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Protein

Cellular retinoic acid-binding protein 1

Gene

Crabp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoic acid binding Source: Ensembl
  • retinoid binding Source: MGI
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular retinoic acid-binding protein 1
Alternative name(s):
Cellular retinoic acid-binding protein I
Short name:
CRABP-I
Gene namesi
Name:Crabp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88490. Crabp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674072 – 137Cellular retinoic acid-binding protein 1Add BLAST136

Proteomic databases

MaxQBiP62965.
PaxDbiP62965.
PeptideAtlasiP62965.
PRIDEiP62965.

2D gel databases

REPRODUCTION-2DPAGEIPI00230721.
P62965.

PTM databases

iPTMnetiP62965.
PhosphoSitePlusiP62965.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032291.
CleanExiMM_CRABP1.
GenevisibleiP62965. MM.

Interactioni

Protein-protein interaction databases

IntActiP62965. 1 interactor.
MINTiMINT-4131563.
STRINGi10090.ENSMUSP00000034830.

Chemistry databases

BindingDBiP62965.

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 15Combined sources10
Helixi16 – 22Combined sources7
Helixi27 – 36Combined sources10
Beta strandi41 – 47Combined sources7
Beta strandi50 – 56Combined sources7
Beta strandi61 – 67Combined sources7
Beta strandi72 – 75Combined sources4
Beta strandi81 – 90Combined sources10
Beta strandi93 – 103Combined sources11
Beta strandi108 – 115Combined sources8
Beta strandi118 – 125Combined sources8
Beta strandi128 – 136Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CBIX-ray2.70A/B2-137[»]
1CBRX-ray2.90A/B2-137[»]
DisProtiDP00340.
ProteinModelPortaliP62965.
SMRiP62965.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62965.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 134Retinoic acid binding3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 31Nuclear localization signalBy similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP62965.
KOiK17337.
OMAiESENKIH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP62965.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031279. CRABP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF62. PTHR11955:SF62. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ
60 70 80 90 100
FYIKTSTTVR TTEINFKVGE GFEEETVDGR KCRSLPTWEN ENKIHCTQTL
110 120 130
LEGDGPKTYW TRELANDELI LTFGADDVVC TRIYVRE
Length:137
Mass (Da):15,592
Last modified:January 23, 2007 - v2
Checksum:iA3DB0494D88943B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15481 mRNA. Translation: CAA33509.1.
M58015, M58013, M58014 Genomic DNA. Translation: AAA40027.1.
X51715, X51716, X51717 Genomic DNA. Translation: CAA36011.1.
X15789 mRNA. Translation: CAA33790.1.
AK045283 mRNA. Translation: BAC32295.1.
AK144397 mRNA. Translation: BAE25869.1.
M31552 mRNA. Translation: AAA37453.1.
CCDSiCCDS23195.1.
PIRiA35825.
RefSeqiNP_038524.1. NM_013496.3.
UniGeneiMm.34797.

Genome annotation databases

EnsembliENSMUST00000034830; ENSMUSP00000034830; ENSMUSG00000032291.
GeneIDi12903.
KEGGimmu:12903.
UCSCiuc009prp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15481 mRNA. Translation: CAA33509.1.
M58015, M58013, M58014 Genomic DNA. Translation: AAA40027.1.
X51715, X51716, X51717 Genomic DNA. Translation: CAA36011.1.
X15789 mRNA. Translation: CAA33790.1.
AK045283 mRNA. Translation: BAC32295.1.
AK144397 mRNA. Translation: BAE25869.1.
M31552 mRNA. Translation: AAA37453.1.
CCDSiCCDS23195.1.
PIRiA35825.
RefSeqiNP_038524.1. NM_013496.3.
UniGeneiMm.34797.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CBIX-ray2.70A/B2-137[»]
1CBRX-ray2.90A/B2-137[»]
DisProtiDP00340.
ProteinModelPortaliP62965.
SMRiP62965.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62965. 1 interactor.
MINTiMINT-4131563.
STRINGi10090.ENSMUSP00000034830.

Chemistry databases

BindingDBiP62965.
ChEMBLiCHEMBL3208.

PTM databases

iPTMnetiP62965.
PhosphoSitePlusiP62965.

2D gel databases

REPRODUCTION-2DPAGEIPI00230721.
P62965.

Proteomic databases

MaxQBiP62965.
PaxDbiP62965.
PeptideAtlasiP62965.
PRIDEiP62965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034830; ENSMUSP00000034830; ENSMUSG00000032291.
GeneIDi12903.
KEGGimmu:12903.
UCSCiuc009prp.2. mouse.

Organism-specific databases

CTDi1381.
MGIiMGI:88490. Crabp1.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP62965.
KOiK17337.
OMAiESENKIH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP62965.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-MMU-5365859. RA biosynthesis pathway.

Miscellaneous databases

ChiTaRSiCrabp1. mouse.
EvolutionaryTraceiP62965.
PROiP62965.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032291.
CleanExiMM_CRABP1.
GenevisibleiP62965. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031279. CRABP1.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF62. PTHR11955:SF62. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRABP1_MOUSE
AccessioniPrimary (citable) accession number: P62965
Secondary accession number(s): P02695
, P02697, P15780, Q3UN78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.