ID   CCG7_HUMAN              Reviewed;         275 AA.
AC   P62955; Q52LL8; Q8VBX3; Q8WXS6; Q9BXT1;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   16-DEC-2008, entry version 40.
DE   RecName: Full=Voltage-dependent calcium channel gamma-7 subunit;
DE   AltName: Full=Neuronal voltage-gated calcium channel gamma-7 subunit;
GN   Name=CACNG7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   MEDLINE=21100909; PubMed=11170751; DOI=10.1006/geno.2000.6440;
RA   Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.;
RT   "A cluster of three novel Ca(2+) channel gamma subunit genes on
RT   chromosome 19q13.4: evolution and expression profile of the gamma
RT   subunit gene family.";
RL   Genomics 71:339-350(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21601102; PubMed=11738816; DOI=10.1016/S0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of
RT   this gene family.";
RL   Gene 280:37-48(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=21924683; PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA   Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A.,
RA   Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT   "The novel product of a five-exon stargazin-related gene abolishes
RT   CaV2.2 calcium channel expression.";
RL   EMBO J. 21:1514-1523(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-258 AND TYR-264, AND
RP   MASS SPECTROMETRY.
RX   PubMed=17053785; DOI=10.1038/sj.emboj.7601384;
RA   Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,
RA   Lottspeich F., Chen Z.;
RT   "Tyrosine phosphorylated Par3 regulates epithelial tight junction
RT   assembly promoted by EGFR signaling.";
RL   EMBO J. 25:5058-5070(2006).
CC   -!- FUNCTION: Thought to stabilize the calcium channel in an
CC       inactivated (closed) state (By similarity).
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG
CC       subfamily.
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DR   EMBL; AF288387; AAK20030.1; -; mRNA.
DR   EMBL; AF361353; AAL50048.1; -; mRNA.
DR   EMBL; AF458897; AAM00594.1; -; mRNA.
DR   EMBL; BC069332; AAH69332.1; -; mRNA.
DR   EMBL; BC093869; AAH93869.1; -; mRNA.
DR   EMBL; BC113503; AAI13504.1; -; mRNA.
DR   RefSeq; NP_114102.2; -.
DR   UniGene; Hs.631597; -.
DR   PhosphoSite; P62955; -.
DR   PRIDE; P62955; -.
DR   Ensembl; ENSG00000105605; Homo sapiens.
DR   GeneID; 59284; -.
DR   KEGG; hsa:59284; -.
DR   GeneCards; GC19P059107; -.
DR   H-InvDB; HIX0039988; -.
DR   HGNC; HGNC:13626; CACNG7.
DR   MIM; 606899; gene.
DR   PharmGKB; PA26021; -.
DR   HOGENOM; P62955; -.
DR   HOVERGEN; P62955; -.
DR   NextBio; 65174; -.
DR   ArrayExpress; P62955; -.
DR   CleanEx; HS_CACNG7; -.
DR   GermOnline; ENSG00000105605; Homo sapiens.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; NAS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; NAS:UniProtKB.
DR   GO; GO:0006816; P:calcium ion transport; NAS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR008371; VDCC_g7su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01795; VDCCGAMMA7.
PE   1: Evidence at protein level;
KW   Calcium; Calcium channel; Calcium transport; Ion transport;
KW   Ionic channel; Membrane; Phosphoprotein; Transmembrane; Transport;
KW   Voltage-gated channel.
FT   CHAIN         1    275       Voltage-dependent calcium channel gamma-7
FT                                subunit.
FT                                /FTId=PRO_0000164687.
FT   TRANSMEM      8     28       Potential.
FT   TRANSMEM    103    123       Potential.
FT   TRANSMEM    129    149       Potential.
FT   TRANSMEM    179    199       Potential.
FT   MOD_RES     258    258       Phosphotyrosine.
FT   MOD_RES     264    264       Phosphotyrosine.
FT   CONFLICT    191    275       GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF
FT                                LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST
FT                                SPC -> VTSVGPRL (in Ref. 1).
SQ   SEQUENCE   275 AA;  31003 MW;  43CC82B9FA6A5C73 CRC64;
     MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
     VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
     GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
     FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
     RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC
//