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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex.

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding, rRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1
Gene namesi
Name:infA
Ordered Locus Names:BMEI1671
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000957541 – 72Translation initiation factor IF-1Add BLAST72

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.

Protein-protein interaction databases

STRINGi224914.BAWG_0558.

Structurei

3D structure databases

ProteinModelPortaliP62923.
SMRiP62923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72S1-likeAdd BLAST72

Sequence similaritiesi

Belongs to the IF-1 family.

Phylogenomic databases

eggNOGiENOG4105K9U. Bacteria.
COG0361. LUCA.
HOGENOMiHOG000221323.
KOiK02518.
OMAiAHVSGKM.

Family and domain databases

CDDicd04451. S1_IF1. 1 hit.
HAMAPiMF_00075. IF_1. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR006196. RNA-binding_domain_S1_IF1.
IPR022967. S1_dom.
IPR004368. TIF_IF1.
PANTHERiPTHR33370. PTHR33370. 1 hit.
PfamiView protein in Pfam
PF01176. eIF-1a. 1 hit.
SMARTiView protein in SMART
SM00316. S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00008. infA. 1 hit.
PROSITEiView protein in PROSITE
PS50832. S1_IF1_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

P62923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEEVLEFP GVVTELLPNA MFRVKLENEH EIIAHTAGRM RKNRIRVLAG
60 70
DKVLVEMTPY DLTKGRITYR FK
Length:72
Mass (Da):8,372
Last modified:August 31, 2004 - v1
Checksum:i67D1320EB09AE093
GO

Sequence cautioni

The sequence AAL52852 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52852.1. Different initiation.
PIRiAI3460.
RefSeqiWP_002965531.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52852; AAL52852; BMEI1671.
GeneIDi5380022.
KEGGibme:BMEI1671.
bmel:DK63_1819.
PATRICifig|224914.52.peg.1920.

Similar proteinsi

Entry informationi

Entry nameiIF1_BRUME
AccessioniPrimary (citable) accession number: P62923
Secondary accession number(s): Q8YF56, Q9ACA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families