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Protein

60S ribosomal protein L41

Gene

RPL41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  4. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  5. translation Source: UniProtKB
  6. translational elongation Source: Reactome
  7. translational initiation Source: Reactome
  8. translational termination Source: Reactome
  9. viral life cycle Source: Reactome
  10. viral process Source: Reactome
  11. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41
Alternative name(s):
HG12
Gene namesi
Name:RPL41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 12, Chromosome 7, Unplaced

Organism-specific databases

HGNCiHGNC:10354. RPL41.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252560S ribosomal protein L41PRO_0000198055Add
BLAST

Expressioni

Gene expression databases

BgeeiP62945.
CleanExiHS_RPL41.
ExpressionAtlasiP62945. baseline.
GenevestigatoriP62945.

Organism-specific databases

HPAiHPA053169.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRNPP041561EBI-2116899,EBI-977302

Protein-protein interaction databases

BioGridi112090. 6 interactions.
DIPiDIP-46893N.
IntActiP62945. 5 interactions.
STRINGi9606.ENSP00000420821.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Cn1-25[»]
SMRiP62945. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L41e family.Curated

Phylogenomic databases

eggNOGiNOG275021.
KOiK02928.

Family and domain databases

InterProiIPR007836. Ribosomal_L41.
[Graphical view]
PfamiPF05162. Ribosomal_L41. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MRAKWRKKRM RRLKRKRRKM RQRSK
Length:25
Mass (Da):3,456
Last modified:August 30, 2004 - v1
Checksum:i9AD629C69ECC039E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12962 mRNA. Translation: CAA78306.1.
AF026844 mRNA. Translation: AAB82715.1.
AB010874 Genomic DNA. Translation: BAA31508.1.
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1.
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
CCDSiCCDS44919.1.
PIRiJQ1617.
RefSeqiNP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGeneiHs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

Genome annotation databases

EnsembliENST00000501597; ENSP00000420821; ENSG00000229117.
ENST00000546591; ENSP00000449026; ENSG00000229117.
ENST00000616602; ENSP00000483695; ENSG00000273716.
ENST00000617112; ENSP00000484734; ENSG00000274700.
ENST00000623936; ENSP00000485567; ENSG00000279483.
GeneIDi6171.
KEGGihsa:6171.
UCSCiuc001sjn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12962 mRNA. Translation: CAA78306.1.
AF026844 mRNA. Translation: AAB82715.1.
AB010874 Genomic DNA. Translation: BAA31508.1.
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1.
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
CCDSiCCDS44919.1.
PIRiJQ1617.
RefSeqiNP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGeneiHs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00Cn1-25[»]
SMRiP62945. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112090. 6 interactions.
DIPiDIP-46893N.
IntActiP62945. 5 interactions.
STRINGi9606.ENSP00000420821.

Protocols and materials databases

DNASUi6171.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000501597; ENSP00000420821; ENSG00000229117.
ENST00000546591; ENSP00000449026; ENSG00000229117.
ENST00000616602; ENSP00000483695; ENSG00000273716.
ENST00000617112; ENSP00000484734; ENSG00000274700.
ENST00000623936; ENSP00000485567; ENSG00000279483.
GeneIDi6171.
KEGGihsa:6171.
UCSCiuc001sjn.3. human.

Organism-specific databases

CTDi6171.
GeneCardsiGC12P056510.
H-InvDBHIX0010716.
HIX0041240.
HGNCiHGNC:10354. RPL41.
HPAiHPA053169.
MIMi613315. gene.
neXtProtiNX_P62945.
PharmGKBiPA34750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275021.
KOiK02928.

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSiRPL41. human.
GeneWikii60S_ribosomal_protein_L41.
GenomeRNAii6171.
NextBioi23975.
PROiP62945.
SOURCEiSearch...

Gene expression databases

BgeeiP62945.
CleanExiHS_RPL41.
ExpressionAtlasiP62945. baseline.
GenevestigatoriP62945.

Family and domain databases

InterProiIPR007836. Ribosomal_L41.
[Graphical view]
PfamiPF05162. Ribosomal_L41. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41."
    Klaudiny J., von der Kammer H., Scheit K.H.
    Biochem. Biophys. Res. Commun. 187:901-906(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII."
    Lee J.-H., Kim J.-M., Kim M.-S., Lee Y.-T., Marshak D.R., Bae Y.-S.
    Biochem. Biophys. Res. Commun. 238:462-467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterization of human ribosomal protein L41 genomic structure."
    Go H., Miyado K., Hasuwa H., Taniguchi S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Prostate and Uterus.
  7. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL41_HUMAN
AccessioniPrimary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2004
Last sequence update: August 30, 2004
Last modified: March 31, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are multiple pseudogenes of this gene dispersed through the genome.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.