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P62921

- GCSP_BRUME

UniProt

P62921 - GCSP_BRUME

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BMEII0561
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Glycine dehydrogenase (decarboxylating)PRO_0000166909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei685 – 6851N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0561.

Structurei

3D structure databases

ProteinModelPortaliP62921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239369.
KOiK00281.
OMAiGTXELVA.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

P62921-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEFLPFVAR HIGPRHEDER AMLAALGLPS METLITQAVP ASIRLNRALN
60 70 80 90 100
LPAALSEADA LAELGTIMGR NVVKKSFIGA GYHGVHTPPV IQRNLFENPA
110 120 130 140 150
WYTAYTPYQS EISQGRLELL FHFQTLVAEL TGLPVACASL LDEATAVAEA
160 170 180 190 200
IGVACRHHRD KRSRILLAGE LHPQTVDVVN TRAEPLGWEI ATGSDVDDNT
210 220 230 240 250
AAIVVPWPDT RGVYGDFAKV IADAKAKGAL VIAVADPLAL TIMEAPARWG
260 270 280 290 300
ADMAVGSMQR YGVPMGFGGP HAAYLAVSEA LTRIIPGRIV GQSVDAHGRA
310 320 330 340 350
AYRLALQTRE QHIRRDKATS NICTAQALLA NMAAAFAIWH GPAGLQAIAT
360 370 380 390 400
RVAALAARFA AALKAAGVEI AGESLFDTVT AKVPGKAAAI AAEADKGGRL
410 420 430 440 450
IRIIDADTVG VTFDETSTEE DLTALASLFG AKLVGGDTVL VPGKERGEGF
460 470 480 490 500
LTQEVFHSHR SETEMMRFLR RLADKDLALD RAMIPLGSCT MKLNAAAEMM
510 520 530 540 550
PVSWNTVANL HPFAPAEQVQ GYAKMTSDLE AWLCEITGFA GVSLQPNAGS
560 570 580 590 600
QGEYAGLMAI RHYHQARGQG HRNICLIPSS AHGTNPASAS MAGMSVVVVN
610 620 630 640 650
CRPDGDIDID DLKAKAEKHR DNLAAFMITY PSTYGVFEEG IKAFCEIVHD
660 670 680 690 700
NGGQVYFDGA NLNALVGLAR PADIGADVCH MNLHKTFCIP HGGGGPGVGP
710 720 730 740 750
IGVAKHLVPY LPGHVEAGSE HAVAAAQFGS ASILVITWMY IRMMGGAGLK
760 770 780 790 800
KATEAAILNA NYIAHRLKGV YPILYTGAHD RVAHECIVDT RVLKDSAGIT
810 820 830 840 850
VEDVAKRLID YGFHAPTMSW PVAGTLMIEP TESEPKLEID RLCDAMIAIA
860 870 880 890 900
GEAKKVADGV WPADDNPLAN APHTASDTLA TEWKHPYTRE EAVFPGGAFD
910 920 930
PTAKYWPPVS RVDNVGGDRN LICSCPPVAA YG
Length:932
Mass (Da):99,240
Last modified:August 31, 2004 - v1
Checksum:iDE3FEFEA2FDCCC29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53803.1.
PIRiAH3579.
RefSeqiNP_541539.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53803; AAL53803; BMEII0561.
GeneIDi1198333.
KEGGibme:BMEII0561.
PATRICi17799988. VBIBruMel146950_2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53803.1 .
PIRi AH3579.
RefSeqi NP_541539.1. NC_003318.1.

3D structure databases

ProteinModelPortali P62921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEII0561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53803 ; AAL53803 ; BMEII0561 .
GeneIDi 1198333.
KEGGi bme:BMEII0561.
PATRICi 17799988. VBIBruMel146950_2328.

Phylogenomic databases

HOGENOMi HOG000239369.
KOi K00281.
OMAi GTXELVA.
OrthoDBi EOG6HMXDX.

Miscellaneous databases

PROi P62921.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiGCSP_BRUME
AccessioniPrimary (citable) accession number: P62921
Secondary accession number(s): Q93MS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3