P62909 (RS3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S3

Gene names

Name:

Rps3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs By similarity.
Subcellular location	Cytoplasm By similarity. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs By similarity.
Sequence similarities	Belongs to the ribosomal protein S3P family. Contains 1 KH type-2 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred by curator PubMed 12876473. Source: RGD
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 12876473PubMed 2328735PubMed 947902. Source: RGD dendrite Inferred from direct assay PubMed 12876473. Source: RGD endomembrane system Inferred from direct assay PubMed 12876473. Source: RGD
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred by curator PubMed 12876473. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 243	242	40S ribosomal protein S3		PRO_0000130322
Regions
	Domain	21 – 92	72	KH type-2
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	62	1	N6-acetyllysine By similarity
	Modified residue	221	1	Phosphothreonine By similarity
	Modified residue	224	1	Phosphoserine By similarity
	Modified residue	242	1	Phosphothreonine By similarity
	Cross-link	90		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	202		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P62909 [UniParc]. Last modified August 31, 2004. Version 1. Checksum: 6B9BB34FDEE04AAF	FASTA	243	26,674
	10 20 30 40 50 60 MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG 70 80 90 100 110 120 EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY 130 140 150 160 170 180 GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG 190 200 210 220 230 240 VLGIKVKIML PWDPSGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV PTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of rat ribosomal protein S3." Devi K.R.G., Chan Y.-L., Wool I.G. Arch. Biochem. Biophys. 283:546-550(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 158-172. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51536 mRNA. Translation: CAA35916.1. BC088450 mRNA. Translation: AAH88450.1.
IPI	IPI00212776.
PIR	R3RT3. S13882.
RefSeq	NP_001009239.1. NM_001009239.1.
UniGene	Rn.127805.
3D structure databases
ProteinModelPortal	P62909.
SMR	P62909. Positions 2-193.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62909. 2 interactions.
PTM databases
PhosphoSite	P62909.
Proteomic databases
PaxDb	P62909.
PRIDE	P62909.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023935; ENSRNOP00000023935; ENSRNOG00000017418.
GeneID	140654.
KEGG	rno:140654.
UCSC	RGD:619888. rat.
Organism-specific databases
CTD	6188.
RGD	619888. Rps3.
Phylogenomic databases
eggNOG	COG0092.
GeneTree	ENSGT00390000008610.
HOGENOM	HOG000210611.
HOVERGEN	HBG002195.
InParanoid	P62909.
KO	K02985.
OMA	CNDYVET.
OrthoDB	EOG4GXFNJ.
Gene expression databases
Genevestigator	P62909.
GermOnline	ENSRNOG00000017418. Rattus norvegicus.
Family and domain databases
Gene3D	3.30.1140.32. 1 hit. 3.30.300.20. 1 hit.
InterPro	IPR004087. KH_dom. IPR015946. KH_dom-like_a/b. IPR004044. KH_dom_type_2. IPR009019. KH_prok-type. IPR001351. Ribosomal_S3_C. IPR018280. Ribosomal_S3_CS. IPR005703. Ribosomal_S3_euk/arc. [Graphical view]
Pfam	PF07650. KH_2. 1 hit. PF00189. Ribosomal_S3_C. 1 hit. [Graphical view]
SMART	SM00322. KH. 1 hit. [Graphical view]
SUPFAM	SSF54814. KH_prok. 1 hit. SSF54821. Ribosomal_S3_C. 1 hit.
TIGRFAMs	TIGR01008. rpsC_E_A. 1 hit.
PROSITE	PS50823. KH_TYPE_2. 1 hit. PS00548. RIBOSOMAL_S3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	304983.

Entry information

Entry name

RS3_RAT

Accession

Primary (citable) accession number: P62909
Secondary accession number(s): P17073, P47933

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program