ID   BLCAP_HUMAN             Reviewed;          87 AA.
AC   P62952; A2A2K7; O60629; Q9D3B5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=Bladder cancer-associated protein;
DE   AltName: Full=Bladder cancer 10 kDa protein;
DE            Short=Bc10;
GN   Name=BLCAP; Synonyms=BC10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Urinary bladder;
RX   PubMed=10197429;
RX   DOI=10.1002/(sici)1522-2683(19990201)20:2<241::aid-elps241>3.0.co;2-a;
RA   Gromova I., Gromov P., Celis J.E.;
RT   "Identification of true differentially expressed mRNAs in a pair of human
RT   bladder transitional cell carcinomas using an improved differential display
RT   procedure.";
RL   Electrophoresis 20:241-248(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=16675915; DOI=10.1159/000093057;
RA   Zuo Z., Zhao M., Liu J., Gao G., Wu X.;
RT   "Functional analysis of bladder cancer-related protein gene: a putative
RT   cervical cancer tumor suppressor gene in cervical carcinoma.";
RL   Tumor Biol. 27:221-226(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=17031575; DOI=10.1007/s11010-006-9332-2;
RA   Yao J., Duan L., Fan M., Yuan J., Wu X.;
RT   "Overexpression of BLCAP induces S phase arrest and apoptosis independent
RT   of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression
RT   induces S phase arrest and apoptosis.";
RL   Mol. Cell. Biochem. 297:81-92(2007).
RN   [6]
RP   RNA EDITING OF POSITIONS 2; 5 AND 15, AND TISSUE SPECIFICITY.
RX   PubMed=19908260; DOI=10.1002/ijc.25022;
RA   Galeano F., Leroy A., Rossetti C., Gromova I., Gautier P., Keegan L.P.,
RA   Massimi L., Di Rocco C., O'Connell M.A., Gallo A.;
RT   "Human BLCAP transcript: new editing events in normal and cancerous
RT   tissues.";
RL   Int. J. Cancer 127:127-137(2010).
CC   -!- FUNCTION: May regulate cell proliferation and coordinate apoptosis and
CC       cell cycle progression via a novel mechanism independent of both
CC       p53/TP53 and NF-kappa-B. {ECO:0000269|PubMed:17031575}.
CC   -!- INTERACTION:
CC       P62952; P07306: ASGR1; NbExp=3; IntAct=EBI-3895726, EBI-1172335;
CC       P62952; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-3895726, EBI-11959453;
CC       P62952; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3895726, EBI-3867333;
CC       P62952; P03372: ESR1; NbExp=2; IntAct=EBI-3895726, EBI-78473;
CC       P62952; Q96D05-2: FAM241B; NbExp=3; IntAct=EBI-3895726, EBI-12118888;
CC       P62952; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-3895726, EBI-11991950;
CC       P62952; P36382: GJA5; NbExp=3; IntAct=EBI-3895726, EBI-750433;
CC       P62952; O14653: GOSR2; NbExp=3; IntAct=EBI-3895726, EBI-4401517;
CC       P62952; P49639: HOXA1; NbExp=3; IntAct=EBI-3895726, EBI-740785;
CC       P62952; Q68G75: LEMD1; NbExp=3; IntAct=EBI-3895726, EBI-12268900;
CC       P62952; O95237: LRAT; NbExp=3; IntAct=EBI-3895726, EBI-13291307;
CC       P62952; Q6N075: MFSD5; NbExp=3; IntAct=EBI-3895726, EBI-3920969;
CC       P62952; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-3895726, EBI-945833;
CC       P62952; Q86WV1: SKAP1; NbExp=3; IntAct=EBI-3895726, EBI-2477305;
CC       P62952; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-3895726, EBI-17280858;
CC       P62952; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-3895726, EBI-8638294;
CC       P62952; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-3895726, EBI-10982110;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Expressed in cervical tissues. Down-
CC       regulated in bladder invasive carcinoma, renal cell carcinoma and in
CC       primary cervical carcinoma. {ECO:0000269|PubMed:10197429,
CC       ECO:0000269|PubMed:16675915, ECO:0000269|PubMed:19908260}.
CC   -!- RNA EDITING: Modified_positions=2 {ECO:0000269|PubMed:19908260}, 5
CC       {ECO:0000269|PubMed:19908260}, 15 {ECO:0000269|PubMed:19908260};
CC       Note=Partially edited. Decreased editing levels seen in astrocytomas,
CC       bladder cancer and colorectal cancer as compared to the related normal
CC       tissues.;
CC   -!- SIMILARITY: Belongs to the BLCAP family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/801/BLCAP";
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DR   EMBL; AF053470; AAC06370.1; -; mRNA.
DR   EMBL; AL109614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC047692; AAH47692.1; -; mRNA.
DR   EMBL; BC071704; AAH71704.1; -; mRNA.
