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P62921

- GCSP_BRUME

UniProt

P62921 - GCSP_BRUME

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BMEII0561
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 932932Glycine dehydrogenase (decarboxylating)PRO_0000166909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei685 – 6851N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEII0561.

    Structurei

    3D structure databases

    ProteinModelPortaliP62921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiGTXELVA.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62921-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEFLPFVAR HIGPRHEDER AMLAALGLPS METLITQAVP ASIRLNRALN    50
    LPAALSEADA LAELGTIMGR NVVKKSFIGA GYHGVHTPPV IQRNLFENPA 100
    WYTAYTPYQS EISQGRLELL FHFQTLVAEL TGLPVACASL LDEATAVAEA 150
    IGVACRHHRD KRSRILLAGE LHPQTVDVVN TRAEPLGWEI ATGSDVDDNT 200
    AAIVVPWPDT RGVYGDFAKV IADAKAKGAL VIAVADPLAL TIMEAPARWG 250
    ADMAVGSMQR YGVPMGFGGP HAAYLAVSEA LTRIIPGRIV GQSVDAHGRA 300
    AYRLALQTRE QHIRRDKATS NICTAQALLA NMAAAFAIWH GPAGLQAIAT 350
    RVAALAARFA AALKAAGVEI AGESLFDTVT AKVPGKAAAI AAEADKGGRL 400
    IRIIDADTVG VTFDETSTEE DLTALASLFG AKLVGGDTVL VPGKERGEGF 450
    LTQEVFHSHR SETEMMRFLR RLADKDLALD RAMIPLGSCT MKLNAAAEMM 500
    PVSWNTVANL HPFAPAEQVQ GYAKMTSDLE AWLCEITGFA GVSLQPNAGS 550
    QGEYAGLMAI RHYHQARGQG HRNICLIPSS AHGTNPASAS MAGMSVVVVN 600
    CRPDGDIDID DLKAKAEKHR DNLAAFMITY PSTYGVFEEG IKAFCEIVHD 650
    NGGQVYFDGA NLNALVGLAR PADIGADVCH MNLHKTFCIP HGGGGPGVGP 700
    IGVAKHLVPY LPGHVEAGSE HAVAAAQFGS ASILVITWMY IRMMGGAGLK 750
    KATEAAILNA NYIAHRLKGV YPILYTGAHD RVAHECIVDT RVLKDSAGIT 800
    VEDVAKRLID YGFHAPTMSW PVAGTLMIEP TESEPKLEID RLCDAMIAIA 850
    GEAKKVADGV WPADDNPLAN APHTASDTLA TEWKHPYTRE EAVFPGGAFD 900
    PTAKYWPPVS RVDNVGGDRN LICSCPPVAA YG 932
    Length:932
    Mass (Da):99,240
    Last modified:August 31, 2004 - v1
    Checksum:iDE3FEFEA2FDCCC29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53803.1.
    PIRiAH3579.
    RefSeqiNP_541539.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53803; AAL53803; BMEII0561.
    GeneIDi1198333.
    KEGGibme:BMEII0561.
    PATRICi17799988. VBIBruMel146950_2328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53803.1 .
    PIRi AH3579.
    RefSeqi NP_541539.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali P62921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII0561.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53803 ; AAL53803 ; BMEII0561 .
    GeneIDi 1198333.
    KEGGi bme:BMEII0561.
    PATRICi 17799988. VBIBruMel146950_2328.

    Phylogenomic databases

    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi GTXELVA.
    OrthoDBi EOG6HMXDX.

    Miscellaneous databases

    PROi P62921.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiGCSP_BRUME
    AccessioniPrimary (citable) accession number: P62921
    Secondary accession number(s): Q93MS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3