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P62910

- RL32_HUMAN

UniProt

P62910 - RL32_HUMAN

Protein

60S ribosomal protein L32

Gene

RPL32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. RNA metabolic process Source: Reactome
    6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    7. translation Source: UniProtKB
    8. translational elongation Source: Reactome
    9. translational initiation Source: Reactome
    10. translational termination Source: Reactome
    11. viral life cycle Source: Reactome
    12. viral process Source: Reactome
    13. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L32
    Gene namesi
    Name:RPL32
    ORF Names:PP9932
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10336. RPL32.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic large ribosomal subunit Source: UniProtKB
    3. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34719.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 13513460S ribosomal protein L32PRO_0000131113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiP62910.
    PaxDbiP62910.
    PRIDEiP62910.

    PTM databases

    PhosphoSiteiP62910.

    Expressioni

    Gene expression databases

    ArrayExpressiP62910.
    BgeeiP62910.
    CleanExiHS_RPL32.
    GenevestigatoriP62910.

    Organism-specific databases

    HPAiHPA047501.
    HPA051994.

    Interactioni

    Protein-protein interaction databases

    BioGridi112080. 55 interactions.
    IntActiP62910. 6 interactions.
    MINTiMINT-1149317.
    STRINGi9606.ENSP00000380156.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00e1-135[»]
    ProteinModelPortaliP62910.
    SMRiP62910. Positions 1-133.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L32e family.Curated

    Phylogenomic databases

    eggNOGiCOG1717.
    HOGENOMiHOG000231288.
    HOVERGENiHBG056057.
    InParanoidiP62910.
    KOiK02912.
    OrthoDBiEOG779P0S.
    PhylomeDBiP62910.
    TreeFamiTF314947.

    Family and domain databases

    InterProiIPR001515. Ribosomal_L32e.
    IPR018263. Ribosomal_L32e_CS.
    [Graphical view]
    PfamiPF01655. Ribosomal_L32e. 1 hit.
    [Graphical view]
    ProDomiPD003823. Ribosomal_L32e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF52042. SSF52042. 1 hit.
    PROSITEiPS00580. RIBOSOMAL_L32E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALRPLVKP KIVKKRTKKF IRHQSDRYVK IKRNWRKPRG IDNRVRRRFK    50
    GQILMPNIGY GSNKKTKHML PSGFRKFLVH NVKELEVLLM CNKSYCAEIA 100
    HNVSSKNRKA IVERAAQLAI RVTNPNARLR SEENE 135
    Length:135
    Mass (Da):15,860
    Last modified:January 23, 2007 - v2
    Checksum:iEDEE48446483966E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03342 mRNA. Translation: CAA27048.1.
    AB061831 Genomic DNA. Translation: BAB79469.1.
    AF370435 mRNA. Translation: AAQ15271.1.
    AK311909 mRNA. Translation: BAG34850.1.
    CH471055 Genomic DNA. Translation: EAW64144.1.
    BC011514 mRNA. Translation: AAH11514.1.
    BC070209 mRNA. Translation: AAH70209.1.
    CCDSiCCDS2614.1.
    PIRiS11393. R5HU32.
    RefSeqiNP_000985.1. NM_000994.3.
    NP_001007074.1. NM_001007073.1.
    NP_001007075.1. NM_001007074.1.
    UniGeneiHs.265174.

    Genome annotation databases

    EnsembliENST00000396953; ENSP00000380156; ENSG00000144713.
    ENST00000396957; ENSP00000380158; ENSG00000144713.
    ENST00000429711; ENSP00000416429; ENSG00000144713.
    ENST00000435983; ENSP00000388674; ENSG00000144713.
    GeneIDi6161.
    KEGGihsa:6161.
    UCSCiuc003bxl.3. human.

    Polymorphism databases

    DMDMi51702809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03342 mRNA. Translation: CAA27048.1 .
    AB061831 Genomic DNA. Translation: BAB79469.1 .
    AF370435 mRNA. Translation: AAQ15271.1 .
    AK311909 mRNA. Translation: BAG34850.1 .
    CH471055 Genomic DNA. Translation: EAW64144.1 .
    BC011514 mRNA. Translation: AAH11514.1 .
    BC070209 mRNA. Translation: AAH70209.1 .
    CCDSi CCDS2614.1.
    PIRi S11393. R5HU32.
    RefSeqi NP_000985.1. NM_000994.3.
    NP_001007074.1. NM_001007073.1.
    NP_001007075.1. NM_001007074.1.
    UniGenei Hs.265174.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 e 1-135 [» ]
    ProteinModelPortali P62910.
    SMRi P62910. Positions 1-133.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112080. 55 interactions.
    IntActi P62910. 6 interactions.
    MINTi MINT-1149317.
    STRINGi 9606.ENSP00000380156.

    PTM databases

    PhosphoSitei P62910.

    Polymorphism databases

    DMDMi 51702809.

    Proteomic databases

    MaxQBi P62910.
    PaxDbi P62910.
    PRIDEi P62910.

    Protocols and materials databases

    DNASUi 6161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396953 ; ENSP00000380156 ; ENSG00000144713 .
    ENST00000396957 ; ENSP00000380158 ; ENSG00000144713 .
    ENST00000429711 ; ENSP00000416429 ; ENSG00000144713 .
    ENST00000435983 ; ENSP00000388674 ; ENSG00000144713 .
    GeneIDi 6161.
    KEGGi hsa:6161.
    UCSCi uc003bxl.3. human.

    Organism-specific databases

    CTDi 6161.
    GeneCardsi GC03M012876.
    HGNCi HGNC:10336. RPL32.
    HPAi HPA047501.
    HPA051994.
    neXtProti NX_P62910.
    PharmGKBi PA34719.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1717.
    HOGENOMi HOG000231288.
    HOVERGENi HBG056057.
    InParanoidi P62910.
    KOi K02912.
    OrthoDBi EOG779P0S.
    PhylomeDBi P62910.
    TreeFami TF314947.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL32. human.
    GeneWikii RPL32.
    GenomeRNAii 6161.
    NextBioi 23931.
    PROi P62910.

    Gene expression databases

    ArrayExpressi P62910.
    Bgeei P62910.
    CleanExi HS_RPL32.
    Genevestigatori P62910.

    Family and domain databases

    InterProi IPR001515. Ribosomal_L32e.
    IPR018263. Ribosomal_L32e_CS.
    [Graphical view ]
    Pfami PF01655. Ribosomal_L32e. 1 hit.
    [Graphical view ]
    ProDomi PD003823. Ribosomal_L32e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF52042. SSF52042. 1 hit.
    PROSITEi PS00580. RIBOSOMAL_L32E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family."
      Young J.A.T., Trowsdale J.
      Nucleic Acids Res. 13:8883-8891(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes."
      Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.
      Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    7. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-11; 84-93 AND 115-121, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRL32_HUMAN
    AccessioniPrimary (citable) accession number: P62910
    Secondary accession number(s): B2R4Q3, P02433
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3