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Protein

F-box only protein 40

Gene

Fbxo40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri53 – 11462TRAF-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • muscle cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 40
Gene namesi
Name:Fbxo40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443753. Fbxo40.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710F-box only protein 40PRO_0000119939Add
BLAST

Proteomic databases

EPDiP62932.
PaxDbiP62932.
PeptideAtlasiP62932.
PRIDEiP62932.

PTM databases

iPTMnetiP62932.
PhosphoSiteiP62932.

Expressioni

Tissue specificityi

Expressed only in heart and skeletal muscle.1 Publication

Developmental stagei

During the development of skeletal muscle, can only be detected 2 weeks after birth.1 Publication

Gene expression databases

BgeeiP62932.
CleanExiMM_FBXO40.
ExpressionAtlasiP62932. baseline and differential.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075266.

Structurei

3D structure databases

ProteinModelPortaliP62932.
SMRiP62932. Positions 12-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini572 – 62655F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TRAF-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri53 – 11462TRAF-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEIY. Eukaryota.
ENOG410ZQ6P. LUCA.
HOVERGENiHBG100177.
InParanoidiP62932.
KOiK10315.
OMAiKNVHTDI.
OrthoDBiEOG71VSS1.
PhylomeDBiP62932.
TreeFamiTF343227.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 1 hit.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRARKPPPA LHRHCEGCFN RHCHVPVEPS VSCLVISCHL LCGATFHMCK
60 70 80 90 100
ESEHTLLCPL EQVPCLNSEY GCPLSMARHK LAKHLQVCPA SVVCCSMEWI
110 120 130 140 150
RWPNVDSETF LHENIMKETP SEECLDTALA LQDQKVLFRS LKMVELFPET
160 170 180 190 200
RDATEEEPDM NGDTSWEETG GAVGGVDARL APNSCLPATS RQMMELSQEE
210 220 230 240 250
RDALAKTKEG MDLDKFGKWE SMFSKEHAAS VLTGSLGKSE DKNGDVAGKE
260 270 280 290 300
QCSSNVRIGD AEGSAERRGP QESQKSQELP ATMEMTGLAP WQDGVLERLK
310 320 330 340 350
TAVDAKDYNM YLVHNGRMLI HFGQMPACTP KERDFVYGNL EAQEVKTVYT
360 370 380 390 400
FKIPVSYCGK RARLGDAMLK CRPSEHKAVD TSDLGISVED LPKSDLIKTT
410 420 430 440 450
LQCALERELK GHVISESRSI DGLFMDLATQ TYNFEPEQFS SETVLADLLG
460 470 480 490 500
TAQPGGLHVE LHSECVTRRH NKSSSAFTFT CNKFFRRDEF PLHFKNVHTD
510 520 530 540 550
IQSSLDGWFQ HRCPLAYLGC TFVQNHFRPP GQKAKVIYSQ ELKTFAIKPE
560 570 580 590 600
VAPELSEKWK SDHLSGRDGK SLNSLTSLPL EVLQYIAGFL DSISLSQLSQ
610 620 630 640 650
VSVLMRNICA TLLQERGMVL SQWKKKRYSH GGTSWKVHNQ IWQFSSLFSK
660 670 680 690 700
INSWEFNDVT SMSEHLKTCP FNIVERKTDP IRLTSMCQPQ EKARESLVST
710
FRARPRGRHF
Length:710
Mass (Da):79,951
Last modified:August 31, 2004 - v1
Checksum:i0315C62EBA9BFC45
GO

Sequence cautioni

The sequence AK036385 differs from that shown. Reason: Frameshift at position 77. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036385 mRNA. No translation available.
CCDSiCCDS37337.1.
RefSeqiNP_001032398.1. NM_001037321.1.
XP_006521944.1. XM_006521881.2.
XP_006521945.1. XM_006521882.2.
UniGeneiMm.211899.

Genome annotation databases

EnsembliENSMUST00000075869; ENSMUSP00000075266; ENSMUSG00000047746.
ENSMUST00000114806; ENSMUSP00000110454; ENSMUSG00000047746.
GeneIDi207215.
KEGGimmu:207215.
UCSCiuc007zdj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036385 mRNA. No translation available.
CCDSiCCDS37337.1.
RefSeqiNP_001032398.1. NM_001037321.1.
XP_006521944.1. XM_006521881.2.
XP_006521945.1. XM_006521882.2.
UniGeneiMm.211899.

3D structure databases

ProteinModelPortaliP62932.
SMRiP62932. Positions 12-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075266.

PTM databases

iPTMnetiP62932.
PhosphoSiteiP62932.

Proteomic databases

EPDiP62932.
PaxDbiP62932.
PeptideAtlasiP62932.
PRIDEiP62932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075869; ENSMUSP00000075266; ENSMUSG00000047746.
ENSMUST00000114806; ENSMUSP00000110454; ENSMUSG00000047746.
GeneIDi207215.
KEGGimmu:207215.
UCSCiuc007zdj.1. mouse.

Organism-specific databases

CTDi51725.
MGIiMGI:2443753. Fbxo40.

Phylogenomic databases

eggNOGiENOG410IEIY. Eukaryota.
ENOG410ZQ6P. LUCA.
HOVERGENiHBG100177.
InParanoidiP62932.
KOiK10315.
OMAiKNVHTDI.
OrthoDBiEOG71VSS1.
PhylomeDBiP62932.
TreeFamiTF343227.

Miscellaneous databases

PROiP62932.
SOURCEiSearch...

Gene expression databases

BgeeiP62932.
CleanExiMM_FBXO40.
ExpressionAtlasiP62932. baseline and differential.

Family and domain databases

Gene3Di3.90.890.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR031890. Fbxo30/Fbxo40.
IPR013323. SIAH-type.
IPR008974. TRAF-like.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR15933. PTHR15933. 1 hit.
PfamiPF15966. F-box_4. 1 hit.
PF15965. zf-TRAF_2. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.
  2. "FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy."
    Ye J., Zhang Y., Xu J., Zhang Q., Zhu D.
    Gene 404:53-60(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiFBX40_MOUSE
AccessioniPrimary (citable) accession number: P62932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.