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Protein

60S ribosomal protein L41

Gene

RPL41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: CAFA
  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41
Alternative name(s):
HG12
Large ribosomal subunit protein eL411 Publication
Gene namesi
Name:RPL41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000229117.8.
HGNCiHGNC:10354. RPL41.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6171.
OpenTargetsiENSG00000229117.
PharmGKBiPA34750.

Polymorphism and mutation databases

BioMutaiRPL41.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980551 – 2560S ribosomal protein L41Add BLAST25

Proteomic databases

PaxDbiP62945.
PRIDEiP62945.

Expressioni

Gene expression databases

BgeeiENSG00000229117.
CleanExiHS_RPL41.
GenevisibleiP62945. HS.

Organism-specific databases

HPAiHPA053169.

Interactioni

Protein-protein interaction databases

BioGridi112090. 6 interactors.
CORUMiP62945.
DIPiDIP-46893N.
IntActiP62945. 6 interactors.
STRINGi9606.ENSP00000420821.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Ln1-25[»]
4V6Xelectron microscopy5.00Cn1-25[»]
5A2Qelectron microscopy3.90h2-25[»]
5AJ0electron microscopy3.50An1-25[»]
5LKSelectron microscopy3.60Ln1-25[»]
ProteinModelPortaliP62945.
SMRiP62945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00850000133577.
KOiK02928.

Family and domain databases

InterProiView protein in InterPro
IPR007836. Ribosomal_L41.
PfamiView protein in Pfam
PF05162. Ribosomal_L41. 1 hit.

Sequencei

Sequence statusi: Complete.

P62945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRAKWRKKRM RRLKRKRRKM RQRSK
Length:25
Mass (Da):3,456
Last modified:August 31, 2004 - v1
Checksum:i9AD629C69ECC039E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12962 mRNA. Translation: CAA78306.1.
AF026844 mRNA. Translation: AAB82715.1.
AB010874 Genomic DNA. Translation: BAA31508.1.
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1.
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
CCDSiCCDS44919.1.
PIRiJQ1617.
RefSeqiNP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGeneiHs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

Genome annotation databases

EnsembliENST00000501597; ENSP00000420821; ENSG00000229117.
ENST00000546591; ENSP00000449026; ENSG00000229117.
GeneIDi6171.
KEGGihsa:6171.
UCSCiuc001sjn.3. human.

Similar proteinsi

Entry informationi

Entry nameiRL41_HUMAN
AccessioniPrimary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 27, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are multiple pseudogenes of this gene dispersed through the genome.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families