ID   CCG7_HUMAN              Reviewed;         275 AA.
AC   P62955; Q52LL8; Q8VBX3; Q8WXS6; Q9BXT1;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   16-SEP-2015, entry version 95.
DE   RecName: Full=Voltage-dependent calcium channel gamma-7 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit;
DE   AltName: Full=Transmembrane AMPAR regulatory protein gamma-7;
DE            Short=TARP gamma-7;
GN   Name=CACNG7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=11170751; DOI=10.1006/geno.2000.6440;
RA   Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.;
RT   "A cluster of three novel Ca(2+) channel gamma subunit genes on
RT   chromosome 19q13.4: evolution and expression profile of the gamma
RT   subunit gene family.";
RL   Genomics 71:339-350(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11738816; DOI=10.1016/S0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of
RT   this gene family.";
RL   Gene 280:37-48(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA   Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A.,
RA   Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT   "The novel product of a five-exon stargazin-related gene abolishes
RT   CaV2.2 calcium channel expression.";
RL   EMBO J. 21:1514-1523(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=21172611; DOI=10.1016/j.neuron.2010.11.026;
RA   Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H.,
RA   Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.;
RT   "Hippocampal AMPA receptor gating controlled by both TARP and
RT   cornichon proteins.";
RL   Neuron 68:1082-1096(2010).
CC   -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC       selective glutamate receptors (AMPARs). Promotes their targeting
CC       to the cell membrane and synapses and modulates their gating
CC       properties by slowing their rates of activation, deactivation and
CC       desensitization and by mediating their resensitization. Displays
CC       subunit-specific AMPA receptor regulation. Shows specificity only
CC       for GRIA1 and GRIA2. Thought to stabilize the calcium channel in
CC       an inactivated (closed) state. {ECO:0000269|PubMed:21172611}.
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary
CC       subunit for AMPA-selective glutamate receptors (AMPARs). Found in
CC       a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2,
CC       CACNG3, CACNG4, CACNG5 and CACNG8.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC       {ECO:0000269|PubMed:11170751}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF288387; AAK20030.1; -; mRNA.
DR   EMBL; AF361353; AAL50048.1; -; mRNA.
DR   EMBL; AF458897; AAM00594.1; -; mRNA.
DR   EMBL; BC069332; AAH69332.1; -; mRNA.
DR   EMBL; BC093869; AAH93869.1; -; mRNA.
DR   EMBL; BC113503; AAI13504.1; -; mRNA.
DR   CCDS; CCDS12868.1; -.
DR   RefSeq; NP_114102.2; NM_031896.4.
DR   UniGene; Hs.631597; -.
DR   ProteinModelPortal; P62955; -.
DR   STRING; 9606.ENSP00000222212; -.
DR   ChEMBL; CHEMBL2363032; -.
DR   TCDB; 8.A.16.2.5; the ca(+) channel auxiliary subunit 1-8 (cca) family.
DR   PhosphoSite; P62955; -.
DR   BioMuta; CACNG7; -.
DR   DMDM; 51702249; -.
DR   PaxDb; P62955; -.
DR   PRIDE; P62955; -.
DR   DNASU; 59284; -.
DR   Ensembl; ENST00000222212; ENSP00000222212; ENSG00000105605.
DR   Ensembl; ENST00000391767; ENSP00000375647; ENSG00000105605.
DR   GeneID; 59284; -.
DR   KEGG; hsa:59284; -.
DR   UCSC; uc002qcr.2; human.
DR   CTD; 59284; -.
DR   GeneCards; GC19P053909; -.
DR   HGNC; HGNC:13626; CACNG7.
DR   HPA; HPA049881; -.
DR   MIM; 606899; gene.
DR   neXtProt; NX_P62955; -.
DR   PharmGKB; PA26021; -.
DR   eggNOG; NOG43394; -.
DR   GeneTree; ENSGT00550000074547; -.
DR   HOGENOM; HOG000233439; -.
DR   HOVERGEN; HBG025923; -.
DR   InParanoid; P62955; -.
DR   KO; K04872; -.
DR   OMA; HTLPRSH; -.
DR   OrthoDB; EOG71P2BZ; -.
DR   PhylomeDB; P62955; -.
DR   TreeFam; TF327980; -.
DR   GenomeRNAi; 59284; -.
DR   NextBio; 65174; -.
DR   PRO; PR:P62955; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; P62955; -.
DR   CleanEx; HS_CACNG7; -.
DR   Genevisible; P62955; HS.
DR   GO; GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; NAS:UniProtKB.
DR   GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; NAS:UniProtKB.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; NAS:UniProtKB.
DR   GO; GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB.
DR   GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008371; VDCC_g7su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   Pfam; PF13903; Claudin_2; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01795; VDCCGAMMA7.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Complete proteome;
KW   Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN         1    275       Voltage-dependent calcium channel gamma-7
FT                                subunit.
FT                                /FTId=PRO_0000164687.
FT   TRANSMEM      8     28       Helical. {ECO:0000255}.
FT   TRANSMEM    103    123       Helical. {ECO:0000255}.
FT   TRANSMEM    129    149       Helical. {ECO:0000255}.
FT   TRANSMEM    179    199       Helical. {ECO:0000255}.
FT   CONFLICT    191    275       GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF
FT                                LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST
FT                                SPC -> VTSVGPRL (in Ref. 1; AAK20030).
FT                                {ECO:0000305}.
SQ   SEQUENCE   275 AA;  31003 MW;  43CC82B9FA6A5C73 CRC64;
     MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
     VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
     GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
     FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
     RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC
//