P62943 (FKB1A_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Short name=PPIase FKBP1A
EC=5.2.1.8

Alternative name(s):
12 kDa FK506-binding protein
Short name=12 kDa FKBP
Short name=FKBP-12
FK506-binding protein 1A
Short name=FKBP-1A
Immunophilin FKBP12
Rotamase

Gene names

Name:	FKBP1A
Synonyms:	FKBP1, FKBP12

Organism

Oryctolagus cuniculus (Rabbit) [Complete proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP1A per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subunit structure	Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation By similarity. Interacts with ACVR1B and SMAD7 By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	microsome Inferred from direct assay. Source: AgBase terminal cisterna Inferred from direct assay Ref.1. Source: BHF-UCL
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction Ref.1. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 108	107	Peptidyl-prolyl cis-trans isomerase FKBP1A		PRO_0000075291
Regions
	Domain	20 – 108	89	PPIase FKBP-type
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	53	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62943 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 9CC8493C802540B4	FASTA	108	11,951
	10 20 30 40 50 60 MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW 70 80 90 100 EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

References

[1]	"FK506 binding protein associated with the calcium release channel (ryanodine receptor)." Jayaraman T., Brillantes A.M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., Marks A.R. J. Biol. Chem. 267:9474-9477(1992) [PubMed: 1374404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M89928 Genomic RNA. Translation: AAA31252.1.
PIR	A42657.
RefSeq	NP_001164597.1. NM_001171126.1.
UniGene	Ocu.7704.
3D structure databases
ProteinModelPortal	P62943.
SMR	P62943. Positions 2-108.
ModBase	Search...
Protein-protein interaction databases
STRING	P62943.
Proteomic databases
PRIDE	P62943.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100328942.
Organism-specific databases
CTD	2280.
Phylogenomic databases
eggNOG	maNOG20348.
HOVERGEN	HBG051623.
Family and domain databases
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P62943.
DrugBank	DB01093. Dimethyl sulfoxide.

Entry information

Entry name

FKB1A_RABIT

Accession

Primary (citable) accession number: P62943
Secondary accession number(s): P20071, Q9H103, Q9H566

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program