endosomal transport Source: Reactome
  28. epidermal growth factor receptor signaling pathway Source: Reactome
  29. fibroblast growth factor receptor signaling pathway Source: Reactome
  30. gene expression Source: Reactome
  31. glucose metabolic process Source: Reactome
  32. glycogen biosynthetic process Source: Reactome
  33. innate immune response Source: Reactome
  34. intracellular transport of virus Source: Reactome
  35. ion transmembrane transport Source: Reactome
  36. mRNA metabolic process Source: Reactome
  37. membrane organization Source: Reactome
  38. mitotic cell cycle Source: Reactome
  39. negative regulation of apoptotic process Source: Reactome
  40. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  41. negative regulation of transcription from RNA polymerase II promoter Source: Reactome
  42. negative regulation of transforming growth factor beta receptor signaling pathway Source: Reactome
  43. negative regulation of type I interferon production Source: Reactome
  44. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  45. neurotrophin TRK receptor signaling pathway Source: Reactome
  46. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  47. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
  48. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  49. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Reactome
  50. positive regulation of NF-kappaB transcription factor activity Source: Reactome
  51. positive regulation of apoptotic process Source: Reactome
  52. positive regulation of transcription from RNA polymerase II promoter Source: Reactome
  53. positive regulation of type I interferon production Source: Reactome
  54. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  55. protein polyubiquitination Source: Reactome
  56. regulation of apoptotic process Source: Reactome
  57. regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
  58. regulation of type I interferon production Source: Reactome
  59. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
  60. small molecule metabolic process Source: Reactome
  61. stress-activated MAPK cascade Source: Reactome
  62. toll-like receptor 10 signaling pathway Source: Reactome
  63. toll-like receptor 2 signaling pathway Source: Reactome
  64. toll-like receptor 3 signaling pathway Source: Reactome
  65. toll-like receptor 4 signaling pathway Source: Reactome
  66. toll-like receptor 5 signaling pathway Source: Reactome
  67. toll-like receptor 9 signaling pathway Source: Reactome
  68. toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
  69. toll-like receptor TLR6:TLR2 signaling pathway Source: Reactome
  70. toll-like receptor signaling pathway Source: Reactome
  71. transcription initiation from RNA polymerase II promoter Source: Reactome
  72. transcription, DNA-templated Source: Reactome
  73. transforming growth factor beta receptor signaling pathway Source: Reactome
  74. translation Source: UniProtKB
  75. translational elongation Source: Reactome
  76. translational initiation Source: Reactome
  77. translational termination Source: Reactome
  78. transmembrane transport Source: Reactome
  79. viral life cycle Source: Reactome
  80. viral process Source: Reactome
  81. viral protein processing Source: Reactome
  82. viral transcription Source: Reactome
  83. virion assembly Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_111080. Spry regulation of FGF signaling.
REACT_111178. ER-Phagosome pathway.
REACT_111184. Negative regulation of FGFR signaling.
REACT_1156. Orc1 removal from chromatin.
REACT_115662. Downregulation of ERBB2:ERBB3 signaling.
REACT_115755. Signaling by ERBB2.
REACT_115828. Downregulation of ERBB4 signaling.
REACT_115831. ISG15 antiviral mechanism.
REACT_115852. Signaling by constitutively active EGFR.
REACT_115893. Membrane binding and targetting of GAG proteins.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1181. Association of licensing factors with the pre-replicative complex.
REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_120727. Downregulation of TGF-beta receptor signaling.
REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_120916. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_12484. EGFR downregulation.
REACT_12555. Downstream TCR signaling.
REACT_13415. p75NTR recruits signalling complexes.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13643. NRIF signals cell death from the nucleus.
REACT_13696. NF-kB is activated and signals survival.
REACT_1404. Peptide chain elongation.
REACT_150471. Separation of Sister Chromatids.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160189. Stimuli-sensing channels.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163994. FCERI mediated NF-kB activation.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_169208. Glycogen synthesis.
REACT_169325. Oncogene Induced Senescence.
REACT_169436. Oxidative Stress Induced Senescence.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_18265. Regulation of the Fanconi anemia pathway.
REACT_18410. Fanconi Anemia pathway.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_200716. regulation of FZD by ubiquitination.
REACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200766. degradation of AXIN.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200783. Myoclonic epilepsy of Lafora.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_23787. Regulation of signaling by CBL.
REACT_24918. IRAK1 recruits IKK complex.
REACT_24941. Circadian Clock.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_25271. Negative regulators of RIG-I/MDA5 signaling.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25354. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
REACT_25359. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
REACT_25374. IKK complex recruitment mediated by RIP1.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6359. Budding and maturation of HIV virion.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6818. Assembly Of The HIV Virion.
REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75776. NOD1/2 Signaling Pathway.
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
REACT_9031. Vpu mediated degradation of CD4.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9453. Vif-mediated degradation of APOBEC3G.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-40S ribosomal protein S27a
Alternative name(s):
Ubiquitin carboxyl extension protein 80
Cleaved into the following 2 chains:
Gene namesi
Name:RPS27A
Synonyms:UBA80, UBCEP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:10417. RPS27A.

