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Protein

60S ribosomal protein L8

Gene

Rpl8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

  • 5.8S rRNA binding Source: RGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cellular response to nerve growth factor stimulus Source: RGD
  • cytoplasmic translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L8
Gene namesi
Name:Rpl8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 3, Chromosome 7

Organism-specific databases

RGDi619827 Rpl8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001297461 – 25760S ribosomal protein L8Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei216(3S)-3-hydroxyhistidineBy similarity1
Cross-linki234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.By similarity

Keywords - PTMi

Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP62919
PRIDEiP62919

PTM databases

iPTMnetiP62919
PhosphoSitePlusiP62919
SwissPalmiP62919

Expressioni

Gene expression databases

BgeeiENSRNOG00000032635
GenevisibleiP62919 RN

Interactioni

Subunit structurei

Component of the large ribosomal subunit (By similarity). Interacts with CRY1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247805, 1 interactor
IntActiP62919, 3 interactors
STRINGi10116.ENSRNOP00000067080

Structurei

3D structure databases

ProteinModelPortaliP62919
SMRiP62919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2309 Eukaryota
COG0090 LUCA
GeneTreeiENSGT00390000009907
HOGENOMiHOG000232983
HOVERGENiHBG079431
InParanoidiP62919
KOiK02938
OMAiHGYIKGV
OrthoDBiEOG091G0K1G
PhylomeDBiP62919
TreeFamiTF300748

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_A Ribosomal_L2_A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR023672 Ribosomal_L2_arc
IPR022669 Ribosomal_L2_C
IPR022671 Ribosomal_L2_CS
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00467 RIBOSOMAL_L2, 1 hit

Sequencei

Sequence statusi: Complete.

P62919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH
60 70 80 90 100
DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN
110 120 130 140 150
VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL
160 170 180 190 200
PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR
210 220 230 240 250
GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK

TVQEKEN
Length:257
Mass (Da):28,025
Last modified:January 23, 2007 - v2
Checksum:iCE1610449749318B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62145 mRNA Translation: CAA44071.1
BC126063 mRNA Translation: AAI26064.1
PIRiJU0177 R5RTL8
RefSeqiNP_001030088.2, NM_001034916.2
XP_002729189.1, XM_002729143.5
XP_017450875.1, XM_017595386.1
UniGeneiRn.127774

Genome annotation databases

EnsembliENSRNOT00000041984; ENSRNOP00000046553; ENSRNOG00000032635
ENSRNOT00000073724; ENSRNOP00000067080; ENSRNOG00000048523
ENSRNOT00000075451; ENSRNOP00000064566; ENSRNOG00000048456
GeneIDi100360117
108348142
26962
KEGGirno:100360117
rno:108348142
rno:26962
UCSCiRGD:619827 rat

Similar proteinsi

Entry informationi

Entry nameiRL8_RAT
AccessioniPrimary (citable) accession number: P62919
Secondary accession number(s): A0JMZ6, P25120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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