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Protein

Bladder cancer-associated protein

Gene

Blcap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name:
Bc10
Gene namesi
Name:Blcap
Synonyms:Bc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858907. Blcap.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648511 – 87Bladder cancer-associated proteinAdd BLAST87

Proteomic databases

PaxDbiP62951.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067787.
ExpressionAtlasiP62951. baseline and differential.
GenevisibleiP62951. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000085849.

Structurei

3D structure databases

ProteinModelPortaliP62951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BLCAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4489. Eukaryota.
ENOG4111WJP. LUCA.
GeneTreeiENSGT00390000014105.
HOVERGENiHBG105413.
InParanoidiP62951.
OMAiTHVMFMV.
OrthoDBiEOG091G18IM.
PhylomeDBiP62951.
TreeFamiTF313306.

Family and domain databases

InterProiView protein in InterPro
IPR009598. BC10.
PANTHERiPTHR13259. PTHR13259. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD062192. BC10-like. 1 hit.
SMARTiView protein in SMART
SM01396. BC10. 1 hit.

Sequencei

Sequence statusi: Complete.

P62951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF
60 70 80
LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT
Length:87
Mass (Da):9,876
Last modified:August 31, 2004 - v1
Checksum:i06A45C03E27D3E87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Y → C in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti2Y → C in AAH83339 (PubMed:15489334).Curated1
Sequence conflicti5Q → R in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti15K → R in BAB31083 (PubMed:16141072).Curated1
Sequence conflicti87T → N in BAE41728 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037891 mRNA. Translation: BAA90646.1.
AF303656 Genomic DNA. Translation: AAL01183.1.
AK011673 mRNA. No translation available.
AK018127 mRNA. Translation: BAB31083.1.
AK170338 mRNA. Translation: BAE41728.1.
AL672259 Genomic DNA. Translation: CAM16144.1.
BC026935 mRNA. Translation: AAH26935.1.
BC083339 mRNA. Translation: AAH83339.1.
CCDSiCCDS16979.1.
RefSeqiNP_058612.3. NM_016916.3.
XP_006499963.1. XM_006499900.2.
UniGeneiMm.480461.
Mm.490288.

Genome annotation databases

EnsembliENSMUST00000088494; ENSMUSP00000085849; ENSMUSG00000067787.
ENSMUST00000109528; ENSMUSP00000105154; ENSMUSG00000067787.
GeneIDi53619.
KEGGimmu:53619.
UCSCiuc008npc.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBLCAP_MOUSE
AccessioniPrimary (citable) accession number: P62951
Secondary accession number(s): A2AFZ4
, O60629, Q3TD76, Q5XJG3, Q9D3B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 10, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families