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P62952

- BLCAP_HUMAN

UniProt

P62952 - BLCAP_HUMAN

Protein

Bladder cancer-associated protein

Gene

BLCAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic nuclear changes Source: UniProtKB
    2. cell cycle Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bladder cancer-associated protein
    Alternative name(s):
    Bladder cancer 10 kDa protein
    Short name:
    Bc10
    Gene namesi
    Name:BLCAP
    Synonyms:BC10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:1055. BLCAP.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25367.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8787Bladder cancer-associated proteinPRO_0000064850Add
    BLAST

    Proteomic databases

    PRIDEiP62952.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.3 Publications

    Gene expression databases

    ArrayExpressiP62952.
    BgeeiP62952.
    CleanExiHS_BLCAP.
    GenevestigatoriP62952.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ESR1P033722EBI-3895726,EBI-78473

    Protein-protein interaction databases

    BioGridi116110. 1 interaction.
    IntActiP62952. 1 interaction.
    STRINGi9606.ENSP00000362637.

    Structurei

    3D structure databases

    ProteinModelPortaliP62952.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BLCAP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255452.
    HOVERGENiHBG105413.
    InParanoidiP62952.
    OMAiQTHVMFM.
    OrthoDBiEOG7J9VS1.
    PhylomeDBiP62952.
    TreeFamiTF313306.

    Family and domain databases

    InterProiIPR009598. BC10.
    IPR018015. BC10-like.
    [Graphical view]
    PANTHERiPTHR13259. PTHR13259. 1 hit.
    PfamiPF06726. BC10. 1 hit.
    [Graphical view]
    ProDomiPD062192. BC10-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P62952-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF   50
    LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT 87
    Length:87
    Mass (Da):9,876
    Last modified:August 31, 2004 - v1
    Checksum:i06A45C03E27D3E87
    GO

    RNA editingi

    Partially edited. Decreased editing levels seen in astrocytomas, bladder cancer and colorectal cancer as compared to the related normal tissues.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21Y → C in RNA edited version.
    VAR_068908
    Natural varianti5 – 51Q → R in RNA edited version.
    VAR_068909
    Natural varianti15 – 151K → R in RNA edited version.
    VAR_068910

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053470 mRNA. Translation: AAC06370.1.
    AL109614 Genomic DNA. Translation: CAC00475.1.
    AL109614 Genomic DNA. Translation: CAM19261.1.
    BC047692 mRNA. Translation: AAH47692.1.
    BC071704 mRNA. Translation: AAH71704.1.
    CCDSiCCDS13295.1.
    RefSeqiNP_001161292.1. NM_001167820.1.
    NP_001161293.1. NM_001167821.1.
    NP_001161294.1. NM_001167822.1.
    NP_001161295.1. NM_001167823.1.
    NP_006689.1. NM_006698.3.
    UniGeneiHs.472651.

    Genome annotation databases

    EnsembliENST00000373537; ENSP00000362637; ENSG00000166619.
    ENST00000397131; ENSP00000380320; ENSG00000166619.
    ENST00000397134; ENSP00000380323; ENSG00000166619.
    ENST00000397135; ENSP00000380324; ENSG00000166619.
    ENST00000397137; ENSP00000380326; ENSG00000166619.
    ENST00000414542; ENSP00000397172; ENSG00000166619.
    ENST00000432507; ENSP00000414973; ENSG00000166619.
    GeneIDi10904.
    KEGGihsa:10904.
    UCSCiuc002xha.3. human.

    Polymorphism databases

    DMDMi51702217.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053470 mRNA. Translation: AAC06370.1 .
    AL109614 Genomic DNA. Translation: CAC00475.1 .
    AL109614 Genomic DNA. Translation: CAM19261.1 .
    BC047692 mRNA. Translation: AAH47692.1 .
    BC071704 mRNA. Translation: AAH71704.1 .
    CCDSi CCDS13295.1.
    RefSeqi NP_001161292.1. NM_001167820.1.
    NP_001161293.1. NM_001167821.1.
    NP_001161294.1. NM_001167822.1.
    NP_001161295.1. NM_001167823.1.
    NP_006689.1. NM_006698.3.
    UniGenei Hs.472651.

    3D structure databases

    ProteinModelPortali P62952.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116110. 1 interaction.
    IntActi P62952. 1 interaction.
    STRINGi 9606.ENSP00000362637.

    Polymorphism databases

    DMDMi 51702217.

    Proteomic databases

    PRIDEi P62952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373537 ; ENSP00000362637 ; ENSG00000166619 .
    ENST00000397131 ; ENSP00000380320 ; ENSG00000166619 .
    ENST00000397134 ; ENSP00000380323 ; ENSG00000166619 .
    ENST00000397135 ; ENSP00000380324 ; ENSG00000166619 .
    ENST00000397137 ; ENSP00000380326 ; ENSG00000166619 .
    ENST00000414542 ; ENSP00000397172 ; ENSG00000166619 .
    ENST00000432507 ; ENSP00000414973 ; ENSG00000166619 .
    GeneIDi 10904.
    KEGGi hsa:10904.
    UCSCi uc002xha.3. human.

    Organism-specific databases

    CTDi 10904.
    GeneCardsi GC20M036130.
    HGNCi HGNC:1055. BLCAP.
    MIMi 613110. gene.
    neXtProti NX_P62952.
    PharmGKBi PA25367.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255452.
    HOVERGENi HBG105413.
    InParanoidi P62952.
    OMAi QTHVMFM.
    OrthoDBi EOG7J9VS1.
    PhylomeDBi P62952.
    TreeFami TF313306.

    Miscellaneous databases

    ChiTaRSi BLCAP. human.
    GeneWikii BLCAP.
    GenomeRNAii 10904.
    NextBioi 41415.
    PROi P62952.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62952.
    Bgeei P62952.
    CleanExi HS_BLCAP.
    Genevestigatori P62952.

    Family and domain databases

    InterProi IPR009598. BC10.
    IPR018015. BC10-like.
    [Graphical view ]
    PANTHERi PTHR13259. PTHR13259. 1 hit.
    Pfami PF06726. BC10. 1 hit.
    [Graphical view ]
    ProDomi PD062192. BC10-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure."
      Gromova I., Gromov P., Celis J.E.
      Electrophoresis 20:241-248(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Urinary bladder.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Lung.
    4. "Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma."
      Zuo Z., Zhao M., Liu J., Gao G., Wu X.
      Tumor Biol. 27:221-226(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."
      Yao J., Duan L., Fan M., Yuan J., Wu X.
      Mol. Cell. Biochem. 297:81-92(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: RNA EDITING OF POSITIONS 2; 5 AND 15, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiBLCAP_HUMAN
    AccessioniPrimary (citable) accession number: P62952
    Secondary accession number(s): A2A2K7, O60629, Q9D3B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3