Subcellular locationi

Chain Ubiquitin : Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic small ribosomal subunit Source: UniProtKB
  3. endocytic vesicle membrane Source: Reactome
  4. endosome membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
  6. nucleoplasm Source: Reactome
  7. plasma membrane Source: Reactome
  8. small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi48 – 481K → R: No effect on HLTF-mediated polyubiquitination of PCNA. 1 Publication
Mutagenesisi63 – 631K → R: Abolishes HLTF-mediated polyubiquitination of PCNA. 1 Publication
Mutagenesisi65 – 651S → A: Prevents phosphorylation in case of mitophagy.

Organism-specific databases

PharmGKBiPA34821.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Ubiquitin
PRO_0000396477Add
BLAST
Chaini77 – 1568040S ribosomal protein S27a
PRO_0000396478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki6 – 6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki27 – 27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Inferred
Cross-linki29 – 29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Cross-linki48 – 48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)3 Publications
Cross-linki63 – 63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei65 – 651Phosphoserine; by PINK1
Cross-linki76 – 76Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Modified residuei104 – 1041N6-acetyllysine1 Publication
Modified residuei113 – 1131N6-acetyllysine1 Publication
Modified residuei152 – 1521N6-acetyllysine By similarity

Post-translational modificationi

Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP62979.
PaxDbiP62979.
PRIDEiP62979.

2D gel databases

UCD-2DPAGEP02248.

PTM databases

PhosphoSiteiP62979.

Expressioni

Gene expression databases

ArrayExpressiP62979.
BgeeiP62979.
CleanExiHS_RPS27A.
GenevestigatoriP62979.

Organism-specific databases

HPAiCAB033319.
HPA041344.

Interactioni

Subunit structurei

Ribosomal protein S27a is part of the 40S ribosomal subunit By similarity.

Protein-protein interaction databases

BioGridi112147. 89 interactions.
IntActiP62979. 14 interactions.
MINTiMINT-1138719.
STRINGi9606.ENSP00000272317.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65
Turni8 – 103
Beta strandi12 – 165
Helixi23 – 3412
Helixi38 – 403
Beta strandi41 – 455
Helixi57 – 593
Beta strandi66 – 716

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KHWNMR-B1-76[»]
2KOXNMR-A1-76[»]
2KTFNMR-A1-76[»]
2KWUNMR-B1-76[»]
2KWVNMR-B1-76[»]
2L0FNMR-A1-76[»]
2L0TNMR-A1-76[»]
2XK5X-ray3.00A/B1-76[»]
3AXCX-ray2.19A1-76[»]
3J3Aelectron microscopy5.00f77-156[»]
3K9PX-ray2.80B1-76[»]
3N30X-ray3.00A/B1-76[»]
3N32X-ray1.80A1-76[»]
3NHEX-ray1.26B1-76[»]
3NOBX-ray2.19A/B/C/D/E/F/G/H1-76[»]
3NS8X-ray1.71A/B1-76[»]
3PHDX-ray3.00E/F/G/H1-76[»]
3PHWX-ray2.00B/D/F/H1-75[»]
3TBLX-ray2.90D/E1-76[»]
ProteinModelPortaliP62979.
SMRiP62979. Positions 1-76, 82-152.

