Reviewed, UniProtKB/Swiss-Prot P62979 (RS27A_HUMAN)

Names and origin

Protein names

Recommended name:
    40S ribosomal protein S27a

Gene names

Name:	RPS27A
Synonyms:	UBA80, UBCEP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	80 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.
Sequence similarities	Belongs to the ribosomal protein S27Ae family.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	translational elongation Inferred from Experiment. Source: Reactome
Cellular component	cytosolic small ribosomal subunit Ref.6 Inferred from direct assay. Source: UniProtKB
Molecular function	structural constituent of ribosome Inferred from direct assay. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 80	80	40S ribosomal protein S27a		PRO_0000137662
Regions
	Zinc finger	45 – 68	24	C4-type
	Compositional bias	1 – 23	23	Lys-rich (highly basic)

Sequences

	Sequence		Length	Mass (Da)
	P62979-1 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 5233F54BB6F9DC1B	FASTA	80	9,418
	10 20 30 40 50 60 AKKRKKKSYT TPKKNKHKRK KVKLAVLKYY KVDENGKISR LRRECPSDEC GAGVFMASHF 70 80 DRHYCGKCCL TYCFNKPEDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor." Lund P.K., Moats-Staats B.M., Simmons J.G., Hoyt E., D'Ercole A.J., Martin F., van Wyk J.J. J. Biol. Chem. 260:7609-7613(1985) [PubMed: 2581967] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL)." Pancre V., Pierce R.J., Fournier F., Mehtali M., Delanoye A., Capron A., Auriault C. Eur. J. Immunol. 21:2735-2741(1991) [PubMed: 1657614] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Differential expression of translation-associated genes in benign and malignant human breast tumours." Adams S.M., Sharp M.G., Walker R.A., Brammar W.J., Varley J.M. Br. J. Cancer 65:65-71(1992) [PubMed: 1370760] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Urinary bladder.
[6]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-22. Tissue: Placenta.
[7]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed: 9582194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-72.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M10939 mRNA. Translation: AAA36788.1. Different initiation. X63237 mRNA. Translation: CAA44911.1. Different initiation. S79522 mRNA. Translation: AAB21188.1. Different initiation. AC012358 Genomic DNA. No translation available. BC001392 mRNA. Translation: AAH01392.1. Different initiation. BC066293 mRNA. Translation: AAH66293.1. Different initiation. AB007163 Genomic DNA. Translation: BAA25826.1.
IPI	IPI00179330.
UniGene	Hs.311640 Hs.546292 Hs.700206
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P62979. 7 interactions.
Proteomic databases
PRIDE	P62979.
Genome annotation databases
Ensembl	ENSG00000143947. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC01P190932. GC02P055313. GC06P114010.
H-InvDB	HIX0002061.
HGNC	HGNC:10417. RPS27A.
MIM	191343. gene.
PharmGKB	PA34821.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P62979.
Enzyme and pathway databases
Reactome	REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
Bgee	P62979.
CleanEx	HS_RPS27A.
GermOnline	ENSG00000143947. Homo sapiens.
Family and domain databases
InterPro	IPR002906. Ribosomal_S27a. [Graphical view]
Pfam	PF01599. Ribosomal_S27. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

RS27A_HUMAN

Accession

Primary (citable) accession number: P62979
Secondary accession number(s): P14798, Q6LBL4, Q9BQ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)