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P62955

- CCG7_HUMAN

UniProt

P62955 - CCG7_HUMAN

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Protein

Voltage-dependent calcium channel gamma-7 subunit

Gene

CACNG7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state.1 Publication

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi8.A.16.2.5. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-7 subunit
Alternative name(s):
Neuronal voltage-gated calcium channel gamma-7 subunit
Transmembrane AMPAR regulatory protein gamma-7
Short name:
TARP gamma-7
Gene namesi
Name:CACNG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13626. CACNG7.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: UniProtKB
  2. voltage-gated calcium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Voltage-dependent calcium channel gamma-7 subunitPRO_0000164687Add
BLAST

Proteomic databases

PaxDbiP62955.
PRIDEiP62955.

PTM databases

PhosphoSiteiP62955.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiP62955.
CleanExiHS_CACNG7.
GenevestigatoriP62955.

Organism-specific databases

HPAiHPA049881.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG8.

Protein-protein interaction databases

STRINGi9606.ENSP00000222212.

Structurei

3D structure databases

ProteinModelPortaliP62955.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43394.
GeneTreeiENSGT00550000074547.
HOGENOMiHOG000233439.
HOVERGENiHBG025923.
InParanoidiP62955.
KOiK04872.
OMAiHTLPRSH.
OrthoDBiEOG71P2BZ.
PhylomeDBiP62955.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR008371. VDCC_g7su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01795. VDCCGAMMA7.

Sequencei

Sequence statusi: Complete.

P62955-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV
60 70 80 90 100
KMALHAGLWR VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA
110 120 130 140 150
TPFPMVSLFL VFTAFVISNI GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV
160 170 180 190 200
LYISSINDEV MNRPSSSEQY FHYRYGWSFA FAASSFLLKE GAGVMSVYLF
210 220 230 240 250
TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG RSPSDISSDV
260 270
SIQMTQNYPP AIKYPDHLHI STSPC
Length:275
Mass (Da):31,003
Last modified:August 31, 2004 - v1
Checksum:i43CC82B9FA6A5C73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 27585GAGVM…STSPC → VTSVGPRL in AAK20030. (PubMed:11170751)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288387 mRNA. Translation: AAK20030.1.
AF361353 mRNA. Translation: AAL50048.1.
AF458897 mRNA. Translation: AAM00594.1.
BC069332 mRNA. Translation: AAH69332.1.
BC093869 mRNA. Translation: AAH93869.1.
BC113503 mRNA. Translation: AAI13504.1.
CCDSiCCDS12868.1.
RefSeqiNP_114102.2. NM_031896.4.
XP_005259182.1. XM_005259125.1.
UniGeneiHs.631597.

Genome annotation databases

EnsembliENST00000222212; ENSP00000222212; ENSG00000105605.
ENST00000391766; ENSP00000375646; ENSG00000105605.
ENST00000391767; ENSP00000375647; ENSG00000105605.
GeneIDi59284.
KEGGihsa:59284.
UCSCiuc002qcr.2. human.

Polymorphism databases

DMDMi51702249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF288387 mRNA. Translation: AAK20030.1 .
AF361353 mRNA. Translation: AAL50048.1 .
AF458897 mRNA. Translation: AAM00594.1 .
BC069332 mRNA. Translation: AAH69332.1 .
BC093869 mRNA. Translation: AAH93869.1 .
BC113503 mRNA. Translation: AAI13504.1 .
CCDSi CCDS12868.1.
RefSeqi NP_114102.2. NM_031896.4.
XP_005259182.1. XM_005259125.1.
UniGenei Hs.631597.

3D structure databases

ProteinModelPortali P62955.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000222212.

Chemistry

ChEMBLi CHEMBL2363032.

Protein family/group databases

TCDBi 8.A.16.2.5. the ca(+) channel auxiliary subunit 1-8 (cca) family.

PTM databases

PhosphoSitei P62955.

Polymorphism databases

DMDMi 51702249.

Proteomic databases

PaxDbi P62955.
PRIDEi P62955.

Protocols and materials databases

DNASUi 59284.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222212 ; ENSP00000222212 ; ENSG00000105605 .
ENST00000391766 ; ENSP00000375646 ; ENSG00000105605 .
ENST00000391767 ; ENSP00000375647 ; ENSG00000105605 .
GeneIDi 59284.
KEGGi hsa:59284.
UCSCi uc002qcr.2. human.

Organism-specific databases

CTDi 59284.
GeneCardsi GC19P054412.
HGNCi HGNC:13626. CACNG7.
HPAi HPA049881.
MIMi 606899. gene.
neXtProti NX_P62955.
PharmGKBi PA26021.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43394.
GeneTreei ENSGT00550000074547.
HOGENOMi HOG000233439.
HOVERGENi HBG025923.
InParanoidi P62955.
KOi K04872.
OMAi HTLPRSH.
OrthoDBi EOG71P2BZ.
PhylomeDBi P62955.
TreeFami TF327980.

Miscellaneous databases

GenomeRNAii 59284.
NextBioi 65174.
PROi P62955.
SOURCEi Search...

Gene expression databases

Bgeei P62955.
CleanExi HS_CACNG7.
Genevestigatori P62955.

Family and domain databases

InterProi IPR004031. PMP22/EMP/MP20/Claudin.
IPR008371. VDCC_g7su.
IPR008368. VDCC_gsu.
[Graphical view ]
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01792. VDCCGAMMA.
PR01795. VDCCGAMMA7.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cluster of three novel Ca(2+) channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family."
    Burgess D.L., Gefrides L.A., Foreman P.J., Noebels J.L.
    Genomics 71:339-350(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Calcium channel gamma subunits provide insights into the evolution of this gene family."
    Chu P.-J., Robertson H.M., Best P.M.
    Gene 280:37-48(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression."
    Moss F.J., Viard P., Davies A., Bertaso F., Page K.M., Graham A., Canti C., Plumpton M., Plumpton C., Clare J.J., Dolphin A.C.
    EMBO J. 21:1514-1523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
    Kato A.S., Gill M.B., Ho M.T., Yu H., Tu Y., Siuda E.R., Wang H., Qian Y.W., Nisenbaum E.S., Tomita S., Bredt D.S.
    Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCCG7_HUMAN
AccessioniPrimary (citable) accession number: P62955
Secondary accession number(s): Q52LL8
, Q8VBX3, Q8WXS6, Q9BXT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3