Miscellaneous databases

EvolutionaryTraceiP62979.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7676Ubiquitin-like
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi77 – 9923Lys-rich (highly basic)
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin family.
In the C-terminal section; belongs to the ribosomal protein S27Ae family.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5272.
HOVERGENiHBG079148.
InParanoidiP62979.
KOiK02977.
OMAiMSILKYY.
OrthoDBiEOG7JDR1W.
PhylomeDBiP62979.
TreeFamiTF300036.

Family and domain databases

InterProiIPR002906. Ribosomal_S27a.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
[Graphical view]
PfamiPF01599. Ribosomal_S27. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62979-1 [UniParc]FASTAAdd to Basket

« Hide

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL    50
EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL 100
AVLKYYKVDE NGKISRLRRE CPSDECGAGV FMASHFDRHY CGKCCLTYCF 150
NKPEDK 156
Length:156
Mass (Da):17,965
Last modified:August 10, 2010 - v2
Checksum:i617BC63DF3A904F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63237 mRNA. Translation: CAA44911.1.
S79522 mRNA. Translation: AAB21188.1.
AC012358 Genomic DNA. No translation available.
BC001392 mRNA. Translation: AAH01392.1.
BC066293 mRNA. Translation: AAH66293.1.
AB062071 Genomic DNA. Translation: BAB79490.1.
M10939 mRNA. Translation: AAA36788.1.
AB007163 Genomic DNA. Translation: BAA25826.1.
CCDSiCCDS33202.1.
RefSeqiNP_001129064.1. NM_001135592.2.
NP_001170884.1. NM_001177413.1.
NP_002945.1. NM_002954.5.
UniGeneiHs.311640.
Hs.546292.
Hs.743392.

Genome annotation databases

EnsembliENST00000272317; ENSP00000272317; ENSG00000143947.
ENST00000402285; ENSP00000383981; ENSG00000143947.
ENST00000404735; ENSP00000385659; ENSG00000143947.
GeneIDi6233.
KEGGihsa:6233.
UCSCiuc002ryk.3. human.

Polymorphism databases

DMDMi302393745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63237 mRNA. Translation: CAA44911.1 .
S79522 mRNA. Translation: AAB21188.1 .
AC012358 Genomic DNA. No translation available.
BC001392 mRNA. Translation: AAH01392.1 .
BC066293 mRNA. Translation: AAH66293.1 .
AB062071 Genomic DNA. Translation: BAB79490.1 .
M10939 mRNA. Translation: AAA36788.1 .
AB007163 Genomic DNA. Translation: BAA25826.1 .
CCDSi CCDS33202.1.
RefSeqi NP_001129064.1. NM_001135592.2.
NP_001170884.1. NM_001177413.1.
NP_002945.1. NM_002954.5.
UniGenei Hs.311640.
Hs.546292.
Hs.743392.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2KHW NMR - B 1-76 [» ]
2KOX NMR - A 1-76 [» ]
2KTF NMR - A 1-76 [» ]
2KWU NMR - B 1-76 [» ]
2KWV NMR - B 1-76 [» ]
2L0F NMR - A 1-76 [» ]
2L0T NMR - A 1-76 [» ]
2XK5 X-ray 3.00 A/B 1-76 [» ]
3AXC X-ray 2.19 A 1-76 [» ]
3J3A electron microscopy 5.00 f 77-156 [» ]
3K9P X-ray 2.80 B 1-76 [» ]
3N30 X-ray 3.00 A/B 1-76 [» ]
3N32 X-ray 1.80 A 1-76 [» ]
3NHE X-ray 1.26 B 1-76 [» ]
3NOB X-ray 2.19 A/B/C/D/E/F/G/H 1-76 [» ]
3NS8 X-ray 1.71 A/B 1-76 [» ]
3PHD X-ray 3.00 E/F/G/H 1-76 [» ]
3PHW X-ray 2.00 B/D/F/H 1-75 [» ]
3TBL X-ray 2.90 D/E 1-76 [» ]
ProteinModelPortali P62979.
SMRi P62979. Positions 1-76, 82-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112147. 89 interactions.
IntActi P62979. 14 interactions.
MINTi MINT-1138719.
STRINGi 9606.ENSP00000272317.

