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P62952 (BLCAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name=Bc10
Gene names
Name:BLCAP
Synonyms:BC10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. Ref.5

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma. Ref.1 Ref.4 Ref.6

Sequence similarities

Belongs to the BLCAP family.

RNA editing

Edited at positions 2, 5 and 15.
Partially edited. Decreased editing levels seen in astrocytomas, bladder cancer and colorectal cancer as compared to the related normal tissues. Ref.6

Ontologies

Keywords
   Biological processApoptosis
Cell cycle
   Cellular componentMembrane
   Coding sequence diversityRNA editing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic nuclear changes

Inferred from direct assay Ref.5. Source: UniProtKB

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 21217774. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ESR1P033722EBI-3895726,EBI-78473

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8787Bladder cancer-associated protein
PRO_0000064850

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane43 – 6321Helical; Potential

Natural variations

Natural variant21Y → C in RNA edited version.
VAR_068908
Natural variant51Q → R in RNA edited version.
VAR_068909
Natural variant151K → R in RNA edited version.
VAR_068910

Sequences

Sequence LengthMass (Da)Tools
P62952 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: 06A45C03E27D3E87

FASTA879,876
        10         20         30         40         50         60 
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS 

        70         80 
CWGNCFLYHC SDSPLPESAH DPGVVGT 

« Hide

References

« Hide 'large scale' references
[1]"Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure."
Gromova I., Gromov P., Celis J.E.
Electrophoresis 20:241-248(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Urinary bladder.
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Lung.
[4]"Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma."
Zuo Z., Zhao M., Liu J., Gao G., Wu X.
Tumor Biol. 27:221-226(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma: BLCAP overexpression induces S phase arrest and apoptosis."
Yao J., Duan L., Fan M., Yuan J., Wu X.
Mol. Cell. Biochem. 297:81-92(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Human BLCAP transcript: new editing events in normal and cancerous tissues."
Galeano F., Leroy A., Rossetti C., Gromova I., Gautier P., Keegan L.P., Massimi L., Di Rocco C., O'Connell M.A., Gallo A.
Int. J. Cancer 127:127-137(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING OF POSITIONS 2; 5 AND 15, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053470 mRNA. Translation: AAC06370.1.
AL109614 Genomic DNA. Translation: CAC00475.1.
AL109614 Genomic DNA. Translation: CAM19261.1.
BC047692 mRNA. Translation: AAH47692.1.
BC071704 mRNA. Translation: AAH71704.1.
CCDSCCDS13295.1.
RefSeqNP_001161292.1. NM_001167820.1.
NP_001161293.1. NM_001167821.1.
NP_001161294.1. NM_001167822.1.
NP_001161295.1. NM_001167823.1.
NP_006689.1. NM_006698.3.
UniGeneHs.472651.

3D structure databases

ProteinModelPortalP62952.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116110. 1 interaction.
IntActP62952. 1 interaction.
STRING9606.ENSP00000362637.

Polymorphism databases

DMDM51702217.

Proteomic databases

PRIDEP62952.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373537; ENSP00000362637; ENSG00000166619.
ENST00000397131; ENSP00000380320; ENSG00000166619.
ENST00000397134; ENSP00000380323; ENSG00000166619.
ENST00000397135; ENSP00000380324; ENSG00000166619.
ENST00000397137; ENSP00000380326; ENSG00000166619.
ENST00000414542; ENSP00000397172; ENSG00000166619.
ENST00000432507; ENSP00000414973; ENSG00000166619.
GeneID10904.
KEGGhsa:10904.
UCSCuc002xha.3. human.

Organism-specific databases

CTD10904.
GeneCardsGC20M036130.
HGNCHGNC:1055. BLCAP.
MIM613110. gene.
neXtProtNX_P62952.
PharmGKBPA25367.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255452.
HOVERGENHBG105413.
InParanoidP62952.
OMAQTHVMFM.
OrthoDBEOG7J9VS1.
PhylomeDBP62952.
TreeFamTF313306.

Gene expression databases

ArrayExpressP62952.
BgeeP62952.
CleanExHS_BLCAP.
GenevestigatorP62952.

Family and domain databases

InterProIPR009598. BC10.
IPR018015. BC10-like.
[Graphical view]
PANTHERPTHR13259. PTHR13259. 1 hit.
PfamPF06726. BC10. 1 hit.
[Graphical view]
ProDomPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

ChiTaRSBLCAP. human.
GeneWikiBLCAP.
GenomeRNAi10904.
NextBio41415.
PROP62952.
SOURCESearch...

Entry information

Entry nameBLCAP_HUMAN
AccessionPrimary (citable) accession number: P62952
Secondary accession number(s): A2A2K7, O60629, Q9D3B5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM