SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P62913

- RL11_HUMAN

UniProt

P62913 - RL11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
60S ribosomal protein L11
Gene
RPL11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to 5S ribosomal RNA By similarity. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML By similarity.1 Publication

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. rRNA binding Source: UniProtKB-KW
  5. structural constituent of ribosome Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. gene expression Source: Reactome
  5. mRNA metabolic process Source: Reactome
  6. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  7. protein localization to nucleus Source: UniProtKB
  8. protein targeting Source: UniProtKB
  9. rRNA processing Source: UniProtKB
  10. ribosomal large subunit biogenesis Source: UniProtKB
  11. translation Source: UniProtKB
  12. translational elongation Source: Reactome
  13. translational initiation Source: Reactome
  14. translational termination Source: Reactome
  15. viral life cycle Source: Reactome
  16. viral process Source: Reactome
  17. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11
Alternative name(s):
CLL-associated antigen KW-12
Gene namesi
Name:RPL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10301. RPL11.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. cytosolic large ribosomal subunit Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 7 (DBA7) [MIM:612562]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201L → H in DBA7. 1 Publication
VAR_055448
Natural varianti161 – 1611Missing in DBA7. 1 Publication
VAR_055449

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

MIMi612562. phenotype.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 17817760S ribosomal protein L11
PRO_0000125082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine4 Publications
Modified residuei44 – 441Phosphothreonine1 Publication
Modified residuei52 – 521N6-acetyllysine1 Publication
Modified residuei85 – 851N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP62913.
PaxDbiP62913.
PRIDEiP62913.

2D gel databases

SWISS-2DPAGEP62913.

PTM databases

PhosphoSiteiP62913.

Miscellaneous databases

PMAP-CutDBP62913.

Expressioni

Gene expression databases

ArrayExpressiP62913.
BgeeiP62913.
CleanExiHS_RPL11.
GenevestigatoriP62913.

Organism-specific databases

HPAiHPA002734.

Interactioni

Subunit structurei

Interacts with PML and MDM2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q0098711EBI-354380,EBI-389668
MYCP011063EBI-354380,EBI-447544
NEDD8Q158434EBI-354380,EBI-716247

Protein-protein interaction databases

BioGridi112055. 138 interactions.
IntActiP62913. 32 interactions.
MINTiMINT-1140097.
STRINGi9606.ENSP00000363676.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00J1-178[»]
ProteinModelPortaliP62913.
SMRiP62913. Positions 9-176.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0094.
HOGENOMiHOG000231312.
HOVERGENiHBG055214.
InParanoidiP62913.
KOiK02868.
OMAiEDTMAWF.
OrthoDBiEOG7ZPNMB.
PhylomeDBiP62913.
TreeFamiTF300017.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view]
PANTHERiPTHR11994. PTHR11994. 1 hit.
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62913-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF    50
SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS 100
DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC 150
IGAKHRISKE EAMRWFQQKY DGIILPGK 178
Length:178
Mass (Da):20,252
Last modified:January 23, 2007 - v2
Checksum:i26EC965C9239774E
GO
Isoform 2 (identifier: P62913-2) [UniParc] [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-3: Missing.

Show »
Length:177
Mass (Da):20,124
Checksum:i534FC28B1D3CF195
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201L → H in DBA7. 1 Publication
VAR_055448
Natural varianti161 – 1611Missing in DBA7. 1 Publication
VAR_055449

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3 – 31Missing in isoform 2.
VSP_008320

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311D → G in CAA55816. 1 Publication
Sequence conflicti73 – 731T → A in CAA55816. 1 Publication
Sequence conflicti92 – 921Y → L in CAA55816. 1 Publication
Sequence conflicti118 – 1181K → E in CAA55816. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79234 mRNA. Translation: CAA55816.1.
L05092 mRNA. Translation: AAC15856.1.
AF101385 Genomic DNA. Translation: AAD20460.3.
BC018970 mRNA. Translation: AAH18970.1.
AF432212 mRNA. Translation: AAL99919.1.
AB007171 Genomic DNA. Translation: BAA25831.1.
CCDSiCCDS238.1.
PIRiS45049.
RefSeqiNP_000966.2. NM_000975.3. [P62913-1]
NP_001186731.1. NM_001199802.1. [P62913-2]
UniGeneiHs.719951.

