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P62955 (CCG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-7 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-7 subunit
Transmembrane AMPAR regulatory protein gamma-7
Short name=TARP gamma-7
Gene names
Name:CACNG7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.5

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Voltage-dependent calcium channel gamma-7 subunit
PRO_0000164687

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane179 – 19921Helical; Potential

Experimental info

Sequence conflict191 – 27585GAGVM…STSPC → VTSVGPRL in AAK20030. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P62955 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: 43CC82B9FA6A5C73

FASTA27531,003
        10         20         30         40         50         60 
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR 

        70         80         90        100        110        120 
VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI 

       130        140        150        160        170        180 
GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA 

       190        200        210        220        230        240 
FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG 

       250        260        270 
RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC 

« Hide

References

« Hide 'large scale' references
[1]"A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Calcium channel gamma subunits provide insights into the evolution of this gene family."
Chu P.-J., Robertson H.M., Best P.M.
Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF288387 mRNA. Translation: AAK20030.1.
AF361353 mRNA. Translation: AAL50048.1.
AF458897 mRNA. Translation: AAM00594.1.
BC069332 mRNA. Translation: AAH69332.1.
BC093869 mRNA. Translation: AAH93869.1.
BC113503 mRNA. Translation: AAI13504.1.
RefSeqNP_114102.2. NM_031896.4.
XP_005259182.1. XM_005259125.1.
UniGeneHs.631597.

3D structure databases

ProteinModelPortalP62955.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000222212.

Chemistry

ChEMBLCHEMBL2363032.

Protein family/group databases

TCDB8.A.16.2.5. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSiteP62955.

Polymorphism databases

DMDM51702249.

Proteomic databases

PaxDbP62955.
PRIDEP62955.

Protocols and materials databases

DNASU59284.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222212; ENSP00000222212; ENSG00000105605.
ENST00000391766; ENSP00000375646; ENSG00000105605.
ENST00000391767; ENSP00000375647; ENSG00000105605.
GeneID59284.
KEGGhsa:59284.
UCSCuc002qcr.2. human.

Organism-specific databases

CTD59284.
GeneCardsGC19P054412.
HGNCHGNC:13626. CACNG7.
HPAHPA049881.
MIM606899. gene.
neXtProtNX_P62955.
PharmGKBPA26021.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43394.
HOGENOMHOG000233439.
HOVERGENHBG025923.
InParanoidP62955.
KOK04872.
OMAHTLPRSH.
OrthoDBEOG71P2BZ.
PhylomeDBP62955.
TreeFamTF327980.

Gene expression databases

BgeeP62955.
CleanExHS_CACNG7.
GenevestigatorP62955.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR008371. VDCC_g7su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01795. VDCCGAMMA7.
ProtoNetSearch...

Other

GenomeRNAi59284.
NextBio65174.
PROP62955.
SOURCESearch...

Entry information

Entry nameCCG7_HUMAN
AccessionPrimary (citable) accession number: P62955
Secondary accession number(s): Q52LL8 expand/collapse secondary AC list , Q8VBX3, Q8WXS6, Q9BXT1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM