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Protein

Bladder cancer-associated protein

Gene

BLCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.1 Publication

GO - Biological processi

  • apoptotic nuclear changes Source: UniProtKB
  • cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name:
Bc10
Gene namesi
Name:BLCAP
Synonyms:BC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1055. BLCAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25367.

Polymorphism and mutation databases

BioMutaiBLCAP.
DMDMi51702217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Bladder cancer-associated proteinPRO_0000064850Add
BLAST

Proteomic databases

PRIDEiP62952.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.3 Publications

Gene expression databases

BgeeiP62952.
CleanExiHS_BLCAP.
ExpressionAtlasiP62952. baseline and differential.
GenevisibleiP62952. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-3895726,EBI-78473
NOTCH2NLQ7Z3S93EBI-3895726,EBI-945833
SKAP1Q86WV13EBI-3895726,EBI-2477305

Protein-protein interaction databases

BioGridi116110. 3 interactions.
IntActiP62952. 3 interactions.
STRINGi9606.ENSP00000362637.

Structurei

3D structure databases

ProteinModelPortaliP62952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BLCAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255452.
GeneTreeiENSGT00390000014105.
HOVERGENiHBG105413.
InParanoidiP62952.
OMAiERKPCTV.
OrthoDBiEOG7J9VS1.
PhylomeDBiP62952.
TreeFamiTF313306.

Family and domain databases

InterProiIPR009598. BC10.
IPR018015. BC10-like.
[Graphical view]
PANTHERiPTHR13259. PTHR13259. 1 hit.
PfamiPF06726. BC10. 1 hit.
[Graphical view]
ProDomiPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P62952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF
60 70 80
LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT
Length:87
Mass (Da):9,876
Last modified:August 31, 2004 - v1
Checksum:i06A45C03E27D3E87
GO

RNA editingi

Edited at positions 2, 5 and 15.1 Publication
Partially edited. Decreased editing levels seen in astrocytomas, bladder cancer and colorectal cancer as compared to the related normal tissues.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21Y → C in RNA edited version.
VAR_068908
Natural varianti5 – 51Q → R in RNA edited version.
VAR_068909
Natural varianti15 – 151K → R in RNA edited version.
VAR_068910

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053470 mRNA. Translation: AAC06370.1.
AL109614 Genomic DNA. Translation: CAC00475.1.
AL109614 Genomic DNA. Translation: CAM19261.1.
BC047692 mRNA. Translation: AAH47692.1.
BC071704 mRNA. Translation: AAH71704.1.
CCDSiCCDS13295.1.
RefSeqiNP_001161292.1. NM_001167820.1.
NP_001161293.1. NM_001167821.1.
NP_001161294.1. NM_001167822.1.
NP_001161295.1. NM_001167823.1.
NP_006689.1. NM_006698.3.
UniGeneiHs.472651.

Genome annotation databases

EnsembliENST00000373537; ENSP00000362637; ENSG00000166619.
ENST00000397131; ENSP00000380320; ENSG00000166619.
ENST00000397134; ENSP00000380323; ENSG00000166619.
ENST00000397135; ENSP00000380324; ENSG00000166619.
ENST00000397137; ENSP00000380326; ENSG00000166619.
ENST00000414542; ENSP00000397172; ENSG00000166619.
ENST00000432507; ENSP00000414973; ENSG00000166619.
GeneIDi10904.
KEGGihsa:10904.
UCSCiuc002xha.3. human.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053470 mRNA. Translation: AAC06370.1.
AL109614 Genomic DNA. Translation: CAC00475.1.
AL109614 Genomic DNA. Translation: CAM19261.1.
BC047692 mRNA. Translation: AAH47692.1.
BC071704 mRNA. Translation: AAH71704.1.
CCDSiCCDS13295.1.
RefSeqiNP_001161292.1. NM_001167820.1.
NP_001161293.1. NM_001167821.1.
NP_001161294.1. NM_001167822.1.
NP_001161295.1. NM_001167823.1.
NP_006689.1. NM_006698.3.
UniGeneiHs.472651.

3D structure databases

ProteinModelPortaliP62952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116110. 3 interactions.
IntActiP62952. 3 interactions.
STRINGi9606.ENSP00000362637.

Polymorphism and mutation databases

BioMutaiBLCAP.
DMDMi51702217.

Proteomic databases

PRIDEiP62952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373537; ENSP00000362637; ENSG00000166619.
ENST00000397131; ENSP00000380320; ENSG00000166619.
ENST00000397134; ENSP00000380323; ENSG00000166619.
ENST00000397135; ENSP00000380324; ENSG00000166619.
ENST00000397137; ENSP00000380326; ENSG00000166619.
ENST00000414542; ENSP00000397172; ENSG00000166619.
ENST00000432507; ENSP00000414973; ENSG00000166619.
GeneIDi10904.
KEGGihsa:10904.
UCSCiuc002xha.3. human.

Organism-specific databases

CTDi10904.
GeneCardsiGC20M036130.
HGNCiHGNC:1055. BLCAP.
MIMi613110. gene.
neXtProtiNX_P62952.
PharmGKBiPA25367.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG255452.
GeneTreeiENSGT00390000014105.
HOVERGENiHBG105413.
InParanoidiP62952.
OMAiERKPCTV.
OrthoDBiEOG7J9VS1.
PhylomeDBiP62952.
TreeFamiTF313306.

Miscellaneous databases

ChiTaRSiBLCAP. human.
GeneWikiiBLCAP.
GenomeRNAii10904.
NextBioi41415.
PROiP62952.
SOURCEiSearch...

Gene expression databases

BgeeiP62952.
CleanExiHS_BLCAP.
ExpressionAtlasiP62952. baseline and differential.
GenevisibleiP62952. HS.

Family and domain databases

InterProiIPR009598. BC10.
IPR018015. BC10-like.
[Graphical view]
PANTHERiPTHR13259. PTHR13259. 1 hit.
PfamiPF06726. BC10. 1 hit.
[Graphical view]
ProDomiPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure."
    Gromova I., Gromov P., Celis J.E.
    Electrophoresis 20:241-248(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Urinary bladder.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Lung.
  4. "Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma."
    Zuo Z., Zhao M., Liu J., Gao G., Wu X.
    Tumor Biol. 27:221-226(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."
    Yao J., Duan L., Fan M., Yuan J., Wu X.
    Mol. Cell. Biochem. 297:81-92(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: RNA EDITING OF POSITIONS 2; 5 AND 15, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBLCAP_HUMAN
AccessioniPrimary (citable) accession number: P62952
Secondary accession number(s): A2A2K7, O60629, Q9D3B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 24, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.