ID   CCG7_HUMAN     STANDARD;      PRT;   275 AA.
AC   P62955; Q8VBX3; Q8WXS6; Q9BXT1;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   25-OCT-2004 (Rel. 45, Last annotation update)
DE   Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage-
DE   gated calcium channel gamma-7 subunit).
GN   Name=CACNG7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RX   MEDLINE=21100909; PubMed=11170751; DOI=10.1006/geno.2000.6440;
RA   Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.;
RT   "A cluster of three novel Ca(2+) channel gamma subunit genes on
RT   chromosome 19q13.4: evolution and expression profile of the gamma
RT   subunit gene family.";
RL   Genomics 71:339-350(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21601102; PubMed=11738816; DOI=10.1016/S0378-1119(01)00738-7;
RA   Chu P.-J., Robertson H.M., Best P.M.;
RT   "Calcium channel gamma subunits provide insights into the evolution of
RT   this gene family.";
RL   Gene 280:37-48(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=21924683; PubMed=11927536; DOI=10.1093/emboj/21.7.1514;
RA   Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A.,
RA   Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.;
RT   "The novel product of a five-exon stargazin-related gene abolishes
RT   CaV2.2 calcium channel expression.";
RL   EMBO J. 21:1514-1523(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Thought to stabilize the calcium channel in an
CC       inactivated (closed) state (By similarity).
CC   -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC       alpha-1, alpha-2/delta, beta and gamma.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Widely expressed.
CC   -!- SIMILARITY: Belongs to the PMP-22 / EMP / MP20 family. CACNG
CC       subfamily.
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DR   EMBL; AF288387; AAK20030.1; -.
DR   EMBL; AF361353; AAL50048.1; -.
DR   EMBL; AF458897; AAM00594.1; -.
DR   EMBL; BC069332; AAH69332.1; -.
DR   Genew; HGNC:13626; CACNG7.
DR   MIM; 606899; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; NAS.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; NAS.
DR   GO; GO:0006816; P:calcium ion transport; NAS.
DR   InterPro; IPR004031; PMP22_Claudin.
DR   InterPro; IPR008368; VDCCGamma.
DR   InterPro; IPR008371; VDCCGamma7.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01795; VDCCGAMMA7.
KW   Calcium channel; Ion transport; Ionic channel; Transmembrane;
KW   Voltage-gated channel.
FT   TRANSMEM      8     28       Potential.
FT   TRANSMEM    103    123       Potential.
FT   TRANSMEM    129    149       Potential.
FT   TRANSMEM    179    199       Potential.
FT   CONFLICT    191    275       GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF
FT                                LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST
FT                                SPC -> VTSVGPRL (in Ref. 1).
SQ   SEQUENCE   275 AA;  31003 MW;  43CC82B9FA6A5C73 CRC64;
     MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
     VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
     GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
     FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
     RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC
//