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Protein

60S ribosomal protein L10a

Gene

Rpl10a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • maturation of LSU-rRNA Source: GO_Central
  • response to ethanol Source: RGD
  • translation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10a
Gene namesi
Name:Rpl10a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620497. Rpl10a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 21721660S ribosomal protein L10aPRO_0000125822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111PhosphotyrosineBy similarity
Modified residuei91 – 911N6-acetyllysineBy similarity
Modified residuei106 – 1061N6-acetyllysineBy similarity
Modified residuei118 – 1181N6-acetyllysine; alternateBy similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62907.
PRIDEiP62907.

PTM databases

iPTMnetiP62907.
PhosphoSiteiP62907.

Expressioni

Gene expression databases

GenevisibleiP62907. RN.

Interactioni

Protein-protein interaction databases

IntActiP62907. 1 interaction.
MINTiMINT-4576640.
STRINGi10116.ENSRNOP00000000603.

Structurei

3D structure databases

ProteinModelPortaliP62907.
SMRiP62907. Positions 5-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L1P family.Curated

Phylogenomic databases

eggNOGiKOG1570. Eukaryota.
COG0081. LUCA.
GeneTreeiENSGT00390000008767.
HOGENOMiHOG000207014.
HOVERGENiHBG055239.
InParanoidiP62907.
KOiK02865.
OMAiDFFIAQA.
OrthoDBiEOG7S7SG8.
PhylomeDBiP62907.
TreeFamiTF300791.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS
60 70 80 90 100
GTVRLKSTPR PKFSVCVLGD QQHCDEAKAV DIPHMDIEAL KKLNKNKKLV
110 120 130 140 150
KKLAKKYDAF LASESLIKQI PRILGPGLNK AGKFPSLLTH NENMVAKVDE
160 170 180 190 200
VKSTIKFQMK KVLCLAVAVG HVKMTDDELV YNIHLAVNFL VSLLKKNWQN
210
VRALYIKSTM GKPQRLY
Length:217
Mass (Da):24,831
Last modified:January 23, 2007 - v2
Checksum:i38F1A31119A751D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93352 mRNA. Translation: CAA63732.1.
BC058468 mRNA. Translation: AAH58468.1.
PIRiJC4677.
RefSeqiNP_112327.1. NM_031065.1.
UniGeneiRn.161731.
Rn.2262.

Genome annotation databases

EnsembliENSRNOT00000000603; ENSRNOP00000000603; ENSRNOG00000000505.
GeneIDi81729.
KEGGirno:81729.
UCSCiRGD:620497. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93352 mRNA. Translation: CAA63732.1.
BC058468 mRNA. Translation: AAH58468.1.
PIRiJC4677.
RefSeqiNP_112327.1. NM_031065.1.
UniGeneiRn.161731.
Rn.2262.

3D structure databases

ProteinModelPortaliP62907.
SMRiP62907. Positions 5-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62907. 1 interaction.
MINTiMINT-4576640.
STRINGi10116.ENSRNOP00000000603.

PTM databases

iPTMnetiP62907.
PhosphoSiteiP62907.

Proteomic databases

PaxDbiP62907.
PRIDEiP62907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000603; ENSRNOP00000000603; ENSRNOG00000000505.
GeneIDi81729.
KEGGirno:81729.
UCSCiRGD:620497. rat.

Organism-specific databases

CTDi4736.
RGDi620497. Rpl10a.

Phylogenomic databases

eggNOGiKOG1570. Eukaryota.
COG0081. LUCA.
GeneTreeiENSGT00390000008767.
HOGENOMiHOG000207014.
HOVERGENiHBG055239.
InParanoidiP62907.
KOiK02865.
OMAiDFFIAQA.
OrthoDBiEOG7S7SG8.
PhylomeDBiP62907.
TreeFamiTF300791.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62907.

Gene expression databases

GenevisibleiP62907. RN.

Family and domain databases

Gene3Di3.30.190.20. 2 hits.
3.40.50.790. 1 hit.
InterProiIPR002143. Ribosomal_L1.
IPR023674. Ribosomal_L1-like.
IPR028364. Ribosomal_L1/biogenesis.
IPR016094. Ribosomal_L1_2-a/b-sand.
IPR016095. Ribosomal_L1_3-a/b-sand.
IPR023673. Ribosomal_L1_CS.
[Graphical view]
PfamiPF00687. Ribosomal_L1. 1 hit.
[Graphical view]
PIRSFiPIRSF002155. Ribosomal_L1. 1 hit.
SUPFAMiSSF56808. SSF56808. 1 hit.
PROSITEiPS01199. RIBOSOMAL_L1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein L10a."
    Olvera J., Wool I.G.
    Biochem. Biophys. Res. Commun. 220:954-957(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 199-213.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiRL10A_RAT
AccessioniPrimary (citable) accession number: P62907
Secondary accession number(s): P52859, P53025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.