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P62945 (RL41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L41
Alternative name(s):
HG12
Gene names
Name:RPL41
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length25 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Sequence similarities

Belongs to the ribosomal protein L41e family.

Caution

There are multiple pseudogenes of this gene dispersed through the genome.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRNPP041561EBI-2116899,EBI-977302

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252560S ribosomal protein L41
PRO_0000198055

Sequences

Sequence LengthMass (Da)Tools
P62945 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: 9AD629C69ECC039E

FASTA253,456
        10         20 
MRAKWRKKRM RRLKRKRRKM RQRSK 

« Hide

References

« Hide 'large scale' references
[1]"Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41."
Klaudiny J., von der Kammer H., Scheit K.H.
Biochem. Biophys. Res. Commun. 187:901-906(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII."
Lee J.-H., Kim J.-M., Kim M.-S., Lee Y.-T., Marshak D.R., Bae Y.-S.
Biochem. Biophys. Res. Commun. 238:462-467(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Characterization of human ribosomal protein L41 genomic structure."
Go H., Miyado K., Hasuwa H., Taniguchi S.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Prostate and Uterus.
[7]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z12962 mRNA. Translation: CAA78306.1.
AF026844 mRNA. Translation: AAB82715.1.
AB010874 Genomic DNA. Translation: BAA31508.1.
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1.
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
PIRJQ1617.
RefSeqNP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGeneHs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00n1-25[»]
ProteinModelPortalP62945.
SMRP62945. Positions 1-26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112090. 5 interactions.
IntActP62945. 5 interactions.
STRING9606.ENSP00000420821.

Protocols and materials databases

DNASU6171.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000501597; ENSP00000420821; ENSG00000229117.
ENST00000546591; ENSP00000449026; ENSG00000229117.
GeneID6171.
KEGGhsa:6171.
UCSCuc001sjn.3. human.

Organism-specific databases

CTD6171.
GeneCardsGC12P056510.
H-InvDBHIX0010716.
HIX0041240.
HGNCHGNC:10354. RPL41.
HPAHPA053169.
MIM613315. gene.
neXtProtNX_P62945.
PharmGKBPA34750.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275021.
KOK02928.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

BgeeP62945.
CleanExHS_RPL41.
GenevestigatorP62945.

Family and domain databases

InterProIPR007836. Ribosomal_L41.
[Graphical view]
PfamPF05162. Ribosomal_L41. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPL41. human.
GeneWiki60S_ribosomal_protein_L41.
GenomeRNAi6171.
NextBio23975.
PROP62945.
SOURCESearch...

Entry information

Entry nameRL41_HUMAN
AccessionPrimary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM