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P62915 (TF2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription initiation factor IIB
Alternative name(s):
General transcription factor TFIIB
RNA polymerase II alpha initiation factor
Gene names
Name:Gtf2b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2 By similarity. Interacts with GPBP1. Ref.2

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TFIIB family.

Contains 1 TFIIB-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Transcription initiation factor IIB
PRO_0000119294

Regions

Repeat124 – 200771
Repeat218 – 294772
Zinc finger11 – 4232TFIIB-type

Sites

Metal binding151Zinc By similarity
Metal binding181Zinc By similarity
Metal binding341Zinc By similarity
Metal binding371Zinc By similarity

Amino acid modifications

Modified residue761Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62915 [UniParc].

Last modified August 31, 2004. Version 1.
Checksum: 9CC7E102526C21F9

FASTA31634,819
        10         20         30         40         50         60 
MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA 

        70         80         90        100        110        120 
TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE 

       130        140        150        160        170        180 
ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI 

       190        200        210        220        230        240 
CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV 

       250        260        270        280        290        300 
ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 

       310 
PSDFKFDTPV DKLPQL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription."
Hsu L.-C., Liu S., Abedinpour F., Beech R.D., Lahti J.M., Kidd V.J., Greenspan J.A., Yeung C.-Y.
Mol. Cell. Biol. 23:8773-8785(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GPBP1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016637 mRNA. Translation: AAH16637.1.
CCDSCCDS17882.1.
RefSeqNP_663521.1. NM_145546.1.
UniGeneMm.271756.

3D structure databases

ProteinModelPortalP62915.
SMRP62915. Positions 2-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid230917. 7 interactions.

PTM databases

PhosphoSiteP62915.

Proteomic databases

MaxQBP62915.
PaxDbP62915.
PRIDEP62915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029938; ENSMUSP00000029938; ENSMUSG00000028271.
GeneID229906.
KEGGmmu:229906.
UCSCuc008rpb.1. mouse.

Organism-specific databases

CTD2959.
MGIMGI:2385191. Gtf2b.

Phylogenomic databases

eggNOGCOG1405.
HOGENOMHOG000108634.
HOVERGENHBG017914.
InParanoidP62915.
KOK03124.
OMAWRAFDHD.
OrthoDBEOG78WKS2.
PhylomeDBP62915.
TreeFamTF105953.

Gene expression databases

ArrayExpressP62915.
BgeeP62915.
CleanExMM_GTF2B.
GenevestigatorP62915.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERPTHR11618. PTHR11618. 1 hit.
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSPR00685. TIFACTORIIB.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio379735.
PROP62915.
SOURCESearch...

Entry information

Entry nameTF2B_MOUSE
AccessionPrimary (citable) accession number: P62915
Secondary accession number(s): P29053
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot