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Protein

60S ribosomal protein L41

Gene

RPL41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Caution

There are multiple pseudogenes of this gene dispersed through the genome.Curated

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: CAFA
  • mRNA 5'-UTR binding Source: CAFA
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41
Alternative name(s):
HG12
Large ribosomal subunit protein eL411 Publication
Gene namesi
Name:RPL41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000229117.8
HGNCiHGNC:10354 RPL41
MIMi613315 gene
neXtProtiNX_P62945

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6171
OpenTargetsiENSG00000229117
PharmGKBiPA34750

Polymorphism and mutation databases

BioMutaiRPL41

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980551 – 2560S ribosomal protein L41Add BLAST25

Proteomic databases

PaxDbiP62945
PRIDEiP62945

Expressioni

Gene expression databases

BgeeiENSG00000229117
CleanExiHS_RPL41
GenevisibleiP62945 HS

Organism-specific databases

HPAiHPA053169

Interactioni

Protein-protein interaction databases

BioGridi112090, 6 interactors
CORUMiP62945
DIPiDIP-46893N
IntActiP62945, 7 interactors
STRINGi9606.ENSP00000420821

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Ln1-25[»]
4V6Xelectron microscopy5.00Cn1-25[»]
5A2Qelectron microscopy3.90h2-25[»]
5AJ0electron microscopy3.50An1-25[»]
5LKSelectron microscopy3.60Ln1-25[»]
5OA3electron microscopy4.30h2-25[»]
5VYCX-ray6.00j1/j2/j3/j4/j5/j61-25[»]
6EK0electron microscopy2.90Ln1-25[»]
ProteinModelPortaliP62945
SMRiP62945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000144387
KOiK02928

Family and domain databases

InterProiView protein in InterPro
IPR007836 Ribosomal_L41
PfamiView protein in Pfam
PF05162 Ribosomal_L41, 1 hit

Sequencei

Sequence statusi: Complete.

P62945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRAKWRKKRM RRLKRKRRKM RQRSK
Length:25
Mass (Da):3,456
Last modified:August 31, 2004 - v1
Checksum:i9AD629C69ECC039E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12962 mRNA Translation: CAA78306.1
AF026844 mRNA Translation: AAB82715.1
AB010874 Genomic DNA Translation: BAA31508.1
AL035562 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96886.1
BC014383 mRNA No translation available.
BC017820 mRNA No translation available.
BC032611 mRNA No translation available.
CCDSiCCDS44919.1
PIRiJQ1617
RefSeqiNP_001030344.1, NM_001035267.1
NP_066927.1, NM_021104.1
UniGeneiHs.112553
Hs.157160
Hs.356799
Hs.485899
Hs.632703
Hs.658436
Hs.660053

Genome annotation databases

EnsembliENST00000501597; ENSP00000420821; ENSG00000229117
ENST00000546591; ENSP00000449026; ENSG00000229117
GeneIDi6171
KEGGihsa:6171
UCSCiuc001sjn.3 human

Similar proteinsi

Entry informationi

Entry nameiRL41_HUMAN
AccessioniPrimary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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