PTM databases

PhosphoSitei P62979.

Polymorphism databases

DMDMi 302393745.

2D gel databases

UCD-2DPAGE P02248.

Proteomic databases

MaxQBi P62979.
PaxDbi P62979.
PRIDEi P62979.

Protocols and materials databases

DNASUi 6233.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272317 ; ENSP00000272317 ; ENSG00000143947 .
ENST00000402285 ; ENSP00000383981 ; ENSG00000143947 .
ENST00000404735 ; ENSP00000385659 ; ENSG00000143947 .
GeneIDi 6233.
KEGGi hsa:6233.
UCSCi uc002ryk.3. human.

Organism-specific databases

CTDi 6233.
GeneCardsi GC02P055459.
H-InvDB HIX0161861.
HGNCi HGNC:10417. RPS27A.
HPAi CAB033319.
HPA041344.
MIMi 191343. gene.
neXtProti NX_P62979.
PharmGKBi PA34821.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5272.
HOVERGENi HBG079148.
InParanoidi P62979.
KOi K02977.
OMAi MSILKYY.
OrthoDBi EOG7JDR1W.
PhylomeDBi P62979.
TreeFami TF300036.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_111080. Spry regulation of FGF signaling.
REACT_111178. ER-Phagosome pathway.
REACT_111184. Negative regulation of FGFR signaling.
REACT_1156. Orc1 removal from chromatin.
REACT_115662. Downregulation of ERBB2:ERBB3 signaling.
REACT_115755. Signaling by ERBB2.
REACT_115828. Downregulation of ERBB4 signaling.
REACT_115831. ISG15 antiviral mechanism.
REACT_115852. Signaling by constitutively active EGFR.
REACT_115893. Membrane binding and targetting of GAG proteins.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1181. Association of licensing factors with the pre-replicative complex.
REACT_118614. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_118656. Activation of NF-kappaB in B cells.
REACT_118780. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_120727. Downregulation of TGF-beta receptor signaling.
REACT_120734. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_120916. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
REACT_12484. EGFR downregulation.
REACT_12555. Downstream TCR signaling.
REACT_13415. p75NTR recruits signalling complexes.
REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_13643. NRIF signals cell death from the nucleus.
REACT_13696. NF-kB is activated and signals survival.
REACT_1404. Peptide chain elongation.
REACT_150471. Separation of Sister Chromatids.
REACT_160089. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_160189. Stimuli-sensing channels.
REACT_160205. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_160243. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_160254. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_160315. Regulation of PLK1 Activity at G2/M Transition.
REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_163977. Regulation of innate immune responses to cytosolic DNA.
REACT_163994. FCERI mediated NF-kB activation.
REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
REACT_169208. Glycogen synthesis.
REACT_169325. Oncogene Induced Senescence.
REACT_169436. Oxidative Stress Induced Senescence.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_18265. Regulation of the Fanconi anemia pathway.
REACT_18410. Fanconi Anemia pathway.
REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_200716. regulation of FZD by ubiquitination.
REACT_200731. deactivation of the beta-catenin transactivating complex.
REACT_200766. degradation of AXIN.
REACT_200777. TCF dependent signaling in response to WNT.
REACT_200783. Myoclonic epilepsy of Lafora.
REACT_200841. degradation of DVL.
REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_21281. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
REACT_21368. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_21399. activated TAK1 mediates p38 MAPK activation.
REACT_22442. Interleukin-1 signaling.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_23787. Regulation of signaling by CBL.
REACT_24918. IRAK1 recruits IKK complex.
REACT_24941. Circadian Clock.
REACT_25018. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
REACT_25120. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_25148. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_25271. Negative regulators of RIG-I/MDA5 signaling.
REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_25351. TRAF6 mediated induction of TAK1 complex.
REACT_25354. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
REACT_25359. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.
REACT_25374. IKK complex recruitment mediated by RIP1.
REACT_25380. IRAK2 mediated activation of TAK1 complex.
REACT_27258. Endosomal Sorting Complex Required For Transport (ESCRT).
REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
REACT_6359. Budding and maturation of HIV virion.
REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_6818. Assembly Of The HIV Virion.
REACT_6820. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75776. NOD1/2 Signaling Pathway.
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_821. Cyclin D associated events in G1.
REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
REACT_9031. Vpu mediated degradation of CD4.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9453. Vif-mediated degradation of APOBEC3G.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS27A. human.
EvolutionaryTracei P62979.
GeneWikii RPS27A.
GenomeRNAii 6233.
NextBioi 24197.
PROi P62979.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62979.
Bgeei P62979.
CleanExi HS_RPS27A.
Genevestigatori P62979.

