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Protein

60S ribosomal protein L32

Gene

RPL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L32
Alternative name(s):
Large ribosomal subunit protein eL321 Publication
Gene namesi
Name:RPL32
ORF Names:PP9932
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144713.12
HGNCiHGNC:10336 RPL32
neXtProtiNX_P62910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6161
OpenTargetsiENSG00000144713
PharmGKBiPA34719

Polymorphism and mutation databases

BioMutaiRPL32
DMDMi51702809

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001311132 – 13560S ribosomal protein L32Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei50N6-succinyllysineBy similarity1
Modified residuei62PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62910
MaxQBiP62910
PaxDbiP62910
PeptideAtlasiP62910
PRIDEiP62910
TopDownProteomicsiP62910

PTM databases

CarbonylDBiP62910
iPTMnetiP62910
PhosphoSitePlusiP62910
SwissPalmiP62910

Expressioni

Gene expression databases

BgeeiENSG00000144713
CleanExiHS_RPL32
ExpressionAtlasiP62910 baseline and differential
GenevisibleiP62910 HS

Organism-specific databases

HPAiHPA047501
HPA051994

Interactioni

Protein-protein interaction databases

BioGridi112080, 128 interactors
CORUMiP62910
IntActiP62910, 24 interactors
MINTiP62910
STRINGi9606.ENSP00000380156

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Le1-135[»]
4V6Xelectron microscopy5.00Ce1-135[»]
5AJ0electron microscopy3.50Ae1-135[»]
5LKSelectron microscopy3.60Le1-135[»]
5T2Celectron microscopy3.60Y1-135[»]
6EK0electron microscopy2.90Le1-135[»]
ProteinModelPortaliP62910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0878 Eukaryota
COG1717 LUCA
GeneTreeiENSGT00390000014729
HOGENOMiHOG000231288
HOVERGENiHBG056057
InParanoidiP62910
KOiK02912
PhylomeDBiP62910
TreeFamiTF314947

Family and domain databases

CDDicd00513 Ribosomal_L32_L32e, 1 hit
InterProiView protein in InterPro
IPR001515 Ribosomal_L32e
IPR018263 Ribosomal_L32e_CS
IPR036351 Ribosomal_L32e_sf
PANTHERiPTHR23413 PTHR23413, 1 hit
PfamiView protein in Pfam
PF01655 Ribosomal_L32e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003823 Ribosomal_L32e, 1 hit
SMARTiView protein in SMART
SM01393 Ribosomal_L32e, 1 hit
SUPFAMiSSF52042 SSF52042, 1 hit
PROSITEiView protein in PROSITE
PS00580 RIBOSOMAL_L32E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK
60 70 80 90 100
GQILMPNIGY GSNKKTKHML PSGFRKFLVH NVKELEVLLM CNKSYCAEIA
110 120 130
HNVSSKNRKA IVERAAQLAI RVTNPNARLR SEENE
Length:135
Mass (Da):15,860
Last modified:January 23, 2007 - v2
Checksum:iEDEE48446483966E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03342 mRNA Translation: CAA27048.1
AB061831 Genomic DNA Translation: BAB79469.1
AF370435 mRNA Translation: AAQ15271.1
AK311909 mRNA Translation: BAG34850.1
CH471055 Genomic DNA Translation: EAW64144.1
BC011514 mRNA Translation: AAH11514.1
BC070209 mRNA Translation: AAH70209.1
CCDSiCCDS2614.1
PIRiS11393 R5HU32
RefSeqiNP_000985.1, NM_000994.3
NP_001007074.1, NM_001007073.1
NP_001007075.1, NM_001007074.1
UniGeneiHs.265174

Genome annotation databases

EnsembliENST00000396953; ENSP00000380156; ENSG00000144713
ENST00000396957; ENSP00000380158; ENSG00000144713
ENST00000429711; ENSP00000416429; ENSG00000144713
ENST00000435983; ENSP00000388674; ENSG00000144713
GeneIDi6161
KEGGihsa:6161
UCSCiuc003bxl.4 human

Similar proteinsi

Entry informationi

Entry nameiRL32_HUMAN
AccessioniPrimary (citable) accession number: P62910
Secondary accession number(s): B2R4Q3, P02433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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