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P62945

- RL41_HUMAN

UniProt

P62945 - RL41_HUMAN

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Protein

60S ribosomal protein L41

Gene
RPL41
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. RNA metabolic process Source: Reactome
  6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  7. translation Source: UniProtKB
  8. translational elongation Source: Reactome
  9. translational initiation Source: Reactome
  10. translational termination Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
  13. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L41
Alternative name(s):
HG12
Gene namesi
Name:RPL41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10354. RPL41.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252560S ribosomal protein L41PRO_0000198055Add
BLAST

Expressioni

Gene expression databases

BgeeiP62945.
CleanExiHS_RPL41.
GenevestigatoriP62945.

Organism-specific databases

HPAiHPA053169.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRNPP041561EBI-2116899,EBI-977302

Protein-protein interaction databases

BioGridi112090. 5 interactions.
IntActiP62945. 5 interactions.
STRINGi9606.ENSP00000420821.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00n1-25[»]
ProteinModelPortaliP62945.
SMRiP62945. Positions 1-26.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG275021.
KOiK02928.
OMAiHICVDIC.

Family and domain databases

InterProiIPR007836. Ribosomal_L41.
[Graphical view]
PfamiPF05162. Ribosomal_L41. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62945-1 [UniParc]FASTAAdd to Basket

« Hide

MRAKWRKKRM RRLKRKRRKM RQRSK                              25
Length:25
Mass (Da):3,456
Last modified:August 31, 2004 - v1
Checksum:i9AD629C69ECC039E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12962 mRNA. Translation: CAA78306.1.
AF026844 mRNA. Translation: AAB82715.1.
AB010874 Genomic DNA. Translation: BAA31508.1.
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1.
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
CCDSiCCDS44919.1.
PIRiJQ1617.
RefSeqiNP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGeneiHs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

Genome annotation databases

EnsembliENST00000501597; ENSP00000420821; ENSG00000229117.
ENST00000546591; ENSP00000449026; ENSG00000229117.
GeneIDi6171.
KEGGihsa:6171.
UCSCiuc001sjn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12962 mRNA. Translation: CAA78306.1 .
AF026844 mRNA. Translation: AAB82715.1 .
AB010874 Genomic DNA. Translation: BAA31508.1 .
AL035562 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96886.1 .
BC014383 mRNA. No translation available.
BC017820 mRNA. No translation available.
BC032611 mRNA. No translation available.
CCDSi CCDS44919.1.
PIRi JQ1617.
RefSeqi NP_001030344.1. NM_001035267.1.
NP_066927.1. NM_021104.1.
UniGenei Hs.112553.
Hs.157160.
Hs.356799.
Hs.485899.
Hs.632703.
Hs.658436.
Hs.660053.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 n 1-25 [» ]
ProteinModelPortali P62945.
SMRi P62945. Positions 1-26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112090. 5 interactions.
IntActi P62945. 5 interactions.
STRINGi 9606.ENSP00000420821.

Protocols and materials databases

DNASUi 6171.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000501597 ; ENSP00000420821 ; ENSG00000229117 .
ENST00000546591 ; ENSP00000449026 ; ENSG00000229117 .
GeneIDi 6171.
KEGGi hsa:6171.
UCSCi uc001sjn.3. human.

Organism-specific databases

CTDi 6171.
GeneCardsi GC12P056510.
H-InvDB HIX0010716.
HIX0041240.
HGNCi HGNC:10354. RPL41.
HPAi HPA053169.
MIMi 613315. gene.
neXtProti NX_P62945.
PharmGKBi PA34750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275021.
KOi K02928.
OMAi HICVDIC.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPL41. human.
GeneWikii 60S_ribosomal_protein_L41.
GenomeRNAii 6171.
NextBioi 23975.
PROi P62945.
SOURCEi Search...

Gene expression databases

Bgeei P62945.
CleanExi HS_RPL41.
Genevestigatori P62945.

Family and domain databases

InterProi IPR007836. Ribosomal_L41.
[Graphical view ]
Pfami PF05162. Ribosomal_L41. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41."
    Klaudiny J., von der Kammer H., Scheit K.H.
    Biochem. Biophys. Res. Commun. 187:901-906(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII."
    Lee J.-H., Kim J.-M., Kim M.-S., Lee Y.-T., Marshak D.R., Bae Y.-S.
    Biochem. Biophys. Res. Commun. 238:462-467(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Characterization of human ribosomal protein L41 genomic structure."
    Go H., Miyado K., Hasuwa H., Taniguchi S.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Prostate and Uterus.
  7. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL41_HUMAN
AccessioniPrimary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are multiple pseudogenes of this gene dispersed through the genome.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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