Reviewed, UniProtKB/Swiss-Prot P62943 (FKB1A_RABIT)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1A
      Short name=PPIase FKBP1A
    EC=5.2.1.8
Alternative name(s):
    FK506-binding protein 1A
      Short name=FKBP-1A
    Rotamase
    Immunophilin FKBP12
      Short name=12 kDa FKBP
      Short name=FKBP-12

Gene names

Name:	FKBP1A
Synonyms:	FKBP1, FKBP12

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
PTM	Acetylation
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	terminal cisterna Ref.1 Inferred from direct assay. Source: UniProtKB
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.1 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 108	107	Peptidyl-prolyl cis-trans isomerase FKBP1A		PRO_0000075291
Regions
	Domain	20 – 108	89	PPIase FKBP-type
Amino acid modifications
	Modified residue	53	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62943-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 9CC8493C802540B4	FASTA	108	11,951
	10 20 30 40 50 60 MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW 70 80 90 100 EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

References

[1]	"FK506 binding protein associated with the calcium release channel (ryanodine receptor)." Jayaraman T., Brillantes A.M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., Marks A.R. J. Biol. Chem. 267:9474-9477(1992) [PubMed: 1374404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M89928 Genomic RNA. Translation: AAA31252.1.
PIR	A42657.
3D structure databases
SMR	P62943. Positions 2-108.
ModBase	Search...
Protein-protein interaction databases
STRING	P62943.
Phylogenomic databases
HOVERGEN	P62943.
Enzyme and pathway databases
BRENDA	5.2.1.8. 255.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	P62943.
DrugBank	DB01093. Dimethyl sulfoxide.

Entry information

Entry name

FKB1A_RABIT

Accession

Primary (citable) accession number: P62943
Secondary accession number(s): P20071, Q9H103, Q9H566

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)