P62955 (CCG7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-7 subunit

Alternative name(s):
Neuronal voltage-gated calcium channel gamma-7 subunit
Transmembrane AMPAR regulatory protein gamma-7
Short name=TARP gamma-7

Gene names

Name:

CACNG7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.5
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Widely expressed. Ref.1
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from sequence or structural similarity. Source: UniProtKB voltage-gated calcium channel complex Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	voltage-gated calcium channel activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Voltage-dependent calcium channel gamma-7 subunit		PRO_0000164687
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
Experimental info
	Sequence conflict	191 – 275	85	GAGVM…STSPC → VTSVGPRL in AAK20030. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P62955 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 43CC82B9FA6A5C73	FASTA	275	31,003
	10 20 30 40 50 60 MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR 70 80 90 100 110 120 VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI 130 140 150 160 170 180 GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA 190 200 210 220 230 240 FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG 250 260 270 RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family." Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L. Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Calcium channel gamma subunits provide insights into the evolution of this gene family." Chu P.-J., Robertson H.M., Best P.M. Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression." Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C. EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins." Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S. Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF288387 mRNA. Translation: AAK20030.1. AF361353 mRNA. Translation: AAL50048.1. AF458897 mRNA. Translation: AAM00594.1. BC069332 mRNA. Translation: AAH69332.1. BC093869 mRNA. Translation: AAH93869.1. BC113503 mRNA. Translation: AAI13504.1.
IPI	IPI00011071.
RefSeq	NP_114102.2. NM_031896.4.
UniGene	Hs.631597.
3D structure databases
ProteinModelPortal	P62955.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000222212.
Protein family/group databases
TCDB	8.A.16.2.5. Ca+ channel auxiliary subunit gamma1-gamma8 (CCAgamma) family.
PTM databases
PhosphoSite	P62955.
Polymorphism databases
DMDM	51702249.
Proteomic databases
PaxDb	P62955.
PRIDE	P62955.
Protocols and materials databases
DNASU	59284.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222212; ENSP00000222212; ENSG00000105605. ENST00000391766; ENSP00000375646; ENSG00000105605. ENST00000391767; ENSP00000375647; ENSG00000105605.
GeneID	59284.
KEGG	hsa:59284.
UCSC	uc002qcr.2. human.
Organism-specific databases
CTD	59284.
GeneCards	GC19P054412.
HGNC	HGNC:13626. CACNG7.
HPA	HPA049881.
MIM	606899. gene.
neXtProt	NX_P62955.
PharmGKB	PA26021.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43394.
HOGENOM	HOG000233439.
HOVERGEN	HBG025923.
InParanoid	P62955.
KO	K04872.
OMA	DSWPPPQ.
OrthoDB	EOG40S0G8.
PhylomeDB	P62955.
Gene expression databases
Bgee	P62955.
CleanEx	HS_CACNG7.
Genevestigator	P62955.
GermOnline	ENSG00000105605. Homo sapiens.
Family and domain databases
InterPro	IPR008371. VDCC_g7su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01795. VDCCGAMMA7.
ProtoNet	Search...
Other
GenomeRNAi	59284.
NextBio	65174.
SOURCE	Search...

Entry information

Entry name

CCG7_HUMAN

Accession

Primary (citable) accession number: P62955
Secondary accession number(s): Q52LL8 , Q8VBX3, Q8WXS6, Q9BXT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.