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Protein

Voltage-dependent calcium channel gamma-7 subunit

Gene

Cacng7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-7 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-7 subunit
Transmembrane AMPAR regulatory protein gamma-7
Short name:
TARP gamma-7
Gene namesi
Name:Cacng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1932374 Cacng7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646881 – 275Voltage-dependent calcium channel gamma-7 subunitAdd BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP62956
PRIDEiP62956

PTM databases

iPTMnetiP62956
PhosphoSitePlusiP62956
SwissPalmiP62956

Expressioni

Gene expression databases

BgeeiENSMUSG00000069806
ExpressionAtlasiP62956 baseline and differential
GenevisibleiP62956 MM

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090567

Structurei

3D structure databases

ProteinModelPortaliP62956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXFC Eukaryota
ENOG410XUAQ LUCA
GeneTreeiENSGT00550000074547
HOGENOMiHOG000233439
HOVERGENiHBG025923
InParanoidiP62956
KOiK04872
OMAiVHMSASP
OrthoDBiEOG091G0F73
PhylomeDBiP62956
TreeFamiTF327980

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR008371 VDCC_g7su
IPR008368 VDCC_gsu
PANTHERiPTHR12107:SF12 PTHR12107:SF12, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01795 VDCCGAMMA7

Sequencei

Sequence statusi: Complete.

P62956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV
60 70 80 90 100
KMALHAGLWR VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA
110 120 130 140 150
TPFPMVSLFL VFTAFVISNI GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEV MNRPSSSEQY FHYRYGWSFA FAASSFLLKE GAGVMSVYLF
210 220 230 240 250
TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG RSPSDISSDV
260 270
SIQMTQNYPP AIKYPDHLHI STSPC
Length:275
Mass (Da):31,003
Last modified:August 31, 2004 - v1
Checksum:i43CC82B9FA6A5C73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361349 mRNA Translation: AAL50044.1
AF458899 mRNA Translation: AAM00596.1
CCDSiCCDS39725.1
RefSeqiNP_573452.3, NM_133189.3
XP_006540504.1, XM_006540441.3
UniGeneiMm.214994

Genome annotation databases

EnsembliENSMUST00000092891; ENSMUSP00000090567; ENSMUSG00000069806
ENSMUST00000181686; ENSMUSP00000137710; ENSMUSG00000096998
GeneIDi81904
KEGGimmu:81904
UCSCiuc009euu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCG7_MOUSE
AccessioniPrimary (citable) accession number: P62956
Secondary accession number(s): Q8VBX3, Q8WXS6, Q9BXT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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