Reviewed, UniProtKB/Swiss-Prot P62952 (BLCAP_HUMAN)

Names and origin

Protein names

Recommended name:
    Bladder cancer-associated protein
Alternative name(s):
    Bladder cancer 10 kDa protein
      Short name=Bc10

Gene names

Name:	BLCAP
Synonyms:	BC10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Tissue specificity	Expressed in cervical tissues. Down-regulated during bladder cancer progression and in most cervical carcinomas.
Sequence similarities	Belongs to the BLCAP family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Bladder cancer-associated protein		PRO_0000064850
Regions
	Transmembrane	19 – 39	21	Potential
	Transmembrane	43 – 63	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P62952-1 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 06A45C03E27D3E87	FASTA	87	9,876
	10 20 30 40 50 60 MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF LAALFLICYS 70 80 CWGNCFLYHC SDSPLPESAH DPGVVGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of true differentially expressed mRNAs in a pair of human bladder transitional cell carcinomas using an improved differential display procedure." Gromova I., Gromov P., Celis J.E. Electrophoresis 20:241-248(1999) [PubMed: 10197429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Urinary bladder.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Lung.
[4]	"Functional analysis of bladder cancer-related protein gene: a putative cervical cancer tumor suppressor gene in cervical carcinoma." Zuo Z., Zhao M., Liu J., Gao G., Wu X. Tumor Biol. 27:221-226(2006) [PubMed: 16675915] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF053470 mRNA. Translation: AAC06370.1. AL109614 Genomic DNA. Translation: CAC00475.1. AL109614 Genomic DNA. Translation: CAM19261.1. BC047692 mRNA. Translation: AAH47692.1. BC071704 mRNA. Translation: AAH71704.1.
RefSeq	NP_006689.1.
UniGene	Hs.472651 Hs.697283
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000166619. Homo sapiens. [Contig view]
GeneID	10904.
KEGG	hsa:10904.
Organism-specific databases
H-InvDB	HIX0015794.
HGNC	HGNC:1055. BLCAP.
PharmGKB	PA25367.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P62952.
HOVERGEN	P62952.
Gene expression databases
ArrayExpress	P62952.
CleanEx	HS_BLCAP.
GermOnline	ENSG00000166619. Homo sapiens.
Family and domain databases
InterPro	IPR009598. BC10. [Graphical view]
PANTHER	PTHR13259. BC10. 1 hit.
Pfam	PF06726. BC10. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	41415.

Entry information

Entry name

BLCAP_HUMAN

Accession

Primary (citable) accession number: P62952
Secondary accession number(s): A2A2K7, O60629, Q9D3B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	November 4, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)