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Protein

Bladder cancer-associated protein

Gene

Blcap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name:
Bc10
Gene namesi
Name:Blcap
Synonyms:Bc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858907. Blcap.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648511 – 87Bladder cancer-associated proteinAdd BLAST87

Proteomic databases

PaxDbiP62951.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067787.
ExpressionAtlasiP62951. baseline and differential.
GenevisibleiP62951. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085849.

Structurei

3D structure databases

ProteinModelPortaliP62951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BLCAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4489. Eukaryota.
ENOG4111WJP. LUCA.
GeneTreeiENSGT00390000014105.
HOVERGENiHBG105413.
InParanoidiP62951.
OMAiTHVMFMV.
OrthoDBiEOG091G18IM.
PhylomeDBiP62951.
TreeFamiTF313306.

Family and domain databases

InterProiIPR009598. BC10.
[Graphical view]
PANTHERiPTHR13259. PTHR13259. 1 hit.
ProDomiPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01396. BC10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF
60 70 80
LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT
Length:87
Mass (Da):9,876
Last modified:August 31, 2004 - v1
Checksum:i06A45C03E27D3E87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Y → C in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti2Y → C in AAH83339 (PubMed:15489334).Curated1
Sequence conflicti5Q → R in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti15K → R in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti87T → N in BAE41728 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037891 mRNA. Translation: BAA90646.1.
AF303656 Genomic DNA. Translation: AAL01183.1.
AK011673 mRNA. No translation available.
AK018127 mRNA. Translation: BAB31083.1.
AK170338 mRNA. Translation: BAE41728.1.
AL672259 Genomic DNA. Translation: CAM16144.1.
BC026935 mRNA. Translation: AAH26935.1.
BC083339 mRNA. Translation: AAH83339.1.
CCDSiCCDS16979.1.
RefSeqiNP_058612.3. NM_016916.3.
XP_006499963.1. XM_006499900.2.
UniGeneiMm.480461.
Mm.490288.

Genome annotation databases

EnsembliENSMUST00000088494; ENSMUSP00000085849; ENSMUSG00000067787.
ENSMUST00000109528; ENSMUSP00000105154; ENSMUSG00000067787.
GeneIDi53619.
KEGGimmu:53619.
UCSCiuc008npc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037891 mRNA. Translation: BAA90646.1.
AF303656 Genomic DNA. Translation: AAL01183.1.
AK011673 mRNA. No translation available.
AK018127 mRNA. Translation: BAB31083.1.
AK170338 mRNA. Translation: BAE41728.1.
AL672259 Genomic DNA. Translation: CAM16144.1.
BC026935 mRNA. Translation: AAH26935.1.
BC083339 mRNA. Translation: AAH83339.1.
CCDSiCCDS16979.1.
RefSeqiNP_058612.3. NM_016916.3.
XP_006499963.1. XM_006499900.2.
UniGeneiMm.480461.
Mm.490288.

3D structure databases

ProteinModelPortaliP62951.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085849.

Proteomic databases

PaxDbiP62951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088494; ENSMUSP00000085849; ENSMUSG00000067787.
ENSMUST00000109528; ENSMUSP00000105154; ENSMUSG00000067787.
GeneIDi53619.
KEGGimmu:53619.
UCSCiuc008npc.1. mouse.

Organism-specific databases

CTDi10904.
MGIiMGI:1858907. Blcap.

Phylogenomic databases

eggNOGiKOG4489. Eukaryota.
ENOG4111WJP. LUCA.
GeneTreeiENSGT00390000014105.
HOVERGENiHBG105413.
InParanoidiP62951.
OMAiTHVMFMV.
OrthoDBiEOG091G18IM.
PhylomeDBiP62951.
TreeFamiTF313306.

Miscellaneous databases

ChiTaRSiBlcap. mouse.
PROiP62951.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067787.
ExpressionAtlasiP62951. baseline and differential.
GenevisibleiP62951. MM.

Family and domain databases

InterProiIPR009598. BC10.
[Graphical view]
PANTHERiPTHR13259. PTHR13259. 1 hit.
ProDomiPD062192. BC10-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01396. BC10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLCAP_MOUSE
AccessioniPrimary (citable) accession number: P62951
Secondary accession number(s): A2AFZ4
, O60629, Q3TD76, Q5XJG3, Q9D3B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.