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P62915

- TF2B_MOUSE

UniProt

P62915 - TF2B_MOUSE

Protein

Transcription initiation factor IIB

Gene

Gtf2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151ZincBy similarity
    Metal bindingi18 – 181ZincBy similarity
    Metal bindingi34 – 341ZincBy similarity
    Metal bindingi37 – 371ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter binding Source: MGI
    2. DNA binding Source: MGI
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIB
    Alternative name(s):
    General transcription factor TFIIB
    RNA polymerase II alpha initiation factor
    Gene namesi
    Name:Gtf2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2385191. Gtf2b.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Transcription initiation factor IIBPRO_0000119294Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP62915.
    PaxDbiP62915.
    PRIDEiP62915.

    PTM databases

    PhosphoSiteiP62915.

    Expressioni

    Gene expression databases

    ArrayExpressiP62915.
    BgeeiP62915.
    CleanExiMM_GTF2B.
    GenevestigatoriP62915.

    Interactioni

    Subunit structurei

    Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2 By similarity. Interacts with GPBP1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi230917. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP62915.
    SMRiP62915. Positions 2-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati124 – 200771Add
    BLAST
    Repeati218 – 294772Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108634.
    HOVERGENiHBG017914.
    InParanoidiP62915.
    KOiK03124.
    OMAiWRAFDHD.
    OrthoDBiEOG78WKS2.
    PhylomeDBiP62915.
    TreeFamiTF105953.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62915-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS    50
    EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK 100
    YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS 150
    LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK 200
    ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP 250
    ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 300
    PSDFKFDTPV DKLPQL 316
    Length:316
    Mass (Da):34,819
    Last modified:August 31, 2004 - v1
    Checksum:i9CC7E102526C21F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016637 mRNA. Translation: AAH16637.1.
    CCDSiCCDS17882.1.
    RefSeqiNP_663521.1. NM_145546.1.
    UniGeneiMm.271756.

    Genome annotation databases

    EnsembliENSMUST00000029938; ENSMUSP00000029938; ENSMUSG00000028271.
    GeneIDi229906.
    KEGGimmu:229906.
    UCSCiuc008rpb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016637 mRNA. Translation: AAH16637.1 .
    CCDSi CCDS17882.1.
    RefSeqi NP_663521.1. NM_145546.1.
    UniGenei Mm.271756.

    3D structure databases

    ProteinModelPortali P62915.
    SMRi P62915. Positions 2-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230917. 7 interactions.

    PTM databases

    PhosphoSitei P62915.

    Proteomic databases

    MaxQBi P62915.
    PaxDbi P62915.
    PRIDEi P62915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029938 ; ENSMUSP00000029938 ; ENSMUSG00000028271 .
    GeneIDi 229906.
    KEGGi mmu:229906.
    UCSCi uc008rpb.1. mouse.

    Organism-specific databases

    CTDi 2959.
    MGIi MGI:2385191. Gtf2b.

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108634.
    HOVERGENi HBG017914.
    InParanoidi P62915.
    KOi K03124.
    OMAi WRAFDHD.
    OrthoDBi EOG78WKS2.
    PhylomeDBi P62915.
    TreeFami TF105953.

    Miscellaneous databases

    NextBioi 379735.
    PROi P62915.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62915.
    Bgeei P62915.
    CleanExi MM_GTF2B.
    Genevestigatori P62915.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription."
      Hsu L.-C., Liu S., Abedinpour F., Beech R.D., Lahti J.M., Kidd V.J., Greenspan J.A., Yeung C.-Y.
      Mol. Cell. Biol. 23:8773-8785(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPBP1.

    Entry informationi

    Entry nameiTF2B_MOUSE
    AccessioniPrimary (citable) accession number: P62915
    Secondary accession number(s): P29053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3