DR   CCDS; CCDS13295.1; -.
DR   RefSeq; NP_001161292.1; NM_001167820.1.
DR   RefSeq; NP_001161293.1; NM_001167821.1.
DR   RefSeq; NP_001161294.1; NM_001167822.2.
DR   RefSeq; NP_001161295.1; NM_001167823.1.
DR   RefSeq; NP_001304003.1; NM_001317074.1.
DR   RefSeq; NP_001304004.1; NM_001317075.1.
DR   RefSeq; NP_006689.1; NM_006698.3.
DR   RefSeq; XP_016883088.1; XM_017027599.1.
DR   AlphaFoldDB; P62952; -.
DR   BioGRID; 116110; 22.
DR   IntAct; P62952; 17.
DR   STRING; 9606.ENSP00000397172; -.
DR   BioMuta; BLCAP; -.
DR   DMDM; 51702217; -.
DR   PaxDb; 9606-ENSP00000397172; -.
DR   PeptideAtlas; P62952; -.
DR   Antibodypedia; 57254; 66 antibodies from 20 providers.
DR   DNASU; 10904; -.
DR   Ensembl; ENST00000373537.7; ENSP00000362637.2; ENSG00000166619.15.
DR   Ensembl; ENST00000397131.1; ENSP00000380320.1; ENSG00000166619.15.
DR   Ensembl; ENST00000397134.1; ENSP00000380323.1; ENSG00000166619.15.
DR   Ensembl; ENST00000397135.1; ENSP00000380324.1; ENSG00000166619.15.
DR   Ensembl; ENST00000397137.5; ENSP00000380326.1; ENSG00000166619.15.
DR   Ensembl; ENST00000414542.6; ENSP00000397172.2; ENSG00000166619.15.
DR   Ensembl; ENST00000432507.1; ENSP00000414973.1; ENSG00000166619.15.
DR   GeneID; 10904; -.
DR   KEGG; hsa:10904; -.
DR   MANE-Select; ENST00000373537.7; ENSP00000362637.2; NM_006698.4; NP_006689.1.
DR   UCSC; uc002xha.4; human.
DR   AGR; HGNC:1055; -.
DR   CTD; 10904; -.
DR   DisGeNET; 10904; -.
DR   GeneCards; BLCAP; -.
DR   HGNC; HGNC:1055; BLCAP.
DR   HPA; ENSG00000166619; Tissue enhanced (skeletal).
DR   MIM; 613110; gene.
DR   neXtProt; NX_P62952; -.
DR   OpenTargets; ENSG00000166619; -.
DR   PharmGKB; PA25367; -.
DR   VEuPathDB; HostDB:ENSG00000166619; -.
DR   eggNOG; KOG4489; Eukaryota.
DR   GeneTree; ENSGT00390000014105; -.
DR   InParanoid; P62952; -.
DR   OMA; FLLCYSC; -.
DR   OrthoDB; 2871594at2759; -.
DR   PhylomeDB; P62952; -.
DR   TreeFam; TF313306; -.
DR   PathwayCommons; P62952; -.
DR   SignaLink; P62952; -.
DR   BioGRID-ORCS; 10904; 26 hits in 1164 CRISPR screens.
DR   ChiTaRS; BLCAP; human.
DR   GeneWiki; BLCAP; -.
DR   GenomeRNAi; 10904; -.
DR   Pharos; P62952; Tbio.
DR   PRO; PR:P62952; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; P62952; Protein.
DR   Bgee; ENSG00000166619; Expressed in secondary oocyte and 209 other cell types or tissues.
DR   ExpressionAtlas; P62952; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030262; P:apoptotic nuclear changes; IDA:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR009598; BC10.
DR   PANTHER; PTHR13259; BLADDER CANCER 10 KD PROTEIN HOMOLOG; 1.
DR   PANTHER; PTHR13259:SF1; BLADDER CANCER-ASSOCIATED PROTEIN; 1.
DR   Pfam; PF06726; BC10; 1.
DR   SMART; SM01396; BC10; 1.
DR   Genevisible; P62952; HS.
PE   1: Evidence at protein level;
KW   Apoptosis; Cell cycle; Membrane; Reference proteome; RNA editing;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..87
FT                   /note="Bladder cancer-associated protein"
FT                   /id="PRO_0000064850"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         2
FT                   /note="Y -> C (in RNA edited version; dbSNP:rs11557677)"
FT                   /id="VAR_068908"
FT   VARIANT         5
FT                   /note="Q -> R (in RNA edited version)"
FT                   /id="VAR_068909"
FT   VARIANT         15
FT                   /note="K -> R (in RNA edited version; dbSNP:rs11557676)"
FT                   /id="VAR_068910"
SQ   SEQUENCE   87 AA;  9876 MW;  06A45C03E27D3E87 CRC64;
     MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS
     CWGNCFLYHC SDSPLPESAH DPGVVGT
//