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Protein

Voltage-dependent calcium channel gamma-7 subunit

Gene

Cacng7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-7 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-7 subunit
Transmembrane AMPAR regulatory protein gamma-7
Short name:
TARP gamma-7
Gene namesi
Name:Cacng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1932374. Cacng7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646881 – 275Voltage-dependent calcium channel gamma-7 subunitAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP62956.
PRIDEiP62956.

PTM databases

iPTMnetiP62956.
PhosphoSitePlusiP62956.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069806.
ExpressionAtlasiP62956. baseline and differential.
GenevisibleiP62956. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090567.

Structurei

3D structure databases

ProteinModelPortaliP62956.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiP62956.
KOiK04872.
OMAiVHMSASP.
OrthoDBiEOG091G0F73.
PhylomeDBiP62956.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008371. VDCC_g7su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01795. VDCCGAMMA7.

Sequencei

Sequence statusi: Complete.

P62956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV
60 70 80 90 100
KMALHAGLWR VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA
110 120 130 140 150
TPFPMVSLFL VFTAFVISNI GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEV MNRPSSSEQY FHYRYGWSFA FAASSFLLKE GAGVMSVYLF
210 220 230 240 250
TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG RSPSDISSDV
260 270
SIQMTQNYPP AIKYPDHLHI STSPC
Length:275
Mass (Da):31,003
Last modified:August 31, 2004 - v1
Checksum:i43CC82B9FA6A5C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361349 mRNA. Translation: AAL50044.1.
AF458899 mRNA. Translation: AAM00596.1.
CCDSiCCDS39725.1.
RefSeqiNP_573452.3. NM_133189.3.
XP_006540504.1. XM_006540441.3.
UniGeneiMm.214994.

Genome annotation databases

EnsembliENSMUST00000092891; ENSMUSP00000090567; ENSMUSG00000069806.
ENSMUST00000181686; ENSMUSP00000137710; ENSMUSG00000096998.
GeneIDi81904.
KEGGimmu:81904.
UCSCiuc009euu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361349 mRNA. Translation: AAL50044.1.
AF458899 mRNA. Translation: AAM00596.1.
CCDSiCCDS39725.1.
RefSeqiNP_573452.3. NM_133189.3.
XP_006540504.1. XM_006540441.3.
UniGeneiMm.214994.

3D structure databases

ProteinModelPortaliP62956.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090567.

PTM databases

iPTMnetiP62956.
PhosphoSitePlusiP62956.

Proteomic databases

PaxDbiP62956.
PRIDEiP62956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092891; ENSMUSP00000090567; ENSMUSG00000069806.
ENSMUST00000181686; ENSMUSP00000137710; ENSMUSG00000096998.
GeneIDi81904.
KEGGimmu:81904.
UCSCiuc009euu.1. mouse.

Organism-specific databases

CTDi59284.
MGIiMGI:1932374. Cacng7.

Phylogenomic databases

eggNOGiENOG410IXFC. Eukaryota.
ENOG410XUAQ. LUCA.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiP62956.
KOiK04872.
OMAiVHMSASP.
OrthoDBiEOG091G0F73.
PhylomeDBiP62956.
TreeFamiTF327980.

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

PROiP62956.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069806.
ExpressionAtlasiP62956. baseline and differential.
GenevisibleiP62956. MM.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008371. VDCC_g7su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01795. VDCCGAMMA7.
ProtoNetiSearch...

Entry informationi

Entry nameiCCG7_MOUSE
AccessioniPrimary (citable) accession number: P62956
Secondary accession number(s): Q8VBX3, Q8WXS6, Q9BXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.