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Protein

60S ribosomal protein L8

Gene

Rpl8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: RGD
  • poly(A) RNA binding Source: Ensembl
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cellular response to nerve growth factor stimulus Source: RGD
  • cytoplasmic translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L8
Gene namesi
Name:Rpl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 3, Chromosome 7

Organism-specific databases

RGDi619827. Rpl8.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • focal adhesion Source: Ensembl
  • membrane Source: Ensembl
  • nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001297462 – 25760S ribosomal protein L8Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216(3S)-3-hydroxyhistidineBy similarity1

Post-translational modificationi

Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia.By similarity

Keywords - PTMi

Hydroxylation

Proteomic databases

PaxDbiP62919.
PRIDEiP62919.

PTM databases

iPTMnetiP62919.
PhosphoSitePlusiP62919.
SwissPalmiP62919.

Expressioni

Gene expression databases

BgeeiENSRNOG00000032635.
GenevisibleiP62919. RN.

Interactioni

Subunit structurei

Interacts with CRY1.By similarity

Protein-protein interaction databases

BioGridi247805. 1 interactor.
IntActiP62919. 2 interactors.
MINTiMINT-1857627.
STRINGi10116.ENSRNOP00000067080.

Structurei

3D structure databases

ProteinModelPortaliP62919.
SMRiP62919.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L2P family.Curated

Phylogenomic databases

eggNOGiKOG2309. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000009907.
HOGENOMiHOG000232983.
HOVERGENiHBG079431.
InParanoidiP62919.
KOiK02938.
OMAiHGYIKGV.
OrthoDBiEOG091G0K1G.
PhylomeDBiP62919.
TreeFamiTF300748.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_A. Ribosomal_L2_A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR023672. Ribosomal_L2_arc.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH
60 70 80 90 100
DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN
110 120 130 140 150
VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL
160 170 180 190 200
PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR
210 220 230 240 250
GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK

TVQEKEN
Length:257
Mass (Da):28,025
Last modified:January 23, 2007 - v2
Checksum:iCE1610449749318B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62145 mRNA. Translation: CAA44071.1.
BC126063 mRNA. Translation: AAI26064.1.
PIRiJU0177. R5RTL8.
RefSeqiNP_001030088.2. NM_001034916.2.
XP_002729189.1. XM_002729143.5.
XP_017450875.1. XM_017595386.1.
UniGeneiRn.127774.

Genome annotation databases

EnsembliENSRNOT00000041984; ENSRNOP00000046553; ENSRNOG00000032635.
ENSRNOT00000073724; ENSRNOP00000067080; ENSRNOG00000048523.
ENSRNOT00000075451; ENSRNOP00000064566; ENSRNOG00000048456.
GeneIDi100360117.
108348142.
26962.
KEGGirno:100360117.
rno:100910370.
rno:26962.
UCSCiRGD:619827. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62145 mRNA. Translation: CAA44071.1.
BC126063 mRNA. Translation: AAI26064.1.
PIRiJU0177. R5RTL8.
RefSeqiNP_001030088.2. NM_001034916.2.
XP_002729189.1. XM_002729143.5.
XP_017450875.1. XM_017595386.1.
UniGeneiRn.127774.

3D structure databases

ProteinModelPortaliP62919.
SMRiP62919.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247805. 1 interactor.
IntActiP62919. 2 interactors.
MINTiMINT-1857627.
STRINGi10116.ENSRNOP00000067080.

PTM databases

iPTMnetiP62919.
PhosphoSitePlusiP62919.
SwissPalmiP62919.

Proteomic databases

PaxDbiP62919.
PRIDEiP62919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000041984; ENSRNOP00000046553; ENSRNOG00000032635.
ENSRNOT00000073724; ENSRNOP00000067080; ENSRNOG00000048523.
ENSRNOT00000075451; ENSRNOP00000064566; ENSRNOG00000048456.
GeneIDi100360117.
108348142.
26962.
KEGGirno:100360117.
rno:100910370.
rno:26962.
UCSCiRGD:619827. rat.

Organism-specific databases

CTDi6132.
RGDi619827. Rpl8.

Phylogenomic databases

eggNOGiKOG2309. Eukaryota.
COG0090. LUCA.
GeneTreeiENSGT00390000009907.
HOGENOMiHOG000232983.
HOVERGENiHBG079431.
InParanoidiP62919.
KOiK02938.
OMAiHGYIKGV.
OrthoDBiEOG091G0K1G.
PhylomeDBiP62919.
TreeFamiTF300748.

Miscellaneous databases

PROiP62919.

Gene expression databases

BgeeiENSRNOG00000032635.
GenevisibleiP62919. RN.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
4.10.950.10. 1 hit.
HAMAPiMF_01320_A. Ribosomal_L2_A. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022666. Rbsml_prot_L2_RNA-bd_dom.
IPR014722. Rib_L2_dom2.
IPR002171. Ribosomal_L2.
IPR023672. Ribosomal_L2_arc.
IPR022669. Ribosomal_L2_C.
IPR022671. Ribosomal_L2_CS.
IPR014726. Ribosomal_L2_dom3.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR13691. PTHR13691. 1 hit.
PfamiPF00181. Ribosomal_L2. 1 hit.
PF03947. Ribosomal_L2_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002158. Ribosomal_L2. 1 hit.
SMARTiSM01383. Ribosomal_L2. 1 hit.
SM01382. Ribosomal_L2_C. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS00467. RIBOSOMAL_L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL8_RAT
AccessioniPrimary (citable) accession number: P62919
Secondary accession number(s): A0JMZ6, P25120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.