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P62945

- RL41_HUMAN

UniProt

P62945 - RL41_HUMAN

Protein

60S ribosomal protein L41

Gene

RPL41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

    GO - Molecular functioni

    1. RNA binding Source: ProtInc
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L41
    Alternative name(s):
    HG12
    Gene namesi
    Name:RPL41
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10354. RPL41.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252560S ribosomal protein L41PRO_0000198055Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiP62945.
    CleanExiHS_RPL41.
    GenevestigatoriP62945.

    Organism-specific databases

    HPAiHPA053169.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRNPP041561EBI-2116899,EBI-977302

    Protein-protein interaction databases

    BioGridi112090. 5 interactions.
    IntActiP62945. 5 interactions.
    STRINGi9606.ENSP00000420821.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00n1-25[»]
    ProteinModelPortaliP62945.
    SMRiP62945. Positions 1-26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L41e family.Curated

    Phylogenomic databases

    eggNOGiNOG275021.
    KOiK02928.
    OMAiHICVDIC.

    Family and domain databases

    InterProiIPR007836. Ribosomal_L41.
    [Graphical view]
    PfamiPF05162. Ribosomal_L41. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAKWRKKRM RRLKRKRRKM RQRSK                              25
    Length:25
    Mass (Da):3,456
    Last modified:August 31, 2004 - v1
    Checksum:i9AD629C69ECC039E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12962 mRNA. Translation: CAA78306.1.
    AF026844 mRNA. Translation: AAB82715.1.
    AB010874 Genomic DNA. Translation: BAA31508.1.
    AL035562 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96886.1.
    BC014383 mRNA. No translation available.
    BC017820 mRNA. No translation available.
    BC032611 mRNA. No translation available.
    CCDSiCCDS44919.1.
    PIRiJQ1617.
    RefSeqiNP_001030344.1. NM_001035267.1.
    NP_066927.1. NM_021104.1.
    UniGeneiHs.112553.
    Hs.157160.
    Hs.356799.
    Hs.485899.
    Hs.632703.
    Hs.658436.
    Hs.660053.

    Genome annotation databases

    EnsembliENST00000501597; ENSP00000420821; ENSG00000229117.
    ENST00000546591; ENSP00000449026; ENSG00000229117.
    GeneIDi6171.
    KEGGihsa:6171.
    UCSCiuc001sjn.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z12962 mRNA. Translation: CAA78306.1 .
    AF026844 mRNA. Translation: AAB82715.1 .
    AB010874 Genomic DNA. Translation: BAA31508.1 .
    AL035562 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW96886.1 .
    BC014383 mRNA. No translation available.
    BC017820 mRNA. No translation available.
    BC032611 mRNA. No translation available.
    CCDSi CCDS44919.1.
    PIRi JQ1617.
    RefSeqi NP_001030344.1. NM_001035267.1.
    NP_066927.1. NM_021104.1.
    UniGenei Hs.112553.
    Hs.157160.
    Hs.356799.
    Hs.485899.
    Hs.632703.
    Hs.658436.
    Hs.660053.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 n 1-25 [» ]
    ProteinModelPortali P62945.
    SMRi P62945. Positions 1-26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112090. 5 interactions.
    IntActi P62945. 5 interactions.
    STRINGi 9606.ENSP00000420821.

    Protocols and materials databases

    DNASUi 6171.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000501597 ; ENSP00000420821 ; ENSG00000229117 .
    ENST00000546591 ; ENSP00000449026 ; ENSG00000229117 .
    GeneIDi 6171.
    KEGGi hsa:6171.
    UCSCi uc001sjn.3. human.

    Organism-specific databases

    CTDi 6171.
    GeneCardsi GC12P056510.
    H-InvDB HIX0010716.
    HIX0041240.
    HGNCi HGNC:10354. RPL41.
    HPAi HPA053169.
    MIMi 613315. gene.
    neXtProti NX_P62945.
    PharmGKBi PA34750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275021.
    KOi K02928.
    OMAi HICVDIC.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL41. human.
    GeneWikii 60S_ribosomal_protein_L41.
    GenomeRNAii 6171.
    NextBioi 23975.
    PROi P62945.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62945.
    CleanExi HS_RPL41.
    Genevestigatori P62945.

    Family and domain databases

    InterProi IPR007836. Ribosomal_L41.
    [Graphical view ]
    Pfami PF05162. Ribosomal_L41. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41."
      Klaudiny J., von der Kammer H., Scheit K.H.
      Biochem. Biophys. Res. Commun. 187:901-906(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII."
      Lee J.-H., Kim J.-M., Kim M.-S., Lee Y.-T., Marshak D.R., Bae Y.-S.
      Biochem. Biophys. Res. Commun. 238:462-467(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Characterization of human ribosomal protein L41 genomic structure."
      Go H., Miyado K., Hasuwa H., Taniguchi S.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Prostate and Uterus.
    7. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL41_HUMAN
    AccessioniPrimary (citable) accession number: P62945
    Secondary accession number(s): A6NG21, P28751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    There are multiple pseudogenes of this gene dispersed through the genome.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3