Genome annotation databases

EnsembliENST00000374550; ENSP00000363676; ENSG00000142676. [P62913-1]
GeneIDi6135.
KEGGihsa:6135.
UCSCiuc001bhk.3. human.
uc001bhl.3. human. [P62913-2]

Polymorphism databases

DMDMi51702795.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79234 mRNA. Translation: CAA55816.1 .
L05092 mRNA. Translation: AAC15856.1 .
AF101385 Genomic DNA. Translation: AAD20460.3 .
BC018970 mRNA. Translation: AAH18970.1 .
AF432212 mRNA. Translation: AAL99919.1 .
AB007171 Genomic DNA. Translation: BAA25831.1 .
CCDSi CCDS238.1.
PIRi S45049.
RefSeqi NP_000966.2. NM_000975.3. [P62913-1 ]
NP_001186731.1. NM_001199802.1. [P62913-2 ]
UniGenei Hs.719951.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 J 1-178 [» ]
ProteinModelPortali P62913.
SMRi P62913. Positions 9-176.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112055. 138 interactions.
IntActi P62913. 32 interactions.
MINTi MINT-1140097.
STRINGi 9606.ENSP00000363676.

PTM databases

PhosphoSitei P62913.

Polymorphism databases

DMDMi 51702795.

2D gel databases

SWISS-2DPAGE P62913.

Proteomic databases

MaxQBi P62913.
PaxDbi P62913.
PRIDEi P62913.

Protocols and materials databases

DNASUi 6135.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374550 ; ENSP00000363676 ; ENSG00000142676 . [P62913-1 ]
GeneIDi 6135.
KEGGi hsa:6135.
UCSCi uc001bhk.3. human.
uc001bhl.3. human. [P62913-2 ]

Organism-specific databases

CTDi 6135.
GeneCardsi GC01P024018.
GeneReviewsi RPL11.
HGNCi HGNC:10301. RPL11.
HPAi HPA002734.
MIMi 604175. gene.
612562. phenotype.
neXtProti NX_P62913.
Orphaneti 124. Blackfan-Diamond anemia.
PharmGKBi PA34664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0094.
HOGENOMi HOG000231312.
HOVERGENi HBG055214.
InParanoidi P62913.
KOi K02868.
OMAi EDTMAWF.
OrthoDBi EOG7ZPNMB.
PhylomeDBi P62913.
TreeFami TF300017.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPL11. human.
GeneWikii RPL11.
GenomeRNAii 6135.
NextBioi 23831.
PMAP-CutDB P62913.
PROi P62913.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62913.
Bgeei P62913.
CleanExi HS_RPL11.
Genevestigatori P62913.

Family and domain databases

Gene3Di 3.30.1440.10. 1 hit.
InterProi IPR002132. Ribosomal_L5.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view ]
PANTHERi PTHR11994. PTHR11994. 1 hit.
Pfami PF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMi SSF55282. SSF55282. 1 hit.
PROSITEi PS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11."
    Mishin V.P., Filipenko M.L., Muravlev A.I., Karpova G.G., Mertvetsov N.P.
    Bioorg. Khim. 21:158-160(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Expressed sequence tags from a human cell line."
    Bhat K.S.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Structural and functional analysis of the human ribosomal protein L11 gene."
    Voronina E.N., Kolokol'tsova T.D., Nechaeva E.A., Filipenko M.L.
    Mol. Biol. (Mosk.) 37:425-435(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Tonsil.
  5. Quadroni M., Bienvenut W.V.
    Submitted (NOV-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 89-95; 119-145 AND 157-164, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  6. "Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches."
    Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-178 (ISOFORM 1).
  7. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-52.
  8. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
    Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
    J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
  9. Cited for: FUNCTION, VARIANT DBA7 GLU-161 DEL.
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-52 AND LYS-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
  16. "Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia."
    Cmejla R., Cmejlova J., Handrkova H., Petrak J., Petrtylova K., Mihal V., Stary J., Cerna Z., Jabali Y., Pospisilova D.
    Hum. Mutat. 30:321-327(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DBA7 HIS-20.

Entry informationi

Entry nameiRL11_HUMAN
AccessioniPrimary (citable) accession number: P62913
Secondary accession number(s): P25121
, P39026, Q8TDH2, Q9Y674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi