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P62952

- BLCAP_HUMAN

UniProt

P62952 - BLCAP_HUMAN

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Protein

Bladder cancer-associated protein

Gene
BLCAP, BC10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic nuclear changes Source: UniProtKB
  2. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name:
Bc10
Gene namesi
Name:BLCAP
Synonyms:BC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:1055. BLCAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Bladder cancer-associated proteinPRO_0000064850Add
BLAST

Proteomic databases

PRIDEiP62952.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.3 Publications

Gene expression databases

ArrayExpressiP62952.
BgeeiP62952.
CleanExiHS_BLCAP.
GenevestigatoriP62952.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ESR1P033722EBI-3895726,EBI-78473

Protein-protein interaction databases

BioGridi116110. 1 interaction.
IntActiP62952. 1 interaction.
STRINGi9606.ENSP00000362637.

Structurei

3D structure databases

ProteinModelPortaliP62952.

Family & Domainsi

Sequence similaritiesi

Belongs to the BLCAP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255452.
HOVERGENiHBG105413.
InParanoidiP62952.
OMAiQTHVMFM.
OrthoDBiEOG7J9VS1.
PhylomeDBiP62952.
TreeFamiTF313306.

Family and domain databases

InterProiIPR009598. BC10.
IPR018015. BC10-like.
[Graphical view]
PANTHERiPTHR13259. PTHR13259. 1 hit.
PfamiPF06726. BC10. 1 hit.
[Graphical view]
ProDomiPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P62952-1 [UniParc]FASTAAdd to Basket

« Hide

MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF   50
LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT 87
Length:87
Mass (Da):9,876
Last modified:August 31, 2004 - v1
Checksum:i06A45C03E27D3E87
GO

RNA editingi

Partially edited. Decreased editing levels seen in astrocytomas, bladder cancer and colorectal cancer as compared to the related normal tissues.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21Y → C in RNA edited version.
VAR_068908
Natural varianti5 – 51Q → R in RNA edited version.
VAR_068909
Natural varianti15 – 151K → R in RNA edited version.
VAR_068910

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053470 mRNA. Translation: AAC06370.1.
AL109614 Genomic DNA. Translation: CAC00475.1.
AL109614 Genomic DNA. Translation: CAM19261.1.
BC047692 mRNA. Translation: AAH47692.1.
BC071704 mRNA. Translation: AAH71704.1.
CCDSiCCDS13295.1.
RefSeqiNP_001161292.1. NM_001167820.1.
NP_001161293.1. NM_001167821.1.
NP_001161294.1. NM_001167822.1.
NP_001161295.1. NM_001167823.1.
NP_006689.1. NM_006698.3.
UniGeneiHs.472651.

Genome annotation databases

EnsembliENST00000373537; ENSP00000362637; ENSG00000166619.
ENST00000397131; ENSP00000380320; ENSG00000166619.
ENST00000397134; ENSP00000380323; ENSG00000166619.
ENST00000397135; ENSP00000380324; ENSG00000166619.
ENST00000397137; ENSP00000380326; ENSG00000166619.
ENST00000414542; ENSP00000397172; ENSG00000166619.
ENST00000432507; ENSP00000414973; ENSG00000166619.
GeneIDi10904.
KEGGihsa:10904.
UCSCiuc002xha.3. human.

Polymorphism databases

DMDMi51702217.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053470 mRNA. Translation: AAC06370.1 .
AL109614 Genomic DNA. Translation: CAC00475.1 .
AL109614 Genomic DNA. Translation: CAM19261.1 .
BC047692 mRNA. Translation: AAH47692.1 .
BC071704 mRNA. Translation: AAH71704.1 .
CCDSi CCDS13295.1.
RefSeqi NP_001161292.1. NM_001167820.1.
NP_001161293.1. NM_001167821.1.
NP_001161294.1. NM_001167822.1.
NP_001161295.1. NM_001167823.1.
NP_006689.1. NM_006698.3.
UniGenei Hs.472651.

3D structure databases

ProteinModelPortali P62952.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116110. 1 interaction.
IntActi P62952. 1 interaction.
STRINGi 9606.ENSP00000362637.

Polymorphism databases

DMDMi 51702217.

Proteomic databases

PRIDEi P62952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373537 ; ENSP00000362637 ; ENSG00000166619 .
ENST00000397131 ; ENSP00000380320 ; ENSG00000166619 .
ENST00000397134 ; ENSP00000380323 ; ENSG00000166619 .
ENST00000397135 ; ENSP00000380324 ; ENSG00000166619 .
ENST00000397137 ; ENSP00000380326 ; ENSG00000166619 .
ENST00000414542 ; ENSP00000397172 ; ENSG00000166619 .
ENST00000432507 ; ENSP00000414973 ; ENSG00000166619 .
GeneIDi 10904.
KEGGi hsa:10904.
UCSCi uc002xha.3. human.

Organism-specific databases

CTDi 10904.
GeneCardsi GC20M036130.
HGNCi HGNC:1055. BLCAP.
MIMi 613110. gene.
neXtProti NX_P62952.
PharmGKBi PA25367.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255452.
HOVERGENi HBG105413.
InParanoidi P62952.
OMAi QTHVMFM.
OrthoDBi EOG7J9VS1.
PhylomeDBi P62952.
TreeFami TF313306.

Miscellaneous databases

ChiTaRSi BLCAP. human.
GeneWikii BLCAP.
GenomeRNAii 10904.
NextBioi 41415.
PROi P62952.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62952.
Bgeei P62952.
CleanExi HS_BLCAP.
Genevestigatori P62952.

Family and domain databases

InterProi IPR009598. BC10.
IPR018015. BC10-like.
[Graphical view ]
PANTHERi PTHR13259. PTHR13259. 1 hit.
Pfami PF06726. BC10. 1 hit.
[Graphical view ]
ProDomi PD062192. BC10-like. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure."
    Gromova I., Gromov P., Celis J.E.
    Electrophoresis 20:241-248(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Urinary bladder.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Lung.
  4. "Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma."
    Zuo Z., Zhao M., Liu J., Gao G., Wu X.
    Tumor Biol. 27:221-226(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."
    Yao J., Duan L., Fan M., Yuan J., Wu X.
    Mol. Cell. Biochem. 297:81-92(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: RNA EDITING OF POSITIONS 2; 5 AND 15, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBLCAP_HUMAN
AccessioniPrimary (citable) accession number: P62952
Secondary accession number(s): A2A2K7, O60629, Q9D3B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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