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P62955

- CCG7_HUMAN

UniProt

P62955 - CCG7_HUMAN

Protein

Voltage-dependent calcium channel gamma-7 subunit

Gene

CACNG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Protein family/group databases

    TCDBi8.A.16.2.5. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-7 subunit
    Alternative name(s):
    Neuronal voltage-gated calcium channel gamma-7 subunit
    Transmembrane AMPAR regulatory protein gamma-7
    Short name:
    TARP gamma-7
    Gene namesi
    Name:CACNG7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13626. CACNG7.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
    2. voltage-gated calcium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26021.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Voltage-dependent calcium channel gamma-7 subunitPRO_0000164687Add
    BLAST

    Proteomic databases

    PaxDbiP62955.
    PRIDEiP62955.

    PTM databases

    PhosphoSiteiP62955.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiP62955.
    CleanExiHS_CACNG7.
    GenevestigatoriP62955.

    Organism-specific databases

    HPAiHPA049881.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000222212.

    Structurei

    3D structure databases

    ProteinModelPortaliP62955.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43394.
    HOGENOMiHOG000233439.
    HOVERGENiHBG025923.
    InParanoidiP62955.
    KOiK04872.
    OMAiHTLPRSH.
    OrthoDBiEOG71P2BZ.
    PhylomeDBiP62955.
    TreeFamiTF327980.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR008371. VDCC_g7su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01795. VDCCGAMMA7.

    Sequencei

    Sequence statusi: Complete.

    P62955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV    50
    KMALHAGLWR VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA 100
    TPFPMVSLFL VFTAFVISNI GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV 150
    LYISSINDEV MNRPSSSEQY FHYRYGWSFA FAASSFLLKE GAGVMSVYLF 200
    TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG RSPSDISSDV 250
    SIQMTQNYPP AIKYPDHLHI STSPC 275
    Length:275
    Mass (Da):31,003
    Last modified:August 31, 2004 - v1
    Checksum:i43CC82B9FA6A5C73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 27585GAGVM…STSPC → VTSVGPRL in AAK20030. (PubMed:11170751)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288387 mRNA. Translation: AAK20030.1.
    AF361353 mRNA. Translation: AAL50048.1.
    AF458897 mRNA. Translation: AAM00594.1.
    BC069332 mRNA. Translation: AAH69332.1.
    BC093869 mRNA. Translation: AAH93869.1.
    BC113503 mRNA. Translation: AAI13504.1.
    CCDSiCCDS12868.1.
    RefSeqiNP_114102.2. NM_031896.4.
    XP_005259182.1. XM_005259125.1.
    UniGeneiHs.631597.

    Genome annotation databases

    EnsembliENST00000222212; ENSP00000222212; ENSG00000105605.
    ENST00000391766; ENSP00000375646; ENSG00000105605.
    ENST00000391767; ENSP00000375647; ENSG00000105605.
    GeneIDi59284.
    KEGGihsa:59284.
    UCSCiuc002qcr.2. human.

    Polymorphism databases

    DMDMi51702249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF288387 mRNA. Translation: AAK20030.1 .
    AF361353 mRNA. Translation: AAL50048.1 .
    AF458897 mRNA. Translation: AAM00594.1 .
    BC069332 mRNA. Translation: AAH69332.1 .
    BC093869 mRNA. Translation: AAH93869.1 .
    BC113503 mRNA. Translation: AAI13504.1 .
    CCDSi CCDS12868.1.
    RefSeqi NP_114102.2. NM_031896.4.
    XP_005259182.1. XM_005259125.1.
    UniGenei Hs.631597.

    3D structure databases

    ProteinModelPortali P62955.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000222212.

    Chemistry

    ChEMBLi CHEMBL2363032.

    Protein family/group databases

    TCDBi 8.A.16.2.5. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    PTM databases

    PhosphoSitei P62955.

    Polymorphism databases

    DMDMi 51702249.

    Proteomic databases

    PaxDbi P62955.
    PRIDEi P62955.

    Protocols and materials databases

    DNASUi 59284.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222212 ; ENSP00000222212 ; ENSG00000105605 .
    ENST00000391766 ; ENSP00000375646 ; ENSG00000105605 .
    ENST00000391767 ; ENSP00000375647 ; ENSG00000105605 .
    GeneIDi 59284.
    KEGGi hsa:59284.
    UCSCi uc002qcr.2. human.

    Organism-specific databases

    CTDi 59284.
    GeneCardsi GC19P054412.
    HGNCi HGNC:13626. CACNG7.
    HPAi HPA049881.
    MIMi 606899. gene.
    neXtProti NX_P62955.
    PharmGKBi PA26021.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43394.
    HOGENOMi HOG000233439.
    HOVERGENi HBG025923.
    InParanoidi P62955.
    KOi K04872.
    OMAi HTLPRSH.
    OrthoDBi EOG71P2BZ.
    PhylomeDBi P62955.
    TreeFami TF327980.

    Miscellaneous databases

    GenomeRNAii 59284.
    NextBioi 65174.
    PROi P62955.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62955.
    CleanExi HS_CACNG7.
    Genevestigatori P62955.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR008371. VDCC_g7su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01795. VDCCGAMMA7.
    ProtoNeti Search...

    Publicationsi

    1. "A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
      Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
      Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
      Chu P.-J., Robertson H.M., Best P.M.
      Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
      Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
      EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
      Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
      Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCCG7_HUMAN
    AccessioniPrimary (citable) accession number: P62955
    Secondary accession number(s): Q52LL8
    , Q8VBX3, Q8WXS6, Q9BXT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3