Family and domain databases

InterProi IPR002906. Ribosomal_S27a.
IPR011332. Ribosomal_zn-bd.
IPR019956. Ubiquitin.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
[Graphical view ]
Pfami PF01599. Ribosomal_S27. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
PRINTSi PR00348. UBIQUITIN.
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
SSF57829. SSF57829. 1 hit.
PROSITEi PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL)."
    Pancre V., Pierce R.J., Fournier F., Mehtali M., Delanoye A., Capron A., Auriault C.
    Eur. J. Immunol. 21:2735-2741(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Differential expression of translation-associated genes in benign and malignant human breast tumours."
    Adams S.M., Sharp M.G., Walker R.A., Brammar W.J., Varley J.M.
    Br. J. Cancer 65:65-71(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  5. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-98.
    Tissue: Placenta.
  6. "Molecular conservation of 74 amino acid sequence of ubiquitin between cattle and man."
    Schlesinger D.H., Goldstein G.
    Nature 255:423-424(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-74.
  7. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-27; 30-42 AND 55-72, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  8. "Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation."
    Cripps D., Thomas S.N., Jeng Y., Yang F., Davies P., Yang A.J.
    J. Biol. Chem. 281:10825-10838(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-27 AND 43-54, UBIQUITINATION AT LYS-6; LYS-11 AND LYS-48, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
    Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
    Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34.
  10. "Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor."
    Lund P.K., Moats-Staats B.M., Simmons J.G., Hoyt E., D'Ercole A.J., Martin F., van Wyk J.J.
    J. Biol. Chem. 260:7609-7613(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-156.
  11. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 98-148.
  12. "Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain."
    Huang F., Kirkpatrick D., Jiang X., Gygi S.P., Sorkin A.
    Mol. Cell 21:737-748(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, UBIQUITINATION AT LYS-11; LYS-29; LYS-48 AND LYS-63, IDENTIFICATION BY MASS SPECTROMETRY.
  13. "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis."
    Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K.
    J. Biol. Chem. 279:53533-53543(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-27.
  14. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-48.
    Tissue: Lung adenocarcinoma.
  15. "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks."
    Motegi A., Liaw H.-J., Lee K.-Y., Roest H.P., Maas A., Wu X., Moinova H., Markowitz S.D., Ding H., Hoeijmakers J.H.J., Myung K.
    Proc. Natl. Acad. Sci. U.S.A. 105:12411-12416(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-63, MUTAGENESIS OF LYS-48 AND LYS-63.
  16. "The emerging complexity of protein ubiquitination."
    Komander D.
    Biochem. Soc. Trans. 37:937-953(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, FUNCTION.
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-104 AND LYS-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. Cited for: PHOSPHORYLATION AT SER-65, MUTAGENESIS OF SER-65.

Entry informationi

Entry nameiRS27A_HUMAN
AccessioniPrimary (citable) accession number: P62979
Secondary accession number(s): P02248
, P02249, P02250, P14798, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BQ77, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 10, 2010
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
For a better understanding, features related to ubiquitin are only indicated for the first chain.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi