P62945 (RL41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L41

Alternative name(s):
HG12

Gene names

Name:

RPL41

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	25 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.
Sequence similarities	Belongs to the ribosomal protein L41e family.
Caution	There are multiple pseudogenes of this gene dispersed through the genome.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRNP	P04156	1	EBI-2116899,EBI-977302

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 25	25	60S ribosomal protein L41		PRO_0000198055

Sequences

	Sequence		Length	Mass (Da)
	P62945 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 9AD629C69ECC039E	FASTA	25	3,456
	10 20 MRAKWRKKRM RRLKRKRRKM RQRSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41." Klaudiny J., von der Kammer H., Scheit K.H. Biochem. Biophys. Res. Commun. 187:901-906(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[2]	"The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII." Lee J.-H., Kim J.-M., Kim M.-S., Lee Y.-T., Marshak D.R., Bae Y.-S. Biochem. Biophys. Res. Commun. 238:462-467(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Characterization of human ribosomal protein L41 genomic structure." Go H., Miyado K., Hasuwa H., Taniguchi S. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Prostate and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z12962 mRNA. Translation: CAA78306.1. AF026844 mRNA. Translation: AAB82715.1. AB010874 Genomic DNA. Translation: BAA31508.1. AL035562 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW96886.1. BC014383 mRNA. No translation available. BC017820 mRNA. No translation available. BC032611 mRNA. No translation available.
IPI	IPI00005147.
PIR	JQ1617.
RefSeq	NP_001030344.1. NM_001035267.1. NP_066927.1. NM_021104.1.
UniGene	Hs.112553. Hs.157160. Hs.356799. Hs.485899. Hs.632703. Hs.658436. Hs.660053.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P62945. 4 interactions.
STRING	9606.ENSP00000420821.
Polymorphism databases
DMDM	51702816.
Protocols and materials databases
DNASU	6171.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000501597; ENSP00000420821; ENSG00000229117. ENST00000546591; ENSP00000449026; ENSG00000229117.
GeneID	6171.
KEGG	hsa:6171.
UCSC	uc001sjn.3. human.
Organism-specific databases
CTD	6171.
GeneCards	GC12P056510.
H-InvDB	HIX0010716. HIX0041240.
HGNC	HGNC:10354. RPL41.
HPA	HPA053169.
MIM	613315. gene.
neXtProt	NX_P62945.
PharmGKB	PA34750.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275021.
KO	K02928.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	P62945.
CleanEx	HS_RPL41.
Genevestigator	P62945.
GermOnline	ENSG00000176534. Homo sapiens. ENSG00000179312. Homo sapiens. ENSG00000187938. Homo sapiens. ENSG00000196681. Homo sapiens.
Family and domain databases
InterPro	IPR007836. Ribosomal_L41. [Graphical view]
Pfam	PF05162. Ribosomal_L41. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL41. human.
GenomeRNAi	6171.
NextBio	23975.
SOURCE	Search...

Entry information

Entry name

RL41_HUMAN

Accession

Primary (citable) accession number: P62945
Secondary accession number(s): A6NG21, P28751

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.